| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F S Hall, G W Fong, S Ghaed, A Per. Locomotor-stimulating effects of indirect dopamine agonists are attenuated in Fawn hooded rats independent of postweaning social experience. Pharmacology, biochemistry, and behavior. vol 69. issue 3-4. 2001-12-04. PMID:11509212. |
the effects of the indirect dopamine (da) agonists cocaine and d-amphetamine on locomotor activity were examined in fawn hooded (fh) rats and wistar rats. |
2001-12-04 |
2023-08-12 |
rat |
| D L Dow-Edwards, Y Busida. Behavioral responses to dopamine agonists in adult rats exposed to cocaine during the preweaning period. Pharmacology, biochemistry, and behavior. vol 70. issue 1. 2001-12-04. PMID:11566139. |
behavioral responses to dopamine agonists in adult rats exposed to cocaine during the preweaning period. |
2001-12-04 |
2023-08-12 |
rat |
| D L Dow-Edwards, Y Busida. Behavioral responses to dopamine agonists in adult rats exposed to cocaine during the preweaning period. Pharmacology, biochemistry, and behavior. vol 70. issue 1. 2001-12-04. PMID:11566139. |
in order to determine whether developmental cocaine exposure altered the functional responses of dopamine systems, the behavioral responses to selective d1 or d2/d3 agonists were examined and compared to rats treated during the same period with a selective inhibitor of the dopamine transporter, gbr 12909. |
2001-12-04 |
2023-08-12 |
rat |
| D L Dow-Edwards, Y Busida. Behavioral responses to dopamine agonists in adult rats exposed to cocaine during the preweaning period. Pharmacology, biochemistry, and behavior. vol 70. issue 1. 2001-12-04. PMID:11566139. |
these results suggest that intermittent inhibition of the dopamine transporter with either cocaine or gbr during pnd 11-20 produces long-term alterations in the functional responses of dopaminergic systems but that the neural substrates for these effects depend upon the sex of the animal. |
2001-12-04 |
2023-08-12 |
rat |
| J D Elsworth, B A Morrow, R H Rot. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse (New York, N.Y.). vol 42. issue 2. 2001-12-04. PMID:11574943. |
prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. |
2001-12-04 |
2023-08-12 |
rat |
| J D Elsworth, B A Morrow, R H Rot. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse (New York, N.Y.). vol 42. issue 2. 2001-12-04. PMID:11574943. |
we have been able to reproduce short-term memory deficits in our rat intravenous model of prenatal cocaine exposure, and as short-term memory is dependent on the function of dopamine neurons innervating the medial prefrontal cortex, we hypothesized that prenatal cocaine induces a dysfunction in the regulation of this pathway. |
2001-12-04 |
2023-08-12 |
rat |
| J D Elsworth, B A Morrow, R H Rot. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse (New York, N.Y.). vol 42. issue 2. 2001-12-04. PMID:11574943. |
here we report that mild footshock stress, which preferentially activates the mesoprefrontal dopamine system, leads to an enhanced increase in dopamine turnover in the ventromedial prefrontal cortex of adolescent (postnatal day 35-37) rats exposed to cocaine in utero, suggesting that the dopamine neurons innervating this region are hyperresponsive in these rats. |
2001-12-04 |
2023-08-12 |
rat |
| C N Haile, T A Koste. Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats. The Journal of pharmacology and experimental therapeutics. vol 299. issue 2. 2001-12-04. PMID:11602661. |
the dopamine agonists had differential effects on cocaine self-administration in the strains. |
2001-12-04 |
2023-08-12 |
rat |
| D M Platt, J K Rowlett, R D Spealma. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 299. issue 2. 2001-12-04. PMID:11602692. |
in contrast, the delta-agonist snc 80, the kappa-agonist spiradoline, and the dopamine uptake blockers/releasers cocaine, methamphetamine, and gbr 12909 did not engender heroin-like ds effects regardless of dose. |
2001-12-04 |
2023-08-12 |
monkey |
| T F el-Moselhy, K S Avor, G P Basmadjia. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie. vol 334. issue 8-9. 2001-12-04. PMID:11688137. |
2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. |
2001-12-04 |
2023-08-12 |
Not clear |
| T F el-Moselhy, K S Avor, G P Basmadjia. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie. vol 334. issue 8-9. 2001-12-04. PMID:11688137. |
a series of 2'-substituted cocaine analogs (4-8) was prepared and evaluated in an in vitro dopamine transporter (dat) binding assay. |
2001-12-04 |
2023-08-12 |
Not clear |
| P E Molina, N Ahmed, J Gatley, N D Volkow, N N Abumra. L-tryptophan attenuation of the dopaminergic and behavioral responses to cocaine. Life sciences. vol 69. issue 16. 2001-12-04. PMID:11693270. |
cocaine increased nucleus accumbens microdialysate dopamine levels (500% at 30 min). |
2001-12-04 |
2023-08-12 |
rat |
| A L Chausmer, J L Kat. The role of D2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice. Psychopharmacology. vol 155. issue 1. 2001-10-25. PMID:11374338. |
the role of d2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice. |
2001-10-25 |
2023-08-12 |
mouse |
| T P Su, T Hayash. Cocaine affects the dynamics of cytoskeletal proteins via sigma(1) receptors. Trends in pharmacological sciences. vol 22. issue 9. 2001-10-25. PMID:11543872. |
furthermore, cocaine might increase [ca(2+)](i) via phospholipase c (plc)-linked dopamine d1 receptors. |
2001-10-25 |
2023-08-12 |
Not clear |
| A Gjedd. [Receptor mapping in living human beings by means of positron emission tomography]. Ugeskrift for laeger. vol 163. issue 38. 2001-10-25. PMID:11577527. |
pet has revealed loss of dopaminergic terminals and dopamine synthetic capacity in parkinson's disease, mptp intoxication, and lesch-nyhan's syndrome; release of dopamine after administration of cocaine and amphetamine, and in motor activity and cognition; increased synaptic dopamine and release of dopamine, and the 70-90% neuroleptic occupancy of dopamine receptors in the striatum, in patients with schizophrenia; loss of muscarinic and nicotinergic receptors in alzheimer's disease, and benzodiazepine and opiate receptors in stroke, epilepsy, and huntington's chorea; altered opiate receptors in chronic pain and drug abuse; and release of opiates in analgesia; but changes in serotonin synthesis, transport, and binding in affective or psychotic disorders remain elusive. |
2001-10-25 |
2023-08-12 |
human |
| S G Holtzma. Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. Psychopharmacology. vol 155. issue 2. 2001-10-18. PMID:11401007. |
differential interaction of gbr 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. |
2001-10-18 |
2023-08-12 |
rat |
| S G Holtzma. Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. Psychopharmacology. vol 155. issue 2. 2001-10-18. PMID:11401007. |
inhibitors of neuronal dopamine uptake, such as gbr 12909, decrease iv cocaine self-administration by laboratory animals and have been proposed as potential therapeutic agents for abuse of psychomotor stimulant drugs. |
2001-10-18 |
2023-08-12 |
rat |
| S R Tella, S R Goldber. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371002. |
in addition to inhibiting the dopamine transporter, cocaine affects a variety of other neurotransmitter systems. |
2001-10-11 |
2023-08-12 |
rat |
| S R Tella, S R Goldber. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371002. |
the sodium channel blocker, dimethocaine which has a relatively high affinity for the dopamine transporter fully generalized to the cocaine stimulus in both groups of rats, while procaine which has a low affinity for the dopamine transporters only partially generalized to the cocaine-training stimulus in both groups of rats 5. |
2001-10-11 |
2023-08-12 |
rat |
| S R Tella, S R Goldber. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371002. |
the findings suggest similarities as well as subtle, but important, differences between the discriminative stimulus effects of cocaine and the dopamine uptake inhibitors, gbr-12909 and gbr12935. |
2001-10-11 |
2023-08-12 |
rat |