| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D M Platt, J K Rowlett, R D Spealma. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 299. issue 2. 2001-12-04. PMID:11602692. |
in contrast, the delta-agonist snc 80, the kappa-agonist spiradoline, and the dopamine uptake blockers/releasers cocaine, methamphetamine, and gbr 12909 did not engender heroin-like ds effects regardless of dose. |
2001-12-04 |
2023-08-12 |
monkey |
| T F el-Moselhy, K S Avor, G P Basmadjia. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie. vol 334. issue 8-9. 2001-12-04. PMID:11688137. |
2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. |
2001-12-04 |
2023-08-12 |
Not clear |
| T F el-Moselhy, K S Avor, G P Basmadjia. 2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies. Archiv der Pharmazie. vol 334. issue 8-9. 2001-12-04. PMID:11688137. |
a series of 2'-substituted cocaine analogs (4-8) was prepared and evaluated in an in vitro dopamine transporter (dat) binding assay. |
2001-12-04 |
2023-08-12 |
Not clear |
| P E Molina, N Ahmed, J Gatley, N D Volkow, N N Abumra. L-tryptophan attenuation of the dopaminergic and behavioral responses to cocaine. Life sciences. vol 69. issue 16. 2001-12-04. PMID:11693270. |
cocaine increased nucleus accumbens microdialysate dopamine levels (500% at 30 min). |
2001-12-04 |
2023-08-12 |
rat |
| A L Chausmer, J L Kat. The role of D2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice. Psychopharmacology. vol 155. issue 1. 2001-10-25. PMID:11374338. |
the role of d2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice. |
2001-10-25 |
2023-08-12 |
mouse |
| T P Su, T Hayash. Cocaine affects the dynamics of cytoskeletal proteins via sigma(1) receptors. Trends in pharmacological sciences. vol 22. issue 9. 2001-10-25. PMID:11543872. |
furthermore, cocaine might increase [ca(2+)](i) via phospholipase c (plc)-linked dopamine d1 receptors. |
2001-10-25 |
2023-08-12 |
Not clear |
| A Gjedd. [Receptor mapping in living human beings by means of positron emission tomography]. Ugeskrift for laeger. vol 163. issue 38. 2001-10-25. PMID:11577527. |
pet has revealed loss of dopaminergic terminals and dopamine synthetic capacity in parkinson's disease, mptp intoxication, and lesch-nyhan's syndrome; release of dopamine after administration of cocaine and amphetamine, and in motor activity and cognition; increased synaptic dopamine and release of dopamine, and the 70-90% neuroleptic occupancy of dopamine receptors in the striatum, in patients with schizophrenia; loss of muscarinic and nicotinergic receptors in alzheimer's disease, and benzodiazepine and opiate receptors in stroke, epilepsy, and huntington's chorea; altered opiate receptors in chronic pain and drug abuse; and release of opiates in analgesia; but changes in serotonin synthesis, transport, and binding in affective or psychotic disorders remain elusive. |
2001-10-25 |
2023-08-12 |
human |
| S G Holtzma. Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. Psychopharmacology. vol 155. issue 2. 2001-10-18. PMID:11401007. |
differential interaction of gbr 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. |
2001-10-18 |
2023-08-12 |
rat |
| S G Holtzma. Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. Psychopharmacology. vol 155. issue 2. 2001-10-18. PMID:11401007. |
inhibitors of neuronal dopamine uptake, such as gbr 12909, decrease iv cocaine self-administration by laboratory animals and have been proposed as potential therapeutic agents for abuse of psychomotor stimulant drugs. |
2001-10-18 |
2023-08-12 |
rat |
| S R Tella, S R Goldber. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371002. |
in addition to inhibiting the dopamine transporter, cocaine affects a variety of other neurotransmitter systems. |
2001-10-11 |
2023-08-12 |
rat |
| S R Tella, S R Goldber. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371002. |
the sodium channel blocker, dimethocaine which has a relatively high affinity for the dopamine transporter fully generalized to the cocaine stimulus in both groups of rats, while procaine which has a low affinity for the dopamine transporters only partially generalized to the cocaine-training stimulus in both groups of rats 5. |
2001-10-11 |
2023-08-12 |
rat |
| S R Tella, S R Goldber. Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371002. |
the findings suggest similarities as well as subtle, but important, differences between the discriminative stimulus effects of cocaine and the dopamine uptake inhibitors, gbr-12909 and gbr12935. |
2001-10-11 |
2023-08-12 |
rat |
| P J Fletcher, S R Robinson, D L Slippo. Pre-exposure to (+/-)3,4-methylenedioxy-methamphetamine (MDMA) facilitates acquisition of intravenous cocaine self-administration in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 2. 2001-10-11. PMID:11425503. |
pre-exposure to (+/-)3,4-methylenedioxymeth-amphetamine (mdma) elevates locomotor activity and extracellular dopamine levels in the nucleus accumbens following a cocaine challenge. |
2001-10-11 |
2023-08-12 |
rat |
| M J Robarge, S M Husbands, A Kieltyka, R Brodbeck, A Thurkauf, A H Newma. Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype. Journal of medicinal chemistry. vol 44. issue 19. 2001-10-11. PMID:11543687. |
the dopamine d3 receptor subtype has been recently targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. |
2001-10-11 |
2023-08-12 |
human |
| L R McMahon, M Filip, K A Cunningha. Differential regulation of the mesoaccumbens circuit by serotonin 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567068. |
serotonin [5-hydroxytryptamine (5-ht)] 5-ht(2a) and 5-ht(2c) receptors (5-ht(2a)rs and 5-ht(2c)rs), which innervate the dopamine mesoaccumbens pathway, may play an important role in the behavioral effects of cocaine. |
2001-10-11 |
2023-08-12 |
Not clear |
| S L Collins, C D'Addario, S Izenwasse. Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. European journal of pharmacology. vol 426. issue 1-2. 2001-10-04. PMID:11525767. |
effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. |
2001-10-04 |
2023-08-12 |
rat |
| S L Collins, M A Edwards, K M Kanta. Effects of nitric oxide synthase inhibitors on the discriminative stimulus effects of cocaine in rats. Psychopharmacology. vol 154. issue 3. 2001-09-20. PMID:11351933. |
nitric oxide synthase (nos) inhibitors may modulate the discriminative stimulus effects of cocaine because they alter dopamine (da) release. |
2001-09-20 |
2023-08-12 |
rat |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, W A Zaman, K M Johnso. Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 9. issue 7. 2001-09-20. PMID:11425577. |
we previously disclosed the discovery of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3) as a novel class of dopamine transporter (dat) inhibitors and showed that (+/-)-3 has a significant functional antagonism against cocaine in vitro. |
2001-09-20 |
2023-08-12 |
Not clear |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, W A Zaman, K M Johnso. Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 9. issue 7. 2001-09-20. PMID:11425577. |
evaluation of cocaine's effect on dopamine uptake in the presence and absence of (+)-3 and (-)-3 showed that (-)-3 is responsible for the functional antagonism obtained with the original lead (+/-)-3. |
2001-09-20 |
2023-08-12 |
Not clear |
| C Chiamulera, M P Epping-Jordan, A Zocchi, C Marcon, C Cottiny, S Tacconi, M Corsi, F Orzi, F Conque. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nature neuroscience. vol 4. issue 9. 2001-09-20. PMID:11528416. |
here we show that mice lacking the mglur5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (nacc) dopamine (da) levels similar to wild-type (wt) mice. |
2001-09-20 |
2023-08-12 |
mouse |