| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
cocaine induction of dopamine transporter trafficking to the plasma membrane. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
several previous human postmortem experiments have detected an increase in striatal [(3)h]win 35428 binding to the dopamine transporter (dat) in chronic cocaine users. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
the present experiments tested the hypothesis that [(3)h]win 35428 binding and [(3)h]dopamine uptake would be increased by exposure to cocaine through alterations in dat cellular trafficking, rather than increased protein synthesis. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
experiments were conducted in stably hdat-transfected n2a cells and assessed the dose response and time course of cocaine effects on [(3)h]win 35428 binding to the dat, [(3)h]dopamine uptake, measures of dat protein and mrna, as well as dat subcellular location. |
2002-02-07 |
2023-08-12 |
human |
| Karley Y Little, Lawrence W Elmer, Huailing Zhong, Joshua O Scheys, Lian Zhan. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Molecular pharmacology. vol 61. issue 2. 2002-02-07. PMID:11809869. |
cocaine doses of 10(-6) m caused statistically significant increases in [(3)h]win 35428 binding and [(3)h]dopamine uptake after 12 and 3 h, respectively. |
2002-02-07 |
2023-08-12 |
human |
| A M Manzardo, J A Del Rio, L Stein, J D Belluzz. Rats choose cocaine over dopamine agonists in a two-lever self-administration preference test. Pharmacology, biochemistry, and behavior. vol 70. issue 2-3. 2002-02-05. PMID:11701196. |
rats choose cocaine over dopamine agonists in a two-lever self-administration preference test. |
2002-02-05 |
2023-08-12 |
rat |
| A M Manzardo, J A Del Rio, L Stein, J D Belluzz. Rats choose cocaine over dopamine agonists in a two-lever self-administration preference test. Pharmacology, biochemistry, and behavior. vol 70. issue 2-3. 2002-02-05. PMID:11701196. |
after response rates had stabilized (+/-10% for 2 days), different groups were offered cocaine (800 microg/kg/injection) at one lever and either another dose (267, 1600, or 2400 microg/kg/injection) of cocaine or a dopamine agonist at the other lever. |
2002-02-05 |
2023-08-12 |
rat |
| A M Manzardo, J A Del Rio, L Stein, J D Belluzz. Rats choose cocaine over dopamine agonists in a two-lever self-administration preference test. Pharmacology, biochemistry, and behavior. vol 70. issue 2-3. 2002-02-05. PMID:11701196. |
in choices between cocaine and dopamine agonists, the preferred cocaine dose (800 microg) was chosen over doses of the d(1) (skf 82958) or d(2) ((+)-phno) agonist. |
2002-02-05 |
2023-08-12 |
rat |
| C E Beyer, J D Stekete. Characterization of the role of medial prefrontal cortex dopamine receptors in cocaine-induced locomotor activity. Behavioral neuroscience. vol 115. issue 5. 2002-02-04. PMID:11584922. |
medial prefrontal cortex (mpfc) dopamine (da) modulates the motor-stimulant response to cocaine. |
2002-02-04 |
2023-08-12 |
Not clear |
| J L Cornish, P W Kaliva. Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens. Journal of addictive diseases. vol 20. issue 3. 2002-02-01. PMID:11681592. |
cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens. |
2002-02-01 |
2023-08-12 |
Not clear |
| J L Cornish, P W Kaliva. Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens. Journal of addictive diseases. vol 20. issue 3. 2002-02-01. PMID:11681592. |
this review describes the effect of chronic cocaine administration on dopamine and glutamate transmission in the nucleus accumbens, and discusses the relevance of these changes in the initiation of drug craving and relapse to drug abuse. |
2002-02-01 |
2023-08-12 |
Not clear |
| J Zhang, M X. Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems. Journal of addictive diseases. vol 20. issue 3. 2002-02-01. PMID:11681595. |
we have used the gene targeting technology to generate dopamine d1 and d3 receptor knockout mice and used these mice as model systems to gain a molecular understanding of acute effects of psychostimulants cocaine and amphetamine. |
2002-02-01 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
we have tested this hypothesis by comparing the effects of inhibitors selective for the three monoamine transporters with those of a nonspecific inhibitor, cocaine, on uptake of 3h-dopamine into synaptosomes from frontal cortex, caudate nucleus, and nucleus accumbens from wild-type, net, and dopamine transporter (dat) knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
dopamine uptake was inhibited by cocaine and nisoxetine, but not by gbr12909, in frontal cortex synaptosomes from wild-type or dat knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
cocaine failed to block dopamine uptake into caudate or nucleus accumbens synaptosomes from dat knock-out mice. |
2002-01-30 |
2023-08-12 |
mouse |
| Jose A Morón, Alicia Brockington, Roy A Wise, Beatriz A Rocha, Bruce T Hop. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 2. 2002-01-30. PMID:11784783. |
cocaine and gbr12909 each inhibited dopamine uptake into caudate synaptosomes from net knock-out mice, but cocaine effectiveness was reduced in the case of nucleus accumbens synaptosomes. |
2002-01-30 |
2023-08-12 |
mouse |
| Candice Drouin, Gérard Blanc, Anne-Sophie Villégier, Jacques Glowinski, Jean-Pol Tassi. Critical role of alpha1-adrenergic receptors in acute and sensitized locomotor effects of D-amphetamine, cocaine, and GBR 12783: influence of preexposure conditions and pharmacological characteristics. Synapse (New York, N.Y.). vol 43. issue 1. 2002-01-24. PMID:11746733. |
this possibility was tested on locomotor responses induced either by d-amphetamine and cocaine, which both interfere with noradrenergic and dopaminergic transmissions, or by gbr 12783, a specific dopamine reuptake inhibitor. |
2002-01-24 |
2023-08-12 |
rat |
| K M Wilcox, K P Lindsey, J R Votaw, M M Goodman, L Martarello, F I Carroll, L L Howel. Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. Synapse (New York, N.Y.). vol 43. issue 1. 2002-01-24. PMID:11746736. |
self-administration of cocaine and the cocaine analog rti-113: relationship to dopamine transporter occupancy determined by pet neuroimaging in rhesus monkeys. |
2002-01-24 |
2023-08-12 |
monkey |
| C W Schindler, J P Gilman, J Bergman, N K Mello, R L Woosley, S R Goldber. Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 300. issue 1. 2002-01-24. PMID:11752114. |
interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. |
2002-01-24 |
2023-08-12 |
monkey |
| C W Schindler, J P Gilman, J Bergman, N K Mello, R L Woosley, S R Goldber. Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 300. issue 1. 2002-01-24. PMID:11752114. |
with cocaine and various dopamine agonist drugs. |
2002-01-24 |
2023-08-12 |
monkey |