| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgeny A Budygin, Carrie E John, Yolanda Mateo, Sara R Jone. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006604. |
cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter (dat) at the level of presynaptic terminals and increasing extracellular levels of dopamine (da). |
2002-05-29 |
2023-08-12 |
mouse |
| Emmanuel N Potho. Regulation of dopamine quantal size in midbrain and hippocampal neurons. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864736. |
(3) reuptake blockade--cocaine and amfonelic acid are dopamine reuptake blockers which reduce quantal size independently of d2-related effects. |
2002-05-16 |
2023-08-12 |
mouse |
| Richard B Rothman, F Ivy Carroll, Marisela Morales, Daniel L Rowley, Kenner C Rice, Christina M Dersch, David M Donova. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 44. issue 2. 2002-05-13. PMID:11891881. |
characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. |
2002-05-13 |
2023-08-12 |
mouse |
| Richard B Rothman, F Ivy Carroll, Marisela Morales, Daniel L Rowley, Kenner C Rice, Christina M Dersch, David M Donova. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 44. issue 2. 2002-05-13. PMID:11891881. |
previous work suggested that the cocaine analog [(125)i]rti-55 labels a novel binding site in rat brain membranes, which is not associated with the dopamine (da), serotonin (5-ht), or norepinephrine (ne) transporters [rothman et al. |
2002-05-13 |
2023-08-12 |
mouse |
| Pascal Romieu, Vân Ly Phan, Rémi Martin-Fardon, Tangui Mauric. Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 4. 2002-05-09. PMID:11927169. |
moreover, the cpp induced by n-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (btcp), a selective dopamine reuptake inhibitor, was blocked by treatments with the sigma(1) receptor antagonists as was similarly observed with cocaine. |
2002-05-09 |
2023-08-12 |
mouse |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
substantial evidence has accumulated that the dopamine transporter (dat) is a key target for cocaine regarding its reinforcing effects. |
2002-05-06 |
2023-08-12 |
Not clear |
| Tarek F El-Moselhy, Kwasi S Avor, Garo P Basmadjia. Synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. European journal of medicinal chemistry. vol 37. issue 2. 2002-05-02. PMID:11858849. |
synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. |
2002-05-02 |
2023-08-12 |
Not clear |
| Tarek F El-Moselhy, Kwasi S Avor, Garo P Basmadjia. Synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. European journal of medicinal chemistry. vol 37. issue 2. 2002-05-02. PMID:11858849. |
a series of 2beta-isopropyl ester analogs of cocaine (7-11) was synthesised and evaluated in an in vitro dopamine transporter (dat) binding assays. |
2002-05-02 |
2023-08-12 |
Not clear |
| Lifen Xu, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Cheryl Klein-Stevens, Naiju Zhu, Stacey A Lomenzo, Leyte Winfield, Mark L Trudel. Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881989. |
furthermore, despite a relatively low potency of 10 for the inhibition of dopamine uptake compared to its affinity for the dat, its behavioral profile did not vary significantly from cocaine. |
2002-04-26 |
2023-08-12 |
Not clear |
| N Thiriet, P Jouvert, S Gobaille, O Solov'eva, B Gough, D Aunis, S Ali, J Zwille. C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. The European journal of neuroscience. vol 14. issue 10. 2002-04-23. PMID:11860464. |
the inhibition by cnp of the early gene expression elicited by cocaine in the caudate-putamen is correlated with a cnp-evoked decrease in cocaine-induced rise in extracellular dopamine, measured by in vivo microdialysis experiments. |
2002-04-23 |
2023-08-12 |
rat |
| Anton N M Schoffelmeer, Taco J De Vries, George Wardeh, Henrica W M van de Ven, Louk J M J Vanderschure. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943828. |
behavioral sensitization induced by nicotine, amphetamine, or cocaine was associated with an increase in the electrically evoked release of [(3)h]dopamine from nucleus accumbens slices. |
2002-04-22 |
2023-08-12 |
rat |
| Anton N M Schoffelmeer, Taco J De Vries, George Wardeh, Henrica W M van de Ven, Louk J M J Vanderschure. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943828. |
coadministration of mecamylamine during pretreatment with nicotine, amphetamine, or cocaine prevented the development of this long-term hyperreactivity of nucleus accumbens dopamine neurons. |
2002-04-22 |
2023-08-12 |
rat |
| Francoise Rouge-Pont, Alessandro Usiello, Marianne Benoit-Marand, Francois Gonon, Pier Vincenzo Piazza, Emiliana Borrell. Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943831. |
changes in extracellular dopamine induced by morphine and cocaine: crucial control by d2 receptors. |
2002-04-22 |
2023-08-12 |
mouse |
| M S Lima, A A Reisser, B G Soares, M Farrel. Antidepressants for cocaine dependence. The Cochrane database of systematic reviews. issue 4. 2002-04-19. PMID:11687168. |
while administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. |
2002-04-19 |
2023-08-12 |
Not clear |
| B G Soares, M S Lima, A A Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 4. 2002-04-19. PMID:11687193. |
dopamine agonists for cocaine dependence. |
2002-04-19 |
2023-08-12 |
human |
| B G Soares, M S Lima, A A Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 4. 2002-04-19. PMID:11687193. |
it was demonstrated that the acute use of cocaine may enhance dopamine transmission and chronically it decreases dopamine concentrations in the brain. |
2002-04-19 |
2023-08-12 |
human |
| Roland D Schönbächler, Pascale M Gucker, Michele Arigoni, Stefan Kneifel, Franz X Vollenweider, Alfred Buck, Cyrill Burger, Thomas Berthold, Matthias Brühlmeier, P August Schubiger, Simon M Ametame. PET imaging of dopamine transporters in the human brain using [(11)C]-beta-CPPIT, a cocaine derivative lacking the 2 beta-ester function. Nuclear medicine and biology. vol 29. issue 1. 2002-04-19. PMID:11786272. |
pet imaging of dopamine transporters in the human brain using [(11)c]-beta-cppit, a cocaine derivative lacking the 2 beta-ester function. |
2002-04-19 |
2023-08-12 |
mouse |
| Roland D Schönbächler, Pascale M Gucker, Michele Arigoni, Stefan Kneifel, Franz X Vollenweider, Alfred Buck, Cyrill Burger, Thomas Berthold, Matthias Brühlmeier, P August Schubiger, Simon M Ametame. PET imaging of dopamine transporters in the human brain using [(11)C]-beta-CPPIT, a cocaine derivative lacking the 2 beta-ester function. Nuclear medicine and biology. vol 29. issue 1. 2002-04-19. PMID:11786272. |
the compound 3 beta-(4'-chlorophenyl)-2 beta-(3'-phenylisoxazol-5'-yl)tropane (cppit or rti 177) is a 2beta-heterocyclic substituted cocaine congener with high in vitro selectivity and affinity for the dopamine transporter relative to serotonin and norepinephrine transporters. |
2002-04-19 |
2023-08-12 |
mouse |
| G R Uhl, F S Hall, I Sor. Cocaine, reward, movement and monoamine transporters. Molecular psychiatry. vol 7. issue 1. 2002-04-19. PMID:11803442. |
dopamine transporter blockade by cocaine appears a sufficient explanation for cocaine-induced locomotion. |
2002-04-19 |
2023-08-12 |
mouse |
| Michele Hummel, Ellen M Unterwal. D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action. Journal of cellular physiology. vol 191. issue 1. 2002-04-15. PMID:11920678. |
cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons (heikkila et al., 1975, biochem pharmacol 24(8):847-852; reith et al., 1986, biochem pharmacol 35(7):1123-1129; ritz et al., 1987, science 237:1219-1223). |
2002-04-15 |
2023-08-12 |
Not clear |