| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margery C Beinfeld, Kelly J Connolly, R Christopher Pierc. Cocaine treatment increases extracellular cholecystokinin (CCK) in the nucleus accumbens shell of awake, freely moving rats, an effect that is enhanced in rats that are behaviorally sensitized to cocaine. Journal of neurochemistry. vol 81. issue 5. 2002-07-09. PMID:12065614. |
these results provide a neurochemical basis for an important role of cck (via modulation of dopamine neurotransmission) in expression of cocaine sensitization. |
2002-07-09 |
2023-08-12 |
rat |
| Susan Schen. Effects of GBR 12909, WIN 35,428 and indatraline on cocaine self-administration and cocaine seeking in rats. Psychopharmacology. vol 160. issue 3. 2002-07-08. PMID:11889495. |
previous studies have suggested that the dopamine uptake inhibitor, gbr 12909, might be such a candidate drug because it decreases cocaine self-administration. |
2002-07-08 |
2023-08-12 |
rat |
| Deborah C Mash, John Pablo, Qinjie Ouyang, W Lee Hearn, Sari Izenwasse. Dopamine transport function is elevated in cocaine users. Journal of neurochemistry. vol 81. issue 2. 2002-06-26. PMID:12064476. |
dopamine transport function is elevated in cocaine users. |
2002-06-26 |
2023-08-12 |
human |
| Deborah C Mash, John Pablo, Qinjie Ouyang, W Lee Hearn, Sari Izenwasse. Dopamine transport function is elevated in cocaine users. Journal of neurochemistry. vol 81. issue 2. 2002-06-26. PMID:12064476. |
dopamine (da) uptake was elevated twofold in the ventral striatum from cocaine users as compared to age-matched drug-free control subjects. |
2002-06-26 |
2023-08-12 |
human |
| Chad E Beyer, Jeffery D Stekete. Cocaine sensitization: modulation by dopamine D2 receptors. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 5. 2002-06-24. PMID:11950770. |
cocaine sensitization: modulation by dopamine d2 receptors. |
2002-06-24 |
2023-08-12 |
Not clear |
| John R Votaw, Leonard L Howell, Laurent Martarello, John M Hoffman, Clinton D Kilts, Kimberly P Lindsey, Mark M Goodma. Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT. Synapse (New York, N.Y.). vol 44. issue 4. 2002-06-24. PMID:11984856. |
measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [f-18]fecnt. |
2002-06-24 |
2023-08-12 |
human |
| John R Votaw, Leonard L Howell, Laurent Martarello, John M Hoffman, Clinton D Kilts, Kimberly P Lindsey, Mark M Goodma. Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT. Synapse (New York, N.Y.). vol 44. issue 4. 2002-06-24. PMID:11984856. |
this work generalizes the reference tissue method to estimate dopamine transporter occupancy for two levels of cocaine administration using only a single injection of [(18)f]fecnt. |
2002-06-24 |
2023-08-12 |
human |
| Nick E Goeder. Stress and cocaine addiction. The Journal of pharmacology and experimental therapeutics. vol 301. issue 3. 2002-06-19. PMID:12023504. |
increasing circulating levels of corticosterone also augments sensitivity to low doses of cocaine, possibly from a sensitization-associated phenomenon involving dopamine, suggesting that exposure to stress can increase individual vulnerability to cocaine. |
2002-06-19 |
2023-08-12 |
Not clear |
| Xu-Feng Zhang, Donald C Cooper, Francis J Whit. Repeated cocaine treatment decreases whole-cell calcium current in rat nucleus accumbens neurons. The Journal of pharmacology and experimental therapeutics. vol 301. issue 3. 2002-06-19. PMID:12023545. |
dopamine d1 receptors within the nucleus accumbens (nac) are intricately involved in the rewarding effects of cocaine and in withdrawal symptoms after cessation of repeated cocaine administration. |
2002-06-19 |
2023-08-12 |
rat |
| Enrico Bracci, Diego Centonze, Giorgio Bernardi, Paolo Calabres. Dopamine excites fast-spiking interneurons in the striatum. Journal of neurophysiology. vol 87. issue 4. 2002-06-12. PMID:11929936. |
cocaine elicited effects similar to those of dopamine on membrane potential and synaptic currents. |
2002-06-12 |
2023-08-12 |
Not clear |
| Michael J Bannon, Barb Pruetz, Amy B Manning-Bog, Christopher J Whitty, Sharon K Michelhaugh, Paola Sacchetti, James G Granneman, Deborah C Mash, Carl J Schmid. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 9. 2002-06-11. PMID:11959923. |
decreased expression of the transcription factor nurr1 in dopamine neurons of cocaine abusers. |
2002-06-11 |
2023-08-12 |
human |
| Michael J Bannon, Barb Pruetz, Amy B Manning-Bog, Christopher J Whitty, Sharon K Michelhaugh, Paola Sacchetti, James G Granneman, Deborah C Mash, Carl J Schmid. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 9. 2002-06-11. PMID:11959923. |
here we show that human nurr1 gene expression is robust within control subjects and reduced markedly within the dopamine neurons of human cocaine abusers. |
2002-06-11 |
2023-08-12 |
human |
| Michael J Bannon, Barb Pruetz, Amy B Manning-Bog, Christopher J Whitty, Sharon K Michelhaugh, Paola Sacchetti, James G Granneman, Deborah C Mash, Carl J Schmid. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 9. 2002-06-11. PMID:11959923. |
we show here that dat gene expression also is reduced markedly in the dopamine neurons of nurr1-deficient cocaine abusers, suggesting that nurr1 plays a critical role in vivo in controlling human dat gene expression and adaptation to repeated exposure to cocaine. |
2002-06-11 |
2023-08-12 |
human |
| Evgeny A Budygin, Carrie E John, Yolanda Mateo, Sara R Jone. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006604. |
lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. |
2002-05-29 |
2023-08-12 |
mouse |
| Evgeny A Budygin, Carrie E John, Yolanda Mateo, Sara R Jone. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006604. |
cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter (dat) at the level of presynaptic terminals and increasing extracellular levels of dopamine (da). |
2002-05-29 |
2023-08-12 |
mouse |
| Emmanuel N Potho. Regulation of dopamine quantal size in midbrain and hippocampal neurons. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864736. |
(3) reuptake blockade--cocaine and amfonelic acid are dopamine reuptake blockers which reduce quantal size independently of d2-related effects. |
2002-05-16 |
2023-08-12 |
mouse |
| Richard B Rothman, F Ivy Carroll, Marisela Morales, Daniel L Rowley, Kenner C Rice, Christina M Dersch, David M Donova. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 44. issue 2. 2002-05-13. PMID:11891881. |
characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. |
2002-05-13 |
2023-08-12 |
mouse |
| Richard B Rothman, F Ivy Carroll, Marisela Morales, Daniel L Rowley, Kenner C Rice, Christina M Dersch, David M Donova. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 44. issue 2. 2002-05-13. PMID:11891881. |
previous work suggested that the cocaine analog [(125)i]rti-55 labels a novel binding site in rat brain membranes, which is not associated with the dopamine (da), serotonin (5-ht), or norepinephrine (ne) transporters [rothman et al. |
2002-05-13 |
2023-08-12 |
mouse |
| Pascal Romieu, Vân Ly Phan, Rémi Martin-Fardon, Tangui Mauric. Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 4. 2002-05-09. PMID:11927169. |
moreover, the cpp induced by n-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (btcp), a selective dopamine reuptake inhibitor, was blocked by treatments with the sigma(1) receptor antagonists as was similarly observed with cocaine. |
2002-05-09 |
2023-08-12 |
mouse |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
substantial evidence has accumulated that the dopamine transporter (dat) is a key target for cocaine regarding its reinforcing effects. |
2002-05-06 |
2023-08-12 |
Not clear |