| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
despite an abundance of studies on mechanisms of behavioral sensitization, considerable uncertainty exists as to whether alterations in dopamine neurotransmission underlie the exacerbated behavioral effects of cocaine observed during the early stages of abstinence. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
the techniques of quantitative microdialysis under transient conditions and rotating disk electrode voltammetry were used to characterize basal dopamine dynamics as well as time-related changes in extracellular dopamine concentrations and dopamine uptake that occur in response to an acute drug challenge in control animals and animals with previous history of cocaine. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
basal extracellular dopamine concentrations were unaltered on abstinence day 3 from repeated cocaine administration (5 days, 20 mg/kg, i.p.). |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
at the same time, a cocaine challenge decreased the extraction fraction and increased the extracellular dopamine concentration in both experimental groups. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
the magnitude of the increase in extracellular dopamine concentration was greater in cocaine-sensitized animals, while the ability of cocaine to decrease the extraction fraction was unaltered, suggesting that the increase in extracellular dopamine concentration reflects an increase in drug-evoked dopamine release. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
these data demonstrate that a cocaine treatment regimen resulting in behavioral sensitization is associated with a reduction in basal dopamine release, an enhancement in both cocaine and k(+)-evoked dopamine release, and a subsensitivity of dopamine d(2) autoreceptors that regulate dopamine release in the nucleus accumbens. |
2002-09-03 |
2023-08-12 |
rat |
| Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli, Steven R Goldber. Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151508. |
an increase in the extracellular concentration of dopamine in the nucleus accumbens (nac) is believed to be one of the main mechanisms involved in the rewarding and motor-activating properties of psychostimulants such as amphetamines and cocaine. |
2002-09-03 |
2023-08-12 |
rat |
| Nicole H Mutschler, Jack Bergma. Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology. vol 160. issue 4. 2002-08-22. PMID:11919663. |
dopamine d1 receptor partial agonists have been proposed as candidate medications for the treatment of cocaine dependence. |
2002-08-22 |
2023-08-12 |
monkey |
| Thomas R Kosten, Tony P George, Therese A Koste. The potential of dopamine agonists in drug addiction. Expert opinion on investigational drugs. vol 11. issue 4. 2002-08-15. PMID:11922858. |
disulfiram may also raise dopamine levels and has shown promise for cocaine dependence. |
2002-08-15 |
2023-08-12 |
Not clear |
| Steven L Batk. Review: dopamine agonists are not effective for cocaine dependence. Evidence-based mental health. vol 5. issue 3. 2002-08-15. PMID:12180450. |
review: dopamine agonists are not effective for cocaine dependence. |
2002-08-15 |
2023-08-12 |
Not clear |
| Wenxia Zhou, Kathryn A Cunningham, Mary L Thoma. Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats. Brain research. Molecular brain research. vol 100. issue 1-2. 2002-08-13. PMID:12008023. |
thus, we hypothesized that estrogen (e) modulates the behavioral response to cocaine via regulation of expression of components of dopamine (da) and serotonin (5-ht) systems in mesolimbic nuclei important in the response to cocaine as well as the hypothalamus, a brain area known to be e-responsive. |
2002-08-13 |
2023-08-12 |
rat |
| Michael A Nader, James B Daunais, Tonya Moore, Susan H Nader, Rodney J Moore, Hilary R Smith, David P Friedman, Linda J Porrin. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 1. 2002-08-08. PMID:12062905. |
effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. |
2002-08-08 |
2023-08-12 |
monkey |
| Michael A Nader, James B Daunais, Tonya Moore, Susan H Nader, Rodney J Moore, Hilary R Smith, David P Friedman, Linda J Porrin. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 1. 2002-08-08. PMID:12062905. |
the purpose of this study was to examine the time course of changes in dopamine d(1)- and d(2)-like receptor densities in monkeys self-administering cocaine. |
2002-08-08 |
2023-08-12 |
monkey |
| Michael A Nader, James B Daunais, Tonya Moore, Susan H Nader, Rodney J Moore, Hilary R Smith, David P Friedman, Linda J Porrin. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 1. 2002-08-08. PMID:12062905. |
these findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion. |
2002-08-08 |
2023-08-12 |
monkey |
| Servet M Yatin, Gregory M Miller, Courtney Norton, Bertha K Madra. Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse (New York, N.Y.). vol 45. issue 1. 2002-08-06. PMID:12112414. |
in untransfected hek cells, methylphenidate and cocaine produced a small but statistically significant increase in c-fos, whereas dopamine and amphetamine did not. |
2002-08-06 |
2023-08-12 |
human |
| Corinne Beurrier, Robert C Malenk. Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 14. 2002-08-06. PMID:12122043. |
enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine. |
2002-08-06 |
2023-08-12 |
mouse |
| Christine Capper-Loup, Juan J Canales, Neena Kadaba, Ann M Graybie. Concurrent activation of dopamine D1 and D2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 14. 2002-08-06. PMID:12122080. |
concurrent activation of dopamine d1 and d2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization. |
2002-08-06 |
2023-08-12 |
rat |
| Rutsuko Ito, Jeffrey W Dalley, Trevor W Robbins, Barry J Everit. Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 14. 2002-08-06. PMID:12122083. |
in this study, in vivo microdialysis in combination with a second-order schedule of cocaine reinforcement was used to investigate the role of the dorsal striatal dopamine innervation in well established drug-seeking behavior under the control of a drug-associated cue [light conditioned stimulus (cs+)]. |
2002-08-06 |
2023-08-12 |
rat |
| P-A H Noailles, J A Angul. Neurokinin receptors modulate the neurochemical actions of cocaine. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105102. |
the psychostimulant cocaine is an indirect agonist that increases synaptic dopamine (da) by binding with high affinity to the da transporter (dat) and blocking the active transport of synaptic da back into the terminal. |
2002-08-02 |
2023-08-12 |
rat |
| Teresa Summavielle, Ana Magalhães, Ivone Castro-Vale, Liliana de Sousa, Maria Amélia Tavare. Neonatal exposure to cocaine: altered dopamine levels in the amygdala and behavioral outcomes in the developing rat. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105126. |
neonatal exposure to cocaine: altered dopamine levels in the amygdala and behavioral outcomes in the developing rat. |
2002-08-02 |
2023-08-12 |
rat |