| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. |
2002-10-01 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
continuous infusion of cocaine or the selective dopamine uptake inhibitors gbr 12909 or rti-117 increases locomotor stimulation, to which partial tolerance occurs. |
2002-10-01 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
to further understand the interaction between cocaine and the kappa-opioid system, the effects of a chronic continuous infusion for 14 days of cocaine or one of the selective dopamine uptake inhibitors gbr 12909 or rti-117 via osmotic minipump were examined on kappa-opioid receptors using the selective kappa-opioid ligand [3h] u-69593. |
2002-10-01 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
the increased kappa-opioid receptor densities observed following cocaine are likely not related to dopamine uptake inhibition, since they were not produced by selective dopamine uptake inhibitors. |
2002-10-01 |
2023-08-12 |
Not clear |
| William J Houlihan, Lawrence Kelly, Jessica Pankuch, Judith Koletar, Leonard Brand, Aaron Janowsky, Theresa A Kopajti. Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213053. |
mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. |
2002-10-01 |
2023-08-12 |
rat |
| William J Houlihan, Umer F Ahmad, Judith Koletar, Lawrence Kelly, Leonard Brand, Theresa A Kopajti. Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213054. |
benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. |
2002-10-01 |
2023-08-12 |
human |
| Bruce E Blough, Kathryn I Keverline, Zhe Nie, Hernán Navarro, Michael J Kuhar, F Ivy Carrol. Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 18. 2002-09-23. PMID:12190324. |
a series of 4'-substituted 3beta-phenyltropane-2beta-carboxylic acid methyl esters were synthesized and evaluated for binding at the dopamine transporter (dat) in order to better define the pharmacophore for the cocaine binding site on the dat. |
2002-09-23 |
2023-08-12 |
Not clear |
| L E Bayer, S Kakumanu, C F Mactutus, R M Booze, B J Strup. Prenatal cocaine exposure alters sensitivity to the effects of idazoxan in a distraction task. Behavioural brain research. vol 133. issue 2. 2002-09-19. PMID:12110452. |
the pattern of effects suggests that the differential treatment response to idz on these latter measures resulted from an alteration in norepinephrine (ne)-modulated dopamine release in the coc animals, reflecting lasting changes in dopaminergic and/or noradrenergic systems as a result of the early cocaine exposure. |
2002-09-19 |
2023-08-12 |
human |
| Li-Bin Li, Xiao-Nan Cui, Maarten A Reit. Is Na(+) required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter? Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 4. 2002-09-18. PMID:11919655. |
recognition was studied via the inhibition of binding of [(3)h]win 35,428 (2beta-carbomethoxy-3beta-(4-fluorophenyl) [(3)h]tropane), a cocaine analog, to the human dopamine transporter in human embryonic kidney 293 cells. |
2002-09-18 |
2023-08-12 |
human |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183681. |
acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. |
2002-09-18 |
2023-08-12 |
rat |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183681. |
the role of the dopamine transporter (dat) in mediating the behavioral differences in cocaine responsiveness in lcrs and hcrs was investigated by high-speed chronoamperometric recording of exogenous dopamine (da) clearance signals in nucleus accumbens (nac) and dorsal striatum (dstr). |
2002-09-18 |
2023-08-12 |
rat |
| Yan Zhou, Rudolph Spangler, Stefan D Schlussman, Vadim P Yuferov, Ichiro Sora, Ann Ho, George R Uhl, Mary Jeanne Kree. Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse (New York, N.Y.). vol 45. issue 4. 2002-09-13. PMID:12125043. |
cocaine administration increases activity at dopamine receptors, increases preprodynorphin (ppdyn) gene expression in the caudate-putamen (cpu), and activates the stress responsive hypothalamic-pituitary-adrenal (hpa) axis. |
2002-09-13 |
2023-08-12 |
mouse |
| Malgorzata Filip, Kathryn A Cunningha. Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888566. |
the serotonin 5-ht(2c) receptor (5-ht(2c)r) is abundant in the nucleus accumbens (nac) shell and is considered an important target for 5-ht to modulate the dopamine (da) mesoaccumbens circuit, which plays a prominent role in the behavioral effects of cocaine. |
2002-09-11 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
despite an abundance of studies on mechanisms of behavioral sensitization, considerable uncertainty exists as to whether alterations in dopamine neurotransmission underlie the exacerbated behavioral effects of cocaine observed during the early stages of abstinence. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
the techniques of quantitative microdialysis under transient conditions and rotating disk electrode voltammetry were used to characterize basal dopamine dynamics as well as time-related changes in extracellular dopamine concentrations and dopamine uptake that occur in response to an acute drug challenge in control animals and animals with previous history of cocaine. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
basal extracellular dopamine concentrations were unaltered on abstinence day 3 from repeated cocaine administration (5 days, 20 mg/kg, i.p.). |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
at the same time, a cocaine challenge decreased the extraction fraction and increased the extracellular dopamine concentration in both experimental groups. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
the magnitude of the increase in extracellular dopamine concentration was greater in cocaine-sensitized animals, while the ability of cocaine to decrease the extraction fraction was unaltered, suggesting that the increase in extracellular dopamine concentration reflects an increase in drug-evoked dopamine release. |
2002-09-03 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
these data demonstrate that a cocaine treatment regimen resulting in behavioral sensitization is associated with a reduction in basal dopamine release, an enhancement in both cocaine and k(+)-evoked dopamine release, and a subsensitivity of dopamine d(2) autoreceptors that regulate dopamine release in the nucleus accumbens. |
2002-09-03 |
2023-08-12 |
rat |