| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W L Woolverton, R Ranaldi, Z Wang, G A Ordway, I A Paul, P Petukhov, A Kozikowsk. Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 303. issue 1. 2002-10-21. PMID:12235253. |
for in vitro binding in monkey brain tissue, (+)-cpca was about one-half as potent as cocaine at the dopamine transporter (dat), and the two compounds had similar affinities at the norepinephrine transporter. |
2002-10-21 |
2023-08-12 |
rat |
| Allison L Chausmer, Gregory I Elmer, Marcelo Rubinstein, Malcolm J Low, David K Grandy, Jonathan L Kat. Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Psychopharmacology. vol 163. issue 1. 2002-10-16. PMID:12185400. |
cocaine-induced locomotor activity and cocaine discrimination in dopamine d2 receptor mutant mice. |
2002-10-16 |
2023-08-12 |
mouse |
| Allison L Chausmer, Gregory I Elmer, Marcelo Rubinstein, Malcolm J Low, David K Grandy, Jonathan L Kat. Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Psychopharmacology. vol 163. issue 1. 2002-10-16. PMID:12185400. |
dopamine (da) d2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. |
2002-10-16 |
2023-08-12 |
mouse |
| Istvan Sziráki, Henry Sershen, Audrey Hashim, Abel Lajth. Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens. Neurochemical research. vol 27. issue 3. 2002-10-04. PMID:11958525. |
nicotine or cocaine, when administered intravenously, induces an increase of extracellular dopamine in the nucleus accumbens. |
2002-10-04 |
2023-08-12 |
Not clear |
| Istvan Sziráki, Henry Sershen, Audrey Hashim, Abel Lajth. Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens. Neurochemical research. vol 27. issue 3. 2002-10-04. PMID:11958525. |
we assayed inhibition of the increase of dopamine in the nucleus accumbens induced by intravenous nicotine or cocaine administration by antagonists administered into the ventral tegmental area. |
2002-10-04 |
2023-08-12 |
Not clear |
| Istvan Sziráki, Henry Sershen, Audrey Hashim, Abel Lajth. Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens. Neurochemical research. vol 27. issue 3. 2002-10-04. PMID:11958525. |
the importance of local receptors in the ventral tegmental area was further indicated by the increase in accumbal dopamine levels after intrategmental administration of nicotine or also cocaine. |
2002-10-04 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. |
2002-10-01 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
continuous infusion of cocaine or the selective dopamine uptake inhibitors gbr 12909 or rti-117 increases locomotor stimulation, to which partial tolerance occurs. |
2002-10-01 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
to further understand the interaction between cocaine and the kappa-opioid system, the effects of a chronic continuous infusion for 14 days of cocaine or one of the selective dopamine uptake inhibitors gbr 12909 or rti-117 via osmotic minipump were examined on kappa-opioid receptors using the selective kappa-opioid ligand [3h] u-69593. |
2002-10-01 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Paul M Kunko, Bruce Ladenheim, Jean-Lud Cadet, F Ivy Carroll, Sari Izenwasse. Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112394. |
the increased kappa-opioid receptor densities observed following cocaine are likely not related to dopamine uptake inhibition, since they were not produced by selective dopamine uptake inhibitors. |
2002-10-01 |
2023-08-12 |
Not clear |
| William J Houlihan, Lawrence Kelly, Jessica Pankuch, Judith Koletar, Leonard Brand, Aaron Janowsky, Theresa A Kopajti. Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213053. |
mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. |
2002-10-01 |
2023-08-12 |
rat |
| William J Houlihan, Umer F Ahmad, Judith Koletar, Lawrence Kelly, Leonard Brand, Theresa A Kopajti. Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213054. |
benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. |
2002-10-01 |
2023-08-12 |
human |
| Bruce E Blough, Kathryn I Keverline, Zhe Nie, Hernán Navarro, Michael J Kuhar, F Ivy Carrol. Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 18. 2002-09-23. PMID:12190324. |
a series of 4'-substituted 3beta-phenyltropane-2beta-carboxylic acid methyl esters were synthesized and evaluated for binding at the dopamine transporter (dat) in order to better define the pharmacophore for the cocaine binding site on the dat. |
2002-09-23 |
2023-08-12 |
Not clear |
| L E Bayer, S Kakumanu, C F Mactutus, R M Booze, B J Strup. Prenatal cocaine exposure alters sensitivity to the effects of idazoxan in a distraction task. Behavioural brain research. vol 133. issue 2. 2002-09-19. PMID:12110452. |
the pattern of effects suggests that the differential treatment response to idz on these latter measures resulted from an alteration in norepinephrine (ne)-modulated dopamine release in the coc animals, reflecting lasting changes in dopaminergic and/or noradrenergic systems as a result of the early cocaine exposure. |
2002-09-19 |
2023-08-12 |
human |
| Li-Bin Li, Xiao-Nan Cui, Maarten A Reit. Is Na(+) required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter? Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 4. 2002-09-18. PMID:11919655. |
recognition was studied via the inhibition of binding of [(3)h]win 35,428 (2beta-carbomethoxy-3beta-(4-fluorophenyl) [(3)h]tropane), a cocaine analog, to the human dopamine transporter in human embryonic kidney 293 cells. |
2002-09-18 |
2023-08-12 |
human |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183681. |
acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. |
2002-09-18 |
2023-08-12 |
rat |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183681. |
the role of the dopamine transporter (dat) in mediating the behavioral differences in cocaine responsiveness in lcrs and hcrs was investigated by high-speed chronoamperometric recording of exogenous dopamine (da) clearance signals in nucleus accumbens (nac) and dorsal striatum (dstr). |
2002-09-18 |
2023-08-12 |
rat |
| Yan Zhou, Rudolph Spangler, Stefan D Schlussman, Vadim P Yuferov, Ichiro Sora, Ann Ho, George R Uhl, Mary Jeanne Kree. Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse (New York, N.Y.). vol 45. issue 4. 2002-09-13. PMID:12125043. |
cocaine administration increases activity at dopamine receptors, increases preprodynorphin (ppdyn) gene expression in the caudate-putamen (cpu), and activates the stress responsive hypothalamic-pituitary-adrenal (hpa) axis. |
2002-09-13 |
2023-08-12 |
mouse |
| Malgorzata Filip, Kathryn A Cunningha. Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888566. |
the serotonin 5-ht(2c) receptor (5-ht(2c)r) is abundant in the nucleus accumbens (nac) shell and is considered an important target for 5-ht to modulate the dopamine (da) mesoaccumbens circuit, which plays a prominent role in the behavioral effects of cocaine. |
2002-09-11 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088750. |
changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. |
2002-09-03 |
2023-08-12 |
rat |