| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefan Paula, Michael R Tabet, Susan M Keenan, William J Welsh, W James Bal. Three-dimensional structure-activity relationship modeling of cocaine binding to two monoclonal antibodies by comparative molecular field analysis. Journal of molecular biology. vol 325. issue 3. 2003-02-19. PMID:12498800. |
furthermore, using previously published data, a 3d-qsar model was developed for cocaine binding to the dopamine reuptake transporter (dat) that was compared to the mab models. |
2003-02-19 |
2023-08-12 |
Not clear |
| Janne A V Mikkola, Sanna Janhunen, Petri Hyytiä, Kalervo Kiianmaa, Liisa Ahte. Rotational behaviour in AA and ANA rats after repeated administration of morphine and cocaine. Pharmacology, biochemistry, and behavior. vol 73. issue 3. 2003-02-13. PMID:12151046. |
the purpose of the present study was to investigate the effects of repeated morphine and cocaine treatments on rotational behaviour in alcohol-preferring aa (alko alcohol) and alcohol-avoiding ana (alko non-alcohol) rats after unilateral 6-hydroxydopamine lesions of the ascending dopamine pathways. |
2003-02-13 |
2023-08-12 |
rat |
| Janne A V Mikkola, Sanna Janhunen, Petri Hyytiä, Kalervo Kiianmaa, Liisa Ahte. Rotational behaviour in AA and ANA rats after repeated administration of morphine and cocaine. Pharmacology, biochemistry, and behavior. vol 73. issue 3. 2003-02-13. PMID:12151046. |
collectively, these results suggest that morphine and cocaine activate the cerebral dopamine pathways to a greater extent in aa than in ana rats. |
2003-02-13 |
2023-08-12 |
rat |
| Bruce R Stevens, Daniel H Feldman, Zhilin Liu, William R Harve. Conserved tyrosine-147 plays a critical role in the ligand-gated current of the epithelial cation/amino acid transporter/channel CAATCH1. The Journal of experimental biology. vol 205. issue Pt 16. 2003-02-07. PMID:12124378. |
this tyrosine residue is conserved within the third transmembrane domain in members of the na(+):neurotransmitter transporter family (snf), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (sert), dopamine (dat) and norepinephrine (net) transporters. |
2003-02-07 |
2023-08-12 |
xenopus_laevis |
| Rita A Fuchs, Ly T L Tran-Nguyen, Suzanne M Weber, Taline V Khroyan, Janet L Neisewande. Effects of 7-OH-DPAT on cocaine-seeking behavior and on re-establishment of cocaine self-administration. Pharmacology, biochemistry, and behavior. vol 72. issue 3. 2003-02-05. PMID:12175459. |
effects of the d2-like dopamine agonist, 7-hydroxy-n,n-di-n-propyl-2-aminotetralin (7-oh-dpat), on cocaine-seeking behavior and re-establishment of cocaine self-administration were examined. |
2003-02-05 |
2023-08-12 |
rat |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine, serotonin and norepinephrine, producing subjective effects in humans that are both euphoric/rewarding and also fearful, jittery and aversive. |
2003-02-05 |
2023-08-12 |
mouse |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
they identify neuroadaptations that may help to explain the retention of cocaine reward by dopamine and serotonin transporter knockout mice. |
2003-02-05 |
2023-08-12 |
mouse |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
they are consistent with emerging hypotheses that actions at the three primary brain molecular targets for cocaine each provide distinct contributions to cocaine reward and cocaine aversion in wildtype mice, and that this balance changes in mice that develop without dopamine, norepinephrine or serotonin transporters. |
2003-02-05 |
2023-08-12 |
mouse |
| Sang-Hun Lee, Mi-Yoon Chang, Dae-Joon Jeon, Dong-Yul Oh, Hyeon Son, Chang-Ho Lee, Young-Seek Lee, Yong-Sung Le. The functional domains of dopamine transporter for cocaine analog, CFT binding. Experimental & molecular medicine. vol 34. issue 1. 2003-01-29. PMID:11989984. |
the functional domains of dopamine transporter for cocaine analog, cft binding. |
2003-01-29 |
2023-08-12 |
human |
| Sang-Hun Lee, Mi-Yoon Chang, Dae-Joon Jeon, Dong-Yul Oh, Hyeon Son, Chang-Ho Lee, Young-Seek Lee, Yong-Sung Le. The functional domains of dopamine transporter for cocaine analog, CFT binding. Experimental & molecular medicine. vol 34. issue 1. 2003-01-29. PMID:11989984. |
cocaine analogue, cft (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) binding to dopamine transporter (dat) in different species is quite heterogeneous. |
2003-01-29 |
2023-08-12 |
human |
| Carlos A Bolaños, George H Trksak, Ori S Cohen, Denise Jackso. Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502023. |
these data support the hypothesis that the enhanced serotonergic modulation of ach neurons in pcoc-exposed animals is largely mediated by dopamine (da) and reflect a major biochemical persistence of neurodevelopmental adaptations elicited by early cocaine exposure. |
2003-01-27 |
2023-08-12 |
rat |
| N Suto, J D Austin, L M Tanabe, M K Kramer, D A Wright, P Vezin. Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464454. |
rats in a separate group pre-exposed to vta amph but co-infused with the d(1)-like dopamine (da) receptor antagonist sch23390 (0.25 microg/0.5 microl/side) did not show enhanced cocaine self-administration. |
2003-01-24 |
2023-08-12 |
rat |
| Hans S Crombag, Jeffrey W Grimm, Yavin Shaha. Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464457. |
we also investigated whether activation of dopamine receptors contributes to context-induced renewal of cocaine seeking by testing the effects of selective d1-like (sch 23390) and d2-like (raclopride) receptor antagonists. |
2003-01-24 |
2023-08-12 |
rat |
| Hans S Crombag, Jeffrey W Grimm, Yavin Shaha. Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464457. |
these data suggest that activation of dopamine receptors is involved in reinstatement of cocaine seeking induced by exposure to the drug self-administration context. |
2003-01-24 |
2023-08-12 |
rat |
| David H Adams, Glen R Hanson, Kristen A Keef. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485404. |
in addition, we determined whether doses of cocaine (30 mg/kg) and methamphetamine (2 mg/kg) that produced equivalent increases in extracellular dopamine differentially affected preprodynorphin mrna expression in striatum of male, sprague-dawley rats. |
2003-01-23 |
2023-08-12 |
rat |
| David H Adams, Glen R Hanson, Kristen A Keef. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485404. |
in contrast, a dose of methamphetamine (2.0 mg/kg) that caused an increase in extracellular dopamine similar to that produced by 30 mg/kg cocaine did not significantly affect preprodynorphin mrna in any region of striatum. |
2003-01-23 |
2023-08-12 |
rat |
| David H Adams, Glen R Hanson, Kristen A Keef. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485404. |
these data provide further evidence that cocaine and amphetamines exert distinct effects on the patch-matrix division of striatum and suggest further that the post-synaptic consequences of elevated extracellular dopamine produced by methamphetamine and cocaine are distinct. |
2003-01-23 |
2023-08-12 |
rat |
| Masato Inazu, Hiroshi Takeda, Teruhiko Matsumiy. Functional expression of the norepinephrine transporter in cultured rat astrocytes. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485410. |
on the other hand, gbr-12935 (a selective dopamine uptake inhibitor), fluvoxamine (a selective serotonin reuptake inhibitor), venlafaxine (a snri) and cocaine had weaker inhibitory activities. |
2003-01-23 |
2023-08-12 |
rat |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
although the effects of psychostimulants on brain dopamine systems are well recognized, the direct actions of cocaine on serotonin systems also appear to be important to its addictive properties. |
2003-01-23 |
2023-08-12 |
Not clear |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
for example, serotonin actions at 5-ht1b receptors in the ventral tegmental area (vta) modulate cocaine-induced dopamine release in the nucleus accumbens (nacc) and alter the rewarding and stimulant properties of cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |