| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krista McFarland, Christopher C Lapish, Peter W Kaliva. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716962. |
when extinguished cocaine self-administration behavior was reinstated by a cocaine-priming injection, extracellular levels of both dopamine and glutamate were elevated in the nucleus accumbens. |
2003-05-30 |
2023-08-12 |
human |
| Krista McFarland, Christopher C Lapish, Peter W Kaliva. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716962. |
however, when yoked cocaine or saline control subjects were administered a cocaine prime, only dopamine levels were elevated. |
2003-05-30 |
2023-08-12 |
human |
| Nobuyoshi Suto, Lauren M Tanabe, Jennifer D Austin, Elizabeth Creekmore, Paul Vezin. Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA/kainate, and metabotropic glutamate receptor-dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655307. |
previous exposure to amphetamine (amph) in the ventral tegmental area (vta) enhances cocaine self-administration in a d(1) dopamine receptor-dependent manner. |
2003-05-29 |
2023-08-12 |
rat |
| A Y Freeman, J-J Soghomonian, R C Pierc. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605901. |
the current results also show that an acute injection of cocaine results in a decrease in the number of tyrosine kinase b and c receptors immunoreactive neuronal profiles in specific regions of the nucleus accumbens and neostriatum, indicating that cocaine-induced increases in extracellular dopamine in the striatal complex result in compensatory decreases in the expression of tyrosine kinase b and c receptors. |
2003-05-21 |
2023-08-12 |
rat |
| J E Smith, T R Koves, C C. Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. Neuroscience. vol 117. issue 2. 2003-05-21. PMID:12614686. |
the turnover rates of dopamine, norepinephrine, serotonin, aspartate, glutamate and gaba were measured in 27 brain regions of rats self-administering cocaine and in yoked cocaine- and yoked vehicle-infused controls using radioactive pulse-labeling procedures to identify brain neuronal systems underlying self-administration. |
2003-05-21 |
2023-08-12 |
rat |
| J E Smith, T R Koves, C C. Brain neurotransmitter turnover rates during rat intravenous cocaine self-administration. Neuroscience. vol 117. issue 2. 2003-05-21. PMID:12614686. |
changes in the activity of heretofore unrecognized dopamine, norepinephrine, serotonin, glutamate and gaba innervations of the forebrain specific to cocaine self-administration were found. |
2003-05-21 |
2023-08-12 |
rat |
| N Levens, C K Akin. Cocaine induces conditioned place preference and increases locomotor activity in male Japanese quail. Pharmacology, biochemistry, and behavior. vol 68. issue 1. 2003-05-20. PMID:11274710. |
finally, the dopamine d(2) receptor subtype antagonist eticlopride did not attenuate acquisition of cocaine cpp in experiment 3. |
2003-05-20 |
2023-08-12 |
human |
| Monica L Andersen, Magda Bignotto, Sergio Tufi. Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery. Physiology & behavior. vol 78. issue 2. 2003-05-20. PMID:12576123. |
even short periods of psd probably cause supersensitivity of dopamine (da) receptors and exacerbate the effects of cocaine on dopaminergic pathways to induce frequent pe and ej. |
2003-05-20 |
2023-08-12 |
rat |
| Xiaohong Wu, Howard H G. Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. Molecular pharmacology. vol 63. issue 3. 2003-05-12. PMID:12606774. |
cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. |
2003-05-12 |
2023-08-12 |
mouse |
| Xiaohong Wu, Howard H G. Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. Molecular pharmacology. vol 63. issue 3. 2003-05-12. PMID:12606774. |
dopamine transporter (dat) is a major target of cocaine, one of the most abused drugs. |
2003-05-12 |
2023-08-12 |
mouse |
| Deog-Il Kim, Margaret M Schweri, Howard M Deutsc. Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672245. |
synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. |
2003-05-08 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Pinglang Wang, Paul Blundell, Bertha K Madra. Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672255. |
methylphenidate (ritalin) binds stereoselectively and enantioselectively to the dopamine transporter (dat) and inhibits dopamine reuptake with in vitro and in vivo potency similar to that of cocaine. |
2003-05-08 |
2023-08-12 |
Not clear |
| M J Bubar, L R McMahon, P De Deurwaerdère, U Spampinato, K A Cunningha. Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens. Neuropharmacology. vol 44. issue 3. 2003-05-02. PMID:12604093. |
the role for serotonin (5-ht) in mediating the behavioral effects of cocaine may be related in part to the ability of 5-ht to modulate the function of the dopamine (da) mesoaccumbens pathways. |
2003-05-02 |
2023-08-12 |
rat |
| Sujit K Ghorai, Charles Cook, Matthew Davis, Sylesh K Venkataraman, Clifford George, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. Journal of medicinal chemistry. vol 46. issue 7. 2003-05-02. PMID:12646032. |
in our effort to develop high-affinity ligands for the dopamine transporter which might find potential use as cocaine medication, a polar hydroxy substituent was introduced into the piperidine ring of one of our disubstituted lead analogues derived from 1-[2-(diphenylmethoxy)-ethyl]-4-(3-phenylpropyl)piperazine (gbr 12935). |
2003-05-02 |
2023-08-12 |
mouse |
| Sujit K Ghorai, Charles Cook, Matthew Davis, Sylesh K Venkataraman, Clifford George, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. Journal of medicinal chemistry. vol 46. issue 7. 2003-05-02. PMID:12646032. |
the two enantiomers (+)-5 and (-)-5 exhibited marked differential affinities at the dopamine transporter with (+)-5 being 122-fold more potent than (-)-5 in inhibiting radiolabeled cocaine analogue binding (ic(50); 0.46 vs 56.7 nm) and 9-fold more active for inhibiting dopamine uptake (ic(50); 4.05 vs 38.0 nm). |
2003-05-02 |
2023-08-12 |
mouse |
| Paul E M Phillips, Garret D Stuber, Michael L A V Heien, R Mark Wightman, Regina M Carell. Subsecond dopamine release promotes cocaine seeking. Nature. vol 422. issue 6932. 2003-04-30. PMID:12687000. |
subsecond dopamine release promotes cocaine seeking. |
2003-04-30 |
2023-08-12 |
rat |
| Paul E M Phillips, Garret D Stuber, Michael L A V Heien, R Mark Wightman, Regina M Carell. Subsecond dopamine release promotes cocaine seeking. Nature. vol 422. issue 6932. 2003-04-30. PMID:12687000. |
before lever presses for cocaine, there was an increase in dopamine that coincided with the initiation of drug-seeking behaviours. |
2003-04-30 |
2023-08-12 |
rat |
| Paul E M Phillips, Garret D Stuber, Michael L A V Heien, R Mark Wightman, Regina M Carell. Subsecond dopamine release promotes cocaine seeking. Nature. vol 422. issue 6932. 2003-04-30. PMID:12687000. |
these cues alone also elicited similar, rapid dopamine signalling, but only in animals where they had previously been paired to cocaine delivery. |
2003-04-30 |
2023-08-12 |
rat |
| Jean-Pol Tassi. [Role of dopamine in drug dependence processes]. Bulletin de l'Academie nationale de medecine. vol 186. issue 2. 2003-04-29. PMID:12145837. |
recent neurobiological data have indicated that almost all drugs of abuse (amphetamine, cocaine, morphine, heroin, cannabis...) increase dopamine release in a sub-cortical structure, the nucleus accumbens. |
2003-04-29 |
2023-08-12 |
Not clear |
| István Gyertyán, Krisztina Gá. Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference. Neuroreport. vol 14. issue 1. 2003-04-25. PMID:12544838. |
the importance of dopamine d3 receptors in reward related processes, especially in cocaine addiction, has been investigated extensively. |
2003-04-25 |
2023-08-12 |
rat |