| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Cumming, Pedro Rosa-Neto, Hideaki Watanabe, Donald Smith, Dirk Bender, Paul B S Clarke, Albert Gjedd. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. NeuroImage. vol 19. issue 3. 2003-09-09. PMID:12880838. |
it is well known that the specific binding of [(11)c]raclopride to dopamine d(2,3) receptors in living striatum is reduced by cocaine and amphetamines, revealing increased competition between endogenous dopamine and [(11)c]raclopride for dopamine d(2,3) receptors. |
2003-09-09 |
2023-08-12 |
Not clear |
| Timothy E Koeltzow, Francis J Whit. Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. Behavioral neuroscience. vol 117. issue 4. 2003-09-09. PMID:12931970. |
behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. |
2003-09-09 |
2023-08-12 |
human |
| Asa Rosin, Ian Kitchen, Jeanette Georgiev. Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study. Brain research. vol 978. issue 1-2. 2003-09-08. PMID:12834892. |
both cocaine and ethanol increase the extracellular dopamine concentration in the nucleus accumbens, a terminal region in the mesolimbic dopamine pathway. |
2003-09-08 |
2023-08-12 |
human |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
bp 897 is a potent (k(i) = 0.92 nm) dopamine d(3) receptor compound developed for the treatment of cocaine abuse and craving. |
2003-09-02 |
2023-08-12 |
human |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
these interesting preclinical findings with bp 897 provide additional validation for dopamine d(3) receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (cns) disorders. |
2003-09-02 |
2023-08-12 |
human |
| Malgorzata Filip, Kathryn A Cunningha. Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 306. issue 2. 2003-08-28. PMID:12721337. |
the serotonin2c (5-hydroxytryptamine2c; 5-ht2c) receptor (5-ht2cr) is found in abundance in dopamine (da) mesocorticolimbic pathways and is one of the important target proteins that modulates the behavioral effects of cocaine. |
2003-08-28 |
2023-08-12 |
rat |
| Xianqi Feng, Keith Fandrick, Robert Johnson, Aaron Janowsky, John R Cashma. Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter. Bioorganic & medicinal chemistry. vol 11. issue 5. 2003-08-26. PMID:12538008. |
the conclusion is that substantial portions of the cocaine structure can be dissected away to provide compounds with significant binding and reuptake inhibition of the human dopamine transporter. |
2003-08-26 |
2023-08-12 |
mouse |
| Serge H Ahmed, Daniel Lin, George F Koob, Loren H Parson. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807430. |
escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. |
2003-08-26 |
2023-08-12 |
rat |
| Serge H Ahmed, Daniel Lin, George F Koob, Loren H Parson. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807430. |
the present experiment employed in vivo microdialysis to test the role of alterations in drug pharmacokinetics and/or efficacy in increasing dopamine (da) levels in the nucleus accumbens (nacc) during cocaine intake escalation. |
2003-08-26 |
2023-08-12 |
rat |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
abnormal dopamine signaling in brain has been implicated in several conditions such as cocaine abuse, parkinson's disease and depression. |
2003-08-15 |
2023-08-12 |
Not clear |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
the most potent compound 18 has a k(i) value of 79 nm in inhibition of win35,248 binding to dopamine transporter and 255 nm in inhibition of dopamine reuptake, respectively, as potent as cocaine. |
2003-08-15 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Thomas Prisinzano, Chavon R Wilkerson, Christina M Dersch, Robert Horel, Arthur E Jacobson, Richard B Rothman, Kenner C Ric. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565970. |
synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. |
2003-08-15 |
2023-08-12 |
Not clear |
| Zia Rahman, Johannes Schwarz, Stephen J Gold, Venetia Zachariou, Marc N Wein, Kwang Ho Choi, Abraham Kovoor, Ching Kang Chen, Ralph J DiLeone, Sigrid C Schwarz, Dana E Selley, Laura J Sim-Selley, Michel Barrot, Robert R Luedtke, David Self, Rachael L Neve, Henry A Lester, Melvin I Simon, Eric J Nestle. RGS9 modulates dopamine signaling in the basal ganglia. Neuron. vol 38. issue 6. 2003-08-15. PMID:12818179. |
viral-mediated overexpression of rgs9-2 in rat nucleus accumbens (ventral striatum) reduced locomotor responses to cocaine (an indirect dopamine agonist) and to d2 but not to d1 receptor agonists. |
2003-08-15 |
2023-08-12 |
mouse |
| Małgorzata Filip, Iwona Papla, Klaudia Czepie. Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866725. |
role of dopamine d3 receptors in controlling the expression of cocaine sensitization in rats. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
cocaine initiates its euphoric effects by binding to the dopamine transporter (dat), blocking uptake of synaptic dopamine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
it has been hypothesized that the dat transmembrane aspartic acid residue d79 forms an ionic interaction with charged nitrogen atoms in both dopamine and cocaine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
we examined the consequences of novel and previously studied mutations of the d79 residue on dat uptake of [3h]dopamine, dat binding of the cocaine analog [3h]win 35,428, and drug inhibition of each process, all under identical conditions. |
2003-08-15 |
2023-08-12 |
rat |
| Ellen S Mitchell, Abigail Snyder-Kelle. Blockade of D1 dopaminergic transmission alleviates c-fos induction and cleaved caspase-3 expression in the brains of rat pups exposed to prenatal cocaine or perinatal asphyxia. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821377. |
we used immediate-early gene and cleaved caspase-3 expression patterns to monitor fetal brain regions affected by intrauterine hypoxia and prenatal cocaine and pretreatment with the d1 dopamine receptor antagonist sch 23390 to determine how much of the induction observed was due to dopamine. |
2003-08-06 |
2023-08-12 |
rat |
| Ellen S Mitchell, Abigail Snyder-Kelle. Blockade of D1 dopaminergic transmission alleviates c-fos induction and cleaved caspase-3 expression in the brains of rat pups exposed to prenatal cocaine or perinatal asphyxia. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821377. |
maternal administration of a d1 dopamine antagonist, sch 23390, before either cocaine or asphyxia exposure dramatically reduced the numbers of fos-immunoreactive cells in the striatum as well as in many other brain regions. |
2003-08-06 |
2023-08-12 |
rat |