| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mitchell Ho, Mariangela Segr. Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. Biochimica et biophysica acta. vol 1638. issue 3. 2003-10-09. PMID:12878327. |
inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. |
2003-10-09 |
2023-08-12 |
human |
| Mitchell Ho, Mariangela Segr. Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. Biochimica et biophysica acta. vol 1638. issue 3. 2003-10-09. PMID:12878327. |
the scfv bound to the human dopamine transporter (hdat) with moderate affinity (k(a)=5.3 x 10(6) m(-1)) and excellent mimicry of the cocaine molecule completely inhibited cocaine binding at a molar concentration closely resembling in vivo conditions while allowing approximately 90% of equimolar dopamine uptake. |
2003-10-09 |
2023-08-12 |
human |
| Susan M Melnick, Diana L Dow-Edward. Blunted metabolic response to SKF 82958 in the mesolimbic system following preweaning cocaine treatment. Brain research. Developmental brain research. vol 143. issue 2. 2003-10-08. PMID:12855197. |
this study examined glucose metabolic rates following dopamine d(1) agonist challenge in adult male rats pretreated with cocaine during postnatal days 11-20. |
2003-10-08 |
2023-08-12 |
rat |
| Mark A Smith, Keith A Gordon, Christopher K Craig, Paul A Bryant, M Eric Ferguson, Adam M French, Jason D Gray, Jacob M McClean, Jonathan C Tetiric. Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor. Psychopharmacology. vol 167. issue 3. 2003-09-24. PMID:12669175. |
cocaine and mu opioid agonists increase central dopamine concentrations and produce robust interactions at both neurochemical and behavioral levels. |
2003-09-24 |
2023-08-12 |
rat |
| B Le Foll, J-C Schwartz, P Sokolof. Disruption of nicotine conditioning by dopamine D(3) receptor ligands. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610655. |
such an approach has been validated for cocaine in animals, by using the dopamine d(3) receptor-selective partial agonist bp 897, which inhibits cocaine cue-induced drug-seeking behavior. |
2003-09-23 |
2023-08-12 |
rat |
| F Scott Hall, Jana Drgonova, Michelle Goeb, George R Uh. Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 8. 2003-09-12. PMID:12784114. |
brain-derived neurotrophic factor (bdnf) affects the development of brain neurotransmitter systems, including dopamine and serotonin systems that are important for cocaine's rewarding and locomotor stimulatory properties. |
2003-09-12 |
2023-08-12 |
mouse |
| Paul Cumming, Pedro Rosa-Neto, Hideaki Watanabe, Donald Smith, Dirk Bender, Paul B S Clarke, Albert Gjedd. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. NeuroImage. vol 19. issue 3. 2003-09-09. PMID:12880838. |
it is well known that the specific binding of [(11)c]raclopride to dopamine d(2,3) receptors in living striatum is reduced by cocaine and amphetamines, revealing increased competition between endogenous dopamine and [(11)c]raclopride for dopamine d(2,3) receptors. |
2003-09-09 |
2023-08-12 |
Not clear |
| Timothy E Koeltzow, Francis J Whit. Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. Behavioral neuroscience. vol 117. issue 4. 2003-09-09. PMID:12931970. |
behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. |
2003-09-09 |
2023-08-12 |
human |
| Asa Rosin, Ian Kitchen, Jeanette Georgiev. Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study. Brain research. vol 978. issue 1-2. 2003-09-08. PMID:12834892. |
both cocaine and ethanol increase the extracellular dopamine concentration in the nucleus accumbens, a terminal region in the mesolimbic dopamine pathway. |
2003-09-08 |
2023-08-12 |
human |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
bp 897 is a potent (k(i) = 0.92 nm) dopamine d(3) receptor compound developed for the treatment of cocaine abuse and craving. |
2003-09-02 |
2023-08-12 |
human |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
these interesting preclinical findings with bp 897 provide additional validation for dopamine d(3) receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (cns) disorders. |
2003-09-02 |
2023-08-12 |
human |
| Malgorzata Filip, Kathryn A Cunningha. Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 306. issue 2. 2003-08-28. PMID:12721337. |
the serotonin2c (5-hydroxytryptamine2c; 5-ht2c) receptor (5-ht2cr) is found in abundance in dopamine (da) mesocorticolimbic pathways and is one of the important target proteins that modulates the behavioral effects of cocaine. |
2003-08-28 |
2023-08-12 |
rat |
| Xianqi Feng, Keith Fandrick, Robert Johnson, Aaron Janowsky, John R Cashma. Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter. Bioorganic & medicinal chemistry. vol 11. issue 5. 2003-08-26. PMID:12538008. |
the conclusion is that substantial portions of the cocaine structure can be dissected away to provide compounds with significant binding and reuptake inhibition of the human dopamine transporter. |
2003-08-26 |
2023-08-12 |
mouse |
| Serge H Ahmed, Daniel Lin, George F Koob, Loren H Parson. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807430. |
escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. |
2003-08-26 |
2023-08-12 |
rat |
| Serge H Ahmed, Daniel Lin, George F Koob, Loren H Parson. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807430. |
the present experiment employed in vivo microdialysis to test the role of alterations in drug pharmacokinetics and/or efficacy in increasing dopamine (da) levels in the nucleus accumbens (nacc) during cocaine intake escalation. |
2003-08-26 |
2023-08-12 |
rat |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
abnormal dopamine signaling in brain has been implicated in several conditions such as cocaine abuse, parkinson's disease and depression. |
2003-08-15 |
2023-08-12 |
Not clear |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
the most potent compound 18 has a k(i) value of 79 nm in inhibition of win35,248 binding to dopamine transporter and 255 nm in inhibition of dopamine reuptake, respectively, as potent as cocaine. |
2003-08-15 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Thomas Prisinzano, Chavon R Wilkerson, Christina M Dersch, Robert Horel, Arthur E Jacobson, Richard B Rothman, Kenner C Ric. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565970. |
synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. |
2003-08-15 |
2023-08-12 |
Not clear |
| Zia Rahman, Johannes Schwarz, Stephen J Gold, Venetia Zachariou, Marc N Wein, Kwang Ho Choi, Abraham Kovoor, Ching Kang Chen, Ralph J DiLeone, Sigrid C Schwarz, Dana E Selley, Laura J Sim-Selley, Michel Barrot, Robert R Luedtke, David Self, Rachael L Neve, Henry A Lester, Melvin I Simon, Eric J Nestle. RGS9 modulates dopamine signaling in the basal ganglia. Neuron. vol 38. issue 6. 2003-08-15. PMID:12818179. |
viral-mediated overexpression of rgs9-2 in rat nucleus accumbens (ventral striatum) reduced locomotor responses to cocaine (an indirect dopamine agonist) and to d2 but not to d1 receptor agonists. |
2003-08-15 |
2023-08-12 |
mouse |
| Małgorzata Filip, Iwona Papla, Klaudia Czepie. Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866725. |
role of dopamine d3 receptors in controlling the expression of cocaine sensitization in rats. |
2003-08-15 |
2023-08-12 |
rat |