| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Serge H Ahmed, Daniel Lin, George F Koob, Loren H Parson. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807430. |
the present experiment employed in vivo microdialysis to test the role of alterations in drug pharmacokinetics and/or efficacy in increasing dopamine (da) levels in the nucleus accumbens (nacc) during cocaine intake escalation. |
2003-08-26 |
2023-08-12 |
rat |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
abnormal dopamine signaling in brain has been implicated in several conditions such as cocaine abuse, parkinson's disease and depression. |
2003-08-15 |
2023-08-12 |
Not clear |
| Istvan J Enyedy, Sukumar Sakamuri, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wan. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565962. |
the most potent compound 18 has a k(i) value of 79 nm in inhibition of win35,248 binding to dopamine transporter and 255 nm in inhibition of dopamine reuptake, respectively, as potent as cocaine. |
2003-08-15 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Thomas Prisinzano, Chavon R Wilkerson, Christina M Dersch, Robert Horel, Arthur E Jacobson, Richard B Rothman, Kenner C Ric. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565970. |
synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. |
2003-08-15 |
2023-08-12 |
Not clear |
| Zia Rahman, Johannes Schwarz, Stephen J Gold, Venetia Zachariou, Marc N Wein, Kwang Ho Choi, Abraham Kovoor, Ching Kang Chen, Ralph J DiLeone, Sigrid C Schwarz, Dana E Selley, Laura J Sim-Selley, Michel Barrot, Robert R Luedtke, David Self, Rachael L Neve, Henry A Lester, Melvin I Simon, Eric J Nestle. RGS9 modulates dopamine signaling in the basal ganglia. Neuron. vol 38. issue 6. 2003-08-15. PMID:12818179. |
viral-mediated overexpression of rgs9-2 in rat nucleus accumbens (ventral striatum) reduced locomotor responses to cocaine (an indirect dopamine agonist) and to d2 but not to d1 receptor agonists. |
2003-08-15 |
2023-08-12 |
mouse |
| Małgorzata Filip, Iwona Papla, Klaudia Czepie. Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866725. |
role of dopamine d3 receptors in controlling the expression of cocaine sensitization in rats. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
cocaine initiates its euphoric effects by binding to the dopamine transporter (dat), blocking uptake of synaptic dopamine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
it has been hypothesized that the dat transmembrane aspartic acid residue d79 forms an ionic interaction with charged nitrogen atoms in both dopamine and cocaine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
we examined the consequences of novel and previously studied mutations of the d79 residue on dat uptake of [3h]dopamine, dat binding of the cocaine analog [3h]win 35,428, and drug inhibition of each process, all under identical conditions. |
2003-08-15 |
2023-08-12 |
rat |
| Ellen S Mitchell, Abigail Snyder-Kelle. Blockade of D1 dopaminergic transmission alleviates c-fos induction and cleaved caspase-3 expression in the brains of rat pups exposed to prenatal cocaine or perinatal asphyxia. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821377. |
we used immediate-early gene and cleaved caspase-3 expression patterns to monitor fetal brain regions affected by intrauterine hypoxia and prenatal cocaine and pretreatment with the d1 dopamine receptor antagonist sch 23390 to determine how much of the induction observed was due to dopamine. |
2003-08-06 |
2023-08-12 |
rat |
| Ellen S Mitchell, Abigail Snyder-Kelle. Blockade of D1 dopaminergic transmission alleviates c-fos induction and cleaved caspase-3 expression in the brains of rat pups exposed to prenatal cocaine or perinatal asphyxia. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821377. |
maternal administration of a d1 dopamine antagonist, sch 23390, before either cocaine or asphyxia exposure dramatically reduced the numbers of fos-immunoreactive cells in the striatum as well as in many other brain regions. |
2003-08-06 |
2023-08-12 |
rat |
| L Cervo, F Carnovali, J A Stark, T Mennin. Cocaine-seeking behavior in response to drug-associated stimuli in rats: involvement of D3 and D2 dopamine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 6. 2003-08-04. PMID:12700684. |
previous studies employed a second-order schedule paradigm maintained by cocaine reinforcement to show that bp897, a dopamine d(3) partial agonist, selectively modulated drug-seeking behavior. |
2003-08-04 |
2023-08-12 |
rat |
| M S Lima, A A Reisser, B G Soares, M Farrel. Antidepressants for cocaine dependence. The Cochrane database of systematic reviews. issue 2. 2003-07-28. PMID:12804445. |
while administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. |
2003-07-28 |
2023-08-12 |
Not clear |
| B G O Soares, M S Lima, A A P Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 2. 2003-07-28. PMID:12804461. |
dopamine agonists for cocaine dependence. |
2003-07-28 |
2023-08-12 |
human |
| B G O Soares, M S Lima, A A P Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 2. 2003-07-28. PMID:12804461. |
it was demonstrated that the acute use of cocaine may enhance dopamine transmission and chronically it decreases dopamine concentrations in the brain. |
2003-07-28 |
2023-08-12 |
human |
| Fatima Martel, Rosario Monteiro, Clara Lemo. Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12682218. |
it was concentration dependently inhibited by several monoamines (with the following rank order of potency: serotonin >> dopamine > or = noradrenaline) and tricyclic and nontricyclic antidepressants (with the following rank order of potency: fluoxetine > desipramine > cocaine > gbr 12909). |
2003-07-24 |
2023-08-12 |
human |
| Merewyn K Loder, Haley E Melikia. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12682063. |
the dopamine transporter (dat) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and methylphenidate (ritalin). |
2003-07-22 |
2023-08-12 |
rat |
| Stefan D Schlussman, Yong Zhang, Vadim Yuferov, K Steven LaForge, Ann Ho, Mary Jeanne Kree. Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742644. |
preprodynorphin mrna was measured in the nucleus accumbens (nac) and caudate putamen (cpu) after 3-day 'binge' pattern cocaine administration in c57bl/6j and 129/j mice, strains which differ in behavior and in dopamine increases in the cpu after 'binge' cocaine. |
2003-07-22 |
2023-08-12 |
mouse |
| Kazuaki Shimosato, Noriki Nagao, Satoru Watanabe, Shigeo Kitayam. Suppressive effects of trihexyphenidyl on methamphetamine-induced dopamine release as measured by in vivo microdialysis. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710014. |
the present study examined using in vivo microdialysis whether thp differentially affects the extracellular dopamine (da) levels in the nucleus accumbens and striatum of mice injected with map and cocaine in comparison with another antimuscarinic agent, scopolamine (scp). |
2003-07-17 |
2023-08-12 |
mouse |