| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
cocaine initiates its euphoric effects by binding to the dopamine transporter (dat), blocking uptake of synaptic dopamine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
it has been hypothesized that the dat transmembrane aspartic acid residue d79 forms an ionic interaction with charged nitrogen atoms in both dopamine and cocaine. |
2003-08-15 |
2023-08-12 |
rat |
| Wenfei Wang, Mark S Sonders, Okechukwu T Ukairo, Helen Scott, Megan K Kloetzel, Christopher K Surrat. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Molecular pharmacology. vol 64. issue 2. 2003-08-15. PMID:12869648. |
we examined the consequences of novel and previously studied mutations of the d79 residue on dat uptake of [3h]dopamine, dat binding of the cocaine analog [3h]win 35,428, and drug inhibition of each process, all under identical conditions. |
2003-08-15 |
2023-08-12 |
rat |
| Ellen S Mitchell, Abigail Snyder-Kelle. Blockade of D1 dopaminergic transmission alleviates c-fos induction and cleaved caspase-3 expression in the brains of rat pups exposed to prenatal cocaine or perinatal asphyxia. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821377. |
we used immediate-early gene and cleaved caspase-3 expression patterns to monitor fetal brain regions affected by intrauterine hypoxia and prenatal cocaine and pretreatment with the d1 dopamine receptor antagonist sch 23390 to determine how much of the induction observed was due to dopamine. |
2003-08-06 |
2023-08-12 |
rat |
| Ellen S Mitchell, Abigail Snyder-Kelle. Blockade of D1 dopaminergic transmission alleviates c-fos induction and cleaved caspase-3 expression in the brains of rat pups exposed to prenatal cocaine or perinatal asphyxia. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821377. |
maternal administration of a d1 dopamine antagonist, sch 23390, before either cocaine or asphyxia exposure dramatically reduced the numbers of fos-immunoreactive cells in the striatum as well as in many other brain regions. |
2003-08-06 |
2023-08-12 |
rat |
| L Cervo, F Carnovali, J A Stark, T Mennin. Cocaine-seeking behavior in response to drug-associated stimuli in rats: involvement of D3 and D2 dopamine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 6. 2003-08-04. PMID:12700684. |
previous studies employed a second-order schedule paradigm maintained by cocaine reinforcement to show that bp897, a dopamine d(3) partial agonist, selectively modulated drug-seeking behavior. |
2003-08-04 |
2023-08-12 |
rat |
| M S Lima, A A Reisser, B G Soares, M Farrel. Antidepressants for cocaine dependence. The Cochrane database of systematic reviews. issue 2. 2003-07-28. PMID:12804445. |
while administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. |
2003-07-28 |
2023-08-12 |
Not clear |
| B G O Soares, M S Lima, A A P Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 2. 2003-07-28. PMID:12804461. |
dopamine agonists for cocaine dependence. |
2003-07-28 |
2023-08-12 |
human |
| B G O Soares, M S Lima, A A P Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 2. 2003-07-28. PMID:12804461. |
it was demonstrated that the acute use of cocaine may enhance dopamine transmission and chronically it decreases dopamine concentrations in the brain. |
2003-07-28 |
2023-08-12 |
human |
| Fatima Martel, Rosario Monteiro, Clara Lemo. Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12682218. |
it was concentration dependently inhibited by several monoamines (with the following rank order of potency: serotonin >> dopamine > or = noradrenaline) and tricyclic and nontricyclic antidepressants (with the following rank order of potency: fluoxetine > desipramine > cocaine > gbr 12909). |
2003-07-24 |
2023-08-12 |
human |
| Merewyn K Loder, Haley E Melikia. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of biological chemistry. vol 278. issue 24. 2003-07-22. PMID:12682063. |
the dopamine transporter (dat) removes dopamine from the extracellular milieu and is potently inhibited by number of psychoactive drugs, including cocaine, amphetamines, and methylphenidate (ritalin). |
2003-07-22 |
2023-08-12 |
rat |
| Stefan D Schlussman, Yong Zhang, Vadim Yuferov, K Steven LaForge, Ann Ho, Mary Jeanne Kree. Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742644. |
preprodynorphin mrna was measured in the nucleus accumbens (nac) and caudate putamen (cpu) after 3-day 'binge' pattern cocaine administration in c57bl/6j and 129/j mice, strains which differ in behavior and in dopamine increases in the cpu after 'binge' cocaine. |
2003-07-22 |
2023-08-12 |
mouse |
| Kazuaki Shimosato, Noriki Nagao, Satoru Watanabe, Shigeo Kitayam. Suppressive effects of trihexyphenidyl on methamphetamine-induced dopamine release as measured by in vivo microdialysis. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710014. |
the present study examined using in vivo microdialysis whether thp differentially affects the extracellular dopamine (da) levels in the nucleus accumbens and striatum of mice injected with map and cocaine in comparison with another antimuscarinic agent, scopolamine (scp). |
2003-07-17 |
2023-08-12 |
mouse |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
the mechanism of action of drugs of abuse like cocaine and amphetamines has been studied extensively in the dopamine terminal field areas of the caudate-putamen (cpu) and the nucleus accumbens (nac) of the rodent brain. |
2003-07-17 |
2023-08-12 |
mouse |
| Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newma. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of medicinal chemistry. vol 46. issue 13. 2003-07-15. PMID:12801223. |
both dopamine uptake inhibitors and sigma(1) receptor antagonists have been implicated as potential pharmacotherapeutics for the treatment of cocaine abuse. |
2003-07-15 |
2023-08-12 |
Not clear |
| Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newma. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of medicinal chemistry. vol 46. issue 13. 2003-07-15. PMID:12801223. |
while the dopamine uptake inhibitors may share with cocaine neurochemical mechanisms underlying reinforcing properties, sigma(1) antagonists have been shown to attenuate some behavioral actions and toxic side effects associated with cocaine overdose. |
2003-07-15 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
selective dat expression by dopaminergic neurons has led to use of cocaine analog dat radioligands to assess rates of progression of dopamine neuronal degeneration in parkinson's disease. |
2003-07-10 |
2023-08-12 |
Not clear |
| Paul N Deslandes, David M Pache, Paul Buckland, Robert D E Sewel. Morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398908. |
morphine treated subjects showed a significant decrease (p<0.05) in striatal dopamine concentration, whilst cocaine and sertraline treatment resulted in a significant increase in striatal dopamine levels. |
2003-07-08 |
2023-08-12 |
human |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
cocaine and morphine elevate dopamine levels in the nucleus accumbens (nac), and the overwhelming actions of dopamine are implicated in reinforcement and addiction of abusive drugs. |
2003-07-01 |
2023-08-12 |
Not clear |