| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
the mechanism of action of drugs of abuse like cocaine and amphetamines has been studied extensively in the dopamine terminal field areas of the caudate-putamen (cpu) and the nucleus accumbens (nac) of the rodent brain. |
2003-07-17 |
2023-08-12 |
mouse |
| Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newma. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of medicinal chemistry. vol 46. issue 13. 2003-07-15. PMID:12801223. |
both dopamine uptake inhibitors and sigma(1) receptor antagonists have been implicated as potential pharmacotherapeutics for the treatment of cocaine abuse. |
2003-07-15 |
2023-08-12 |
Not clear |
| Jianjing Cao, Santosh S Kulkarni, Stephen M Husbands, Wayne D Bowen, Wanda Williams, Theresa Kopajtic, Jonathan L Katz, Clifford George, Amy Hauck Newma. Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Journal of medicinal chemistry. vol 46. issue 13. 2003-07-15. PMID:12801223. |
while the dopamine uptake inhibitors may share with cocaine neurochemical mechanisms underlying reinforcing properties, sigma(1) antagonists have been shown to attenuate some behavioral actions and toxic side effects associated with cocaine overdose. |
2003-07-15 |
2023-08-12 |
Not clear |
| Zhicheng Lin, Ping-Wu Zhang, Xuguang Zhu, Jean-Marc Melgari, Robin Huff, Rachel L Spieldoch, George R Uh. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. The Journal of biological chemistry. vol 278. issue 22. 2003-07-10. PMID:12660249. |
selective dat expression by dopaminergic neurons has led to use of cocaine analog dat radioligands to assess rates of progression of dopamine neuronal degeneration in parkinson's disease. |
2003-07-10 |
2023-08-12 |
Not clear |
| Paul N Deslandes, David M Pache, Paul Buckland, Robert D E Sewel. Morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398908. |
morphine treated subjects showed a significant decrease (p<0.05) in striatal dopamine concentration, whilst cocaine and sertraline treatment resulted in a significant increase in striatal dopamine levels. |
2003-07-08 |
2023-08-12 |
human |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
cocaine and morphine elevate dopamine levels in the nucleus accumbens (nac), and the overwhelming actions of dopamine are implicated in reinforcement and addiction of abusive drugs. |
2003-07-01 |
2023-08-12 |
Not clear |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
these studies indicated that ach and dopamine acted convergently but oppositely on the nac circuit and that cholinergic cell ablation enhanced long-lasting behavioral changes of cocaine addiction. |
2003-07-01 |
2023-08-12 |
Not clear |
| Shinichi Naka. Is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats? Anesthesiology. vol 98. issue 6. 2003-06-24. PMID:12766673. |
is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats? |
2003-06-24 |
2023-08-12 |
rat |
| D A Lubin, J B Cannon, M C Black, L E Brown, J M John. Effects of chronic cocaine on monoamine levels in discrete brain structures of lactating rat dams. Pharmacology, biochemistry, and behavior. vol 74. issue 2. 2003-06-18. PMID:12479966. |
dams given 30 mg/kg cocaine throughout gestation had significantly higher levels of dopamine (da) and nonsignificantly elevated serotonin (5-ht) levels relative to saline-treated controls. |
2003-06-18 |
2023-08-12 |
rat |
| Wen-Xue Tang, Wendy H Fasulo, Deborah C Mash, Scott E Hemb. Molecular profiling of midbrain dopamine regions in cocaine overdose victims. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716423. |
molecular profiling of midbrain dopamine regions in cocaine overdose victims. |
2003-06-18 |
2023-08-12 |
Not clear |
| Wen-Xue Tang, Wendy H Fasulo, Deborah C Mash, Scott E Hemb. Molecular profiling of midbrain dopamine regions in cocaine overdose victims. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716423. |
to evaluate whether the alterations in gene expression in cocaine overdose victims are associated with specific dopamine populations in the midbrain, cdna arrays and western blotting were used to compare gene and protein expression patterns between cocaine overdose victims and age-matched controls in the ventral tegmental area (vta) and lateral substantia nigra (l-sn). |
2003-06-18 |
2023-08-12 |
Not clear |
| Wen-Xue Tang, Wendy H Fasulo, Deborah C Mash, Scott E Hemb. Molecular profiling of midbrain dopamine regions in cocaine overdose victims. Journal of neurochemistry. vol 85. issue 4. 2003-06-18. PMID:12716423. |
moreover, as subunit composition determines the functional properties of iglurs, the observed changes may indicate alterations in the excitability of dopamine transmission underlying long-term biochemical and behavioral effects of cocaine in humans. |
2003-06-18 |
2023-08-12 |
Not clear |
| Caroline Prunier, Pierre Payoux, Denis Guilloteau, Sylvie Chalon, Bruno Giraudeau, Cynthia Majorel, Mathieu Tafani, Erwan Bezard, Jean-Paul Esquerré, Jean-Louis Baulie. Quantification of dopamine transporter by 123I-PE2I SPECT and the noninvasive Logan graphical method in Parkinson's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 5. 2003-06-16. PMID:12732666. |
(e)-n-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methyl-phenyl) nortropane (pe2i), a cocaine analog, is a new, highly specific tracer for imaging dopamine transporter labeled with (123)i for in vivo spect. |
2003-06-16 |
2023-08-12 |
human |
| Therese A Kosten, Xiang Yang Zhang, Priscilla Keho. Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups. Brain research. Developmental brain research. vol 141. issue 1-2. 2003-06-10. PMID:12644254. |
whether chronic neonatal isolation cross-sensitizes to cocaine leading to greater increases in ventral striatal dopamine levels was assessed in this study. |
2003-06-10 |
2023-08-12 |
rat |
| Therese A Kosten, Xiang Yang Zhang, Priscilla Keho. Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups. Brain research. Developmental brain research. vol 141. issue 1-2. 2003-06-10. PMID:12644254. |
separate groups of male and female pups were then administered 0, 2.5, 5.0, or 10 mg/kg cocaine and samples were collected for 2-h. isolate pups showed greater cocaine-induced increases in ventral striatal dopamine levels than non-handled pups. |
2003-06-10 |
2023-08-12 |
rat |
| Therese A Kosten, Xiang Yang Zhang, Priscilla Keho. Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups. Brain research. Developmental brain research. vol 141. issue 1-2. 2003-06-10. PMID:12644254. |
neonatal isolation-induced increases in the effects of cocaine on ventral striatal dopamine levels are consistent with our previous study using amphetamine in 10-day-old pups and show that chronic stress sensitizes the dopamine response to psychostimulants in infant rats. |
2003-06-10 |
2023-08-12 |
rat |
| Deborah C Mash, Qinjie Ouyang, John Pablo, Margaret Basile, Sari Izenwasser, Abraham Lieberman, Richard J Perri. Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684441. |
cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. |
2003-05-30 |
2023-08-12 |
human |
| Deborah C Mash, Qinjie Ouyang, John Pablo, Margaret Basile, Sari Izenwasser, Abraham Lieberman, Richard J Perri. Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684441. |
here we present evidence that alpha-synuclein levels are elevated in midbrain dopamine (da) neurons of chronic cocaine abusers. |
2003-05-30 |
2023-08-12 |
human |
| Vladimir I Chefer, Irina Zakharova, Toni S Shippenber. Enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684494. |
enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. |
2003-05-30 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Sammanda Ramamoorthy, Hui Shen, Russell Lake, Devadoss J Samuvel, Peter W Kaliva. GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716959. |
repeated cocaine causes enduring changes in dopamine and glutamate transmission in the nucleus accumbens, and dopamine and glutamate terminals synapse on gabaergic accumbens neurons. |
2003-05-30 |
2023-08-12 |
human |