| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taline V Khroyan, Donna M Platt, James K Rowlett, Roger D Spealma. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology. vol 168. issue 1-2. 2003-11-18. PMID:12607074. |
attenuation of relapse to cocaine seeking by dopamine d1 receptor agonists and antagonists in non-human primates. |
2003-11-18 |
2023-08-12 |
Not clear |
| Taline V Khroyan, Donna M Platt, James K Rowlett, Roger D Spealma. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology. vol 168. issue 1-2. 2003-11-18. PMID:12607074. |
dopamine d(1) receptor agonists and antagonists attenuate reinstatement of cocaine seeking in a non-human primate model of relapse. |
2003-11-18 |
2023-08-12 |
Not clear |
| Satoshi Ikemot. Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 28. 2003-11-17. PMID:14561857. |
evidence from pharmacological studies indicates that it is the ability of cocaine to block dopamine uptake and elevate extracellular dopamine concentrations, and thus increase dopaminergic receptor activation, that makes cocaine rewarding. |
2003-11-17 |
2023-08-12 |
Not clear |
| Satoshi Ikemot. Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 28. 2003-11-17. PMID:14561857. |
rewarding effects of cocaine in the tubercle were blocked by coadministration of dopamine d1 or d2 antagonists (1 mm sch 23390 or 3 mm raclopride) and were not mimicked by injections of the local anesthetic procaine (800 mm). |
2003-11-17 |
2023-08-12 |
Not clear |
| Lene Norregaard, Claus Juul Loland, Ulrik Gethe. Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12773538. |
in contrast to m371c, cocaine decreased the reaction rate of a399c with mtset, whereas dopamine had no effect. |
2003-11-10 |
2023-08-12 |
human |
| Aina Westrheim Ravna, Ingebrigt Sylte, Svein G Dah. Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12944499. |
cocaine also binds to the dopamine transporter (dat) and to the noradrenaline transporter (net) and inhibits presynaptic reuptake of dopamine and noradrenaline. |
2003-10-23 |
2023-08-12 |
Not clear |
| Mitchell Ho, Mariangela Segr. Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. Biochimica et biophysica acta. vol 1638. issue 3. 2003-10-09. PMID:12878327. |
inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. |
2003-10-09 |
2023-08-12 |
human |
| Mitchell Ho, Mariangela Segr. Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. Biochimica et biophysica acta. vol 1638. issue 3. 2003-10-09. PMID:12878327. |
the scfv bound to the human dopamine transporter (hdat) with moderate affinity (k(a)=5.3 x 10(6) m(-1)) and excellent mimicry of the cocaine molecule completely inhibited cocaine binding at a molar concentration closely resembling in vivo conditions while allowing approximately 90% of equimolar dopamine uptake. |
2003-10-09 |
2023-08-12 |
human |
| Susan M Melnick, Diana L Dow-Edward. Blunted metabolic response to SKF 82958 in the mesolimbic system following preweaning cocaine treatment. Brain research. Developmental brain research. vol 143. issue 2. 2003-10-08. PMID:12855197. |
this study examined glucose metabolic rates following dopamine d(1) agonist challenge in adult male rats pretreated with cocaine during postnatal days 11-20. |
2003-10-08 |
2023-08-12 |
rat |
| Mark A Smith, Keith A Gordon, Christopher K Craig, Paul A Bryant, M Eric Ferguson, Adam M French, Jason D Gray, Jacob M McClean, Jonathan C Tetiric. Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor. Psychopharmacology. vol 167. issue 3. 2003-09-24. PMID:12669175. |
cocaine and mu opioid agonists increase central dopamine concentrations and produce robust interactions at both neurochemical and behavioral levels. |
2003-09-24 |
2023-08-12 |
rat |
| B Le Foll, J-C Schwartz, P Sokolof. Disruption of nicotine conditioning by dopamine D(3) receptor ligands. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610655. |
such an approach has been validated for cocaine in animals, by using the dopamine d(3) receptor-selective partial agonist bp 897, which inhibits cocaine cue-induced drug-seeking behavior. |
2003-09-23 |
2023-08-12 |
rat |
| F Scott Hall, Jana Drgonova, Michelle Goeb, George R Uh. Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 8. 2003-09-12. PMID:12784114. |
brain-derived neurotrophic factor (bdnf) affects the development of brain neurotransmitter systems, including dopamine and serotonin systems that are important for cocaine's rewarding and locomotor stimulatory properties. |
2003-09-12 |
2023-08-12 |
mouse |
| Paul Cumming, Pedro Rosa-Neto, Hideaki Watanabe, Donald Smith, Dirk Bender, Paul B S Clarke, Albert Gjedd. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. NeuroImage. vol 19. issue 3. 2003-09-09. PMID:12880838. |
it is well known that the specific binding of [(11)c]raclopride to dopamine d(2,3) receptors in living striatum is reduced by cocaine and amphetamines, revealing increased competition between endogenous dopamine and [(11)c]raclopride for dopamine d(2,3) receptors. |
2003-09-09 |
2023-08-12 |
Not clear |
| Timothy E Koeltzow, Francis J Whit. Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. Behavioral neuroscience. vol 117. issue 4. 2003-09-09. PMID:12931970. |
behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons. |
2003-09-09 |
2023-08-12 |
human |
| Asa Rosin, Ian Kitchen, Jeanette Georgiev. Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study. Brain research. vol 978. issue 1-2. 2003-09-08. PMID:12834892. |
both cocaine and ethanol increase the extracellular dopamine concentration in the nucleus accumbens, a terminal region in the mesolimbic dopamine pathway. |
2003-09-08 |
2023-08-12 |
human |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
bp 897 is a potent (k(i) = 0.92 nm) dopamine d(3) receptor compound developed for the treatment of cocaine abuse and craving. |
2003-09-02 |
2023-08-12 |
human |
| F J Garcia-Ladona, B F Co. BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847556. |
these interesting preclinical findings with bp 897 provide additional validation for dopamine d(3) receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (cns) disorders. |
2003-09-02 |
2023-08-12 |
human |
| Malgorzata Filip, Kathryn A Cunningha. Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 306. issue 2. 2003-08-28. PMID:12721337. |
the serotonin2c (5-hydroxytryptamine2c; 5-ht2c) receptor (5-ht2cr) is found in abundance in dopamine (da) mesocorticolimbic pathways and is one of the important target proteins that modulates the behavioral effects of cocaine. |
2003-08-28 |
2023-08-12 |
rat |
| Xianqi Feng, Keith Fandrick, Robert Johnson, Aaron Janowsky, John R Cashma. Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter. Bioorganic & medicinal chemistry. vol 11. issue 5. 2003-08-26. PMID:12538008. |
the conclusion is that substantial portions of the cocaine structure can be dissected away to provide compounds with significant binding and reuptake inhibition of the human dopamine transporter. |
2003-08-26 |
2023-08-12 |
mouse |
| Serge H Ahmed, Daniel Lin, George F Koob, Loren H Parson. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807430. |
escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. |
2003-08-26 |
2023-08-12 |
rat |