| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura M Bohn, Raul R Gainetdinov, Tatyana D Sotnikova, Ivan O Medvedev, Robert J Lefkowitz, Linda A Dykstra, Marc G Caro. Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 32. 2003-12-08. PMID:14614085. |
in the present study, we examined this question by assessing the effects of morphine and cocaine on locomotor activity, behavioral sensitization, conditioned place preference, and striatal dopamine release in beta(arr2) knock-out (beta(arr2)-ko) mice and their wild-type (wt) controls. |
2003-12-08 |
2023-08-12 |
mouse |
| Cindy L Brandon, Heinz Steine. Repeated methylphenidate treatment in adolescent rats alters gene regulation in the striatum. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511337. |
methylphenidate is a psychostimulant which inhibits the dopamine transporter and produces dopamine overflow in the striatum, similar to the effects of cocaine. |
2003-12-05 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Lindsay K Permenter, Russell Lake, Paul F Worley, Peter W Kaliva. Homer1 proteins and AMPA receptors modulate cocaine-induced behavioural plasticity. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511343. |
to examine this possibility, rats were pretreated in the accumbens with drugs to block ampa/kainate, n-methyl-d-aspartate, group 1 metabotropic glutamate or dopamine receptors prior to each daily injection of cocaine. |
2003-12-05 |
2023-08-12 |
rat |
| Krisztina Gál, István Gyertyá. Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats. Brain research bulletin. vol 61. issue 6. 2003-12-05. PMID:14519456. |
targeting the dopamine d3 receptor cannot influence continuous reinforcement cocaine self-administration in rats. |
2003-12-05 |
2023-08-12 |
rat |
| Krisztina Gál, István Gyertyá. Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats. Brain research bulletin. vol 61. issue 6. 2003-12-05. PMID:14519456. |
the present study was designed to compare several dopamine d3 ligands of various selectivity in an animal model of drug-dependence, the cocaine self-administration paradigm. |
2003-12-05 |
2023-08-12 |
rat |
| Krisztina Gál, István Gyertyá. Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats. Brain research bulletin. vol 61. issue 6. 2003-12-05. PMID:14519456. |
in all, in contrast to the dopamine d1 and d2 receptors acute inhibition or stimulation of the d3 receptor do not appear to exert considerable influence on the acute reinforcing effect of cocaine. |
2003-12-05 |
2023-08-12 |
rat |
| Susan M Melnick, Diana L Dow-Edward. Correlating brain metabolism with stereotypic and locomotor behavior. Behavior research methods, instruments, & computers : a journal of the Psychonomic Society, Inc. vol 35. issue 3. 2003-12-04. PMID:14587554. |
therefore, cocaine exposure during development enhances the coupling of metabolism in components of the mesolimbic and nigrostriatal dopamine systems with the behavioral output associated with these systems under drug-challenge conditions. |
2003-12-04 |
2023-08-12 |
rat |
| M Freimer, H Kranzler, S Satel, J Lacobelle, K Skipsey, D Charney, J Gelernte. No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. Addiction biology. vol 1. issue 3. 2003-11-28. PMID:12893467. |
cocaine is thought to act in the brain primarily by blocking dopamine re-uptake. |
2003-11-28 |
2023-08-12 |
human |
| M Freimer, H Kranzler, S Satel, J Lacobelle, K Skipsey, D Charney, J Gelernte. No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. Addiction biology. vol 1. issue 3. 2003-11-28. PMID:12893467. |
the dopamine d3 receptor (genetic locus drd3) is localized to brain regions that have been implicated in the reinforcing effects of a number of substances of abuse, including cocaine. |
2003-11-28 |
2023-08-12 |
human |
| Takeshi Sakura. [Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 122. issue 3. 2003-11-25. PMID:12939541. |
many hypothalamic neuropeptides are involved in the regulation of energy homeostasis and feeding behavior, including melanocortins, agouti-related peptide, neuropeptide-y, cocaine, and amphetamine-regulated transcript, orexin, and melanine concentrating hormone (mch) as well as monamines (serotonin, dopamine, norepinephrine). |
2003-11-25 |
2023-08-12 |
Not clear |
| Sukumar Sakamuri, Istvan J Enyedy, Wahiduz A Zaman, Srihari R Tella, Alan P Kozikowski, Judith L Flippen-Anderson, Tivadar Farkas, Kenneth M Johnson, Shaomeng Wan. 2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry. vol 11. issue 6. 2003-11-24. PMID:12614900. |
there is considerable interest in developing dopamine transporter (dat) inhibitors as potential therapies for the treatment of cocaine abuse. |
2003-11-24 |
2023-08-12 |
mouse |
| Christine E Headin. Recent advances against substance abuse. IDrugs : the investigational drugs journal. vol 6. issue 7. 2003-11-21. PMID:12861473. |
for cocaine abuse, the main focus is on products targeting the dopamine reuptake system. |
2003-11-21 |
2023-08-12 |
Not clear |
| Colin N Haile, Matthew J During, Peter I Jatlow, Thomas R Kosten, Therese A Koste. Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats. Biological psychiatry. vol 54. issue 9. 2003-11-21. PMID:14573319. |
disulfiram (ds; antabuse) inhibits dopamine-beta-hydroxylase leading to increased brain dopamine levels and shows treatment efficacy for cocaine addiction. |
2003-11-21 |
2023-08-12 |
rat |
| Andrea T Alleweireldt, Kenneth F Kirschner, Camille B Blake, Janet L Neisewande. D1-receptor drugs and cocaine-seeking behavior: investigation of receptor mediation and behavioral disruption in rats. Psychopharmacology. vol 168. issue 1-2. 2003-11-18. PMID:12520312. |
dopamine d1-receptor antagonists and agonists both attenuate cocaine-seeking behavior (i.e., operant responding in the absence of cocaine reinforcement) elicited by a cocaine prime or cocaine-paired stimuli. |
2003-11-18 |
2023-08-12 |
rat |
| Taline V Khroyan, Donna M Platt, James K Rowlett, Roger D Spealma. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology. vol 168. issue 1-2. 2003-11-18. PMID:12607074. |
attenuation of relapse to cocaine seeking by dopamine d1 receptor agonists and antagonists in non-human primates. |
2003-11-18 |
2023-08-12 |
Not clear |
| Taline V Khroyan, Donna M Platt, James K Rowlett, Roger D Spealma. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology. vol 168. issue 1-2. 2003-11-18. PMID:12607074. |
dopamine d(1) receptor agonists and antagonists attenuate reinstatement of cocaine seeking in a non-human primate model of relapse. |
2003-11-18 |
2023-08-12 |
Not clear |
| Satoshi Ikemot. Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 28. 2003-11-17. PMID:14561857. |
evidence from pharmacological studies indicates that it is the ability of cocaine to block dopamine uptake and elevate extracellular dopamine concentrations, and thus increase dopaminergic receptor activation, that makes cocaine rewarding. |
2003-11-17 |
2023-08-12 |
Not clear |
| Satoshi Ikemot. Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 28. 2003-11-17. PMID:14561857. |
rewarding effects of cocaine in the tubercle were blocked by coadministration of dopamine d1 or d2 antagonists (1 mm sch 23390 or 3 mm raclopride) and were not mimicked by injections of the local anesthetic procaine (800 mm). |
2003-11-17 |
2023-08-12 |
Not clear |
| Lene Norregaard, Claus Juul Loland, Ulrik Gethe. Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12773538. |
in contrast to m371c, cocaine decreased the reaction rate of a399c with mtset, whereas dopamine had no effect. |
2003-11-10 |
2023-08-12 |
human |
| Aina Westrheim Ravna, Ingebrigt Sylte, Svein G Dah. Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12944499. |
cocaine also binds to the dopamine transporter (dat) and to the noradrenaline transporter (net) and inhibits presynaptic reuptake of dopamine and noradrenaline. |
2003-10-23 |
2023-08-12 |
Not clear |