| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Appell, Janet L Berfield, Lijuan C Wang, William J Dunn, Nianhang Chen, Maarten E A Reit. Structure-activity relationships for substrate recognition by the human dopamine transporter. Biochemical pharmacology. vol 67. issue 2. 2004-02-11. PMID:14698042. |
a substrate-based compound, inhibiting cocaine analog binding without interfering with dopamine recognition, could be a cocaine antagonist allowing conformational changes to occur during dopamine uptake. |
2004-02-11 |
2023-08-12 |
human |
| Elizabeth E Elliot, David R Sibley, Jonathan L Kat. Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12768268. |
locomotor and discriminative-stimulus effects of cocaine in dopamine d5 receptor knockout mice. |
2004-02-10 |
2023-08-12 |
mouse |
| Elizabeth E Elliot, David R Sibley, Jonathan L Kat. Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12768268. |
dopamine d1-like antagonists block several effects of cocaine, including its locomotor-stimulant and discriminative-stimulus effects. |
2004-02-10 |
2023-08-12 |
mouse |
| Louk J M J Vanderschuren, Patricia Beemster, Anton N M Schoffelmee. On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12768274. |
augmented dopamine activity is thought to play a critical role in the psychomotor stimulant effects of amphetamine and cocaine, as well as in the development of long-term behavioral sensitization evoked by repeated exposure to amphetamine. |
2004-02-10 |
2023-08-12 |
Not clear |
| Joshua M Gulley, Brian R Hoover, Gaynor A Larson, Nancy R Zahnise. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 12. 2004-02-10. PMID:12902997. |
individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. |
2004-02-10 |
2023-08-12 |
rat |
| Joshua M Gulley, Brian R Hoover, Gaynor A Larson, Nancy R Zahnise. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 12. 2004-02-10. PMID:12902997. |
concomitant measurement of dopamine clearance in these rats revealed that the differential behavioral responses are associated with the magnitude of dopamine transporter (dat) inhibition by cocaine. |
2004-02-10 |
2023-08-12 |
rat |
| Kyle M Kampman, Helen Pettinati, Kevin G Lynch, Thorne Sparkman, Charles P O'Brie. A pilot trial of olanzapine for the treatment of cocaine dependence. Drug and alcohol dependence. vol 70. issue 3. 2004-02-04. PMID:12757964. |
medications such as olanzapine, which block dopamine d2 receptors, as well as serotonin receptors 5ht2a and 5ht2c may be able to reduce cocaine use in cocaine dependent patients by reducing the euphoric effects of cocaine and attenuating cocaine craving. |
2004-02-04 |
2023-08-12 |
Not clear |
| Jason N Jaworski, Marie A Kozel, Kelly B Philpot, Michael J Kuha. Intra-accumbal injection of CART (cocaine-amphetamine regulated transcript) peptide reduces cocaine-induced locomotor activity. The Journal of pharmacology and experimental therapeutics. vol 307. issue 3. 2004-01-29. PMID:14551286. |
because the actions of cocaine involve dopamine, the effect of rlcart 55-102 on dopamine-induced locomotor activity was examined. |
2004-01-29 |
2023-08-12 |
rat |
| Monica L Andersen, Magda Bignotto, Sergio Tufi. The effect of apomorphine on genital reflexes in male rats deprived of paradoxical sleep. Physiology & behavior. vol 80. issue 2-3. 2004-01-26. PMID:14637218. |
drugs that stimulate dopamine (da) systems can stimulate sexual arousal in male rats and humans, and previous work has shown that cocaine enhances genital reflexes [penile erection (pe) and ejaculation (ej)] in rats deprived of paradoxical sleep (ps). |
2004-01-26 |
2023-08-12 |
rat |
| Cindy L Brandon, Michela Marinelli, Francis J Whit. Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons. Biological psychiatry. vol 54. issue 12. 2004-01-26. PMID:14675797. |
we also showed that enhanced vulnerability to cocaine is associated with elevated impulse and bursting activity of midbrain dopamine neurons in drug-naïve adult rats and might constitute a substrate critically associated with abuse liability. |
2004-01-26 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. |
2004-01-22 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
on extracellular dopamine levels in the medial prefrontal cortex (mpfc) after challenge with cocaine or stressful predatory odor presentation given 1 week (early withdrawal) or 3 weeks later (late withdrawal). |
2004-01-22 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
cocaine challenge at early withdrawal produced an increase in dopamine levels that was temporally shifted so that maximal levels of dopamine were significantly higher and attained 20 min earlier in the cocaine-pretreated group (maximal levels of saline controls=378% increase, cocaine=494% increase above baseline). |
2004-01-22 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
cocaine challenge at late withdrawal produced a similar effect on the temporal shift of maximal dopamine levels, with a significantly higher maximal percent increase of dopamine in cocaine-pretreated rats (saline-pretreated=420% increase, cocaine-pretreated=515% increase). |
2004-01-22 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
as with cocaine challenge, daily cocaine produced a leftward shift in the time at which maximal dopamine levels were attained in response to tmt. |
2004-01-22 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
these results suggest that there are long-term changes in the mpfc dopamine response to subsequent challenge with cocaine as well as a stressful predatory odor. |
2004-01-22 |
2023-08-12 |
rat |
| Wei-Ran Wu, Na Li, Barbara A Sor. Prolonged effects of repeated cocaine on medial prefrontal cortex dopamine response to cocaine and a stressful predatory odor challenge in rats. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575896. |
the altered response of mpfc dopamine after repeated daily cocaine may impact relapse to drug-seeking or drug-taking behavior. |
2004-01-22 |
2023-08-12 |
rat |
| Herbert D Klebe. Pharmacologic treatments for heroin and cocaine dependence. The American journal on addictions. vol 12. issue s2. 2004-01-20. PMID:12857659. |
treatment of cocaine addiction includes anti-craving agents, dopamine agonists or blocking agents, antidepressants, and treatment of co-morbid psychiatric disorders, but all with mixed results. |
2004-01-20 |
2023-08-12 |
Not clear |
| Chin-Chang Huang, Yi-Hsin Weng, Chin-Song Lu, Nai-Shin Chu, Tzu-Chen Ye. Dopamine transporter binding in chronic manganese intoxication. Journal of neurology. vol 250. issue 11. 2004-01-16. PMID:14648150. |
(99m)tc-trodat-1 is a cocaine analogue that can bind to the dopamine transporter (dat) site reflecting the function of presynaptic dopaminergic terminals. |
2004-01-16 |
2023-08-12 |
human |
| Ezio Carboni, Alessandra Silvagni, Valentina Valentini, Gaetano Di Chiar. Effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of SHR rats. An in vivo microdyalisis study. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624809. |
effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of shr rats. |
2004-01-15 |
2023-08-12 |
human |