| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Ivy Carroll, Neil Pawlush, Michael J Kuhar, Gerald T Pollard, James L Howar. Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. Journal of medicinal chemistry. vol 47. issue 2. 2004-03-05. PMID:14711303. |
this provides further support for the dopamine hypothesis of cocaine abuse. |
2004-03-05 |
2023-08-12 |
mouse |
| Tamaki Hayase, Yoshiko Yamamoto, Keiichi Yamamot. Brain excitatory amino acid transporters (EAATs) and treatment of methamphetamine toxicity. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 38. issue 6. 2004-03-02. PMID:14750360. |
based on the phenomenon of the abnormally increased transport of brain excitatory amino acids induced by the increased release of dopamine (da) in the brain, the effects of intraperitoneal l-trans-pyrrolidine-2,4-dicarboxylic acid (pdc), a non-selective excitatory amino acid transporter (eaat) inhibitor, and (+/-)-threo-3-methylglutamic acid (mg), a specific eaat2 inhibitor, were examined against methamphetamine (ma) and cocaine (coc) toxicity in mice. |
2004-03-02 |
2023-08-12 |
mouse |
| Amy Hauck Newman, Jianjing Cao, Christina J Bennett, Michael J Robarge, Rebekah A Freeman, Robert R Luedtk. N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists. Bioorganic & medicinal chemistry letters. vol 13. issue 13. 2004-03-01. PMID:12798330. |
the dopamine d(3) receptor subtype has been targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. |
2004-03-01 |
2023-08-12 |
rat |
| J R Homberg, G Wardeh, H S Raasø, A N M Schoffelmeer, T J De Vrie. Neuroadaptive changes in mesocorticolimbic dopamine and acetylcholine neurons following cocaine or saline self-administration are dependent on pre-existing individual differences. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580932. |
neuroadaptive changes in mesocorticolimbic dopamine and acetylcholine neurons following cocaine or saline self-administration are dependent on pre-existing individual differences. |
2004-03-01 |
2023-08-12 |
rat |
| J R Homberg, G Wardeh, H S Raasø, A N M Schoffelmeer, T J De Vrie. Neuroadaptive changes in mesocorticolimbic dopamine and acetylcholine neurons following cocaine or saline self-administration are dependent on pre-existing individual differences. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580932. |
in the present study, we studied the effect of cocaine and saline self-administration on these pre-existing differences in neurochemical profile by determining the electrically evoked release of [3h]dopamine and [14c]acetylcholine from superfused slices of the nucleus accumbens shell and core, medial prefrontal cortex and amygdala of hg and low grooming (lg) rats. |
2004-03-01 |
2023-08-12 |
rat |
| Yolanda Mateo, Evgeny A Budygin, Carrie E John, Sara R Jone. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 1. 2004-02-25. PMID:14691264. |
role of serotonin in cocaine effects in mice with reduced dopamine transporter function. |
2004-02-25 |
2023-08-12 |
mouse |
| Yolanda Mateo, Evgeny A Budygin, Carrie E John, Sara R Jone. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 1. 2004-02-25. PMID:14691264. |
it is generally accepted that the ability of cocaine to inhibit the dopamine transporter (dat) is directly related to its reinforcing actions. |
2004-02-25 |
2023-08-12 |
mouse |
| Patricia A Broderick, Omotola Hope, Catherine Okonji, David N Rahni, Yueping Zho. Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 1. 2004-02-18. PMID:14687870. |
clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal. |
2004-02-18 |
2023-08-12 |
rat |
| Ming Hu, Hans S Crombag, Terry E Robinson, Jill B Becke. Biological basis of sex differences in the propensity to self-administer cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 1. 2004-02-17. PMID:12955098. |
for example, estradiol enhances dopamine release in the striatum and nucleus accumbens, and facilitates the behavioral sensitization induced by repeated cocaine exposure. |
2004-02-17 |
2023-08-12 |
human |
| Marina E Wolf, Simona Mangiavacchi, Xiu Su. Mechanisms by which dopamine receptors may influence synaptic plasticity. Annals of the New York Academy of Sciences. vol 1003. 2004-02-13. PMID:14684450. |
while dopamine (da) receptors mediate acute effects of amphetamine and cocaine, chronic drug administration produces many glutamate-dependent adaptations, including ltp in reward-related neuronal circuits. |
2004-02-13 |
2023-08-12 |
rat |
| Maciej Gasior, Carol A Paronis, Jack Bergma. Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys. The Journal of pharmacology and experimental therapeutics. vol 308. issue 1. 2004-02-11. PMID:14563783. |
these results agree with previous findings of similarity in the behavioral effects of cocaine and indirect or direct dopamine agonists and suggest, furthermore, that i.v. |
2004-02-11 |
2023-08-12 |
monkey |
| Maciej Gasior, Carol A Paronis, Jack Bergma. Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys. The Journal of pharmacology and experimental therapeutics. vol 308. issue 1. 2004-02-11. PMID:14563783. |
self-administration behavior engendered by priming doses of cocaine may involve actions mediated through both d1 and d2 families of dopamine receptors. |
2004-02-11 |
2023-08-12 |
monkey |
| Carolina Demarchi Munhoz, Isaias Glezer, Elisa Mitiko Kawamoto, Ana Paula Natalini Araújo, Lucília B Lepscha, Cleopatra S Planeta, Roberto DeLucia, Cristoforo Scavon. Changes in sodium, potassium-ATPase induced by repeated fencamfamine: the roles of cyclic AMP-dependent protein kinase and the nitric oxide-cyclic GMP pathway. Neuropharmacology. vol 45. issue 8. 2004-02-11. PMID:14614957. |
fencamfamine (fcf) is an indirect dopamine agent with effects similar to amphetamine and cocaine. |
2004-02-11 |
2023-08-12 |
Not clear |
| Michael Appell, Janet L Berfield, Lijuan C Wang, William J Dunn, Nianhang Chen, Maarten E A Reit. Structure-activity relationships for substrate recognition by the human dopamine transporter. Biochemical pharmacology. vol 67. issue 2. 2004-02-11. PMID:14698042. |
the present study examines only the substrate recognition step by assessment of the potency of various dopamine-related compounds in inhibiting the binding of the cocaine analog [3h]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane ([3h]win 35,428) to human dopamine transporters expressed in hek-293 cells. |
2004-02-11 |
2023-08-12 |
human |
| Michael Appell, Janet L Berfield, Lijuan C Wang, William J Dunn, Nianhang Chen, Maarten E A Reit. Structure-activity relationships for substrate recognition by the human dopamine transporter. Biochemical pharmacology. vol 67. issue 2. 2004-02-11. PMID:14698042. |
a substrate-based compound, inhibiting cocaine analog binding without interfering with dopamine recognition, could be a cocaine antagonist allowing conformational changes to occur during dopamine uptake. |
2004-02-11 |
2023-08-12 |
human |
| Elizabeth E Elliot, David R Sibley, Jonathan L Kat. Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12768268. |
locomotor and discriminative-stimulus effects of cocaine in dopamine d5 receptor knockout mice. |
2004-02-10 |
2023-08-12 |
mouse |
| Elizabeth E Elliot, David R Sibley, Jonathan L Kat. Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12768268. |
dopamine d1-like antagonists block several effects of cocaine, including its locomotor-stimulant and discriminative-stimulus effects. |
2004-02-10 |
2023-08-12 |
mouse |
| Louk J M J Vanderschuren, Patricia Beemster, Anton N M Schoffelmee. On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization. Psychopharmacology. vol 169. issue 2. 2004-02-10. PMID:12768274. |
augmented dopamine activity is thought to play a critical role in the psychomotor stimulant effects of amphetamine and cocaine, as well as in the development of long-term behavioral sensitization evoked by repeated exposure to amphetamine. |
2004-02-10 |
2023-08-12 |
Not clear |
| Joshua M Gulley, Brian R Hoover, Gaynor A Larson, Nancy R Zahnise. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 12. 2004-02-10. PMID:12902997. |
individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. |
2004-02-10 |
2023-08-12 |
rat |
| Joshua M Gulley, Brian R Hoover, Gaynor A Larson, Nancy R Zahnise. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 12. 2004-02-10. PMID:12902997. |
concomitant measurement of dopamine clearance in these rats revealed that the differential behavioral responses are associated with the magnitude of dopamine transporter (dat) inhibition by cocaine. |
2004-02-10 |
2023-08-12 |
rat |