| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul E M Phillips, Josephine M Johns, Deborah A Lubin, Evgeny A Budygin, Raul R Gainetdinov, Jeffery A Lieberman, R Mark Wightma. Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine. Brain research. vol 961. issue 1. 2003-04-01. PMID:12535777. |
the ability of terminals in the caudate putamen and nucleus accumbens to release and regulate dopamine is unaltered by prenatal cocaine exposure. |
2003-04-01 |
2023-08-12 |
rat |
| Lin Lu, Zhiyuan Liu, Mingsheng Huang, Zhangying Zhan. Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes. Journal of neurochemistry. vol 84. issue 6. 2003-03-28. PMID:12614338. |
the effects on locomotor response to cocaine challenge, acquisition of cocaine conditioned place preference and cocaine-induced dopamine (da) release in nucleus accumbens and ventral tegmental area by the non-specific corticotropin-releasing factor (crf) receptors antagonist alpha-helical crf, the selective crf receptor subtype 1 antagonist cp-154,526 and the selective crf receptor subtype 2 antagonist anti-sauvagine-30 (as-30) were investigated in rats. |
2003-03-28 |
2023-08-12 |
rat |
| Anita J Bechtholt, Gregory P Mar. Enhancement of cocaine-seeking behavior by repeated nicotine exposure in rats. Psychopharmacology. vol 162. issue 2. 2003-03-26. PMID:12110995. |
previous work has provided evidence that nicotine and cocaine have interactive neurochemical effects, particularly with regard to dopamine (da) transmission. |
2003-03-26 |
2023-08-12 |
rat |
| Peter S Talbot, Marc Laruell. The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 6. 2003-03-25. PMID:12468013. |
for methylphenidate and cocaine, typical doses occupy more than 50% of dopamine transporters, and their profiles are extremely similar. |
2003-03-25 |
2023-08-12 |
human |
| Grégory Porras, Vincenzo Di Matteo, Philippe De Deurwaerdère, Ennio Esposito, Umberto Spampinat. Central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of dopamine in the rat striatum: in vivo studies with morphine, amphetamine and cocaine. Neuropharmacology. vol 43. issue 7. 2003-03-21. PMID:12504916. |
central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of dopamine in the rat striatum: in vivo studies with morphine, amphetamine and cocaine. |
2003-03-21 |
2023-08-12 |
rat |
| Evan L Riddle, Matthew K Topham, John W Haycock, Glen R Hanson, Annette E Fleckenstei. Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine. European journal of pharmacology. vol 449. issue 1-2. 2003-03-20. PMID:12163108. |
high-dose administration of cocaine or methamphetamine to rats acutely (< or = 24 h) alters vesicular dopamine transport. |
2003-03-20 |
2023-08-12 |
rat |
| Michael A Nader, Rachna S Sinnott, Robert H Mach, Drake Morga. Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist. Psychopharmacology. vol 163. issue 3-4. 2003-03-20. PMID:12373430. |
the hypothesis was that changes in the magnitude of food reinforcement would affect cocaine-maintained response rates and influence the behavioral potency of a dopamine antagonist to decrease cocaine self-administration. |
2003-03-20 |
2023-08-12 |
monkey |
| Charles W Bradberr. Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals. Psychopharmacology. vol 165. issue 1. 2003-03-20. PMID:12474120. |
dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals. |
2003-03-20 |
2023-08-12 |
monkey |
| I Roth-Deri, A Zangen, M Aleli, R G Goelman, G Pelled, R Nakash, I Gispan-Herman, T Green, Y Shaham, G Yadi. Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603818. |
the effect of cocaine on beta-endorphin release in the nucleus accumbens was mimicked by a local perfusion of dopamine (5 microm) and was blocked by coadministration of sch-23390 (10 microm). |
2003-03-19 |
2023-08-12 |
Not clear |
| Glenda C Harris, Gary Aston-Jone. Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 1. 2003-03-17. PMID:12496942. |
this activation has been linked to the behavioral effects of cocaine and recently to the induction of long-term potentiation in dopamine neurons within the ventral tegmental area (vta). |
2003-03-17 |
2023-08-12 |
rat |
| R J Grant, P B S Clark. Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453497. |
the continued survival of mesolimbic dopamine cell bodies after a 6-ohda lesion may have functional implications relating to drugs of abuse, as somatodendritic release of dopamine in the vta has been shown to play a role in the effectiveness of cocaine reward. |
2003-03-12 |
2023-08-12 |
rat |
| Niki Sharan, Victor Z Chong, Venugopalan D Nair, Ram K Mishra, Robert J Hayes, Eliot L Gardne. Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regions. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422371. |
since cocaine has been shown to increase extracellular dopamine levels, these findings suggest that increased expression of crp40 is associated with high extracellular levels of dopamine (or its metabolites). |
2003-03-07 |
2023-08-12 |
Not clear |
| Niki Sharan, Victor Z Chong, Venugopalan D Nair, Ram K Mishra, Robert J Hayes, Eliot L Gardne. Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regions. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422371. |
elevated levels of crp40 could play a protective role for dopamine neurons in response to increased oxidative stress that has been shown to be induced by cocaine and that can lead to apoptosis and neurodegeneration. |
2003-03-07 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
the search for a functional antagonist to the addictive properties of cocaine has focused on the discovery of a molecule that can inhibit cocaine binding to the dopamine transporter (dat) but continue to allow dopamine transport by the dat. |
2003-03-04 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
a unique approach is utilized to deliver an inhibitor that binds irreversibly to the dat, then cleaves and leaves behind a small fragment attached to the dat that blocks access by cocaine but permits dopamine transport. |
2003-03-04 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
this group is hypothesized to attack the incoming inhibitor and lead to selective inhibition of the cocaine binding site while sparing dopamine transport. |
2003-03-04 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
this concept of a mechanism based irreversible dopamine-sparing cocaine antagonist has now been demonstrated to be viable and, as example, the unsaturated 6 showed inhibition of cocaine (63%) at the dat after 24h incubation, while at that point considerably less inhibition of dopamine is manifested (23%). |
2003-03-04 |
2023-08-12 |
Not clear |
| Peter C Meltzer, Shanghao Liu, Heather Blanchette, Paul Blundell, Bertha K Madra. Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorganic & medicinal chemistry. vol 10. issue 11. 2003-03-04. PMID:12213473. |
in contrast, the epoxide 7 showed a greater inhibition of dopamine reuptake than cocaine binding at 24h (68% versus 18%). |
2003-03-04 |
2023-08-12 |
Not clear |
| Edward F Domin. Conflicting evidence for the dopamine release theory of nicotine/tobacco dependence. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 5. 2003-02-20. PMID:12451690. |
a review of the published data is appropriate to evaluate the basis for the current widely held view that nicotine/tobacco, like much stronger central nervous system stimulants including amphetamine and cocaine, acts primarily through a brain dopamine release mechanism. |
2003-02-20 |
2023-08-12 |
mouse |
| Edward F Domin. Conflicting evidence for the dopamine release theory of nicotine/tobacco dependence. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 5. 2003-02-20. PMID:12451690. |
the data for a primary role of nicotine release of brain dopamine are unimpressive compared to that of amphetamines and cocaine in conscious unanesthetized primates, both subhuman and human. |
2003-02-20 |
2023-08-12 |
mouse |