| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alan P Kozikowski, Kenneth M Johnson, Olivier Deschaux, Bidhan C Bandyopadhyay, Gian Luca Araldi, Gilberto Carmona, Patrik Munzar, Miles P Smith, Robert L Balster, Patrick M Beardsley, Srihari R Tell. Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine. The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649362. |
like cocaine, (+)-cpca inhibited rat synaptosomal dopamine and norepinephrine uptake with high affinity, but was 33-fold less potent than cocaine in inhibiting serotonin uptake. |
2003-04-22 |
2023-08-12 |
mouse |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649367. |
individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens. |
2003-04-22 |
2023-08-12 |
rat |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649367. |
because cocaine inhibits the dopamine (da) transporter (dat), we investigated whether altered dat function contributes to these individual differences. |
2003-04-22 |
2023-08-12 |
rat |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649367. |
baseline behavioral and dopamine clearance indices were unaltered by repeated cocaine or after withdrawal. |
2003-04-22 |
2023-08-12 |
rat |
| Patricia Di Ciano, Rachel J Underwood, Jim J Hagan, Barry J Everit. Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589386. |
these results therefore suggest that d(3) dopamine receptors may be critically involved in cue-controlled drug-seeking behavior independently of any interaction with the reinforcing effects of cocaine itself, and may therefore provide a therapeutic target in the treatment of relapse to cocaine use induced by css. |
2003-04-21 |
2023-08-12 |
Not clear |
| Ruggero Galici, Aurelio Galli, David J Jones, Teresa A Sanchez, Christine Saunders, Alan Frazer, Georgianna G Gould, Richard Z Lin, Charles P Franc. Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats. Neuroendocrinology. vol 77. issue 2. 2003-04-11. PMID:12624535. |
the dopamine transporter (dat) regulates extracellular dopamine da levels and is an important site of action for amphetamine and cocaine. |
2003-04-11 |
2023-08-12 |
rat |
| Agustin Zapata, Vladimir I Chefer, Robert Ator, Toni S Shippenberg, Beatriz A Roch. Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581176. |
behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. |
2003-04-10 |
2023-08-12 |
mouse |
| Agustin Zapata, Vladimir I Chefer, Robert Ator, Toni S Shippenberg, Beatriz A Roch. Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581176. |
the present study used the technique of in vivo microdialysis in conjunction with operant self-administration to characterize cocaine-evoked locomotor activity and dopamine levels in the nucleus accumbens in mice with a prior history of intravenous cocaine self-administration or those that had received yoked infusions of cocaine. |
2003-04-10 |
2023-08-12 |
mouse |
| Agustin Zapata, Vladimir I Chefer, Robert Ator, Toni S Shippenberg, Beatriz A Roch. Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581176. |
mice that had received contingent or non-contingent infusions of cocaine exhibited an enhanced behavioural response to cocaine and increased cocaine-evoked dopamine levels in the nucleus accumbens. |
2003-04-10 |
2023-08-12 |
mouse |
| Agustin Zapata, Vladimir I Chefer, Robert Ator, Toni S Shippenberg, Beatriz A Roch. Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581176. |
prior exposure to cocaine did not modify baseline dopamine levels in the nucleus accumbens. |
2003-04-10 |
2023-08-12 |
mouse |
| Agustin Zapata, Vladimir I Chefer, Robert Ator, Toni S Shippenberg, Beatriz A Roch. Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581176. |
these data demonstrate that mice with previous cocaine self-administration experience show an enhanced behavioural and dopamine response to cocaine in the nucleus accumbens. |
2003-04-10 |
2023-08-12 |
mouse |
| Agustin Zapata, Vladimir I Chefer, Robert Ator, Toni S Shippenberg, Beatriz A Roch. Behavioural sensitization and enhanced dopamine response in the nucleus accumbens after intravenous cocaine self-administration in mice. The European journal of neuroscience. vol 17. issue 3. 2003-04-10. PMID:12581176. |
furthermore, control over cocaine infusion does not significantly alter the magnitude of the sensitized behavioural and presynaptic dopamine responses observed in response to a challenge dose of cocaine. |
2003-04-10 |
2023-08-12 |
mouse |
| Alec Roy, Jeffrey Berman, Bienvenido Gonzalez, Monique Ro. Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving. Journal of psychopharmacology (Oxford, England). vol 16. issue 3. 2003-04-07. PMID:12236629. |
there were no significant relationships between cocaine craving scores and csf concentrations of the dopamine metabolite, homovanillic acid, the serotonin metabolite, 5-hydroxyindoleacetic acid, or the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylglycol. |
2003-04-07 |
2023-08-12 |
Not clear |
| Fanny Autret, Stéphane Dauger, Sylvain Renolleau, Guy Vardon Eng, Barry E Kosofsky, Pierre Gressens, Claude Gaultier, Jorge Galleg. Ventilatory control in newborn mice prenatally exposed to cocaine. Pediatric pulmonology. vol 34. issue 6. 2003-04-01. PMID:12422341. |
v'(e) responses to hypoxia were significantly smaller in coc than in sal pups (+27 +/- 35% vs. +38 +/- 25%), but v'(e) responses to hypercapnia were similar (29 +/- 15% vs. 25 +/- 23%).thus, breathing control was impaired by prenatal cocaine exposure, possibly because of abnormal development of neurotransmitter systems, such as the dopamine and serotonin systems. |
2003-04-01 |
2023-08-12 |
mouse |
| Paul E M Phillips, Josephine M Johns, Deborah A Lubin, Evgeny A Budygin, Raul R Gainetdinov, Jeffery A Lieberman, R Mark Wightma. Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine. Brain research. vol 961. issue 1. 2003-04-01. PMID:12535777. |
the ability of terminals in the caudate putamen and nucleus accumbens to release and regulate dopamine is unaltered by prenatal cocaine exposure. |
2003-04-01 |
2023-08-12 |
rat |
| Lin Lu, Zhiyuan Liu, Mingsheng Huang, Zhangying Zhan. Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes. Journal of neurochemistry. vol 84. issue 6. 2003-03-28. PMID:12614338. |
the effects on locomotor response to cocaine challenge, acquisition of cocaine conditioned place preference and cocaine-induced dopamine (da) release in nucleus accumbens and ventral tegmental area by the non-specific corticotropin-releasing factor (crf) receptors antagonist alpha-helical crf, the selective crf receptor subtype 1 antagonist cp-154,526 and the selective crf receptor subtype 2 antagonist anti-sauvagine-30 (as-30) were investigated in rats. |
2003-03-28 |
2023-08-12 |
rat |
| Anita J Bechtholt, Gregory P Mar. Enhancement of cocaine-seeking behavior by repeated nicotine exposure in rats. Psychopharmacology. vol 162. issue 2. 2003-03-26. PMID:12110995. |
previous work has provided evidence that nicotine and cocaine have interactive neurochemical effects, particularly with regard to dopamine (da) transmission. |
2003-03-26 |
2023-08-12 |
rat |
| Peter S Talbot, Marc Laruell. The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 6. 2003-03-25. PMID:12468013. |
for methylphenidate and cocaine, typical doses occupy more than 50% of dopamine transporters, and their profiles are extremely similar. |
2003-03-25 |
2023-08-12 |
human |
| Grégory Porras, Vincenzo Di Matteo, Philippe De Deurwaerdère, Ennio Esposito, Umberto Spampinat. Central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of dopamine in the rat striatum: in vivo studies with morphine, amphetamine and cocaine. Neuropharmacology. vol 43. issue 7. 2003-03-21. PMID:12504916. |
central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of dopamine in the rat striatum: in vivo studies with morphine, amphetamine and cocaine. |
2003-03-21 |
2023-08-12 |
rat |
| Evan L Riddle, Matthew K Topham, John W Haycock, Glen R Hanson, Annette E Fleckenstei. Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine. European journal of pharmacology. vol 449. issue 1-2. 2003-03-20. PMID:12163108. |
high-dose administration of cocaine or methamphetamine to rats acutely (< or = 24 h) alters vesicular dopamine transport. |
2003-03-20 |
2023-08-12 |
rat |