| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W-R Wu, N Li, B A Sor. Regulation of medial prefrontal cortex dopamine by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptors. Neuroscience. vol 114. issue 2. 2002-11-26. PMID:12204218. |
local medial prefrontal cortex infusion of the 30 microm dose blocked the small increase in dopamine levels elicited by systemic saline injection (maximum of 26%), as well as the much larger increase in response to acute cocaine injection (maximum of 340%). |
2002-11-26 |
2023-08-12 |
Not clear |
| Stanislav R Vorel, Charles R Ashby, Mousumi Paul, Xinhe Liu, Robert Hayes, Jim J Hagan, Derek N Middlemiss, Geoffrey Stemp, Eliot L Gardne. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417684. |
dopamine d3 receptor is preferentially localized to the mesocorticolimbic dopaminergic system and has been hypothesized to play a role in cocaine addiction. |
2002-11-25 |
2023-08-12 |
rat |
| Stanislav R Vorel, Charles R Ashby, Mousumi Paul, Xinhe Liu, Robert Hayes, Jim J Hagan, Derek N Middlemiss, Geoffrey Stemp, Eliot L Gardne. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417684. |
these data suggest an important role for d3 receptors in mediating the addictive properties of cocaine and suggest that blockade of dopamine d3 receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction. |
2002-11-25 |
2023-08-12 |
rat |
| Tangui Maurice, Rémi Martin-Fardon, Pascal Romieu, Rae R Matsumot. Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neuroscience and biobehavioral reviews. vol 26. issue 4. 2002-11-22. PMID:12204195. |
current therapeutic strategies focus on counteracting the cocaine effects directly on the dopamine transporter, through post-synaptic d(1), d(2) or d(3) receptors or through the glutamatergic, serotoninergic, opioid or corticotropin-releasing hormone systems. |
2002-11-22 |
2023-08-12 |
Not clear |
| Joshua A Lile, Drake Morgan, Anne M Birmingham, Zhixia Wang, William L Woolverton, Huw M L Davies, Michael A Nade. The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388646. |
the time of onset for dopamine transporter (dat) occupancy of the long-acting, high-affinity dat blocker 2beta-propanoyl-3beta-(4-tolyl)-tropane (ptt) was measured using an ex vivo binding assay in rodents and was determined to be significantly longer than for cocaine (30 min versus 2 min). |
2002-11-22 |
2023-08-12 |
monkey |
| Christian P Müller, Maria A De Souza Silva, Gail DePalma, Carlos Tomaz, Robert J Carey, Joseph P Husto. The selective serotonin(1A)-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191821. |
the selective serotonin(1a)-receptor antagonist way 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase. |
2002-11-19 |
2023-08-12 |
rat |
| Christian P Müller, Maria A De Souza Silva, Gail DePalma, Carlos Tomaz, Robert J Carey, Joseph P Husto. The selective serotonin(1A)-receptor antagonist WAY 100635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase. Behavioural brain research. vol 134. issue 1-2. 2002-11-19. PMID:12191821. |
an increase in the extracellular dopamine (da) concentration is generally accepted as an important neurochemical mediator of the behavioral effects of cocaine. |
2002-11-19 |
2023-08-12 |
rat |
| Douglas S Kim, Glenda J Froelick, Richard D Palmite. Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427840. |
control mice and mutant mice, in which dopamine production is inactivated in dopaminergic neurons by gene targeting, were treated with saline; a synthetic dopamine precursor, l-3,4-dihydroxyphenylalanine (l-dopa) methyl ester; a direct dopamine d(1) receptor agonist, n-allyl-skf 38393; or a dopamine reuptake inhibitor, cocaine. |
2002-11-18 |
2023-08-12 |
mouse |
| Beatriz A Rocha, Evan H Goulding, Laura E O'Dell, Andy N Mead, Nicole G Coufal, Loren H Parsons, Laurence H Tecot. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427861. |
moreover, mutants exhibit enhanced cocaine-induced elevations of dopamine (da) levels in the nucleus accumbens, a brain region implicated in the stimulant and rewarding properties of cocaine. |
2002-11-18 |
2023-08-12 |
mouse |
| Gaylord Elliso. Neural degeneration following chronic stimulant abuse reveals a weak link in brain, fasciculus retroflexus, implying the loss of forebrain control circuitry. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 4. 2002-11-15. PMID:12126867. |
a variety of drugs which predominantly potentiate dopamine, including d-amphetamine, methamphetamine, mdma, cocaine, and cathinone, all induce degeneration in axons from lateral habenula, through the sheath of fr, to midbrain cells such as sn, vta, and raphe. |
2002-11-15 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Sari Izenwasse. Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats. Brain research. Developmental brain research. vol 138. issue 1. 2002-11-15. PMID:12234655. |
ten days later (day 17), rats either were challenged with cocaine, or dopamine transporter and receptor and serotonin transporter binding were examined. |
2002-11-15 |
2023-08-12 |
rat |
| Stephanie L Collins, Sari Izenwasse. Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats. Brain research. Developmental brain research. vol 138. issue 1. 2002-11-15. PMID:12234655. |
adult rats became sensitized to the locomotor-activating effects of cocaine and there were increases in dopamine transporter density in the caudate putamen compared to vehicle-treated adult rats. |
2002-11-15 |
2023-08-12 |
rat |
| Stephanie L Collins, Sari Izenwasse. Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats. Brain research. Developmental brain research. vol 138. issue 1. 2002-11-15. PMID:12234655. |
in contrast, periadolescent rats did not show sensitization to cocaine and there was no effect of cocaine on either dopamine or serotonin transporter densities. |
2002-11-15 |
2023-08-12 |
rat |
| Lars H Pinborg, Charlotte Videbaek, Claus Svarer, Stig Yndgaard, Olaf B Paulson, Gitte M Knudse. Quantification of [(123)I]PE2I binding to dopamine transporters with SPET. European journal of nuclear medicine and molecular imaging. vol 29. issue 5. 2002-11-13. PMID:11976800. |
the iodinated cocaine derivative [(123)i]pe2i is a new selective ligand for in vivo studies of the dopamine transporter (dat) with single-photon emission tomography (spet). |
2002-11-13 |
2023-08-12 |
human |
| Andrew B Norman, Jeffrey A Welge, Vladimir L Tsibulsk. Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390. Brain research. vol 946. issue 2. 2002-11-12. PMID:12137929. |
in the presence of the d(1) dopamine receptor-selective antagonist sch23390, the geometric means of the cocaine priming threshold were significantly increased in a dose-dependent manner, implying a role for d(1) dopamine receptors in the priming response. |
2002-11-12 |
2023-08-12 |
rat |
| Andy N Mead, Beatriz A Rocha, David M Donovan, Jonathan L Kat. Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. The European journal of neuroscience. vol 16. issue 3. 2002-11-08. PMID:12193195. |
previously, it was reported that both norepinephrine transporter (net) and dopamine transporter (dat) knockout (ko) mice were sensitive to the reinforcing effects of cocaine. |
2002-11-08 |
2023-08-12 |
mouse |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
the results of these studies have been consistent with the inhibition of dopamine uptake, at the dopamine transporter (dat), which results in a rapid and excessive accumulation of extracellular dopamine in the synapse as being the mechanism primarily responsible for the locomotor stimulant actions of cocaine. |
2002-10-24 |
2023-08-12 |
Not clear |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
however, there have been exceptions noted in several classes of dopamine uptake inhibitors that demonstrate behavioral profiles that are distinctive from cocaine. |
2002-10-24 |
2023-08-12 |
Not clear |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
these studies suggest that novel dopamine uptake inhibitors, which are structurally and pharmacologically distinct from cocaine, may be developed as potential cocaine-abuse therapeutics. |
2002-10-24 |
2023-08-12 |
Not clear |
| Dongsheng Zhang, Lu Zhang, Dan Wen Lou, Yusaku Nakabeppu, Jianhua Zhang, Ming X. The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. Journal of neurochemistry. vol 82. issue 6. 2002-10-22. PMID:12354293. |
the dopamine d1 receptor plays a major role in mediating behavioral responses to cocaine administration. |
2002-10-22 |
2023-08-12 |
mouse |