| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
they identify neuroadaptations that may help to explain the retention of cocaine reward by dopamine and serotonin transporter knockout mice. |
2003-02-05 |
2023-08-12 |
mouse |
| F S Hall, X F Li, I Sora, F Xu, M Caron, K P Lesch, D L Murphy, G R Uh. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401330. |
they are consistent with emerging hypotheses that actions at the three primary brain molecular targets for cocaine each provide distinct contributions to cocaine reward and cocaine aversion in wildtype mice, and that this balance changes in mice that develop without dopamine, norepinephrine or serotonin transporters. |
2003-02-05 |
2023-08-12 |
mouse |
| Sang-Hun Lee, Mi-Yoon Chang, Dae-Joon Jeon, Dong-Yul Oh, Hyeon Son, Chang-Ho Lee, Young-Seek Lee, Yong-Sung Le. The functional domains of dopamine transporter for cocaine analog, CFT binding. Experimental & molecular medicine. vol 34. issue 1. 2003-01-29. PMID:11989984. |
the functional domains of dopamine transporter for cocaine analog, cft binding. |
2003-01-29 |
2023-08-12 |
human |
| Sang-Hun Lee, Mi-Yoon Chang, Dae-Joon Jeon, Dong-Yul Oh, Hyeon Son, Chang-Ho Lee, Young-Seek Lee, Yong-Sung Le. The functional domains of dopamine transporter for cocaine analog, CFT binding. Experimental & molecular medicine. vol 34. issue 1. 2003-01-29. PMID:11989984. |
cocaine analogue, cft (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) binding to dopamine transporter (dat) in different species is quite heterogeneous. |
2003-01-29 |
2023-08-12 |
human |
| Carlos A Bolaños, George H Trksak, Ori S Cohen, Denise Jackso. Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502023. |
these data support the hypothesis that the enhanced serotonergic modulation of ach neurons in pcoc-exposed animals is largely mediated by dopamine (da) and reflect a major biochemical persistence of neurodevelopmental adaptations elicited by early cocaine exposure. |
2003-01-27 |
2023-08-12 |
rat |
| N Suto, J D Austin, L M Tanabe, M K Kramer, D A Wright, P Vezin. Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464454. |
rats in a separate group pre-exposed to vta amph but co-infused with the d(1)-like dopamine (da) receptor antagonist sch23390 (0.25 microg/0.5 microl/side) did not show enhanced cocaine self-administration. |
2003-01-24 |
2023-08-12 |
rat |
| Hans S Crombag, Jeffrey W Grimm, Yavin Shaha. Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464457. |
we also investigated whether activation of dopamine receptors contributes to context-induced renewal of cocaine seeking by testing the effects of selective d1-like (sch 23390) and d2-like (raclopride) receptor antagonists. |
2003-01-24 |
2023-08-12 |
rat |
| Hans S Crombag, Jeffrey W Grimm, Yavin Shaha. Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464457. |
these data suggest that activation of dopamine receptors is involved in reinstatement of cocaine seeking induced by exposure to the drug self-administration context. |
2003-01-24 |
2023-08-12 |
rat |
| David H Adams, Glen R Hanson, Kristen A Keef. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485404. |
in addition, we determined whether doses of cocaine (30 mg/kg) and methamphetamine (2 mg/kg) that produced equivalent increases in extracellular dopamine differentially affected preprodynorphin mrna expression in striatum of male, sprague-dawley rats. |
2003-01-23 |
2023-08-12 |
rat |
| David H Adams, Glen R Hanson, Kristen A Keef. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485404. |
in contrast, a dose of methamphetamine (2.0 mg/kg) that caused an increase in extracellular dopamine similar to that produced by 30 mg/kg cocaine did not significantly affect preprodynorphin mrna in any region of striatum. |
2003-01-23 |
2023-08-12 |
rat |
| David H Adams, Glen R Hanson, Kristen A Keef. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485404. |
these data provide further evidence that cocaine and amphetamines exert distinct effects on the patch-matrix division of striatum and suggest further that the post-synaptic consequences of elevated extracellular dopamine produced by methamphetamine and cocaine are distinct. |
2003-01-23 |
2023-08-12 |
rat |
| Masato Inazu, Hiroshi Takeda, Teruhiko Matsumiy. Functional expression of the norepinephrine transporter in cultured rat astrocytes. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485410. |
on the other hand, gbr-12935 (a selective dopamine uptake inhibitor), fluvoxamine (a selective serotonin reuptake inhibitor), venlafaxine (a snri) and cocaine had weaker inhibitory activities. |
2003-01-23 |
2023-08-12 |
rat |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
although the effects of psychostimulants on brain dopamine systems are well recognized, the direct actions of cocaine on serotonin systems also appear to be important to its addictive properties. |
2003-01-23 |
2023-08-12 |
Not clear |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
for example, serotonin actions at 5-ht1b receptors in the ventral tegmental area (vta) modulate cocaine-induced dopamine release in the nucleus accumbens (nacc) and alter the rewarding and stimulant properties of cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. |
2003-01-23 |
2023-08-12 |
rat |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
several studies have shown that repeated cocaine administration, followed by withdrawal, alters dopamine transporter (dat) levels in the rat. |
2003-01-23 |
2023-08-12 |
rat |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
these initial studies showed that: 1) the half-life of the transporter was between 2 and 3 days in these two brain regions; 2) pretreatment with dopamine d1 and d2 receptor agonists and antagonists over several days differentially altered dat half-lives in the striatum and nucleus accumbens; and 3) pretreatment with cocaine for several days increased the half-life of dat by decreasing the degradation rate constant in both brain regions. |
2003-01-23 |
2023-08-12 |
rat |
| Charles W Bradberr. Dynamics of extracellular dopamine in the acute and chronic actions of cocaine. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 8. issue 4. 2003-01-15. PMID:12194500. |
dynamics of extracellular dopamine in the acute and chronic actions of cocaine. |
2003-01-15 |
2023-08-12 |
rat |
| Charles W Bradberr. Dynamics of extracellular dopamine in the acute and chronic actions of cocaine. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 8. issue 4. 2003-01-15. PMID:12194500. |
this review will provide a brief overview of extracellular dopamine dynamics associated with cocaine. |
2003-01-15 |
2023-08-12 |
rat |
| Charles W Schindler, Gilberto N Carmon. Effects of dopamine agonists and antagonists on locomotor activity in male and female rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062575. |
male and female sprague-dawley rats were treated with cocaine, the specific dopamine uptake inhibitor gbr 12909, the dopamine d1 agonist skf 82958 or the dopamine d2 agonist quinpirole. |
2003-01-08 |
2023-08-12 |
rat |