| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele Hummel, Ellen M Unterwal. D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action. Journal of cellular physiology. vol 191. issue 1. 2002-04-15. PMID:11920678. |
in light of cocaine's multifarious effects on numerous neuronal systems, its effect on dopaminergic neurotransmission has attracted the most attention, particularly because of the implicated role of dopamine in brain reward. |
2002-04-15 |
2023-08-12 |
Not clear |
| S Porat, A Premkumar, R Simanto. Dopamine induces phenotypic differentiation or apoptosis in a dose-dependent fashion: involvement of the dopamine transporter and p53. Developmental neuroscience. vol 23. issue 6. 2002-04-12. PMID:11872944. |
the observed effects of both low and high doses of dopamine were blocked by cocaine, which suggested involvement of dopamine transporters. |
2002-04-12 |
2023-08-12 |
human |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
cocaine's blockade of dopamine reuptake by brain dopamine transporters (dat) is a central feature of current understanding of cocaine reward and addiction. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
empirical screening of small-molecule chemical libraries has thus far failed to provide successful cocaine blockers that allow dopamine reuptake in the presence of cocaine and provide cocaine "antagonism". |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
we have approached this problem by assessing expression, dopamine uptake, and cocaine analog affinities of 56 dat mutants in residues located in or near transmembrane domains likely to play significant roles in cocaine recognition and dopamine uptake. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
a phenylalanine-to-alanine mutant in putative dat transmembrane domain 3, f154a, retains normal dopamine uptake, lowers cocaine affinity 10-fold, and reduces cocaine stereospecificity. |
2002-04-11 |
2023-08-12 |
Not clear |
| J L Cornish, P W Kaliva. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2002-04-08. PMID:10899176. |
elevated dopamine transmission in the nucleus accumbens is thought to be a primary mediator of addiction to cocaine. |
2002-04-08 |
2023-08-12 |
Not clear |
| J L Cornish, P W Kaliva. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2002-04-08. PMID:10899176. |
this poses the possibility that the behaviors characterizing cocaine addiction, such as craving-induced relapse, may not be preferentially mediated by dopamine transmission. |
2002-04-08 |
2023-08-12 |
Not clear |
| J L Cornish, P W Kaliva. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2002-04-08. PMID:10899176. |
reinstatement was produced by a systemic injection of cocaine or by the microinjection of the glutamate receptor agonist ampa or dopamine into the nucleus accumbens. |
2002-04-08 |
2023-08-12 |
Not clear |
| J U Adams, J M Careri, T R Efferen, J Rotrose. Differential effects of dopamine antagonists on locomotor activity, conditioned activity and conditioned place preference induced by cocaine in rats. Behavioural pharmacology. vol 12. issue 8. 2002-04-08. PMID:11856897. |
differential effects of dopamine antagonists on locomotor activity, conditioned activity and conditioned place preference induced by cocaine in rats. |
2002-04-08 |
2023-08-12 |
rat |
| W-K Park, A A Bari, A R Jey, S M Anderson, R D Spealman, J K Rowlett, R C Pierc. Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923456. |
results indicated that reinstatement induced by a systemic cocaine injection was blocked by intra-mpfc administration of the dopamine antagonist flupenthixol. |
2002-04-08 |
2023-08-12 |
human |
| Andrew C Glatz, Michelle Ehrlich, Richard S Bae, Michelle J Clarke, Patricia A Quinlan, Emily C Brown, Pedro Rada, Bartley G Hoebe. Inhibition of cocaine self-administration by fluoxetine or D-fenfluramine combined with phentermine. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812523. |
based on related research with the same dose of d-fen/phen, it is suggested that effectiveness in reducing cocaine reinforcement is due in part to a satiating effect in which dopamine and acetylcholine are released in the nucleus accumbens. |
2002-04-05 |
2023-08-12 |
rat |
| F A Paczkowski, L J Bryan-Lluk. Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. Brain research. Molecular brain research. vol 97. issue 1. 2002-04-04. PMID:11744160. |
the effects of the mutations on net function were examined by expressing the mutant and wildtype nets in cos-7 cells and measuring the k(m) and v(max) for uptake of the substrates, [3h]norepinephrine, [3h]mpp(+) and [3h]dopamine, the k(d) and b(max) for [3h]nisoxetine binding and the k(i) of the inhibitors, nisoxetine, desipramine and cocaine, for inhibition of [3h]norepinephrine uptake. |
2002-04-04 |
2023-08-12 |
human |
| Allison L Chausmer, Jonathan L Kat. Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents. Psychopharmacology. vol 159. issue 2. 2002-04-02. PMID:11862342. |
recent data suggest that dopamine (da) d1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. |
2002-04-02 |
2023-08-12 |
Not clear |
| K Shimosato, S Watanabe, S Kitayam. Differential effects of trihexyphenidyl on place preference conditioning and locomotor stimulant activity of cocaine and methamphetamine. Naunyn-Schmiedeberg's archives of pharmacology. vol 364. issue 1. 2002-03-28. PMID:11485042. |
cocaine produces rewarding and locomotor stimulant effects by increasing extracellular dopamine (da) levels in the terminal areas of the mesolimbic da system. |
2002-03-28 |
2023-08-12 |
mouse |
| Christina A Schad, Joseph B Justice, Stephen G Holtzma. Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. The Journal of pharmacology and experimental therapeutics. vol 300. issue 3. 2002-03-28. PMID:11861800. |
opioid antagonists attenuate behavioral effects of amphetamine and amphetamine-induced increases in extracellular dopamine levels in nucleus accumbens and striatum of rats but do not alter those effects of cocaine. |
2002-03-28 |
2023-08-12 |
rat |
| Christina A Schad, Joseph B Justice, Stephen G Holtzma. Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. The Journal of pharmacology and experimental therapeutics. vol 300. issue 3. 2002-03-28. PMID:11861800. |
this study was performed to determine 1) if the effect of opioid antagonists on the dopamine response to amphetamine is mediated in either the terminal or cell body region of the nigrostriatal and mesolimbic pathways, and 2) if the enkephalinase inhibitor thiorphan, which slows degradation of endogenous opioid peptides, increases the dopamine response to amphetamine but not to cocaine. |
2002-03-28 |
2023-08-12 |
rat |
| Christina A Schad, Joseph B Justice, Stephen G Holtzma. Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. The Journal of pharmacology and experimental therapeutics. vol 300. issue 3. 2002-03-28. PMID:11861800. |
thiorphan (10 microm) administered into substantia nigra increased significantly the dopamine response to amphetamine in the ipsilateral striatum by as much as 42% but did not affect the dopamine response to cocaine (3.0-56 mg/kg, i.p.). |
2002-03-28 |
2023-08-12 |
rat |
| Michael J Meaney, Wayne Brake, Alain Gratto. Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse? Psychoneuroendocrinology. vol 27. issue 1-2. 2002-03-18. PMID:11750774. |
repeated periods of maternal separation in the early life of rats decreased dopamine transporter expression and significantly increased dopamine responses to stress, and behavioral responses to either stress or cocaine. |
2002-03-18 |
2023-08-12 |
rat |