| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tarek F El-Moselhy, Kwasi S Avor, Garo P Basmadjia. Synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. European journal of medicinal chemistry. vol 37. issue 2. 2002-05-02. PMID:11858849. |
synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. |
2002-05-02 |
2023-08-12 |
Not clear |
| Tarek F El-Moselhy, Kwasi S Avor, Garo P Basmadjia. Synthesis and dopamine transporter binding of 2beta-isopropyl ester analogs of cocaine. European journal of medicinal chemistry. vol 37. issue 2. 2002-05-02. PMID:11858849. |
a series of 2beta-isopropyl ester analogs of cocaine (7-11) was synthesised and evaluated in an in vitro dopamine transporter (dat) binding assays. |
2002-05-02 |
2023-08-12 |
Not clear |
| Lifen Xu, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Cheryl Klein-Stevens, Naiju Zhu, Stacey A Lomenzo, Leyte Winfield, Mark L Trudel. Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881989. |
furthermore, despite a relatively low potency of 10 for the inhibition of dopamine uptake compared to its affinity for the dat, its behavioral profile did not vary significantly from cocaine. |
2002-04-26 |
2023-08-12 |
Not clear |
| N Thiriet, P Jouvert, S Gobaille, O Solov'eva, B Gough, D Aunis, S Ali, J Zwille. C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. The European journal of neuroscience. vol 14. issue 10. 2002-04-23. PMID:11860464. |
the inhibition by cnp of the early gene expression elicited by cocaine in the caudate-putamen is correlated with a cnp-evoked decrease in cocaine-induced rise in extracellular dopamine, measured by in vivo microdialysis experiments. |
2002-04-23 |
2023-08-12 |
rat |
| Anton N M Schoffelmeer, Taco J De Vries, George Wardeh, Henrica W M van de Ven, Louk J M J Vanderschure. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943828. |
behavioral sensitization induced by nicotine, amphetamine, or cocaine was associated with an increase in the electrically evoked release of [(3)h]dopamine from nucleus accumbens slices. |
2002-04-22 |
2023-08-12 |
rat |
| Anton N M Schoffelmeer, Taco J De Vries, George Wardeh, Henrica W M van de Ven, Louk J M J Vanderschure. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943828. |
coadministration of mecamylamine during pretreatment with nicotine, amphetamine, or cocaine prevented the development of this long-term hyperreactivity of nucleus accumbens dopamine neurons. |
2002-04-22 |
2023-08-12 |
rat |
| Francoise Rouge-Pont, Alessandro Usiello, Marianne Benoit-Marand, Francois Gonon, Pier Vincenzo Piazza, Emiliana Borrell. Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943831. |
changes in extracellular dopamine induced by morphine and cocaine: crucial control by d2 receptors. |
2002-04-22 |
2023-08-12 |
mouse |
| M S Lima, A A Reisser, B G Soares, M Farrel. Antidepressants for cocaine dependence. The Cochrane database of systematic reviews. issue 4. 2002-04-19. PMID:11687168. |
while administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. |
2002-04-19 |
2023-08-12 |
Not clear |
| B G Soares, M S Lima, A A Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 4. 2002-04-19. PMID:11687193. |
dopamine agonists for cocaine dependence. |
2002-04-19 |
2023-08-12 |
human |
| B G Soares, M S Lima, A A Reisser, M Farrel. Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews. issue 4. 2002-04-19. PMID:11687193. |
it was demonstrated that the acute use of cocaine may enhance dopamine transmission and chronically it decreases dopamine concentrations in the brain. |
2002-04-19 |
2023-08-12 |
human |
| Roland D Schönbächler, Pascale M Gucker, Michele Arigoni, Stefan Kneifel, Franz X Vollenweider, Alfred Buck, Cyrill Burger, Thomas Berthold, Matthias Brühlmeier, P August Schubiger, Simon M Ametame. PET imaging of dopamine transporters in the human brain using [(11)C]-beta-CPPIT, a cocaine derivative lacking the 2 beta-ester function. Nuclear medicine and biology. vol 29. issue 1. 2002-04-19. PMID:11786272. |
pet imaging of dopamine transporters in the human brain using [(11)c]-beta-cppit, a cocaine derivative lacking the 2 beta-ester function. |
2002-04-19 |
2023-08-12 |
mouse |
| Roland D Schönbächler, Pascale M Gucker, Michele Arigoni, Stefan Kneifel, Franz X Vollenweider, Alfred Buck, Cyrill Burger, Thomas Berthold, Matthias Brühlmeier, P August Schubiger, Simon M Ametame. PET imaging of dopamine transporters in the human brain using [(11)C]-beta-CPPIT, a cocaine derivative lacking the 2 beta-ester function. Nuclear medicine and biology. vol 29. issue 1. 2002-04-19. PMID:11786272. |
the compound 3 beta-(4'-chlorophenyl)-2 beta-(3'-phenylisoxazol-5'-yl)tropane (cppit or rti 177) is a 2beta-heterocyclic substituted cocaine congener with high in vitro selectivity and affinity for the dopamine transporter relative to serotonin and norepinephrine transporters. |
2002-04-19 |
2023-08-12 |
mouse |
| G R Uhl, F S Hall, I Sor. Cocaine, reward, movement and monoamine transporters. Molecular psychiatry. vol 7. issue 1. 2002-04-19. PMID:11803442. |
dopamine transporter blockade by cocaine appears a sufficient explanation for cocaine-induced locomotion. |
2002-04-19 |
2023-08-12 |
mouse |
| Michele Hummel, Ellen M Unterwal. D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action. Journal of cellular physiology. vol 191. issue 1. 2002-04-15. PMID:11920678. |
cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons (heikkila et al., 1975, biochem pharmacol 24(8):847-852; reith et al., 1986, biochem pharmacol 35(7):1123-1129; ritz et al., 1987, science 237:1219-1223). |
2002-04-15 |
2023-08-12 |
Not clear |
| Michele Hummel, Ellen M Unterwal. D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action. Journal of cellular physiology. vol 191. issue 1. 2002-04-15. PMID:11920678. |
in light of cocaine's multifarious effects on numerous neuronal systems, its effect on dopaminergic neurotransmission has attracted the most attention, particularly because of the implicated role of dopamine in brain reward. |
2002-04-15 |
2023-08-12 |
Not clear |
| S Porat, A Premkumar, R Simanto. Dopamine induces phenotypic differentiation or apoptosis in a dose-dependent fashion: involvement of the dopamine transporter and p53. Developmental neuroscience. vol 23. issue 6. 2002-04-12. PMID:11872944. |
the observed effects of both low and high doses of dopamine were blocked by cocaine, which suggested involvement of dopamine transporters. |
2002-04-12 |
2023-08-12 |
human |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
cocaine's blockade of dopamine reuptake by brain dopamine transporters (dat) is a central feature of current understanding of cocaine reward and addiction. |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
empirical screening of small-molecule chemical libraries has thus far failed to provide successful cocaine blockers that allow dopamine reuptake in the presence of cocaine and provide cocaine "antagonism". |
2002-04-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology. vol 61. issue 4. 2002-04-11. PMID:11901228. |
we have approached this problem by assessing expression, dopamine uptake, and cocaine analog affinities of 56 dat mutants in residues located in or near transmembrane domains likely to play significant roles in cocaine recognition and dopamine uptake. |
2002-04-11 |
2023-08-12 |
Not clear |