| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lynette C Daws, Paul D Callaghan, José A Morón, Kris M Kahlig, Toni S Shippenberg, Jonathan A Javitch, Aurelio Gall. Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochemical and biophysical research communications. vol 290. issue 5. 2002-03-15. PMID:11820798. |
cocaine increases dopamine uptake and cell surface expression of dopamine transporters. |
2002-03-15 |
2023-08-12 |
human |
| Lynette C Daws, Paul D Callaghan, José A Morón, Kris M Kahlig, Toni S Shippenberg, Jonathan A Javitch, Aurelio Gall. Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochemical and biophysical research communications. vol 290. issue 5. 2002-03-15. PMID:11820798. |
in hek 293 cells expressing the human dopamine transporter (dat), a 10-min incubation with 10 microm cocaine followed by extensive washing resulted in a 30% increase in [3h]dopamine (da) uptake as well as an increase in cell surface dat in biotinylation experiments. |
2002-03-15 |
2023-08-12 |
human |
| G M Honoré, T S King, M H Samuels, A Moreno, T M Siler-Khodr, C A Eddy, R S Schenke. Effects of cocaine on basal and pulsatile prolactin levels in rhesus monkeys. Journal of the Society for Gynecologic Investigation. vol 8. issue 6. 2002-03-13. PMID:11750871. |
cocaine might also alter prolactin (prl) secretion, presumably through the effects of this drug on hypothalamic dopamine, the primary factor regulating pituitary prl secretion. |
2002-03-13 |
2023-08-12 |
monkey |
| C D Cook, I F Carroll, P M Beardsle. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797070. |
although cocaine is an indirect da agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (dat) than norepinephrine (net) and serotonin (sert) transporters in the behavioral effects of cocaine. |
2002-03-13 |
2023-08-12 |
rat |
| K Park, U Vora, S F Darling, M G Kolta, K F Solima. The role of inducible nitric oxide synthase in cocaine-induced locomotor sensitization. Physiology & behavior. vol 74. issue 4-5. 2002-03-07. PMID:11790403. |
dopamine (da) receptor binding in the nucleus accumbens (nac) showed a significant decrease in the density of d(2) receptor and the affinity of d(1) receptor after cocaine treatment. |
2002-03-07 |
2023-08-12 |
rat |
| K H Chung, C H Lim, D R Lee, C Jin, D Y Ch. Synthesis and binding affinities of 2 beta-(3-iodoallyloxycarbonyl)-3 beta-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies. Bioorganic & medicinal chemistry letters. vol 11. issue 23. 2002-03-05. PMID:11714614. |
tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (da) in brain. |
2002-03-05 |
2023-08-12 |
rat |
| Y Zhang, S D Schlussman, A Ho, M J Kree. Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743985. |
effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male c57bl/6j and 129/j mice. |
2002-03-05 |
2023-08-12 |
mouse |
| Y Zhang, S D Schlussman, A Ho, M J Kree. Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743985. |
levels of dopamine, both basal and after binge-pattern cocaine administration, were measured in the caudate putamen and nucleus accumbens of c57bl/6j and 129/j mice by in vivo microdialysis. |
2002-03-05 |
2023-08-12 |
mouse |
| Y Zhang, S D Schlussman, A Ho, M J Kree. Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743985. |
binge cocaine administration significantly increased mean dopamine levels in the caudate putamen in the c57bl/6j mice (with a 3-h mean of 6.80 nm) and in the 129j mice (9.94 nm). |
2002-03-05 |
2023-08-12 |
mouse |
| Y Zhang, S D Schlussman, A Ho, M J Kree. Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743985. |
in the nucleus accumbens, administration of cocaine also significantly increased dopamine levels in both strains (1.32 nm in c57bl/6j and 1.43 nm in 129/j), but with no difference between strains. |
2002-03-05 |
2023-08-12 |
mouse |
| Wenxiao Lu, Lisa M Monteggia, Marina E Wol. Repeated administration of amphetamine or cocaine does not alter AMPA receptor subunit expression in the rat midbrain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 1. 2002-03-05. PMID:11751027. |
we previously reported that ventral tegmental area (vta) dopamine neurons are supersensitive to ampa when recorded three days after discontinuing repeated amphetamine or cocaine administration. |
2002-03-05 |
2023-08-12 |
rat |
| Taco J De Vries, Anton N M Schoffelmeer, Rob Binnekade, Halfdan Raasø, Louk J M J Vanderschure. Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 1. 2002-03-05. PMID:11751029. |
we decided to evaluate the temporal relationship of dopamine d2 receptor-mediated drug seeking behavior and behavioral sensitization in animals with a history of cocaine and heroin self-administration. |
2002-03-05 |
2023-08-12 |
rat |
| Taco J De Vries, Anton N M Schoffelmeer, Rob Binnekade, Halfdan Raasø, Louk J M J Vanderschure. Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 1. 2002-03-05. PMID:11751029. |
thus, it appears that dopamine d2 receptors have a time-dependent role in relapse to cocaine and heroin seeking which is strongly associated with a behaviorally sensitized state. |
2002-03-05 |
2023-08-12 |
rat |
| D M Platt, J K Rowlett, R D Spealma. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology. vol 157. issue 2. 2002-02-26. PMID:11594448. |
dopamine d1 ligands have been proposed as candidate medications for cocaine abuse. |
2002-02-26 |
2023-08-12 |
monkey |
| Drake Morgan, Kathleen A Grant, H Donald Gage, Robert H Mach, Jay R Kaplan, Osric Prioleau, Susan H Nader, Nancy Buchheimer, Richard L Ehrenkaufer, Michael A Nade. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature neuroscience. vol 5. issue 2. 2002-02-26. PMID:11802171. |
social dominance in monkeys: dopamine d2 receptors and cocaine self-administration. |
2002-02-26 |
2023-08-12 |
monkey |
| M Filip, E Nowak, I Papl. On the role of serotonin2A/2C receptors in the sensitization to cocaine. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 52. issue 3. 2002-02-21. PMID:11596864. |
apart from showing involvement of dopamine, recent studies also indicate a role of serotonin (5-ht) in the behavioral effects of cocaine in rodents. |
2002-02-21 |
2023-08-12 |
rat |
| Diego Centonze, Barbara Picconi, Christelle Baunez, Emiliana Borrelli, Antonio Pisani, Giorgio Bernardi, Paolo Calabres. Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 2. 2002-02-20. PMID:11790512. |
cocaine and amphetamine depress striatal gabaergic synaptic transmission through d2 dopamine receptors. |
2002-02-20 |
2023-08-12 |
mouse |
| Z Liu, J Zhang, J Fei, L Gu. A novel mechanism of dopamine neurotoxicity involving the peripheral extracellular and the plasma membrane dopamine transporter. Neuroreport. vol 12. issue 15. 2002-02-19. PMID:11711873. |
furthermore, cocaine, an inhibitor of dopamine uptake, could not block cell death induced by dopamine. |
2002-02-19 |
2023-08-12 |
rat |
| A C Barrett, D Morgan, S Izenwasser, M J Picke. Cocaine-like discriminative stimulus effects and [3H]dopamine uptake inhibition produced by selected partial opioid agonists. Behavioural pharmacology. vol 12. issue 4. 2002-02-11. PMID:11548108. |
cocaine and the direct-acting dopamine agonist (-)-quinpirole, but not (+)-propoxyphene, butorphanol, morphine, u50,488 and pentobarbital, substituted completely for the cocaine stimulus. |
2002-02-11 |
2023-08-12 |
rat |
| A C Barrett, D Morgan, S Izenwasser, M J Picke. Cocaine-like discriminative stimulus effects and [3H]dopamine uptake inhibition produced by selected partial opioid agonists. Behavioural pharmacology. vol 12. issue 4. 2002-02-11. PMID:11548108. |
dezocine and meperidine inhibited [3h]dopamine uptake in a manner consistent with that produced by cocaine. |
2002-02-11 |
2023-08-12 |
rat |