| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. |
2001-08-09 |
2023-08-12 |
human |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
variant i displayed dopamine transport kinetics and binding affinities for various dat blockers (including cocaine) versus [3h] cft (win 35, 428) that were identical to wild-type dat (n=7 drugs; r(2)=0.991). |
2001-08-09 |
2023-08-12 |
human |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. |
2001-08-02 |
2023-08-12 |
rat |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
to investigate possible modulation by endogenous dopamine and by other monoamines, and by drugs with abuse potential, cocaine or selective monoamine uptake blockers were injected systemically during extracellular recording of single globus pallidus neurons and the results analyzed with spectral and wavelet methods. |
2001-08-02 |
2023-08-12 |
rat |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
both cocaine and the selective dopamine uptake blocker gbr-12909 significantly shortened the period of multisecond oscillations, as well as increasing overall firing rate. |
2001-08-02 |
2023-08-12 |
rat |
| D N Ruskin, D A Bergstrom, D Baek, L E Freeman, J R Walter. Cocaine or selective block of dopamine transporters influences multisecond oscillations in firing rate in the globus pallidus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 1. 2001-08-02. PMID:11377917. |
cocaine effects were blocked by dopamine antagonist pretreatment, as well as by n-methyl-d-aspartate receptor antagonist (mk-801) pretreatment. |
2001-08-02 |
2023-08-12 |
rat |
| M Kraft, P Noailles, J A Angul. Substance P modulates cocaine-evoked dopamine overflow in the striatum of the rat brain. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458533. |
in a separate experiment, infusion through the microdialysis probe of the neurokinin-1 receptor antagonist l-733,060 significantly decreased cocaine-evoked striatal dopamine overflow (approximately 50% inhibition at 30 minutes after cocaine administration). |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
acute injection of methamphetamine (1 mg/kg of body weight) or cocaine (10 mg/kg) resulted in elevated levels of extracellular dopamine in all brain regions measured, although the magnitude of increase varied between brain regions. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
overall, methamphetamine caused more dopamine to accumulate in the extracellular space than did cocaine when administered to animals during early withdrawal (7 days of daily injections and challenge on day 11). |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
by contrast, a challenge injection of cocaine resulted in dopamine levels in the caudate putamen that were lower than those observed for acute exposure. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
in the ventral tegmental area and the substantia nigra compacta, a challenge injection of methamphetamine or cocaine resulted in extracellular dopamine levels that were lower than those for acute exposure. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
thus, it appears that behavioral sensitization to cocaine can be sustained during early withdrawal in the absence of augmented drug-evoked dopamine overflow. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
moreover, the sensitized augmentation of locomotor activity observed by us and others in response to a challenge injection of cocaine is not dependent on elevation of the extracellular concentration of dopamine in the neostriatum. |
2001-08-02 |
2023-08-12 |
rat |
| Y Zhang, T M Loonam, P A Noailles, J A Angul. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Annals of the New York Academy of Sciences. vol 937. 2001-08-02. PMID:11458542. |
we are currently investigating the hypothesis that cocaine activates peptidergic systems of the neostriatum and that these systems modulate the synaptic release of dopamine in response to psychostimulants. |
2001-08-02 |
2023-08-12 |
rat |
| E M Unterwald, M J Kreek, M Cuntapa. The frequency of cocaine administration impacts cocaine-induced receptor alterations. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325352. |
increased dopamine d1 receptor binding was found in the nucleus accumbens and olfactory tubercle following twice daily cocaine injections, but not after single daily injections of the same total daily dose. |
2001-07-26 |
2023-08-12 |
rat |
| C K Hwang, U M D'Souza, A J Eisch, S Yajima, C H Lammers, Y Yang, S H Lee, Y M Kim, E J Nestler, M M Mouradia. Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 13. 2001-07-26. PMID:11390978. |
mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in drrf mrna. |
2001-07-26 |
2023-08-12 |
mouse |
| B A Mattingly, A Caudill, M Abe. Differential effects of 7-OH-DPAT on the development of behavioral sensitization to apomorphine and cocaine. Pharmacology, biochemistry, and behavior. vol 68. issue 3. 2001-07-19. PMID:11325394. |
the primary objective of this study was to determine whether concurrent treatments with a low dose of the dopamine d(3)-preferring receptor agonist 7-oh-dpat would attenuate the development of behavioral sensitization to the indirect dopamine receptor agonist, cocaine, or the direct dopamine receptor agonist, apomorphine. |
2001-07-19 |
2023-08-12 |
rat |
| L L Howell, K M Wilco. The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408518. |
the dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates. |
2001-07-19 |
2023-08-12 |
human |
| L L Howell, K M Wilco. The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408518. |
given the obvious importance of the dopamine transporter in the addictive properties of cocaine, the development and use of compounds that target the dopamine transporter represents a reasonable approach for the pharmacological treatment of cocaine abuse. |
2001-07-19 |
2023-08-12 |
human |
| L L Howell, K M Wilco. The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408518. |
a number of preclinical studies with dopamine transporter inhibitors provide evidence that substitute agonists may be used effectively to reduce cocaine use. |
2001-07-19 |
2023-08-12 |
human |