| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Fowler, N D Volkow, J Logan, D Franceschi, G J Wang, R MacGregor, C Shea, V Garza, N Pappas, P Carter, N Netusil, P Bridge, D Liederman, A Elkashef, J Rotrosen, R Hitzeman. Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain. Life sciences. vol 68. issue 24. 2001-06-28. PMID:11400918. |
each session included one scan with [11c]clorgyline (to assess mao a) and one scan 2 hours later with [11c]cocaine (to assess dopamine transporter availability). |
2001-06-28 |
2023-08-12 |
human |
| C Roubert, P J Cox, M Bruss, M Hamon, H Bönisch, B Giro. Determination of residues in the norepinephrine transporter that are critical for tricyclic antidepressant affinity. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11092898. |
both transport dopamine with higher affinity than norepinephrine and are targets for the psychostimulants cocaine and amphetamine. |
2001-06-21 |
2023-08-12 |
human |
| R R Matsumoto, K A McCracken, B Pouw, J Miller, W D Bowen, W Williams, B R De Cost. N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice. European journal of pharmacology. vol 411. issue 3. 2001-06-21. PMID:11164383. |
cocaine binds to sigma receptors with comparable affinity to its well-established interaction with dopamine transporters. |
2001-06-21 |
2023-08-12 |
mouse |
| M R Gerasimov, W K Schiffer, E L Gardner, D A Marsteller, I C Lennon, S J Taylor, J D Brodie, C R Ashby, S L Dewe. GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine. European journal of pharmacology. vol 414. issue 2-3. 2001-06-21. PMID:11239920. |
to better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously paired with cocaine administration. |
2001-06-21 |
2023-08-12 |
Not clear |
| E G Eising, T H Müller, L Freudenberg, S P Müller, K Dutschka, W Sonnenschein, H Przuntek, A Bockisc. SPECT imaging with [123I]-beta-CIT in Parkinsonism: comparison of SPECT images obtained by a single-headed and a three-headed gamma camera. Nuclear medicine communications. vol 22. issue 2. 2001-06-21. PMID:11258400. |
single photon emission computed tomography (spect) imaging of dopamine transporters by using the cocaine derivative [123i]-(1r)-2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane ([123i]-beta-cit) has been shown to be useful in patients with parkinsonism. |
2001-06-21 |
2023-08-12 |
Not clear |
| K Lutfy, T Do, N T Maidmen. Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. Psychopharmacology. vol 154. issue 1. 2001-06-21. PMID:11291998. |
orphanin fq/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. |
2001-06-21 |
2023-08-12 |
rat |
| E Carboni, A Silvagni, M T Rolando, G Di Chiar. Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by reinforcing drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027253. |
we report that morphine, nicotine, cocaine, ethanol, and the selective dopamine uptake inhibitor gbr 12909 increase effectively and dose dependently extracellular dopamine in the bed nucleus of stria terminalis. |
2001-06-07 |
2023-08-12 |
Not clear |
| R S Sinnott, M A Nade. Modulation of cocaine's discriminative stimulus effects by dopamine D(1) agonists in rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 68. issue 2. 2001-06-07. PMID:11267635. |
modulation of cocaine's discriminative stimulus effects by dopamine d(1) agonists in rhesus monkeys. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the present study examined the time course of alterations in levels of dopamine transporter (dat) binding sites that accompany cocaine self-administration using quantitative in vitro receptor autoradiography with [(3)h]win 35,428. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the density of dopamine transporter binding sites in the striatum of rhesus monkeys with 5 d, 3.3 months, or 1.5 years of cocaine self-administration experience was compared with dat levels in cocaine-naive control monkeys. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the similarity of these findings to previous studies in human cocaine addicts strongly suggest that the increased density of dopamine transporters observed in studies of human drug abusers are the result of the neurobiological effects of cocaine, ruling out confounds such as polydrug abuse, preexisting differences in dat levels, or comorbid psychiatric conditions. |
2001-06-07 |
2023-08-12 |
human |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
recently, this hypothesis has been challenged on the basis of the observation that, in mice genetically lacking the plasma membrane dopamine transporter [dat-knock out (dat-ko)], cocaine maintained its reinforcing properties of being self-administered and inducing place preference, despite the failure to increase extracellular dopamine in the dorsal striatum. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
here we report that, in dat-ko mice, cocaine and amphetamine increase dialysate dopamine in the medial part of the nucleus accumbens. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
these observations provide an explanation for the persistence of cocaine reinforcement in dat-ko mice and support the hypothesis of a primary role of nucleus accumbens dopamine in drug reinforcement. |
2001-06-07 |
2023-08-12 |
mouse |
| K K Szumlinski, A M Goodwill, H Szechtma. Locomotor sensitization to quinpirole in rats: effects of drug abstinence and sex. Psychopharmacology. vol 152. issue 3. 2001-05-31. PMID:11105941. |
although many factors are known to influence the sensitization produced by indirect dopamine agonists, such as cocaine and the amphetamines, less is known about factors that influence the behavioral sensitization produced by direct dopamine receptor agonists. |
2001-05-31 |
2023-08-12 |
rat |
| P Romualdi, C D'Addario, S Ferri, B M Cox, S Izenwasse. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. European journal of pharmacology. vol 413. issue 2-3. 2001-05-31. PMID:11226394. |
in contrast, the increase in the caudate putamen following cocaine administration may not be related to the inhibition of dopamine uptake, since it was not produced by a selective dopamine uptake inhibitor. |
2001-05-31 |
2023-08-12 |
rat |
| D Alvarez Fischer, M K Schäfer, B Ferger, S Gross, R Westermann, E Weihe, K Kuschinsk. Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284443. |
on day 7, or after an administration of the same dose 10 days after the last administration of cocaine, respectively, revealed significant acute increases of extracellular dopamine to about 200% of basal values. |
2001-05-24 |
2023-08-12 |
rat |
| M Ho, M Segr. Individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines. Neuroscience letters. vol 299. issue 3. 2001-05-21. PMID:11165777. |
individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines. |
2001-05-21 |
2023-08-12 |
mouse |