| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the present study examined the time course of alterations in levels of dopamine transporter (dat) binding sites that accompany cocaine self-administration using quantitative in vitro receptor autoradiography with [(3)h]win 35,428. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the density of dopamine transporter binding sites in the striatum of rhesus monkeys with 5 d, 3.3 months, or 1.5 years of cocaine self-administration experience was compared with dat levels in cocaine-naive control monkeys. |
2001-06-07 |
2023-08-12 |
human |
| S R Letchworth, M A Nader, H R Smith, D P Friedman, L J Porrin. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 8. 2001-06-07. PMID:11306632. |
the similarity of these findings to previous studies in human cocaine addicts strongly suggest that the increased density of dopamine transporters observed in studies of human drug abusers are the result of the neurobiological effects of cocaine, ruling out confounds such as polydrug abuse, preexisting differences in dat levels, or comorbid psychiatric conditions. |
2001-06-07 |
2023-08-12 |
human |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
recently, this hypothesis has been challenged on the basis of the observation that, in mice genetically lacking the plasma membrane dopamine transporter [dat-knock out (dat-ko)], cocaine maintained its reinforcing properties of being self-administered and inducing place preference, despite the failure to increase extracellular dopamine in the dorsal striatum. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
here we report that, in dat-ko mice, cocaine and amphetamine increase dialysate dopamine in the medial part of the nucleus accumbens. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
these observations provide an explanation for the persistence of cocaine reinforcement in dat-ko mice and support the hypothesis of a primary role of nucleus accumbens dopamine in drug reinforcement. |
2001-06-07 |
2023-08-12 |
mouse |
| K K Szumlinski, A M Goodwill, H Szechtma. Locomotor sensitization to quinpirole in rats: effects of drug abstinence and sex. Psychopharmacology. vol 152. issue 3. 2001-05-31. PMID:11105941. |
although many factors are known to influence the sensitization produced by indirect dopamine agonists, such as cocaine and the amphetamines, less is known about factors that influence the behavioral sensitization produced by direct dopamine receptor agonists. |
2001-05-31 |
2023-08-12 |
rat |
| P Romualdi, C D'Addario, S Ferri, B M Cox, S Izenwasse. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. European journal of pharmacology. vol 413. issue 2-3. 2001-05-31. PMID:11226394. |
in contrast, the increase in the caudate putamen following cocaine administration may not be related to the inhibition of dopamine uptake, since it was not produced by a selective dopamine uptake inhibitor. |
2001-05-31 |
2023-08-12 |
rat |
| D Alvarez Fischer, M K Schäfer, B Ferger, S Gross, R Westermann, E Weihe, K Kuschinsk. Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284443. |
on day 7, or after an administration of the same dose 10 days after the last administration of cocaine, respectively, revealed significant acute increases of extracellular dopamine to about 200% of basal values. |
2001-05-24 |
2023-08-12 |
rat |
| M Ho, M Segr. Individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines. Neuroscience letters. vol 299. issue 3. 2001-05-21. PMID:11165777. |
individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines. |
2001-05-21 |
2023-08-12 |
mouse |
| M Ho, M Segr. Individual and combined effects of ethanol and cocaine on the human dopamine transporter in neuronal cell lines. Neuroscience letters. vol 299. issue 3. 2001-05-21. PMID:11165777. |
we report here that a 24-h exposure of the human dopamine transporter (hdat)-transfected mouse neuroblastoma n1e-115 cell line (6c6) to cocaine (1 microm), or ethanol (1%) or both, increased dopamine re-uptake by approximately 25, 29 and 44%, respectively. |
2001-05-21 |
2023-08-12 |
mouse |
| B A Sorg, N Li, W R W. Dopamine D1 receptor activation in the medial prefrontal cortex prevents the expression of cocaine sensitization. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303036. |
dopamine d1 receptor activation in the medial prefrontal cortex prevents the expression of cocaine sensitization. |
2001-05-21 |
2023-08-12 |
rat |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. |
2001-05-21 |
2023-08-12 |
mouse |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (dat), serotonin (sert), and norepinephrine (net). |
2001-05-21 |
2023-08-12 |
mouse |
| D Stafford, M G LeSage, K C Rice, J R Glow. A comparison of cocaine, GBR 12909, and phentermine self-administration by rhesus monkeys on a progressive-ratio schedule. Drug and alcohol dependence. vol 62. issue 1. 2001-05-17. PMID:11173166. |
the dopamine reuptake inhibitor gbr 12909 and the dopamine releaser phentermine may have potential for the treatment of cocaine abuse in humans. |
2001-05-17 |
2023-08-12 |
human |
| T Yamamoto, K Yabuuchi, T Yamaguchi, M Nakamich. [Animal models of drug dependence using the drug self-administration method]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 117. issue 1. 2001-05-10. PMID:11233296. |
given that an ampa receptor antagonist, but not dopamine antagonist, prevented cocaine-seeking behavior induced by cocaine, glutamate transmission in the nucleus accumbens is thought to be important for expression of craving or drug-seeking behavior. |
2001-05-10 |
2023-08-12 |
Not clear |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring aa and alcohol-avoiding ana rats. |
2001-05-03 |
2023-08-12 |
rat |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
modulation of striatal dopamine (da) release by acute or repeated cocaine treatment was studied in the nucleus accumbens and caudate-putamen of alcohol-preferring (aa, alko alcohol) and alcohol-avoiding (ana, alko non-alcohol) rats. |
2001-05-03 |
2023-08-12 |
rat |