| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W M Freeman, G J Yohrling, J B Daunais, L Gioia, S L Hart, L J Porrino, H M Davies, K E Vran. A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. Drug and alcohol dependence. vol 61. issue 1. 2001-02-08. PMID:11064180. |
this drug has similar actions to cocaine, but possesses markedly different pharmacokinetics (20 times more potent at binding the dopamine transporter, markedly increased metabolic stability, and 10-20 times more potent in behavioral measures). |
2001-02-08 |
2023-08-12 |
rat |
| W M Freeman, G J Yohrling, J B Daunais, L Gioia, S L Hart, L J Porrino, H M Davies, K E Vran. A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. Drug and alcohol dependence. vol 61. issue 1. 2001-02-08. PMID:11064180. |
moreover, ptt demonstrates an increased selectivity for the dopamine (da) and norepinephrine (ne) transporters compared with cocaine. |
2001-02-08 |
2023-08-12 |
rat |
| A Margolin, S K Avants, J F Setaro, H M Rinder, L Grup. Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy? Drug and alcohol dependence. vol 61. issue 1. 2001-02-08. PMID:11064182. |
in this article we discuss the rationale for the investigation of angiotensin converting enzyme (ace) inhibitors, commonly used to treat hypertension, for treatment in cocaine-abusing populations, based on their potential to reduce cocaine use by modulating levels of dopamine and corticotropin releasing factor in the brain, and on their ability to reverse cardiovascular and platelet abnormalities. |
2001-02-08 |
2023-08-12 |
Not clear |
| E Valjent, J C Corvol, C Pages, M J Besson, R Maldonado, J Caboch. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102476. |
this activation was blocked when sch 23390 [a specific dopamine (da)-d1 antagonist] but not raclopride (a da-d2 antagonist) was injected before cocaine. |
2001-02-08 |
2023-08-12 |
Not clear |
| M Marinelli, F J Whit. Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102497. |
enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. |
2001-02-08 |
2023-08-12 |
rat |
| L E Bayer, A Brown, C F Mactutus, R M Booze, B J Strup. Prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine D1 agonist SKF81297. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102500. |
prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine d1 agonist skf81297. |
2001-02-08 |
2023-08-12 |
human |
| L E Bayer, A Brown, C F Mactutus, R M Booze, B J Strup. Prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine D1 agonist SKF81297. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102500. |
sensitivity to the attentional effects of skf81297, a selective full agonist at dopamine d(1) receptors, was assessed in adult rats exposed to cocaine prenatally (via intravenous injections) and controls. |
2001-02-08 |
2023-08-12 |
human |
| J A Lile, D Morgan, C S Freedland, R S Sinnott, H M Davies, M A Nade. Self-administration of two long-acting monoamine transport blockers in rhesus monkeys. Psychopharmacology. vol 152. issue 4. 2001-02-08. PMID:11140334. |
2beta-propanoyl-3beta-(4-tolyl)-tropane (ptt) is a cocaine analog with high affinity at and selectivity for the dopamine transporter (dat). |
2001-02-08 |
2023-08-12 |
monkey |
| H K Wayment, J O Schenk, B A Sor. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150317. |
rde studies indicate that inhibition by cocaine, specific inhibitors of the dopamine transporter (dat) and norepinephrine transporter (net), and low na(+) produced a 50-70% decrease in the velocity of dopamine clearance. |
2001-02-08 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Iboga interactions with psychomotor stimulants: panacea in the paradox? Toxicon : official journal of the International Society on Toxinology. vol 39. issue 1. 2001-02-02. PMID:10936624. |
however, this interpretation is contradicted by very recent observations that 18-mc is without effect on the dopamine response to acute cocaine and that both ibogaine and 18-mc block the expression of sensitized levels of dopamine in the nucleus accumbens produced by chronic cocaine administration. |
2001-02-02 |
2023-08-12 |
Not clear |
| E H Ellinwood, G R King, C Davidson, T H Le. The dopamine D2/D3 antagonist DS121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080548. |
the dopamine d2/d3 antagonist ds121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. |
2001-02-02 |
2023-08-12 |
rat |
| E H Ellinwood, G R King, C Davidson, T H Le. The dopamine D2/D3 antagonist DS121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080548. |
to explore the significance of dopamine (da) autoreceptors in cocaine tolerance and cocaine induced locomotor activity rats were treated with saline and cocaine (40 mg/kg per day via osmotic minipump; normal and cocaine tolerant rats, respectively). |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
potentiation of mesolimbic dopamine levels is generally hypothesized to be reinforcing and contribute to the self-administration of addictive drugs such as cocaine. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the present study, the in vivo microdialysis technique was used to directly manipulate extracellular dopamine concentrations in the nucleus accumbens (nac) shell and the amygdala (amy) in rats maintaining stable patterns of cocaine (1.5 mg/kg/infusion) intake under a fixed ratio 1 schedule of reinforcement. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the nac, a perfusate dopamine concentration of 90 nm was found to reduce cocaine self-administration, whereas a perfusate concentration of 450 nm increased the intake of cocaine. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
in the amy, 45 nm perfusate dopamine inhibited cocaine self-administration, whereas 90 nm perfusate dopamine enhanced cocaine intake. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
the attenuation or potentiation of cocaine intake behavior was maintained throughout the time period (30 or 60 min) of the manipulation of the perfusate dopamine (da) concentrations in the nac and amy. |
2001-02-02 |
2023-08-12 |
rat |
| Y L Hurd, M Ponté. Cocaine self-administration behavior can be reduced or potentiated by the addition of specific dopamine concentrations in the nucleus accumbens and amygdala using in vivo microdialysis. Behavioural brain research. vol 116. issue 2. 2001-02-02. PMID:11080549. |
overall, these experiments show that elevated mesolimbic dopamine concentrations can differentially modulate cocaine self-administration behavior. |
2001-02-02 |
2023-08-12 |
rat |
| M Froimowitz, K M Wu, A Moussa, R M Haidar, J Jurayj, C George, E L Gardne. Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse. Journal of medicinal chemistry. vol 43. issue 26. 2001-02-01. PMID:11150168. |
since the effects of cocaine on dopamine (da) and serotonin (5ht) transporters are important components of its pharmacological activity, the focus was on nonselective inhibitors of monoamine transport. |
2001-02-01 |
2023-08-12 |
mouse |