| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V I Chefer, J A Morón, B Hope, W Rea, T S Shippenber. Kappa-opioid receptor activation prevents alterations in mesocortical dopamine neurotransmission that occur during abstinence from cocaine. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113311. |
these results demonstrate that the early phase of abstinence from cocaine is associated with marked alterations in medial prefrontal cortex dopamine neurotransmission and that these neuroadaptations are prevented by the activation of kappa-opioid receptors. |
2001-03-01 |
2023-08-12 |
rat |
| I Ushijima, Y Mizuki, T Kobayashi, T Aoki, M Suetsugi, K Usami, Y Watanab. Effects of pertussis toxin on behavioral responses during different withdrawal periods from chronic cocaine treatment. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 8. 2001-03-01. PMID:11125860. |
the stimulatory effects of ptx on the enhanced sch23390-induced cataleptic response (d1 receptor subsensitivity induced during long-term withdrawal periods from chronic cocaine treatment), may be due to an indirect inhibition of d1 receptors (a synergistic effect) via blockade of postsynaptic dopamine d2 receptors. |
2001-03-01 |
2023-08-12 |
mouse |
| M Filip, M L Thomas, K A Cunningha. Dopamine D5 receptors in nucleus accumbens contribute to the detection of cocaine in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11000198. |
dopamine d5 receptors in nucleus accumbens contribute to the detection of cocaine in rats. |
2001-02-22 |
2023-08-12 |
rat |
| M Filip, M L Thomas, K A Cunningha. Dopamine D5 receptors in nucleus accumbens contribute to the detection of cocaine in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11000198. |
dopamine d(1)/d(5) receptor antagonism has been shown to block the euphoric and stimulatory effects of cocaine in humans and rats. |
2001-02-22 |
2023-08-12 |
rat |
| R Ito, J W Dalley, S R Howes, T W Robbins, B J Everit. Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11007908. |
dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. |
2001-02-22 |
2023-08-12 |
rat |
| M V Solbrig, G F Koob, L H Parsons, T Kadota, N Horscroft, T Briese, W I Lipki. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 21. 2001-02-22. PMID:11050146. |
hypothesized risk factors for psychostimulant, amphetamine, and cocaine abuse include dopamine (da) receptor polymorphisms, hiv infection, schizophrenia, drug-induced paranoias, and movement disorders; however, the molecular, cellular, and biochemical mechanisms that predispose to drug sensitivity or drive the development of addiction are incompletely understood. |
2001-02-22 |
2023-08-12 |
rat |
| A C Thompson, A Zapata, J B Justice, R A Vaughan, L G Sharpe, T S Shippenber. Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11125013. |
kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. |
2001-02-22 |
2023-08-12 |
rat |
| A C Thompson, A Zapata, J B Justice, R A Vaughan, L G Sharpe, T S Shippenber. Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11125013. |
coadministration of kappa-opioid receptor agonists (kappa-agonists) with cocaine prevents alterations in dialysate dopamine (da) concentration in the nucleus accumbens (acb) that occur during abstinence from repeated cocaine treatment. |
2001-02-22 |
2023-08-12 |
rat |
| P A Fall, S Ekberg, A K Granérus, G Granéru. ECT in Parkinson's disease-dopamine transporter visualised by [123I]-beta-CIT SPECT. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041278. |
these neurones may be visualised by single photon emission computed tomography (spect) with the cocaine analogue 2beta-carboxymethyl-3-beta-(4-iodophenyl)tropane ([123i]beta-cit), which labels the dopamine reuptake sites in the nerve terminals. |
2001-02-15 |
2023-08-12 |
Not clear |
| M Arroyo, W A Baker, B J Everit. Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides. Brain research. Molecular brain research. vol 83. issue 1-2. 2001-02-15. PMID:11072100. |
monoamine transporter expression was differentially altered by cocaine; dopamine transporter mrna levels in the ventral tegmental area, but not in the substantia nigra, were increased following withdrawal from cocaine, suggesting a role for the upregulated mesolimbic dopamine transporter in the mechanisms underlying relapse to cocaine taking. |
2001-02-15 |
2023-08-12 |
rat |
| C Betancur, I Lépée-Lorgeoux, M Cazillis, D Accili, S Fuchs, W Rostèn. Neurotensin gene expression and behavioral responses following administration of psychostimulants and antipsychotic drugs in dopamine D(3) receptor deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 2. 2001-02-15. PMID:11120399. |
these findings demonstrate that dopamine d(3) receptors are not necessary for the acute nt mrna response to drugs of abuse and antipsychotics but appear to play a role in the regulation of nt gene induction in striatal neurons after repeated cocaine. |
2001-02-15 |
2023-08-12 |
mouse |
| M Barrot, M C Rettori, B Guardiola-Lemaître, C Jarry, M Le Moal, P V Piazz. Interactions between imidazoline binding sites and dopamine levels in the rat nucleus accumbens. The European journal of neuroscience. vol 12. issue 12. 2001-02-15. PMID:11122366. |
we compared these imidazoline ligands to cocaine, a dopamine uptake blocker known to increase extracellular dopamine concentrations. |
2001-02-15 |
2023-08-12 |
rat |
| M Barrot, M C Rettori, B Guardiola-Lemaître, C Jarry, M Le Moal, P V Piazz. Interactions between imidazoline binding sites and dopamine levels in the rat nucleus accumbens. The European journal of neuroscience. vol 12. issue 12. 2001-02-15. PMID:11122366. |
s23229 had a stronger efficacy than s23230 and increased dopamine levels in the nucleus accumbens at an extent similar to the one of cocaine. |
2001-02-15 |
2023-08-12 |
rat |
| J N Worsley, A Moszczynska, P Falardeau, K S Kalasinsky, G Schmunk, M Guttman, Y Furukawa, L Ang, V Adams, G Reiber, R A Anthony, D Wickham, S J Kis. Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Molecular psychiatry. vol 5. issue 6. 2001-02-15. PMID:11126397. |
we measured by quantitative immunoblotting protein levels of dopamine d1 and, for comparison, d2 receptors in brain of chronic users of methamphetamine, cocaine, and heroin. |
2001-02-15 |
2023-08-12 |
human |
| W M Freeman, G J Yohrling, J B Daunais, L Gioia, S L Hart, L J Porrino, H M Davies, K E Vran. A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. Drug and alcohol dependence. vol 61. issue 1. 2001-02-08. PMID:11064180. |
this drug has similar actions to cocaine, but possesses markedly different pharmacokinetics (20 times more potent at binding the dopamine transporter, markedly increased metabolic stability, and 10-20 times more potent in behavioral measures). |
2001-02-08 |
2023-08-12 |
rat |
| W M Freeman, G J Yohrling, J B Daunais, L Gioia, S L Hart, L J Porrino, H M Davies, K E Vran. A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. Drug and alcohol dependence. vol 61. issue 1. 2001-02-08. PMID:11064180. |
moreover, ptt demonstrates an increased selectivity for the dopamine (da) and norepinephrine (ne) transporters compared with cocaine. |
2001-02-08 |
2023-08-12 |
rat |
| A Margolin, S K Avants, J F Setaro, H M Rinder, L Grup. Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy? Drug and alcohol dependence. vol 61. issue 1. 2001-02-08. PMID:11064182. |
in this article we discuss the rationale for the investigation of angiotensin converting enzyme (ace) inhibitors, commonly used to treat hypertension, for treatment in cocaine-abusing populations, based on their potential to reduce cocaine use by modulating levels of dopamine and corticotropin releasing factor in the brain, and on their ability to reverse cardiovascular and platelet abnormalities. |
2001-02-08 |
2023-08-12 |
Not clear |
| E Valjent, J C Corvol, C Pages, M J Besson, R Maldonado, J Caboch. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102476. |
this activation was blocked when sch 23390 [a specific dopamine (da)-d1 antagonist] but not raclopride (a da-d2 antagonist) was injected before cocaine. |
2001-02-08 |
2023-08-12 |
Not clear |
| M Marinelli, F J Whit. Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102497. |
enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. |
2001-02-08 |
2023-08-12 |
rat |
| L E Bayer, A Brown, C F Mactutus, R M Booze, B J Strup. Prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine D1 agonist SKF81297. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102500. |
prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine d1 agonist skf81297. |
2001-02-08 |
2023-08-12 |
human |