| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Martin-Fardon, F Weis. N-[1-(2-benzo[b]thiophenyl)Cyclohexyl]- piperidine (BTCP) exerts cocaine-like actions on drug-maintained responding in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942855. |
the effects of n-[1-(2-benzo[b]thiophenyl)cyclohexyl]- piperidine (btcp), a phencyclidine derivative that acts as a potent dopamine reuptake inhibitor, were examined on cocaine self-administration in rats. |
2000-10-11 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. European journal of pharmacology. vol 398. issue 2. 2000-10-05. PMID:10854838. |
differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. |
2000-10-05 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. European journal of pharmacology. vol 398. issue 2. 2000-10-05. PMID:10854838. |
however, while ibogaine pretreatment did not significantly alter the dopamine response in the nucleus accumbens to acute cocaine, it abolished the expression of cocaine-induced dopamine sensitization. |
2000-10-05 |
2023-08-12 |
rat |
| R Martin-Fardon, O Ben-Shahar, F Weis. Non reciprocal cross-sensitization between cocaine and BTCP on locomotor activity in the rat. Pharmacology, biochemistry, and behavior. vol 66. issue 3. 2000-10-05. PMID:10899381. |
like cocaine, btcp possesses high affinity for the dopamine transporter and inhibits dopamine reuptake. |
2000-10-05 |
2023-08-12 |
rat |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
in contrast to the highly patchy patterns of fos-like immunoreactivity seen in the rostral striatum after administration of a number of dopamine agonists, the monoamine uptake blocker cocaine has been reported to produce a relatively homogeneous pattern of gene expression. |
2000-10-02 |
2023-08-12 |
rat |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
in the current study we extended these observations by using a quantitative technique to demonstrate that while amphetamine and apomorphine produce patchy striatal fos expression, the selective dopamine uptake inhibitors amfonelic acid, nomifensine and gbr-12909 all, like cocaine, produce near random patterns of gene expression. |
2000-10-02 |
2023-08-12 |
rat |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
these findings suggest that the production of relatively 'non-patchy' patterns of immediate early gene expression may be a general property of dopamine transport inhibitors unrelated to any unique pharmacological properties of cocaine. |
2000-10-02 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
a new approach combining fast-scan cyclic voltammetry with iontophoretic dopamine delivery was used in freely behaving rats to evaluate the time-course of dopamine uptake inhibition in nucleus accumbens induced by intravenous cocaine at a dose (1.0mg/kg) known to maintain self-administration behavior. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
cocaine significantly increased the decay time of the dopamine response without altering its magnitude or time to peak. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
our data provide direct evidence for a phasic change in dopamine uptake induced by intravenous cocaine under behaviorally relevant conditions. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
the relatively slow and gradual development of dopamine uptake inhibition, which peaks at times when behaving rats self-inject cocaine, is inconsistent with the suggested role of this mechanism in the acute rewarding (euphoric) effects of self-injected cocaine, but supports its role in the activational and motivational aspects of drug-seeking and drug-taking behavior. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
because intravenous cocaine enters the brain rapidly and peaks in neural tissue (1-2 min) long before it effectively inhibits dopamine uptake (6 min), it appears that some of the acute psychoemotional ("rush"), behavioral, autonomic, and neuronal effects of this drug, which are apparently resistant to dopamine receptor blockade, are mediated via rapid central or peripheral mechanisms independent of monoamine uptake. |
2000-09-27 |
2023-08-12 |
rat |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
here we assessed whether there were differences in the efficacy of cocaine to block the dopamine transporters (major target for cocaine's reinforcing effects), as a function of route of administration. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
positron emission tomography and [11c]cocaine, a dopamine transporter radioligand, were used to compare the levels of dopamine transporter blockade induced by intravenous, smoked and intranasal cocaine in 32 current cocaine abusers. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
cocaine significantly blocked dopamine transporters. |
2000-09-25 |
2023-08-12 |
human |
| N D Volkow, G J Wang, M W Fischman, R Foltin, J S Fowler, D Franceschi, M Franceschi, J Logan, S J Gatley, C Wong, Y S Ding, R Hitzemann, N Pappa. Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983846. |
differences in the reinforcing effects of cocaine as a function of the route of administration are not due to differences in the efficacy of cocaine to block the dopamine transporters. |
2000-09-25 |
2023-08-12 |
human |
| A Parada, P Soares-da-Silv. The dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization. Neuropharmacology. vol 39. issue 9. 2000-09-20. PMID:10854909. |
the dopamine antagonist sch 23390 reverses dizocilpine-induced blockade of cocaine sensitization. |
2000-09-20 |
2023-08-12 |
rat |
| M Ho, M Segr. Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924700. |
dopamine uptake by mouse neuroblastoma n1e-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. |
2000-09-20 |
2023-08-12 |
mouse |