| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
the agonist- and antagonist-like properties of gbr12909 were evaluated on only vta dopamine cells since these neurons were more fully inhibited by cocaine and have been implicated in its rewarding effects. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
we conclude that electrophysiological testing of putative "anti-cocaine" drugs for their abilities to inhibit the firing of vta dopamine neurons, and to block their inhibitory responses to cocaine, may provide a rapid in vivo screen for compounds expected to behave as functional cocaine antagonists in the dopamine reward system. |
2000-11-28 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, S B Douglas, T H Le. Effect of cocaine, nomifensine, GBR 12909 and WIN 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine. Journal of neuroscience methods. vol 101. issue 1. 2000-11-27. PMID:10967364. |
effect of cocaine, nomifensine, gbr 12909 and win 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine. |
2000-11-27 |
2023-08-12 |
Not clear |
| R Carey, E Damianopoulos, G De Palm. 8-OH DPAT can restore the locomotor stimulant effects of cocaine blocked by haloperidol. Pharmacology, biochemistry, and behavior. vol 66. issue 4. 2000-11-07. PMID:10973527. |
ex vivo measurements of dopamine and 5-hydroxytryptamine metabolism in limbic tissue were consistent with the established effects of cocaine, haloperidol, and 8-oh dpat upon dopamine and 5-hydroxytryptamine neurotransmission. |
2000-11-07 |
2023-08-12 |
rat |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. |
2000-10-18 |
2023-08-12 |
monkey |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
within a cocaine self-administration session, acute tolerance to the ability of cocaine to elevate extracellular striatal dopamine was observed. |
2000-10-18 |
2023-08-12 |
monkey |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
over a period of 6 months of repeated self-administration, there was a significant increase in the impact of a fixed dose on extracellular dopamine, indicating that neurochemical sensitization to the effects of self-administered cocaine occurs in primates. |
2000-10-18 |
2023-08-12 |
monkey |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
a pronounced dopaminergic response to noncontingent cocaine was also observed, with no increases in extracellular dopamine in response to an unexpected saline substitution, indicating that the neurochemical response to self-administered cocaine is primarily caused by direct pharmacological effects of the drug rather than by conditioning to external environmental cues. |
2000-10-18 |
2023-08-12 |
monkey |
| R Martin-Fardon, F Weis. N-[1-(2-benzo[b]thiophenyl)Cyclohexyl]- piperidine (BTCP) exerts cocaine-like actions on drug-maintained responding in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 3. 2000-10-11. PMID:10942855. |
the effects of n-[1-(2-benzo[b]thiophenyl)cyclohexyl]- piperidine (btcp), a phencyclidine derivative that acts as a potent dopamine reuptake inhibitor, were examined on cocaine self-administration in rats. |
2000-10-11 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. European journal of pharmacology. vol 398. issue 2. 2000-10-05. PMID:10854838. |
differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. |
2000-10-05 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine. European journal of pharmacology. vol 398. issue 2. 2000-10-05. PMID:10854838. |
however, while ibogaine pretreatment did not significantly alter the dopamine response in the nucleus accumbens to acute cocaine, it abolished the expression of cocaine-induced dopamine sensitization. |
2000-10-05 |
2023-08-12 |
rat |
| R Martin-Fardon, O Ben-Shahar, F Weis. Non reciprocal cross-sensitization between cocaine and BTCP on locomotor activity in the rat. Pharmacology, biochemistry, and behavior. vol 66. issue 3. 2000-10-05. PMID:10899381. |
like cocaine, btcp possesses high affinity for the dopamine transporter and inhibits dopamine reuptake. |
2000-10-05 |
2023-08-12 |
rat |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
in contrast to the highly patchy patterns of fos-like immunoreactivity seen in the rostral striatum after administration of a number of dopamine agonists, the monoamine uptake blocker cocaine has been reported to produce a relatively homogeneous pattern of gene expression. |
2000-10-02 |
2023-08-12 |
rat |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
in the current study we extended these observations by using a quantitative technique to demonstrate that while amphetamine and apomorphine produce patchy striatal fos expression, the selective dopamine uptake inhibitors amfonelic acid, nomifensine and gbr-12909 all, like cocaine, produce near random patterns of gene expression. |
2000-10-02 |
2023-08-12 |
rat |
| D Wirtshafte. A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats. Neuroscience letters. vol 289. issue 2. 2000-10-02. PMID:10904129. |
these findings suggest that the production of relatively 'non-patchy' patterns of immediate early gene expression may be a general property of dopamine transport inhibitors unrelated to any unique pharmacological properties of cocaine. |
2000-10-02 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
a new approach combining fast-scan cyclic voltammetry with iontophoretic dopamine delivery was used in freely behaving rats to evaluate the time-course of dopamine uptake inhibition in nucleus accumbens induced by intravenous cocaine at a dose (1.0mg/kg) known to maintain self-administration behavior. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
cocaine significantly increased the decay time of the dopamine response without altering its magnitude or time to peak. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
our data provide direct evidence for a phasic change in dopamine uptake induced by intravenous cocaine under behaviorally relevant conditions. |
2000-09-27 |
2023-08-12 |
rat |
| E A Kiyatkin, D E Kiyatkin, G V Rebe. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience. vol 98. issue 4. 2000-09-27. PMID:10891616. |
the relatively slow and gradual development of dopamine uptake inhibition, which peaks at times when behaving rats self-inject cocaine, is inconsistent with the suggested role of this mechanism in the acute rewarding (euphoric) effects of self-injected cocaine, but supports its role in the activational and motivational aspects of drug-seeking and drug-taking behavior. |
2000-09-27 |
2023-08-12 |
rat |