| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M F Olive, K K Mehmert, R O Messing, C W Hodg. Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCepsilon-deficient mice. The European journal of neuroscience. vol 12. issue 11. 2000-12-22. PMID:11069609. |
), while mesolimbic dopamine responses to cocaine (20 mg/kg i.p.) |
2000-12-22 |
2023-08-12 |
mouse |
| M R Gerasimov, M Franceschi, N D Volkow, O Rice, W K Schiffer, S L Dewe. Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044890. |
synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. |
2000-12-14 |
2023-08-12 |
Not clear |
| S J Gatley, A N Gifford, F I Carroll, N D Volko. Sensitivity of binding of high-affinity dopamine receptor radioligands to increased synaptic dopamine. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044896. |
the objective of this work was to determine whether the brain kinetics of high-affinity radioligands for dopamine d1 ([(3)h]sch 23390) and d2 ([(123)i]epidepride) receptors were altered by a prolonged elevation of synaptic dopamine induced by the potent cocaine analog rti-55. |
2000-12-14 |
2023-08-12 |
mouse |
| A E Fleckenstein, J W Gibb, G R Hanso. Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. European journal of pharmacology. vol 406. issue 1. 2000-12-07. PMID:11011026. |
some, such as cocaine, prevent the reuptake of newly released dopamine, serotonin or norepinephrine into their associated neurons. |
2000-12-07 |
2023-08-12 |
Not clear |
| B T Hoffman, T Kopajtic, J L Katz, A H Newma. 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. Journal of medicinal chemistry. vol 43. issue 22. 2000-12-07. PMID:11063611. |
in light of the chronic problem of abuse of the controlled substance cocaine, we have investigated novel approaches toward both understanding the activity of inhibitors of the dopamine transporter (dat) and identifying novel inhibitors that may be of therapeutic potential. |
2000-12-07 |
2023-08-12 |
Not clear |
| G M Sizemore, C Co, J E Smit. Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats. Psychopharmacology. vol 150. issue 4. 2000-11-30. PMID:10958080. |
ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats. |
2000-11-30 |
2023-08-12 |
rat |
| G M Sizemore, C Co, J E Smit. Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats. Psychopharmacology. vol 150. issue 4. 2000-11-30. PMID:10958080. |
dopamine innervation of the nucleus accumbens is thought to have a major role in the biological processes underlying cocaine self-administration. |
2000-11-30 |
2023-08-12 |
rat |
| L I Perrotti, K D Beck, V N Luine, V Quiñone. Progesterone and cocaine administration affect serotonin in the medial prefrontal cortex of ovariectomized rats. Neuroscience letters. vol 291. issue 3. 2000-11-30. PMID:10984630. |
although levels of dopamine, dopac, and homovanillic acid were decreased after cocaine, these alterations failed to reach significance. |
2000-11-30 |
2023-08-12 |
rat |
| T S Shippenberg, W Rea, B S Slushe. Modulation of behavioral sensitization to cocaine by NAALADase inhibition. Synapse (New York, N.Y.). vol 38. issue 2. 2000-11-28. PMID:11018790. |
sensitization to cocaine has been attributed to alterations in excitatory amino acid and dopamine neurotransmission in the mesolimbic system. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
the aim of these studies was to establish a rapid in vivo assay for evaluating potential "cocaine antagonists," i.e., drugs postulated to block cocaine binding to the dopamine transporter (dat) without corresponding blockade of dopamine reuptake. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
we next evaluated gbr12909, a piperazine analog promoted as a "cocaine antagonist" because of its ability to bind with high affinity to the dat, while only modestly elevating extracellular dopamine levels. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
the agonist- and antagonist-like properties of gbr12909 were evaluated on only vta dopamine cells since these neurons were more fully inhibited by cocaine and have been implicated in its rewarding effects. |
2000-11-28 |
2023-08-12 |
rat |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
we conclude that electrophysiological testing of putative "anti-cocaine" drugs for their abilities to inhibit the firing of vta dopamine neurons, and to block their inhibitory responses to cocaine, may provide a rapid in vivo screen for compounds expected to behave as functional cocaine antagonists in the dopamine reward system. |
2000-11-28 |
2023-08-12 |
rat |
| C Davidson, E H Ellinwood, S B Douglas, T H Le. Effect of cocaine, nomifensine, GBR 12909 and WIN 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine. Journal of neuroscience methods. vol 101. issue 1. 2000-11-27. PMID:10967364. |
effect of cocaine, nomifensine, gbr 12909 and win 35428 on carbon fiber microelectrode sensitivity for voltammetric recording of dopamine. |
2000-11-27 |
2023-08-12 |
Not clear |
| R Carey, E Damianopoulos, G De Palm. 8-OH DPAT can restore the locomotor stimulant effects of cocaine blocked by haloperidol. Pharmacology, biochemistry, and behavior. vol 66. issue 4. 2000-11-07. PMID:10973527. |
ex vivo measurements of dopamine and 5-hydroxytryptamine metabolism in limbic tissue were consistent with the established effects of cocaine, haloperidol, and 8-oh dpat upon dopamine and 5-hydroxytryptamine neurotransmission. |
2000-11-07 |
2023-08-12 |
rat |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. |
2000-10-18 |
2023-08-12 |
monkey |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
within a cocaine self-administration session, acute tolerance to the ability of cocaine to elevate extracellular striatal dopamine was observed. |
2000-10-18 |
2023-08-12 |
monkey |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
over a period of 6 months of repeated self-administration, there was a significant increase in the impact of a fixed dose on extracellular dopamine, indicating that neurochemical sensitization to the effects of self-administered cocaine occurs in primates. |
2000-10-18 |
2023-08-12 |
monkey |
| C W Bradberr. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995858. |
a pronounced dopaminergic response to noncontingent cocaine was also observed, with no increases in extracellular dopamine in response to an unexpected saline substitution, indicating that the neurochemical response to self-administered cocaine is primarily caused by direct pharmacological effects of the drug rather than by conditioning to external environmental cues. |
2000-10-18 |
2023-08-12 |
monkey |