| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R W Keller, A Snyder-Kelle. Prenatal cocaine exposure. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911932. |
since cocaine is known to act by blocking the inactivation of the neurotransmitters dopamine, serotonin and norepinephrine, our studies have focused on brain dopamine (da) and serotonin (5-ht) pathways. |
2000-08-10 |
2023-08-12 |
rat |
| E A Kiyatkin, G V Rebe. Dopamine-independent action of cocaine on striatal and accumbal neurons. The European journal of neuroscience. vol 12. issue 5. 2000-07-24. PMID:10792456. |
increasing evidence suggests that dopamine (da) mechanisms alone cannot fully explain the psychoemotional and behavioural effects of cocaine, including its ability to induce drug-taking behaviour. |
2000-07-24 |
2023-08-12 |
rat |
| T S Shippenberg, R Hen, M H. Region-specific enhancement of basal extracellular and cocaine-evoked dopamine levels following constitutive deletion of the Serotonin(1B) receptor. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854269. |
conventional microdialysis techniques were used to quantify cocaine (0, 5.0, and 20.0 mg/kg)-evoked dopamine overflow. |
2000-07-17 |
2023-08-12 |
mouse |
| Q Yan, M E Reith, S Ya. Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773215. |
enhanced accumbal dopamine release following 5-ht(2a) receptor stimulation in rats pretreated with intermittent cocaine. |
2000-07-14 |
2023-08-12 |
rat |
| Q Yan, M E Reith, S Ya. Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773215. |
this study was conducted to determine whether dopamine (da) release in the nucleus accumbens (nacc) following 5-ht(2a) receptor stimulation is potentiated by intermittent cocaine. |
2000-07-14 |
2023-08-12 |
rat |
| C Saunders, J V Ferrer, L Shi, J Chen, G Merrill, M E Lamb, L M Leeb-Lundberg, L Carvelli, J A Javitch, A Gall. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 12. 2000-07-13. PMID:10823899. |
the dopamine transporter (dat) is a target of amphetamine (amph) and cocaine. |
2000-07-13 |
2023-08-12 |
human |
| B E Scanley, M S Gandelman, M Laruelle, M S Al-Tikriti, R M Baldwin, S S Zoghbi, P B Hoffer, S Wang, J L Neumeyer, R B Inni. [123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates. Nuclear medicine and biology. vol 27. issue 1. 2000-07-07. PMID:10755641. |
[123i]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123i]-cit) and its isopropylester analog [123i]pcit, both of which are phenyltropane derivatives of cocaine with high affinity for the dopamine (da) transporter, were compared using single photon emission computed tomography in nonhuman primates. |
2000-07-07 |
2023-08-12 |
Not clear |
| A Hoepping, K M Johnson, C George, J Flippen-Anderson, A P Kozikowsk. Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. Journal of medicinal chemistry. vol 43. issue 10. 2000-06-29. PMID:10821718. |
the ability to inhibit reuptake of dopamine in comparison to cocaine is generally decreased in this series but for one compound. |
2000-06-29 |
2023-08-12 |
rat |
| M Itokawa, Z Lin, N S Cai, C Wu, S Kitayama, J B Wang, G R Uh. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825379. |
polar residues in dopamine transporter (dat) transmembrane domains (tms) are likely to act individually and even interactively in recognizing cocaine and dopamine. |
2000-06-22 |
2023-08-12 |
Not clear |
| M Itokawa, Z Lin, N S Cai, C Wu, S Kitayama, J B Wang, G R Uh. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825379. |
we initially evaluated the effects of alanine substitution mutants that remove the polar side chains from residues in each of the 12 putative dat tms on the recognition of dopamine and the cocaine analog cft. |
2000-06-22 |
2023-08-12 |
Not clear |
| M Itokawa, Z Lin, N S Cai, C Wu, S Kitayama, J B Wang, G R Uh. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825379. |
eleven combination mutants with multiple substitutions in dat tms 4, 5, 7, or 11 were then selected as candidates for more detailed evaluation based on mutation effects on dopamine and cocaine analog affinities. |
2000-06-22 |
2023-08-12 |
Not clear |
| C Cadoni, M Solinas, G Di Chiar. Psychostimulant sensitization: differential changes in accumbal shell and core dopamine. European journal of pharmacology. vol 388. issue 1. 2000-06-21. PMID:10657548. |
subjects pre-exposed to cocaine showed sensitization of dopamine transmission in the core only to the lower dose of cocaine. |
2000-06-21 |
2023-08-12 |
human |
| C Cadoni, M Solinas, G Di Chiar. Psychostimulant sensitization: differential changes in accumbal shell and core dopamine. European journal of pharmacology. vol 388. issue 1. 2000-06-21. PMID:10657548. |
in the shell no change was observed after the lower dose of cocaine while a significant reduction of the dopamine response was observed after the higher dose. |
2000-06-21 |
2023-08-12 |
human |
| C L Duvauchelle, A Ikegami, S Asami, J Robens, K Kressin, E Castaned. Effects of cocaine context on NAcc dopamine and behavioral activity after repeated intravenous cocaine administration. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799668. |
effects of cocaine context on nacc dopamine and behavioral activity after repeated intravenous cocaine administration. |
2000-06-21 |
2023-08-12 |
Not clear |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
dose-response and duration effects of acute administrations of cocaine and gbr12909 on dopamine synthesis and transporter in the conscious monkey brain: pet studies combined with microdialysis. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
the dose-response and duration effects of acute administration of the dopamine transporter (dat) blocker cocaine and gbr12909 on dopamine synthesis and transporter availability were evaluated in the brains of conscious monkeys using high-resolution positron emission tomography (pet) in combination with microdialysis. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
administration of cocaine (0.5, 2 and 5 mg/kg) resulted in dose-dependent elevation of dopamine level in the striatal extracellular fluid (ecf) at 0.5 h after injection, and returned to the baseline level within 1.5 h post-injection. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
at 0.5 post-injection, cocaine reduced dopamine synthesis rate and dat availability in a dose-dependent manner. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
gbr12909 induced dose-dependent elevation of dopamine level in ecf, and the elevation lasted up to 7 h. the present results indicated that cocaine and gbr12909 affect dopamine synthesis rate and dat availability in the striatum with difference time courses as measured by pet in the conscious monkey brains. |
2000-06-15 |
2023-08-12 |
monkey |
| P C Meltzer, P Blundell, H Huang, S Liu, Y F Yong, B K Madra. 3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter. Bioorganic & medicinal chemistry. vol 8. issue 3. 2000-06-01. PMID:10732975. |
the search for medications for cocaine abuse has focused upon the design of potential cocaine antagonists or cocaine substitutes which interact at the dopamine transporter of mammalian systems. |
2000-06-01 |
2023-08-12 |
Not clear |