| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Grabowski, H Rhoades, P Silverman, J M Schmitz, A Stotts, D Creson, R Baile. Risperidone for the treatment of cocaine dependence: randomized, double-blind trial. Journal of clinical psychopharmacology. vol 20. issue 3. 2000-09-01. PMID:10831016. |
risperidone, a 5-hydroxytryptamine and dopamine d2 antagonist, is an atypical antipsychotic and was a candidate medication for the treatment of cocaine dependence. |
2000-09-01 |
2023-08-12 |
human |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
extracellular dopamine levels were determined by microdialysis in the core and shell of the nucleus accumbens and the frontal cortex of rats before and after an injection of cocaine (20 mg/kg, ip). |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
baseline dopamine levels and their responses to an injection of cocaine differed among the three brain areas. |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
no significant correlations were found between baseline dopamine levels in any of the three brain regions and the voluntary cocaine consumption. |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
a significant negative correlation was found between cocaine-induced increases in extracellular dopamine in the shell of the nucleus accumbens and the voluntary intake of cocaine (r = -0.73, p < 0.01). |
2000-08-28 |
2023-08-12 |
rat |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
these results provide further evidence of the role of the accumbal shell region in cocaine preference, and indicate that cocaine-induced increases in dopamine levels play a role in oral cocaine self-administration or preference. |
2000-08-28 |
2023-08-12 |
rat |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
cocaine inhibits ngf-induced pc12 cells differentiation through d(1)-type dopamine receptors. |
2000-08-25 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
to determine if cocaine inhibits neurite outgrowth through the effects of these neurotransmitters, we applied dopamine, norepinephrine, serotonin, and acetylcholine to ngf-induced pc12 cells. |
2000-08-25 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
dopamine uptake measured over time was significantly blocked by cocaine and gbr 12909 which may result in elevated extracellular dopamine. |
2000-08-25 |
2023-08-12 |
Not clear |
| D A Zachor, J F Moore, C Brezausek, A Theibert, A K Perc. Cocaine inhibits NGF-induced PC12 cells differentiation through D(1)-type dopamine receptors. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865062. |
these findings suggest that cocaine inhibitory effects on neuronal differentiation are mediated through its binding to the dopamine transporter, resulting in increased dopamine level in the synapses. |
2000-08-25 |
2023-08-12 |
Not clear |
| T M Cabrera-Vera, F Garcia, W Pinto, G Battagli. Neurochemical changes in brain serotonin neurons in immature and adult offspring prenatally exposed to cocaine. Brain research. vol 870. issue 1-2. 2000-08-21. PMID:10869495. |
consistent with the maturational onset of changes in 5-ht, striatal dopamine was significantly reduced (-10%) by prenatal exposure to cocaine only in adult offspring. |
2000-08-21 |
2023-08-12 |
rat |
| N K Mello, S S Negu. Interactions between kappa opioid agonists and cocaine. Preclinical studies. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911926. |
kappa opioid agonists inhibit dopamine release from mesolimbic dopaminergic neurons and attenuate some behavioral effects of cocaine in rodents. |
2000-08-10 |
2023-08-12 |
monkey |
| D W Self, D A Karanian, J J Spence. Effects of the novel D1 dopamine receptor agonist ABT-431 on cocaine self-administration and reinstatement. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911927. |
selective d1 dopamine agonists represent a potential pharmacotherapy for the treatment of cocaine addiction. |
2000-08-10 |
2023-08-12 |
rat |
| R W Keller, A Snyder-Kelle. Prenatal cocaine exposure. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911932. |
since cocaine is known to act by blocking the inactivation of the neurotransmitters dopamine, serotonin and norepinephrine, our studies have focused on brain dopamine (da) and serotonin (5-ht) pathways. |
2000-08-10 |
2023-08-12 |
rat |
| E A Kiyatkin, G V Rebe. Dopamine-independent action of cocaine on striatal and accumbal neurons. The European journal of neuroscience. vol 12. issue 5. 2000-07-24. PMID:10792456. |
increasing evidence suggests that dopamine (da) mechanisms alone cannot fully explain the psychoemotional and behavioural effects of cocaine, including its ability to induce drug-taking behaviour. |
2000-07-24 |
2023-08-12 |
rat |
| T S Shippenberg, R Hen, M H. Region-specific enhancement of basal extracellular and cocaine-evoked dopamine levels following constitutive deletion of the Serotonin(1B) receptor. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854269. |
conventional microdialysis techniques were used to quantify cocaine (0, 5.0, and 20.0 mg/kg)-evoked dopamine overflow. |
2000-07-17 |
2023-08-12 |
mouse |
| Q Yan, M E Reith, S Ya. Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773215. |
enhanced accumbal dopamine release following 5-ht(2a) receptor stimulation in rats pretreated with intermittent cocaine. |
2000-07-14 |
2023-08-12 |
rat |
| Q Yan, M E Reith, S Ya. Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773215. |
this study was conducted to determine whether dopamine (da) release in the nucleus accumbens (nacc) following 5-ht(2a) receptor stimulation is potentiated by intermittent cocaine. |
2000-07-14 |
2023-08-12 |
rat |
| C Saunders, J V Ferrer, L Shi, J Chen, G Merrill, M E Lamb, L M Leeb-Lundberg, L Carvelli, J A Javitch, A Gall. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 12. 2000-07-13. PMID:10823899. |
the dopamine transporter (dat) is a target of amphetamine (amph) and cocaine. |
2000-07-13 |
2023-08-12 |
human |