| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W J Lynch, J R Taylo. Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. The European journal of neuroscience. vol 22. issue 5. 2006-01-10. PMID:16176364. |
as a direct test of this hypothesis, we examined the effects in rats of pka activation (sp-camps infusions of 10 and 20 nmol/side) and inhibition (rp-camps infusions of 10 and 20 nmol/side) in the nucleus accumbens on motivation to obtain cocaine as measured by responding under the progressive-ratio schedule. |
2006-01-10 |
2023-08-12 |
rat |
| W J Lynch, J R Taylo. Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. The European journal of neuroscience. vol 22. issue 5. 2006-01-10. PMID:16176364. |
these data suggest that alternations in pka activity within the nucleus accumbens as a consequence of repeated cocaine exposure may contribute to addiction by producing persistent increases in motivation to obtain cocaine. |
2006-01-10 |
2023-08-12 |
rat |
| A A Bari, R C Pierc. D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16111825. |
d1-like and d2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement. |
2005-12-22 |
2023-08-12 |
rat |
| A A Bari, R C Pierc. D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement. Neuroscience. vol 135. issue 3. 2005-12-22. PMID:16111825. |
the results indicated that administration of a d1/5 (sch-23390) or a d2/d3/d4 (eticlopride), but not a d3 (u99194a) or d4 (l-750,667), dopamine receptor antagonist into the core and shell of the nucleus accumbens decreased the reinforcing efficacy of cocaine. |
2005-12-22 |
2023-08-12 |
rat |
| Stefan D Schlussman, Yan Zhou, Alexis Bailey, Ann Ho, Mary Jeanne Kree. Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats. Brain research bulletin. vol 67. issue 3. 2005-12-15. PMID:16144651. |
cocaine, independent of dose, increased ppdyn mrna levels in the caudate putamen (cpu), but not in the nucleus accumbens (nac). |
2005-12-15 |
2023-08-12 |
rat |
| Kirstie H Stansfield, Cheryl L Kirstei. Neurochemical effects of cocaine in adolescence compared to adulthood. Brain research. Developmental brain research. vol 159. issue 2. 2005-11-30. PMID:16112203. |
the purpose of the present study was to characterize the neurochemical responsivity of the nucleus accumbens septi (nacc) in hr and lr adolescent and adult animals in response to a systemic challenge of cocaine. |
2005-11-30 |
2023-08-12 |
human |
| Yolanda Mateo, Christopher M Lack, Drake Morgan, David C S Roberts, Sara R Jone. Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 8. 2005-11-29. PMID:15702135. |
following binge cocaine sa and deprivation, the status of da terminals in the nucleus accumbens (nac) was investigated using microdialysis in freely moving rats and voltammetry in brain slices. |
2005-11-29 |
2023-08-12 |
rat |
| Jonathan A Hollander, Regina M Carell. Abstinence from cocaine self-administration heightens neural encoding of goal-directed behaviors in the accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 8. 2005-11-29. PMID:15856078. |
here, electrophysiological recording procedures were used to determine whether nucleus accumbens (acb) neuronal firing properties are altered following interruption and resumption of cocaine self-administration. |
2005-11-29 |
2023-08-12 |
rat |
| Jonathan A Hollander, Regina M Carell. Abstinence from cocaine self-administration heightens neural encoding of goal-directed behaviors in the accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 8. 2005-11-29. PMID:15856078. |
the results show that abstinence from cocaine self-administration causes a dramatic increase in the number and strength of acb neurons that encode cocaine-related information, thus representing the first neurophysiological correlate of heightened activation of the 'brain reward system' following abstinence and resumption (relapse) of cocaine consumption. |
2005-11-29 |
2023-08-12 |
rat |
| Amy C Boudreau, Marina E Wol. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 40. 2005-11-21. PMID:16207873. |
behavioral sensitization to cocaine is associated with increased ampa receptor surface expression in the nucleus accumbens. |
2005-11-21 |
2023-08-12 |
rat |
| Amy C Boudreau, Marina E Wol. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 40. 2005-11-21. PMID:16207873. |
cross-linking was used to distinguish between cell surface and intracellular ampa receptors in nucleus accumbens (nac) tissue obtained from rats treated repeatedly with saline or cocaine. |
2005-11-21 |
2023-08-12 |
rat |
| Guadalupe Soria, Victoria Mendizábal, Clara Touriño, Patricia Robledo, Catherine Ledent, Marc Parmentier, Rafael Maldonado, Olga Valverd. Lack of CB1 cannabinoid receptor impairs cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 9. 2005-11-07. PMID:15742004. |
acute cocaine administration induced a similar enhancement in the extracellular levels of dopamine in the nucleus accumbens of both cb1 knockout and wild-type mice. |
2005-11-07 |
2023-08-12 |
mouse |
| Olga V Gurkovskaya, Vitaly Palamarchouk, Gennady Smagin, Nick E Goeder. Effects of corticotropin-releasing hormone receptor antagonists on cocaine-induced dopamine overflow in the medial prefrontal cortex and nucleus accumbens of rats. Synapse (New York, N.Y.). vol 57. issue 4. 2005-10-27. PMID:15986362. |
crh has been shown to increase dopaminergic transmission in regions relevant for cocaine reinforcement, such as the medial prefrontal cortex and the nucleus accumbens. |
2005-10-27 |
2023-08-12 |
rat |
| Yukiori Goto, Anthony A Grac. Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron. vol 47. issue 2. 2005-10-11. PMID:16039567. |
dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. |
2005-10-11 |
2023-08-12 |
Not clear |
| Laxman Korutla, Nicholas Champtiaux, Hao-Wei Shen, Matthias Klugmann, Matthias Klugman, Peter W Kalivas, Scott A Mackle. Activity-dependent subcellular localization of NAC1. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045493. |
the expression of the transcriptional regulator nac1 is increased in the nucleus accumbens of rats withdrawn from cocaine self-administration, and in vivo studies indicate that the up-regulation is a compensatory mechanism opposing the acute effects of cocaine. |
2005-09-23 |
2023-08-12 |
rat |
| Richard G Hunter, Aleksandra Vicentic, George Rogge, Michael J Kuha. The effects of cocaine on CART expression in the rat nucleus accumbens: a possible role for corticosterone. European journal of pharmacology. vol 517. issue 1-2. 2005-09-19. PMID:15972209. |
the effects of cocaine on cart expression in the rat nucleus accumbens: a possible role for corticosterone. |
2005-09-19 |
2023-08-12 |
rat |
| Richard G Hunter, Aleksandra Vicentic, George Rogge, Michael J Kuha. The effects of cocaine on CART expression in the rat nucleus accumbens: a possible role for corticosterone. European journal of pharmacology. vol 517. issue 1-2. 2005-09-19. PMID:15972209. |
the present study aimed to repeat experiments with conflicting results and to reexamine and extend the original finding of acute regulation of nucleus accumbens cart mrna by cocaine. |
2005-09-19 |
2023-08-12 |
rat |
| Amine Bahi, Frederic Boyer, Gaelle Bussard, Jean-Luc Dreye. Silencing dopamine D3-receptors in the nucleus accumbens shell in vivo induces changes in cocaine-induced hyperlocomotion. The European journal of neuroscience. vol 21. issue 12. 2005-09-14. PMID:16026479. |
these viruses were stereotaxically injected into the shell part of the nucleus accumbens (nacc) and effects of passive cocaine delivery on locomotor activity were assessed. |
2005-09-14 |
2023-08-12 |
rat |
| D J Lodge, A A Grac. Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activity. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15784652. |
taken as a whole, these data demonstrate that, although da neuron population activity exhibits tolerance to chronic crf1 receptor antagonism (by cra-0450), tolerance does not develop to the selective inhibition of cocaine-induced da release (in the acb) and, as such, may be beneficial in the treatment of cocaine addiction. |
2005-08-26 |
2023-08-12 |
Not clear |
| Rejean M Guerriero, Anjali Rajadhyaksha, Claire Crozatier, Bruno Giros, Marika Nosten-Bertrand, Barry E Kosofsk. Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Developmental neuroscience. vol 27. issue 2-4. 2005-08-25. PMID:16046859. |
augmented constitutive creb expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. |
2005-08-25 |
2023-08-12 |
mouse |