| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yilin Li, Martin J Acerbo, Terry E Robinso. The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355332. |
in the acb core (acbc) cocaine treatment increased spine density only in the group that developed psychomotor sensitization (i.e. |
2004-12-20 |
2023-08-12 |
rat |
| Yilin Li, Martin J Acerbo, Terry E Robinso. The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355332. |
in the acb shell (acbs) cocaine increased spine density to the same extent in both groups; i.e. |
2004-12-20 |
2023-08-12 |
rat |
| Yilin Li, Martin J Acerbo, Terry E Robinso. The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355332. |
thus, the context in which cocaine is experienced influences its ability to reorganize patterns of synaptic connectivity in the acb and mpfc, and the induction of psychomotor sensitization is associated with structural plasticity in the acbc and mpfc, but not the acbs. |
2004-12-20 |
2023-08-12 |
rat |
| Terry E Robinson, Bryan Kol. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464124. |
in this paper we summarize evidence that, indeed, exposure to amphetamine, cocaine, nicotine or morphine produces persistent changes in the structure of dendrites and dendritic spines on cells in brain regions involved in incentive motivation and reward (such as the nucleus accumbens), and judgment and the inhibitory control of behavior (such as the prefrontal cortex). |
2004-12-20 |
2023-08-12 |
Not clear |
| Regina M Carell. Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464136. |
electrophysiological studies are reviewed showing that acb neurons exhibit patterned discharges relative to operant responding for intravenous self-administration of cocaine versus 'natural' reinforcement in rodents. |
2004-12-20 |
2023-08-12 |
rat |
| Regina M Carell. Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464136. |
importantly, subsequent studies showed that discrete subsets of acb neurons are selectively activated during multiple schedules for a natural reward (water or food) versus cocaine self-administration. |
2004-12-20 |
2023-08-12 |
rat |
| Regina M Carell. Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464136. |
next, electrochemical studies are summarized that used fast scan cyclic voltammetry to measure rapid (subsecond) changes in dopamine in the acb during cocaine self-administration as well as 'natural' reinforcement in rodents. |
2004-12-20 |
2023-08-12 |
rat |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
to help determine mechanisms underlying these effects, we now report examination of baselines and drug-induced changes of extracellular dopamine (daex) and serotonin (5-ht(ex)) levels in microdialysates from nucleus accumbens (nac), caudate putamen (cpu), and prefrontal cortex (pfc) of wild-type, homozygous dat- or sert-ko and heterozygous or homozygous dat/sert double-ko mice, which are differentially rewarded by cocaine. |
2004-11-22 |
2023-08-12 |
mouse |
| Xiu-Ti Hu, Somnath Basu, Francis J Whit. Repeated cocaine administration suppresses HVA-Ca2+ potentials and enhances activity of K+ channels in rat nucleus accumbens neurons. Journal of neurophysiology. vol 92. issue 3. 2004-11-04. PMID:15331648. |
repeated cocaine administration suppresses hva-ca2+ potentials and enhances activity of k+ channels in rat nucleus accumbens neurons. |
2004-11-04 |
2023-08-12 |
rat |
| Xiu-Ti Hu, Somnath Basu, Francis J Whit. Repeated cocaine administration suppresses HVA-Ca2+ potentials and enhances activity of K+ channels in rat nucleus accumbens neurons. Journal of neurophysiology. vol 92. issue 3. 2004-11-04. PMID:15331648. |
the nucleus accumbens (nac) is an important forebrain area involved in sensitization, withdrawal effects, and self-administration of cocaine. |
2004-11-04 |
2023-08-12 |
rat |
| Karen K Szumlinski, Marlin H Dehoff, Shin H Kang, Kelly A Frys, Kevin D Lominac, Matthias Klugmann, Jason Rohrer, William Griffin, Shigenobu Toda, Nicolas P Champtiaux, Thomas Berry, Jian C Tu, Stephanie E Shealy, Matthew J During, Lawrence D Middaugh, Paul F Worley, Peter W Kaliva. Homer proteins regulate sensitivity to cocaine. Neuron. vol 43. issue 3. 2004-11-02. PMID:15294147. |
here, we report that deletion of homer1 or homer2 in mice caused the same increase in sensitivity to cocaine-induced locomotion, conditioned reward, and augmented extracellular glutamate in nucleus accumbens as that elicited by withdrawal from repeated cocaine administration. |
2004-11-02 |
2023-08-12 |
mouse |
| Christian P Müller, Heike Thönnessen, Marilia Barros, Carlos Tomaz, Robert J Carey, Joseph P Husto. Hippocampus 5-HT(1A)-receptors attenuate cocaine-induced hyperlocomotion and the increase in hippocampal but not nucleus accumbens 5-HT. Hippocampus. vol 14. issue 6. 2004-11-01. PMID:15318330. |
cocaine induces an increase in hippocampal and nucleus accumbens (nac) serotonin (5-ht) concentration parallel to locomotor activation. |
2004-11-01 |
2023-08-12 |
rat |
| Prathiba Jayaram, Jeffery D Stekete. Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine system. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287889. |
baclofen minimally affected glutamate levels in the medial prefrontal cortex, nucleus accumbens or ventral tegmental area of control animals, but dose-dependently increased glutamate levels in each of these regions in animals sensitized to cocaine. |
2004-10-28 |
2023-08-12 |
Not clear |
| Joseph A Schroeder, Michele Hummel, Ellen M Unterwal. Repeated intracerebroventricular forskolin administration enhances behavioral sensitization to cocaine. Behavioural brain research. vol 153. issue 1. 2004-09-27. PMID:15219727. |
chronic cocaine administration also results in increased activity of adenylyl cyclase and cyclic-amp (camp) dependent protein kinase (pka) in the nucleus accumbens. |
2004-09-27 |
2023-08-12 |
rat |
| Qing-Shan Ya. Involvement of non-exocytotic mechanisms in ethanol-induced in vivo dopamine release: comparisons with cocaine. European journal of pharmacology. vol 477. issue 1. 2004-08-24. PMID:14512096. |
effects of ethanol on dopamine release in the nucleus accumbens were compared with those by cocaine, a drug that increases synaptic dopamine by a mechanism, which depends on neuronal activity and involves an exocytotic process. |
2004-08-24 |
2023-08-12 |
rat |
| Qing-Shan Ya. Involvement of non-exocytotic mechanisms in ethanol-induced in vivo dopamine release: comparisons with cocaine. European journal of pharmacology. vol 477. issue 1. 2004-08-24. PMID:14512096. |
administration of ethanol (80 mm) or cocaine (10 microm) via a dialysis probe increased extracellular dopamine concentrations in the nucleus accumbens. |
2004-08-24 |
2023-08-12 |
rat |
| M Solinas, A Zangen, N Thiriet, S R Goldber. Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of Delta-9-tetrahydrocannabinol. The European journal of neuroscience. vol 19. issue 12. 2004-08-18. PMID:15217374. |
beta-endorphin is an endogenous opioid that produces behavioral effects similar to heroin and morphine and is released in the nucleus accumbens by cocaine, amphetamine and ethanol, suggesting a general involvement in the reinforcing effects of abused drugs. |
2004-08-18 |
2023-08-12 |
rat |
| Stephanie C Licata, R Christopher Pierc. Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shell. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158168. |
numerous reports have demonstrated augmented cocaine-evoked release of dopamine in the nucleus accumbens of rats pre-treated with cocaine. |
2004-08-17 |
2023-08-12 |
rat |
| Stephanie C Licata, R Christopher Pierc. Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shell. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158168. |
the present study assessed the activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the nucleus accumbens following either acute or repeated cocaine administration. |
2004-08-17 |
2023-08-12 |
rat |
| Richard J Beninger, Todor Gerdjiko. The role of signaling molecules in reward-related incentive learning. Neurotoxicity research. vol 6. issue 1. 2004-08-03. PMID:15184110. |
thus, inhibition of cyclic adenosine monophosphate-dependent protein kinase (pka) in the nucleus accumbens (nac), that is activated by da acting at d1-like receptors, blocks the acquisition of conditioned approach responses, lever pressing for food, conditioned place preference (cpp) based on nac injections of amphetamine or cocaine, and conditioned activity based on nac injections of amphetamine. |
2004-08-03 |
2023-08-12 |
Not clear |