| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawn N Albertson, Carl J Schmidt, Gregory Kapatos, Michael J Banno. Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16710320. |
distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. |
2006-11-01 |
2023-08-12 |
human |
| Dawn N Albertson, Carl J Schmidt, Gregory Kapatos, Michael J Banno. Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16710320. |
these data suggest that the profiles of nucleus accumbens gene expression associated with chronic heroin or cocaine abuse are largely unique, despite what are thought to be common effects of these drugs on dopamine neurotransmission in this brain region. |
2006-11-01 |
2023-08-12 |
human |
| Bruce T Hope, Danielle E Simmons, Tim B Mitchell, Justin D Kreuter, Brandi J Mattso. Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930414. |
cocaine-induced locomotor activity and fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. |
2006-11-01 |
2023-08-12 |
rat |
| Bruce T Hope, Danielle E Simmons, Tim B Mitchell, Justin D Kreuter, Brandi J Mattso. Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930414. |
in contrast, cocaine-induced fos expression was absent altogether in nucleus accumbens and unaltered in caudate-putamen 1 month after repeated cocaine administration in the home cage. |
2006-11-01 |
2023-08-12 |
rat |
| Bruce T Hope, Danielle E Simmons, Tim B Mitchell, Justin D Kreuter, Brandi J Mattso. Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930414. |
as cocaine-induced locomotor activity was also enhanced 1 and 6 months after repeated cocaine administration in locomotor activity chambers, we wanted to confirm that neuronal activity in nucleus accumbens mediates cocaine-induced locomotor activity using our particular treatment regimen. |
2006-11-01 |
2023-08-12 |
rat |
| Robert E Sorge, Jane Stewar. The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16806444. |
the effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats. |
2006-10-05 |
2023-08-12 |
rat |
| Robert E Sorge, Jane Stewar. The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16806444. |
we have previously shown that chronic treatment with the partial mu-opioid receptor agonist, buprenorphine, blocks the nucleus accumbens dopamine response to an acute injection of heroin, whereas it potentiates the response to an acute injection of cocaine after 4-5 days of treatment. |
2006-10-05 |
2023-08-12 |
rat |
| Robert E Sorge, Jane Stewar. The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16806444. |
using in vivo microdialysis we found that both the suppression of the dopaminergic response in the nucleus accumbens to heroin and the potentiation to cocaine seen early in treatment diminished over the 26-27 days, whereas basal dopamine levels remained elevated throughout. |
2006-10-05 |
2023-08-12 |
rat |
| Heather C Brenhouse, Stefanie Montalto, James R Stella. Electrolytic lesions of a discrete area within the nucleus accumbens shell attenuate the long-term expression, but not early phase, of sensitization to cocaine. Behavioural brain research. vol 170. issue 2. 2006-09-14. PMID:16580740. |
the nucleus accumbens (nac), a major termination site of dopaminergic neurons, is believed to be involved in behavioral sensitization and studies have demonstrated that the nac shell can be split into five zones of analysis; the vertex, arch, cone, intermediate and ventrolateral zones [todtenkopf ms, stellar jr. assessment of tyrosine hydroxylase immunoreactive innervation in five subregions of the nucleus accumbens shell in rats treated with repeated cocaine. |
2006-09-14 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Jeremy G Gilbert, Xiao-Qing Peng, Arlene C Pak, Xia Li, Eliot L Gardne. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914679. |
given the importance of dopamine, glutamate, and gaba in cocaine reward and relapse, we studied the effects of am251 [n-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide], a novel highly selective cb1 receptor antagonist, on cocaine-primed reinstatement of drug-seeking behavior and on cocaine-induced changes in extracellular da, glutamate, and gaba in the nucleus accumbens (nac) under reinstatement conditions. |
2006-09-12 |
2023-08-12 |
rat |
| Sharon M Anderson, Heath D Schmidt, R Christopher Pierc. Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16205775. |
administration of the d2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. |
2006-09-05 |
2023-08-12 |
rat |
| Sharon M Anderson, Heath D Schmidt, R Christopher Pierc. Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16205775. |
enhanced dopamine transmission in the nucleus accumbens plays an important role in cocaine priming-induced reinstatement of drug-seeking behavior. |
2006-09-05 |
2023-08-12 |
rat |
| Sharon M Anderson, Heath D Schmidt, R Christopher Pierc. Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16205775. |
collectively, these findings indicate that activation of d2 dopamine receptors mediates cocaine priming-induced reinstatement of cocaine seeking in a region-specific manner within the nucleus accumbens. |
2006-09-05 |
2023-08-12 |
rat |
| Nicole L Schramm-Sapyta, Christopher M Olsen, Danny G Winde. Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16205778. |
previous research examining the effects of intraperitoneally administered cocaine has revealed that cocaine alters excitatory glutamatergic signaling, both directly through regulation of synaptic function, and indirectly through regulation of cellular excitability in areas of the drug reward circuitry such as the nucleus accumbens (nacc) and ventral tegmental area. |
2006-09-05 |
2023-08-12 |
mouse |
| Miquel Martin, Billy T Chen, F Woodward Hopf, M Scott Bowers, Antonello Bonc. Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nature neuroscience. vol 9. issue 7. 2006-09-05. PMID:16732275. |
cocaine self-administration selectively abolishes ltd in the core of the nucleus accumbens. |
2006-09-05 |
2023-08-12 |
rat |
| Zhen Li, Lin Gao, Qiang Liu, Cong Cao, Xiu Lan Sun, Jian Hua Ding, Gang H. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797122. |
the results reveal that aqp4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (nac), a brain region known to be critically involved in the addictive properties of cocaine. |
2006-09-01 |
2023-08-12 |
mouse |
| Weixia Zhong, Zhifang Dong, Meng Tian, Jun Cao, Tianle Xu, Lin Xu, Jianhong Lu. Opiate withdrawal induces dynamic expressions of AMPA receptors and its regulatory molecule CaMKIIalpha in hippocampal synapses. Life sciences. vol 79. issue 9. 2006-08-18. PMID:16616767. |
cocaine withdrawal alters the expression of glur1 and glur2/3 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa) receptors in nucleus accumbens or amygdala, but the influence of drug withdrawal on hippocampus is little known. |
2006-08-18 |
2023-08-12 |
Not clear |
| J M Silvers, D R Wallace, S B Harrod, C F Mactutus, R M Booz. Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. Neurotoxicology and teratology. vol 28. issue 2. 2006-06-28. PMID:16529908. |
prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. |
2006-06-28 |
2023-08-12 |
rat |
| J M Silvers, D R Wallace, S B Harrod, C F Mactutus, R M Booz. Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. Neurotoxicology and teratology. vol 28. issue 2. 2006-06-28. PMID:16529908. |
the present study was designed to study alterations in d2, d3 and sigma receptor density in nucleus accumbens and striatum of dams and male and female offspring following gestational cocaine. |
2006-06-28 |
2023-08-12 |
rat |
| Masahiko Funada, Mio Sato, Naoya Aoo, Kiyoshi Wad. [Role of the monoamine system in the brain on the development of psychological dependence on toluene]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619847. |
the mesolimbic dopamine pathway, which includes dopaminergic neurons in the ventral tegmental area (vta) of the midbrain and their targets in the limbic forebrain, especially the nucleus accumbens (nac), is one of the most important substrates for the development of psychological dependence on drugs such as stimulants, cocaine, and heroin. |
2006-05-30 |
2023-08-12 |
Not clear |