| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sharon M Anderson, Heath D Schmidt, R Christopher Pierc. Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16205775. |
collectively, these findings indicate that activation of d2 dopamine receptors mediates cocaine priming-induced reinstatement of cocaine seeking in a region-specific manner within the nucleus accumbens. |
2006-09-05 |
2023-08-12 |
rat |
| Nicole L Schramm-Sapyta, Christopher M Olsen, Danny G Winde. Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 7. 2006-09-05. PMID:16205778. |
previous research examining the effects of intraperitoneally administered cocaine has revealed that cocaine alters excitatory glutamatergic signaling, both directly through regulation of synaptic function, and indirectly through regulation of cellular excitability in areas of the drug reward circuitry such as the nucleus accumbens (nacc) and ventral tegmental area. |
2006-09-05 |
2023-08-12 |
mouse |
| Miquel Martin, Billy T Chen, F Woodward Hopf, M Scott Bowers, Antonello Bonc. Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nature neuroscience. vol 9. issue 7. 2006-09-05. PMID:16732275. |
cocaine self-administration selectively abolishes ltd in the core of the nucleus accumbens. |
2006-09-05 |
2023-08-12 |
rat |
| Zhen Li, Lin Gao, Qiang Liu, Cong Cao, Xiu Lan Sun, Jian Hua Ding, Gang H. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797122. |
the results reveal that aqp4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (nac), a brain region known to be critically involved in the addictive properties of cocaine. |
2006-09-01 |
2023-08-12 |
mouse |
| Weixia Zhong, Zhifang Dong, Meng Tian, Jun Cao, Tianle Xu, Lin Xu, Jianhong Lu. Opiate withdrawal induces dynamic expressions of AMPA receptors and its regulatory molecule CaMKIIalpha in hippocampal synapses. Life sciences. vol 79. issue 9. 2006-08-18. PMID:16616767. |
cocaine withdrawal alters the expression of glur1 and glur2/3 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa) receptors in nucleus accumbens or amygdala, but the influence of drug withdrawal on hippocampus is little known. |
2006-08-18 |
2023-08-12 |
Not clear |
| J M Silvers, D R Wallace, S B Harrod, C F Mactutus, R M Booz. Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. Neurotoxicology and teratology. vol 28. issue 2. 2006-06-28. PMID:16529908. |
prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. |
2006-06-28 |
2023-08-12 |
rat |
| J M Silvers, D R Wallace, S B Harrod, C F Mactutus, R M Booz. Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and adolescent offspring. Neurotoxicology and teratology. vol 28. issue 2. 2006-06-28. PMID:16529908. |
the present study was designed to study alterations in d2, d3 and sigma receptor density in nucleus accumbens and striatum of dams and male and female offspring following gestational cocaine. |
2006-06-28 |
2023-08-12 |
rat |
| Masahiko Funada, Mio Sato, Naoya Aoo, Kiyoshi Wad. [Role of the monoamine system in the brain on the development of psychological dependence on toluene]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619847. |
the mesolimbic dopamine pathway, which includes dopaminergic neurons in the ventral tegmental area (vta) of the midbrain and their targets in the limbic forebrain, especially the nucleus accumbens (nac), is one of the most important substrates for the development of psychological dependence on drugs such as stimulants, cocaine, and heroin. |
2006-05-30 |
2023-08-12 |
Not clear |
| Karen K Szumlinski, Kenneth E Abernathy, Erik B Oleson, Matthias Klugmann, Kevin D Lominac, Dao-Yao He, Dorit Ron, Matthew During, Peter W Kaliva. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 4. 2006-05-25. PMID:16160706. |
the long vs short homer isoforms were overexpressed in the rat nucleus accumbens during drug abstinence, and the adaptations elicited by repeated cocaine on glutamate transmission and motor behavior were measured. |
2006-05-25 |
2023-08-12 |
rat |
| Douglas C Jones, Michael J Kuha. Cocaine-amphetamine-regulated transcript expression in the rat nucleus accumbens is regulated by adenylyl cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second messenger system. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16322355. |
under certain conditions, cocaine increases cart mrna levels; thus, we examined the effects of cocaine on forskolin-induced cart mrna expression in the rat nucleus accumbens. |
2006-05-25 |
2023-08-12 |
rat |
| James E Smith, Conchita Co, Michael D Coller, Scott E Hemby, Thomas J Marti. Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:15956989. |
self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. |
2006-05-12 |
2023-08-12 |
rat |
| James E Smith, Conchita Co, Michael D Coller, Scott E Hemby, Thomas J Marti. Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:15956989. |
a second experiment used microdialysis to determine the effects of this drug combination on nucleus accumbens (nac) extracellular levels of dopamine ([da](e)) in rats self-administering low doses of cocaine, heroin, or cocaine/heroin combinations. |
2006-05-12 |
2023-08-12 |
rat |
| Venetia Zachariou, Véronique Sgambato-Faure, Teresa Sasaki, Per Svenningsson, Olivier Berton, Allen A Fienberg, Angus C Nairn, Paul Greengard, Eric J Nestle. Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 3. 2006-05-12. PMID:16123776. |
similarly, induction of the transcription factor deltafosb in the ventral striatum (nucleus accumbens) by chronic cocaine was diminished by the thr-34, but not the thr-75, mutation. |
2006-05-12 |
2023-08-12 |
mouse |
| K-H Choi, K Whisler, D L Graham, D W Sel. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16359811. |
antisense-induced reduction in nucleus accumbens cyclic amp response element binding protein attenuates cocaine reinforcement. |
2006-05-03 |
2023-08-12 |
rat |
| K-H Choi, K Whisler, D L Graham, D W Sel. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16359811. |
repeated cocaine exposure up-regulates cyclic amp signaling and increases the transcriptional activity of cyclic amp response element binding protein (creb) in the nucleus accumbens. |
2006-05-03 |
2023-08-12 |
rat |
| K-H Choi, K Whisler, D L Graham, D W Sel. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16359811. |
to study the possibility that nucleus accumbens creb activity regulates self-administration behavior, we tested the effects of a single, bilateral infusion of creb antisense oligonucleotide into nucleus accumbens core and shell sub-regions on cocaine self-administration in rats. |
2006-05-03 |
2023-08-12 |
rat |
| K-H Choi, K Whisler, D L Graham, D W Sel. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16359811. |
creb antisense also increased the threshold dose of cocaine required for reinstating cocaine self-administration, indicating that nucleus accumbens creb levels regulate the incentive properties of cocaine. |
2006-05-03 |
2023-08-12 |
rat |
| K-H Choi, K Whisler, D L Graham, D W Sel. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16359811. |
these results suggest a necessary role for nucleus accumbens creb activity in cocaine reinforcement, and, by converse analogy, up-regulation in creb activity after chronic cocaine use could contribute to addiction-related increases in cocaine self-administration. |
2006-05-03 |
2023-08-12 |
rat |
| Shigenobu Toda, Hao-Wei Shen, Jamie Peters, Stephanie Cagle, Peter W Kaliva. Cocaine increases actin cycling: effects in the reinstatement model of drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 5. 2006-04-27. PMID:16452681. |
the cycling of actin between polymerized [f (for filamentous)] and depolymerized forms contributes to synaptic plasticity, and acute and withdrawal from repeated cocaine administration produced reversible and enduring elevations, respectively, in f-actin in the nucleus accumbens. |
2006-04-27 |
2023-08-12 |
rat |
| U E Ghitza, V F Prokopenko, M O West, A T Fabbricator. Higher magnitude accumbal phasic firing changes among core neurons exhibiting tonic firing increases during cocaine self-administration. Neuroscience. vol 137. issue 3. 2006-04-12. PMID:16325346. |
cocaine self-administration in rats have documented rapid-phasic changes in the firing rate of nucleus accumbens neurons within seconds of cocaine-reinforced lever presses, as well as changes that occur over the course of the cocaine self-administration experiment, i.e. |
2006-04-12 |
2023-08-12 |
rat |