| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Brenhouse, J R Stella. c-Fos and deltaFosB expression are differentially altered in distinct subregions of the nucleus accumbens shell in cocaine-sensitized rats. Neuroscience. vol 137. issue 3. 2006-04-12. PMID:16337088. |
the present study quantified c-fos- and deltafosb-immunoreactive nuclei in subterritories of the nucleus accumbens in animals behaviorally sensitized to cocaine. |
2006-04-12 |
2023-08-12 |
rat |
| Heath D Schmidt, Sharon M Anderson, R Christopher Pierc. Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat. The European journal of neuroscience. vol 23. issue 1. 2006-04-06. PMID:16420431. |
although increases in dopamine transmission in the brain are clearly involved in the reinstatement of cocaine seeking, the role of nucleus accumbens dopamine in cocaine priming-induced reinstatement remains controversial. |
2006-04-06 |
2023-08-12 |
rat |
| V I Chefer, T S Shippenber. Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens. The European journal of neuroscience. vol 23. issue 1. 2006-04-06. PMID:16420432. |
quantitative and conventional microdialysis were used to investigate the effects of constitutive deletion of the prodynorphin gene on basal dopamine (da) dynamics in the nucleus accumbens (nac) and the responsiveness of da neurons to an acute cocaine challenge. |
2006-04-06 |
2023-08-12 |
mouse |
| Regina M Carelli, Joyce Wondolowsk. Anatomic distribution of reinforcer selective cell firing in the core and shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 59. issue 2. 2006-04-05. PMID:16270303. |
we have previously reported that distinct populations of nucleus accumbens (nac) neurons differentially encode information about goal-directed behaviors for "natural" (food/water) vs. cocaine reinforcement [j neurosci 20:4255-4266, (2000)]. |
2006-04-05 |
2023-08-12 |
rat |
| Xing-Chun Tang, Krista McFarland, Stephanie Cagle, Peter W Kaliva. Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 18. 2006-03-23. PMID:15872098. |
the projection from the nucleus accumbens to the ventral pallidum regulates the reinstatement of cocaine seeking in rats extinguished from cocaine self-administration. |
2006-03-23 |
2023-08-12 |
rat |
| Vladimir I Chefer, Traci Czyzyk, Elizabeth A Bolan, Jose Moron, John E Pintar, Toni S Shippenber. Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 20. 2006-03-23. PMID:15901784. |
genetic and pharmacological approaches were used to examine kappa-opioid receptor (kor-1) regulation of dopamine (da) dynamics in the nucleus accumbens and vulnerability to cocaine. |
2006-03-23 |
2023-08-12 |
mouse |
| Karen Brami-Cherrier, Emmanuel Valjent, Denis Hervé, Joanne Darragh, Jean-Christophe Corvol, Christiane Pages, Simon J Arthur, Arthur J Simon, Jean-Antoine Girault, Jocelyne Caboch. Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 49. 2006-03-23. PMID:16339038. |
here we show that in mice a single injection of cocaine (10 mg/kg) activates mitogen- and stress-activated protein kinase 1 (msk1) in dorsal striatum and nucleus accumbens. |
2006-03-23 |
2023-08-12 |
mouse |
| Louk J M J Vanderschuren, Patricia Di Ciano, Barry J Everit. Involvement of the dorsal striatum in cue-controlled cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 38. 2006-03-10. PMID:16177034. |
nucleus accumbens dopamine (da) neurotransmission plays an important role in the reinforcing effect of cocaine itself, but, unlike nucleus accumbens glutamate, it seems not to mediate the conditioned reinforcing properties of cocaine-paired stimuli. |
2006-03-10 |
2023-08-12 |
Not clear |
| Jason M Uslaner, Pengwei Yang, Terry E Robinso. Subthalamic nucleus lesions enhance the psychomotor-activating, incentive motivational, and neurobiological effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 37. 2006-03-06. PMID:16162923. |
furthermore, bilateral stn lesions enhanced the ability of cocaine to induce gene expression in the nucleus accumbens and caudate-putamen, two structures known to be involved in mediating the psychomotor-activating and incentive motivational effects of drugs of abuse. |
2006-03-06 |
2023-08-12 |
Not clear |
| Megan M Moran, Krista McFarland, Roberto I Melendez, Peter W Kalivas, Jeremy K Seaman. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 27. 2006-02-28. PMID:16000629. |
withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus accumbens by decreasing cystine/glutamate exchange (xc-). |
2006-02-28 |
2023-08-12 |
rat |
| Michael J Kuhar, Jason N Jaworski, George W Hubert, Kelly B Philpot, Geraldina Domingue. Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets. The AAPS journal. vol 7. issue 1. 2006-02-23. PMID:16146347. |
third, creb in the nucleus accumbens has been shown to have an opposing effect on cocaine self-administration. |
2006-02-23 |
2023-08-12 |
Not clear |
| Krzysztof Wedzony, Katarzyna Markowicz-Kula, Agnieszka Chocyk, Katarzyna Fijał, Marzena Maćkowia. The effect of 'binge' cocaine administration on the expression of cyclin-dependent kinase 5 and its activator p35 in various regions of rat brain. Brain research. vol 1063. issue 2. 2006-02-15. PMID:16263094. |
the present study was aimed at determining whether the administration of cocaine in 'binge' pattern regimen that evoked tolerance to the locomotor stimulant effects of cocaine also influenced the expression of cyclin-dependent kinase 5 (cdk5) and its activator p35 in the amygdala, medial prefrontal cortex, nucleus accumbens septi and caudate-putamen. |
2006-02-15 |
2023-08-12 |
rat |
| Krzysztof Wedzony, Katarzyna Markowicz-Kula, Agnieszka Chocyk, Katarzyna Fijał, Marzena Maćkowia. The effect of 'binge' cocaine administration on the expression of cyclin-dependent kinase 5 and its activator p35 in various regions of rat brain. Brain research. vol 1063. issue 2. 2006-02-15. PMID:16263094. |
in neither the nucleus accumbens septi nor the caudate-putamen acute or repeated 'binge' cocaine modified the expression of cdk5 and p35. |
2006-02-15 |
2023-08-12 |
rat |
| Jennifer L Cornish, Jaclyn M Lontos, Kelly J Clemens, Iain S McGrego. Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. Psychopharmacology. vol 180. issue 1. 2006-02-13. PMID:15682301. |
cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. |
2006-02-13 |
2023-08-12 |
Not clear |
| Jennifer L Cornish, Jaclyn M Lontos, Kelly J Clemens, Iain S McGrego. Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. Psychopharmacology. vol 180. issue 1. 2006-02-13. PMID:15682301. |
dopamine receptors in the nucleus accumbens play a key role in cocaine self-administration; however, their role in speedball self-administration is unknown, as is the role of opiate receptors in this region. |
2006-02-13 |
2023-08-12 |
Not clear |
| Brandi J Mattson, Jennifer M Bossert, Danielle E Simmons, Naohito Nozaki, Deepti Nagarkar, Justin D Kreuter, Bruce T Hop. Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A. Journal of neurochemistry. vol 95. issue 5. 2006-02-07. PMID:16219028. |
repeated cocaine administration to rats outside their home cages sensitizes the behavioral effects of the drug, and enhances induction of the immediate early gene product fos in nucleus accumbens. |
2006-02-07 |
2023-08-12 |
rat |
| Brandi J Mattson, Jennifer M Bossert, Danielle E Simmons, Naohito Nozaki, Deepti Nagarkar, Justin D Kreuter, Bruce T Hop. Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A. Journal of neurochemistry. vol 95. issue 5. 2006-02-07. PMID:16219028. |
therefore, enhanced activation of erk, but not pka, enables and mediates cocaine-induced creb phosphorylation in nucleus accumbens of rats that are sensitized by repeated cocaine administration outside their home cages. |
2006-02-07 |
2023-08-12 |
rat |
| Joanna M Karasinska, Susan R George, Regina Cheng, Brian F O'Dow. Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation. The European journal of neuroscience. vol 22. issue 7. 2006-01-23. PMID:16197514. |
after repeated administration of 2.5 mg/kg of cocaine, d1-/- mice had lower pcreb levels in caudate-putamen and nucleus accumbens. |
2006-01-23 |
2023-08-12 |
mouse |
| Scott E Hemby, Wenxue Tang, Emil C Muly, Michael J Kuhar, Leonard Howell, Deborah C Mas. Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16363995. |
chronic cocaine and withdrawal induce significant alterations in nucleus accumbens (nac) glutamatergic function in humans and rodent models of cocaine addiction. |
2006-01-20 |
2023-08-12 |
human |
| W J Lynch, J R Taylo. Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. The European journal of neuroscience. vol 22. issue 5. 2006-01-10. PMID:16176364. |
persistent changes in motivation to self-administer cocaine following modulation of cyclic amp-dependent protein kinase a (pka) activity in the nucleus accumbens. |
2006-01-10 |
2023-08-12 |
rat |