| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William Renthal, Ian Maze, Vaishnav Krishnan, Herbert E Covington, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. vol 56. issue 3. 2008-01-08. PMID:17988634. |
chronic, but not acute, exposure to cocaine or stress decreases hdac5 function in the nucleus accumbens (nac), a major brain reward region, which allows for increased histone acetylation and transcription of hdac5 target genes. |
2008-01-08 |
2023-08-12 |
Not clear |
| Simona Scheggi, Anna Raone, Maria Graziella De Montis, Alessandro Tagliamonte, Carla Gambaran. Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17680995. |
this study further investigated the correlations between cocaine sensitization and modifications in the darpp-32 phosphorylation pattern, camp-dependent protein kinase (pka) activity, and mglur5 tone in the medial prefrontal cortex and nucleus accumbens. |
2007-12-21 |
2023-08-12 |
rat |
| Simona Scheggi, Anna Raone, Maria Graziella De Montis, Alessandro Tagliamonte, Carla Gambaran. Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17680995. |
moreover, in sensitized rats acute cocaine administration modified phosphorylation levels of thr75- and thr34-darpp-32, glur1, and nr1 subunits in the nucleus accumbens only at a dose double the efficacious dose in control rats. |
2007-12-21 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Zheng Yang, Shi-Jiang Li, Xia Li, Christopher Dillon, Xiao-Qing Peng, Krista Spiller, Eliot L Gardne. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology. vol 53. issue 6. 2007-12-21. PMID:17888459. |
in vivo microdialysis demonstrated that l-thp slightly elevates extracellular nucleus accumbens da by itself, but dose-dependently potentiates cocaine-augmented da, suggesting that a postsynaptic, rather than presynaptic, da receptor antagonism underlies l-thp's actions on cocaine reward. |
2007-12-21 |
2023-08-12 |
rat |
| Pernilla Fagergren, Yasmin Hur. CART mRNA expression in rat monkey and human brain: relevance to cocaine abuse. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17631364. |
cocaine self-administration in the rat (1.5 mg/kg/inj, on a fixed ratio 1 schedule of reinforcement for 1 week) and monkey (0.03 or 0.3 mg/kg/inj on a fixed 3 min interval schedule of reinforcement for 5 or 100 days) did not alter transcript levels in cart expressing nucleus accumbens (monkey not studied), amygdala nuclei or cortical areas. |
2007-12-06 |
2023-08-12 |
human |
| L L Peoples, A V Kravitz, K Guille. The role of accumbal hypoactivity in cocaine addiction. TheScientificWorldJournal. vol 7. 2007-12-06. PMID:17982574. |
cocaine-induced hypoactivity of the nucleus accumbens (nac) is hypothesized to contribute to cocaine addiction. |
2007-12-06 |
2023-08-12 |
Not clear |
| Hyung Shin Yoon, Seungwoo Kim, Hye Kyung Park, Jeong-Hoon Ki. Microinjection of CART peptide 55-102 into the nucleus accumbens blocks both the expression of behavioral sensitization and ERK phosphorylation by cocaine. Neuropharmacology. vol 53. issue 2. 2007-11-28. PMID:17610912. |
microinjection of cart peptide 55-102 into the nucleus accumbens blocks both the expression of behavioral sensitization and erk phosphorylation by cocaine. |
2007-11-28 |
2023-08-12 |
rat |
| Danielle L Graham, Scott Edwards, Ryan K Bachtell, Ralph J DiLeone, Maribel Rios, David W Sel. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nature neuroscience. vol 10. issue 8. 2007-11-07. PMID:17618281. |
dynamic bdnf activity in nucleus accumbens with cocaine use increases self-administration and relapse. |
2007-11-07 |
2023-08-12 |
mouse |
| Danielle L Graham, Scott Edwards, Ryan K Bachtell, Ralph J DiLeone, Maribel Rios, David W Sel. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nature neuroscience. vol 10. issue 8. 2007-11-07. PMID:17618281. |
we found that 4 h of intravenous cocaine self-administration in rats induced a transient increase in brain-derived neurotrophic factor (bdnf) and activation of trkb-mediated signaling in the nucleus accumbens (nac). |
2007-11-07 |
2023-08-12 |
mouse |
| Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu, John Q Wan. Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17623047. |
long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration. |
2007-11-07 |
2023-08-12 |
rat |
| Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu, John Q Wan. Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17623047. |
repeated cocaine administration at the same withdrawal time also increased oxr2 protein levels in the nucleus accumbens while repeated cocaine had no effect on oxr1 and orexin neuropeptide (both orexin-a and orexin-b) levels in this region. |
2007-11-07 |
2023-08-12 |
rat |
| Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu, John Q Wan. Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17623047. |
remarkably, the up-regulated oxr2 levels in the nucleus accumbens showed a long-lasting nature as it persisted up to 60 days after the discontinuation of repeated cocaine treatments. |
2007-11-07 |
2023-08-12 |
rat |
| Amy C Boudreau, Jeremy M Reimers, Michael Milovanovic, Marina E Wol. Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898233. |
cell surface ampa receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases. |
2007-11-07 |
2023-08-12 |
rat |
| Amy C Boudreau, Jeremy M Reimers, Michael Milovanovic, Marina E Wol. Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 39. 2007-11-07. PMID:17898233. |
although some studies report increased responsiveness of nucleus accumbens (nac) ampa receptors (ampars) after withdrawal from repeated cocaine treatment, others report decreased responsiveness after withdrawal plus cocaine challenge. |
2007-11-07 |
2023-08-12 |
rat |
| G C Harris, M Hummel, M Wimmer, S D Mague, G Aston-Jone. Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17560044. |
elevations of fosb in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. |
2007-10-19 |
2023-08-12 |
rat |
| William J Berglind, Ronald E See, Rita A Fuchs, Shannon M Ghee, Timothy W Whitfield, Scott W Miller, Jacqueline F McGint. A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. The European journal of neuroscience. vol 26. issue 3. 2007-10-17. PMID:17651427. |
bdnf pretreatment administered after the last session attenuated cocaine seeking 22 h later and, remarkably, it also blocked cocaine-induced suppression of phospho-extracellular-regulated kinase and elevated bdnf immunoreactivity in the nucleus accumbens. |
2007-10-17 |
2023-08-12 |
rat |
| Kristiina Marttila, T Petteri Piepponen, Kalervo Kiianmaa, Liisa Ahte. Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine. Brain research. vol 1160. 2007-10-12. PMID:17572394. |
cocaine treatment increased the fosb/deltafosb immunoreactivity (ir) in the nucleus accumbens of aa rats but not in ana rats. |
2007-10-12 |
2023-08-12 |
rat |
| Kristiina Marttila, T Petteri Piepponen, Kalervo Kiianmaa, Liisa Ahte. Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine. Brain research. vol 1160. 2007-10-12. PMID:17572394. |
in conclusion, our findings show that aa rats are more sensitive to cocaine than ana rats, and suggest that one possible mediator for this increased sensitivity could be the increased expression of fosb-derived proteins in the nucleus accumbens of aa rats. |
2007-10-12 |
2023-08-12 |
rat |
| Sara Jane Ward, David C S Robert. Microinjection of the delta-opioid receptor selective antagonist naltrindole 5'-isothiocyanate site specifically affects cocaine self-administration in rats responding under a progressive ratio schedule of reinforcement. Behavioural brain research. vol 182. issue 1. 2007-10-12. PMID:17572514. |
the dor antagonist naltrindole 5'-isothiocyanate (5'-ntii; 5nmol) was microinjected into the nucleus accumbens (nacc), ventral tegmental area (vta), or amygdala (amyg) in rats self-administering 1.5mg/kg cocaine under a progressive ratio (pr) schedule. |
2007-10-12 |
2023-08-12 |
rat |
| K Mills, T A Ansah, S F Ali, S Mukherjee, D C Shockle. Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers. Life sciences. vol 81. issue 7. 2007-10-03. PMID:17689567. |
cocaine administration for 18 days produced increases in calcium uptake in synaptosomes prepared from the nucleus accumbens and frontal cortex. |
2007-10-03 |
2023-08-12 |
rat |