| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joshua L Jone. Cocaine experience guides dynamic changes in AMPA receptors within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 12. 2008-04-25. PMID:18354000. |
cocaine experience guides dynamic changes in ampa receptors within the nucleus accumbens. |
2008-04-25 |
2023-08-12 |
Not clear |
| Devadoss J Samuvel, Lankupalle D Jayanthi, Senthilvelan Manohar, Kolanjiappan Kaliyaperumal, Ronald E See, Sammanda Ramamoorth. Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18198344. |
dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens. |
2008-04-22 |
2023-08-12 |
rat |
| BomBi Lee, Chae Ha Yang, Dae-Hyun Hahm, Hye-Jung Lee, Seung-Moo Han, Kyung-Soo Kim, Insop Shi. Inhibitory effects of ginseng total saponins on behavioral sensitization and dopamine release induced by cocaine. Biological & pharmaceutical bulletin. vol 31. issue 3. 2008-04-21. PMID:18310906. |
it has been shown that repeated injections of cocaine produce an increase in locomotor activity, the expression of the immediate-early gene, c-fos, and the release of dopamine (da) in the nucleus accumbens (nac), which is one of the main dopaminergic terminal areas. |
2008-04-21 |
2023-08-12 |
rat |
| Joshua L Jones, Robert A Wheeler, Regina M Carell. Behavioral responding and nucleus accumbens cell firing are unaltered following periods of abstinence from sucrose. Synapse (New York, N.Y.). vol 62. issue 3. 2008-04-11. PMID:18088061. |
here, we examined whether abstinence from sucrose self-administration in rats altered behavioral responding and nucleus accumbens (nac) cell firing in a manner similar to that observed following cocaine abstinence. |
2008-04-11 |
2023-08-12 |
rat |
| Alexis W Ary, Karen Kathleen Szumlinsk. Regional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: a two-species comparison. Brain research. vol 1184. 2008-04-08. PMID:17950706. |
in both species, withdrawal from repeated cocaine administration down-regulated homer1b/c and homer2a/b within the shell, but not the core, of the nucleus accumbens (nac), and the reduced homer levels were accompanied by decreases in mglur1a, nr2a and nr2b. |
2008-04-08 |
2023-08-12 |
mouse |
| Susan M Ferguson, Ellen S Mitchell, John F Neumaie. Increased expression of 5-HT6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine. Biological psychiatry. vol 63. issue 2. 2008-02-27. PMID:17631868. |
increased expression of 5-ht6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine. |
2008-02-27 |
2023-08-12 |
Not clear |
| Susan M Ferguson, Ellen S Mitchell, John F Neumaie. Increased expression of 5-HT6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine. Biological psychiatry. vol 63. issue 2. 2008-02-27. PMID:17631868. |
although serotonin-6 receptors (5-ht6rs) are abundantly expressed in the brain regions thought to underlie these phenomena, such as the nucleus accumbens (nac), surprisingly little is known about the role of 5-ht6rs in the rewarding and psychomotor activating effects of cocaine. |
2008-02-27 |
2023-08-12 |
Not clear |
| Frederic Boyer, Jean-Luc Dreye. Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. The European journal of neuroscience. vol 26. issue 10. 2008-02-25. PMID:18001274. |
alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. |
2008-02-25 |
2023-08-12 |
rat |
| Sylvia Navailles, Delphine Moison, Kathryn A Cunningham, Umberto Spampinat. Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429406. |
differential regulation of the mesoaccumbens dopamine circuit by serotonin2c receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. |
2008-02-06 |
2023-08-12 |
rat |
| Sylvia Navailles, Delphine Moison, Kathryn A Cunningham, Umberto Spampinat. Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429406. |
stimulation of central serotonin2c receptor (5-ht(2c)r) inhibits dopamine (da)-dependent neurochemical and behavioral effects of cocaine, while 5-ht(2c)rs locally expressed into the ventral tegmental area (vta) and the nucleus accumbens (nac) exert opposite functional control over cocaine-induced behavioral effects. |
2008-02-06 |
2023-08-12 |
rat |
| Guo-Chi Zhang, Jason Hoffmann, Nikhil K Parelkar, Xian-Yu Liu, Li-Min Mao, Eugene E Fibuch, John Q Wan. Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo. Neuroscience letters. vol 427. issue 2. 2008-01-23. PMID:17931779. |
a single systemic injection of cocaine induced an increase in ras-grf1 protein levels in both the dorsal (caudoputamen) and ventral (nucleus accumbens) striatum. |
2008-01-23 |
2023-08-12 |
rat |
| Aric Madayag, Doug Lobner, Kristen S Kau, John R Mantsch, Omer Abdulhameed, Matthew Hearing, Mark D Grier, David A Bake. Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094234. |
cocaine produces a persistent reduction in cystine-glutamate exchange via system x(c)- in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction. |
2008-01-14 |
2023-08-12 |
Not clear |
| William Renthal, Ian Maze, Vaishnav Krishnan, Herbert E Covington, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. vol 56. issue 3. 2008-01-08. PMID:17988634. |
chronic, but not acute, exposure to cocaine or stress decreases hdac5 function in the nucleus accumbens (nac), a major brain reward region, which allows for increased histone acetylation and transcription of hdac5 target genes. |
2008-01-08 |
2023-08-12 |
Not clear |
| Simona Scheggi, Anna Raone, Maria Graziella De Montis, Alessandro Tagliamonte, Carla Gambaran. Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17680995. |
this study further investigated the correlations between cocaine sensitization and modifications in the darpp-32 phosphorylation pattern, camp-dependent protein kinase (pka) activity, and mglur5 tone in the medial prefrontal cortex and nucleus accumbens. |
2007-12-21 |
2023-08-12 |
rat |
| Simona Scheggi, Anna Raone, Maria Graziella De Montis, Alessandro Tagliamonte, Carla Gambaran. Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17680995. |
moreover, in sensitized rats acute cocaine administration modified phosphorylation levels of thr75- and thr34-darpp-32, glur1, and nr1 subunits in the nucleus accumbens only at a dose double the efficacious dose in control rats. |
2007-12-21 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Zheng Yang, Shi-Jiang Li, Xia Li, Christopher Dillon, Xiao-Qing Peng, Krista Spiller, Eliot L Gardne. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology. vol 53. issue 6. 2007-12-21. PMID:17888459. |
in vivo microdialysis demonstrated that l-thp slightly elevates extracellular nucleus accumbens da by itself, but dose-dependently potentiates cocaine-augmented da, suggesting that a postsynaptic, rather than presynaptic, da receptor antagonism underlies l-thp's actions on cocaine reward. |
2007-12-21 |
2023-08-12 |
rat |
| Pernilla Fagergren, Yasmin Hur. CART mRNA expression in rat monkey and human brain: relevance to cocaine abuse. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17631364. |
cocaine self-administration in the rat (1.5 mg/kg/inj, on a fixed ratio 1 schedule of reinforcement for 1 week) and monkey (0.03 or 0.3 mg/kg/inj on a fixed 3 min interval schedule of reinforcement for 5 or 100 days) did not alter transcript levels in cart expressing nucleus accumbens (monkey not studied), amygdala nuclei or cortical areas. |
2007-12-06 |
2023-08-12 |
human |
| L L Peoples, A V Kravitz, K Guille. The role of accumbal hypoactivity in cocaine addiction. TheScientificWorldJournal. vol 7. 2007-12-06. PMID:17982574. |
cocaine-induced hypoactivity of the nucleus accumbens (nac) is hypothesized to contribute to cocaine addiction. |
2007-12-06 |
2023-08-12 |
Not clear |
| Hyung Shin Yoon, Seungwoo Kim, Hye Kyung Park, Jeong-Hoon Ki. Microinjection of CART peptide 55-102 into the nucleus accumbens blocks both the expression of behavioral sensitization and ERK phosphorylation by cocaine. Neuropharmacology. vol 53. issue 2. 2007-11-28. PMID:17610912. |
microinjection of cart peptide 55-102 into the nucleus accumbens blocks both the expression of behavioral sensitization and erk phosphorylation by cocaine. |
2007-11-28 |
2023-08-12 |
rat |
| Danielle L Graham, Scott Edwards, Ryan K Bachtell, Ralph J DiLeone, Maribel Rios, David W Sel. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nature neuroscience. vol 10. issue 8. 2007-11-07. PMID:17618281. |
dynamic bdnf activity in nucleus accumbens with cocaine use increases self-administration and relapse. |
2007-11-07 |
2023-08-12 |
mouse |