| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hitoki Sasase, Shoma Izumi, Satoshi Deyama, Eiichi Hinoi, Katsuyuki Kaned. Acute Cocaine Reduces Excitatory Synaptic Transmission in Pyramidal Neurons of the Mouse Medial Prefrontal Cortex. Biological & pharmaceutical bulletin. vol 42. issue 8. 2020-01-14. PMID:31366880. |
numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a limited number of studies have reported the effect of cocaine on mpfc neuronal activity. |
2020-01-14 |
2023-08-13 |
mouse |
| Rajesh Narendran, Savannah Tollefson, Michael L Himes, Jennifer Paris, Brian Lopresti, Roberto Ciccocioppo, N Scott Maso. Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [ The American journal of psychiatry. vol 176. issue 6. 2019-12-30. PMID:31055968. |
chronic cocaine administration in rodents has been shown to decrease n/ofq and increase nociceptive opioid peptide (nop) receptors in the nucleus accumbens. |
2019-12-30 |
2023-08-13 |
Not clear |
| Xue Shao, Yunxuan Tang, Hailei Long, Hui Gu, Jie Zhang, Pengchi Deng, Yinglan Zhao, Xiaobo Ce. HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure. Neuropharmacology. vol 148. 2019-12-27. PMID:28987936. |
here, we profiled the metabolites and metabolic enzymes from brain nucleus accumbens (nac) of mice exposed to cocaine. |
2019-12-27 |
2023-08-13 |
mouse |
| Hannah M Cates, Rosemary C Bagot, Elizabeth A Heller, Immanuel Purushothaman, Casey K Lardner, Deena M Walker, Catherine J Peña, Rachael L Neve, Li Shen, Eric J Nestle. A novel role for E2F3b in regulating cocaine action in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-11-25. PMID:30552390. |
we reported recently that the transcription factor e2f3a is a critical mediator of cocaine responses in the nucleus accumbens. |
2019-11-25 |
2023-08-13 |
Not clear |
| F.J. Whit. Electrophysiological basis of the reinforcing effects of cocaine. Behavioural pharmacology. vol 1. issue 4. 2019-11-20. PMID:11175415. |
it is concluded that the powerful rewarding effects of cocaine may be related to its preferential actions at da and serotonin nerve terminals within the nucleus accumbens and a relatively poor compensatory reduction of impulse generation in mesoaccumbens da cells. |
2019-11-20 |
2023-08-12 |
Not clear |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. |
2019-11-20 |
2023-08-12 |
rat |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
changes in extracellular concentrations of dopamine (da) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). |
2019-11-20 |
2023-08-12 |
rat |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
data from the microdialysis experiments indicated that the high dose of d-amphetamine (0.2mg/infusion) produced a significantly greater increase in extracellular da concentrations in the nucleus accumbens than did the high dose of cocaine (1.0mg/infusion), but that comparable changes were induced by doses of 0.1mg/infusion of d-amphetamine and 1.0mg/infusion of cocaine, respectively. |
2019-11-20 |
2023-08-12 |
rat |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
these results confirm that self-administration of cocaine or d-amphetamine by the rat is accompanied by a significant increase in extracellular da concentrations in the nucleus accumbens. |
2019-11-20 |
2023-08-12 |
rat |
| Gopakumar P. Panikka. Cocaine Addiction: Neurobiology and Related Current Research in Pharmacotherapy. Substance abuse. vol 20. issue 3. 2019-11-20. PMID:12511828. |
these findings support the role of specific brain regions within the dopaminergic system such as the ventral tegmentum and nucleus accumbens in the induction of the cocaine "high" and craving, respectively. |
2019-11-20 |
2023-08-12 |
Not clear |
| Bing Xue, Thomas J Berry, Ming-Lei Guo, Dao-Zhong Jin, Eugene E Fibuch, Eun Sang Choe, Li-Min Mao, John Q Wan. WITHDRAWN: Upregulation of conventional protein kinase C phosphorylation and translocation in the rat nucleus accumbens following cocaine administration. Neuroscience. 2019-11-20. PMID:22100275. |
withdrawn: upregulation of conventional protein kinase c phosphorylation and translocation in the rat nucleus accumbens following cocaine administration. |
2019-11-20 |
2023-08-12 |
rat |
| Luyi Zhou, Haley Andersen, Adrian C Arreola, Jill R Turner, Pavel I Ortinsk. Behavioral History of Withdrawal Influences Regulation of Cocaine Seeking by Glutamate Re-Uptake. PloS one. vol 11. issue 9. 2019-11-20. PMID:27685834. |
withdrawal from cocaine regulates expression of distinct glutamate re-uptake transporters in the nucleus accumbens (nac). |
2019-11-20 |
2023-08-13 |
rat |
| Bruce T Hop. Cocaine and the AP-1 Transcription Factor Complex. Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090793. |
in the striatum (str) and nucleus accumbens (nac) of rats, pretreatment with repeated cocaine administrations downregulates the induction of various immediate early genes (iegs) by a subsequent acute challenge with cocaine. |
2019-11-20 |
2023-08-13 |
rat |
| Stanley D Glick, Isabelle M Maisonneuv. Mechanisms of Antiaddictive Actions of Ibogaine Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090809. |
some effects of ibogaine (e.g., on morphine and cocaine self-administration, morphine-induced hyperactivity, cocaine-induced increases in nucleus accumbens dopamine) are mimicked by a kappa agonist (u50,488) and/or a nmda antagonist (mk-801). |
2019-11-20 |
2023-08-13 |
rat |
| K Mills, T A Ansah, S F Ali, D C Shockle. Calcium Channel Antagonist Isradipine Attenuates Cocaine-Induced Motor Activity in Rats: Correlation with Brain Monoamine Levels Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090812. |
in the nucleus accumbens cocaine (20 mg/kg, i.p.) |
2019-11-20 |
2023-08-13 |
rat |
| Lynne H Clay, Elizabeth A Mazzio, Malak G Kolta, Karam F A Solima. Repeated Administration of Cocaine Alters Dopamine Uptake and Release in the Striatum Nucleus Accumbens Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090828. |
repeated administration of cocaine alters dopamine uptake and release in the striatum nucleus accumbens male sprague-dawley rats were administered 25 mg/kg, intraperitoneally (i.p.) |
2019-11-20 |
2023-08-13 |
rat |
| Jeffery D Steketee, Kun Li. Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission. Brain research. vol 1698. 2019-11-04. PMID:30075100. |
repeated cocaine exposure alters medial prefrontal cortex (mpfc) function to allow for enhanced excitatory transmission to the nucleus accumbens and ventral tegmental area (vta). |
2019-11-04 |
2023-08-13 |
Not clear |
| Jeffery D Steketee, Kun Li. Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission. Brain research. vol 1698. 2019-11-04. PMID:30075100. |
the present report tested the hypothesis that daily injections of cocaine would enhance d1 receptor responsiveness by infusing the d1 receptor agonist skf 38393 into the mpfc and monitoring glutamate and/or gaba release in the mpfc, nucleus accumbens and vta of saline- and cocaine-pretreated animals using in vivo microdialysis. |
2019-11-04 |
2023-08-13 |
Not clear |
| Jeffery D Steketee, Kun Li. Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission. Brain research. vol 1698. 2019-11-04. PMID:30075100. |
infusion of skf 38393 into the mpfc of animals previously exposed to cocaine increased and reduced glutamate release in the nucleus accumbens after 7 and 30 days of withdrawal, respectively and increased glutamate levels in the vta 7 and 30 days after daily cocaine injections. |
2019-11-04 |
2023-08-13 |
Not clear |
| David L Bernstein, Preeti S Badve, Jessica R Barson, Caroline E Bass, Rodrigo A Españ. Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine. Addiction biology. vol 23. issue 5. 2019-10-22. PMID:28971565. |
we injected virus into the vta and examined the effects of hcrtr1 knockdown on cocaine self-administration and da signaling in the nucleus accumbens (nac) core. |
2019-10-22 |
2023-08-13 |
human |