| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C T Werner, S Mitra, J A Martin, A F Stewart, A E Lepack, A Ramakrishnan, P H Gobira, Z-J Wang, R L Neve, A M Gancarz, L Shen, I Maze, D M Diet. Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving. Science advances. vol 5. issue 10. 2020-05-19. PMID:31633032. |
neuroadaptations in the nucleus accumbens (nac) underlie cue-induced cocaine craving that intensifies ("incubates") during abstinence and is believed to contribute to persistent relapse vulnerability. |
2020-05-19 |
2023-08-13 |
Not clear |
| Nicole S Hernandez, Bernadette O'Donovan, Pavel I Ortinski, Heath D Schmid. Activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats. Addiction biology. vol 24. issue 2. 2020-05-08. PMID:29226617. |
activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats. |
2020-05-08 |
2023-08-13 |
rat |
| Ernesto Solis, Anum Afzal, Eugene A Kiyatki. Intravenous Cocaine Increases Oxygen Entry into Brain Tissue: Critical Role of Peripheral Drug Actions. ACS chemical neuroscience. vol 10. issue 4. 2020-04-24. PMID:30040399. |
we employed oxygen sensors coupled with high-speed amperometery to examine the effects of standard cocaine hcl that easily enters the blood-brain barrier and its blood-brain barrier-impermeable methiodide analogue on oxygen levels in the nucleus accumbens in awake, freely moving rats. |
2020-04-24 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Karolina Wydra, Wilber Romero-Fernandez, Zilong Zhou, Malgorzata Frankowska, Malgorzata Filip, Kjell Fux. A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration. International journal of molecular sciences. vol 20. issue 23. 2020-04-16. PMID:31816953. |
it was previously demonstrated that rat adenosine a2ar transmembrane v peptide administration into the nucleus accumbens enhances cocaine self-administration through disruption of the a2ar-dopamine (d2r) heteroreceptor complex of this region. |
2020-04-16 |
2023-08-13 |
human |
| William J Wright, Nicholas M Graziane, Peter A Neumann, Peter J Hamilton, Hannah M Cates, Lauren Fuerst, Alexander Spenceley, Natalie MacKinnon-Booth, Kartik Iyer, Yanhua H Huang, Yavin Shaham, Oliver M Schlüter, Eric J Nestler, Yan Don. Silent synapses dictate cocaine memory destabilization and reconsolidation. Nature neuroscience. vol 23. issue 1. 2020-04-13. PMID:31792465. |
to explore the synaptic underpinnings for these memory dynamics, we studied ampa receptor (ampar)-silent excitatory synapses, which are generated in the nucleus accumbens by cocaine self-administration, and subsequently mature after prolonged withdrawal by recruiting ampars, echoing acquisition and consolidation of cocaine memories. |
2020-04-13 |
2023-08-13 |
Not clear |
| Anna Kruyer, Lauren E Ball, Danyelle M Townsend, Peter W Kalivas, Joachim D Uy. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking. PloS one. vol 14. issue 9. 2020-04-02. PMID:31550273. |
using this technique, we show that cofilin in the rat nucleus accumbens undergoes s-glutathionylation during 15-minutes of cued cocaine seeking in the absence of cocaine. |
2020-04-02 |
2023-08-13 |
rat |
| Jacqueline-Marie N Ferland, Tristan J Hynes, Celine D Hounjet, David Lindenbach, Cole Vonder Haar, Wendy K Adams, Anthony G Phillips, Catharine A Winstanle. Prior Exposure to Salient Win-Paired Cues in a Rat Gambling Task Increases Sensitivity to Cocaine Self-Administration and Suppresses Dopamine Efflux in Nucleus Accumbens: Support for the Reward Deficiency Hypothesis of Addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 10. 2020-03-23. PMID:30626700. |
prior exposure to salient win-paired cues in a rat gambling task increases sensitivity to cocaine self-administration and suppresses dopamine efflux in nucleus accumbens: support for the reward deficiency hypothesis of addiction. |
2020-03-23 |
2023-08-13 |
rat |
| Conor H Murray, Jessica A Loweth, Mike Milovanovic, Michael T Stefanik, Aaron J Caccamise, Hubert Dolubizno, Jonathan R Funke, M Foster Olive, Marina E Wol. AMPA receptor and metabotropic glutamate receptor 1 adaptations in the nucleus accumbens core during incubation of methamphetamine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 9. 2020-03-17. PMID:31146278. |
for cocaine and methamphetamine, expression of incubated craving ultimately depends on strengthening of nucleus accumbens (nac) synapses through an accumulation of high conductance ca |
2020-03-17 |
2023-08-13 |
Not clear |
| Bruno G Berardino, Estefanía A Fesser, Laura M Belluscio, Octavio Gianatiempo, Nicolás Pregi, Eduardo T Cánep. Effects of cocaine base paste on anxiety-like behavior and immediate-early gene expression in nucleus accumbens and medial prefrontal cortex of female mice. Psychopharmacology. vol 236. issue 12. 2020-03-03. PMID:31280332. |
effects of cocaine base paste on anxiety-like behavior and immediate-early gene expression in nucleus accumbens and medial prefrontal cortex of female mice. |
2020-03-03 |
2023-08-13 |
mouse |
| Paul Girardeau, Sylvia Navailles, Audrey Durand, Caroline Vouillac-Mendoza, Karine Guillem, Serge H Ahme. Relapse to cocaine use persists following extinction of drug-primed craving. Neuropharmacology. vol 155. 2020-02-28. PMID:31167108. |
this lack of effect occurred despite evidence for post-extinction loss of neuronal responses to cocaine priming in brain regions causally involved in cocaine reinstatement (i.e., the dorsomedial prefrontal cortex and the core of the nucleus accumbens). |
2020-02-28 |
2023-08-13 |
rat |
| Hannah M Cates, Casey K Lardner, Rosemary C Bagot, Rachael L Neve, Eric J Nestle. eNeuro. vol 6. issue 2. 2020-02-10. PMID:30963104. |
in this study, we find a novel regulatory role for the transcription factor e2f3, recently implicated in transcriptional regulation by cocaine, in controlling Δfosb induction in the mouse nucleus accumbens (nac) following cocaine administration. |
2020-02-10 |
2023-08-13 |
mouse |
| Yiming Zhou, Huiwen Zhu, Zhiyuan Liu, Xi Chen, XiuJuan Su, Chaonan Ma, Zhen Tian, Bing Huang, Enhui Yan, Xing Liu, Lan M. A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine. Nature neuroscience. vol 22. issue 12. 2020-01-31. PMID:31719672. |
here we tagged engram cells in the ventral ca1 region of the hippocampus (vca1) and the core of the nucleus accumbens (acbc) during cocaine conditioned place preference (cpp) training and show that the vca1 engram projects preferentially to the acbc and that the engram circuit from the vca1 to the acbc mediates memory recall. |
2020-01-31 |
2023-08-13 |
Not clear |
| Hitoki Sasase, Shoma Izumi, Satoshi Deyama, Eiichi Hinoi, Katsuyuki Kaned. Acute Cocaine Reduces Excitatory Synaptic Transmission in Pyramidal Neurons of the Mouse Medial Prefrontal Cortex. Biological & pharmaceutical bulletin. vol 42. issue 8. 2020-01-14. PMID:31366880. |
numerous studies have reported about the effects of cocaine on neuronal and synaptic activities in the nucleus accumbens and ventral tegmental area, which are brain regions associated with cocaine addiction; however, a limited number of studies have reported the effect of cocaine on mpfc neuronal activity. |
2020-01-14 |
2023-08-13 |
mouse |
| Rajesh Narendran, Savannah Tollefson, Michael L Himes, Jennifer Paris, Brian Lopresti, Roberto Ciccocioppo, N Scott Maso. Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [ The American journal of psychiatry. vol 176. issue 6. 2019-12-30. PMID:31055968. |
chronic cocaine administration in rodents has been shown to decrease n/ofq and increase nociceptive opioid peptide (nop) receptors in the nucleus accumbens. |
2019-12-30 |
2023-08-13 |
Not clear |
| Xue Shao, Yunxuan Tang, Hailei Long, Hui Gu, Jie Zhang, Pengchi Deng, Yinglan Zhao, Xiaobo Ce. HMG-CoA synthase 2 drives brain metabolic reprogramming in cocaine exposure. Neuropharmacology. vol 148. 2019-12-27. PMID:28987936. |
here, we profiled the metabolites and metabolic enzymes from brain nucleus accumbens (nac) of mice exposed to cocaine. |
2019-12-27 |
2023-08-13 |
mouse |
| Hannah M Cates, Rosemary C Bagot, Elizabeth A Heller, Immanuel Purushothaman, Casey K Lardner, Deena M Walker, Catherine J Peña, Rachael L Neve, Li Shen, Eric J Nestle. A novel role for E2F3b in regulating cocaine action in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-11-25. PMID:30552390. |
we reported recently that the transcription factor e2f3a is a critical mediator of cocaine responses in the nucleus accumbens. |
2019-11-25 |
2023-08-13 |
Not clear |
| F.J. Whit. Electrophysiological basis of the reinforcing effects of cocaine. Behavioural pharmacology. vol 1. issue 4. 2019-11-20. PMID:11175415. |
it is concluded that the powerful rewarding effects of cocaine may be related to its preferential actions at da and serotonin nerve terminals within the nucleus accumbens and a relatively poor compensatory reduction of impulse generation in mesoaccumbens da cells. |
2019-11-20 |
2023-08-12 |
Not clear |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. |
2019-11-20 |
2023-08-12 |
rat |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
changes in extracellular concentrations of dopamine (da) were measured in vivo in the nucleus accumbens of the rat during intravenous self-administration of either cocaine (0.25, 0.5, 1.0mg/infusion) or d-amphetamine (0.05, 0.1, 0.2mg/infusion). |
2019-11-20 |
2023-08-12 |
rat |
| P. Di Ciano, A. Coury, R.Y. Depoortere, Y. Egilmez, J.D. Lane, M.W. Emmett-Oglesby, F.G. Lepiane, A.G. Phillips, C.D. Blah. Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine. Behavioural pharmacology. vol 6. issue 4. 2019-11-20. PMID:11224340. |
data from the microdialysis experiments indicated that the high dose of d-amphetamine (0.2mg/infusion) produced a significantly greater increase in extracellular da concentrations in the nucleus accumbens than did the high dose of cocaine (1.0mg/infusion), but that comparable changes were induced by doses of 0.1mg/infusion of d-amphetamine and 1.0mg/infusion of cocaine, respectively. |
2019-11-20 |
2023-08-12 |
rat |