| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Freedman, Dan Goldowit. Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Progress in neurobiology. vol 90. issue 2. 2010-05-26. PMID:19853005. |
evidence for the role of the alpha 7-nicotinic acetylcholine receptor in the development and function of these neurons in rodents has led to human trials of nicotinic agonists for cognitive dysfunction in schizophrenia and the possibility of improving hippocampal development in children at risk for schizophrenia by perinatal supplementation with choline, which can act as an alpha 7-nicotinic acetylcholine receptor agonist. |
2010-05-26 |
2023-08-12 |
human |
| Göran Starck, Barbro Vkhoff-Baaz, Maria Ljungberg, Kristina Malmgren, Eva Forssell-Aronsson, Lars Jönsson, Sven Ekhol. Anterior to posterior hippocampal MRS metabolite difference is mainly a partial volume effect. Acta radiologica (Stockholm, Sweden : 1987). vol 51. issue 3. 2010-04-02. PMID:20201639. |
the concentration of n-acetylaspartate (naa) in hippocampus, as measured with magnetic resonance spectroscopy (mrs), and the ratio of naa/(choline (cho) + creatine (cr)) are valuable tools in the lateralization of temporal lobe epilepsy (tle). |
2010-04-02 |
2023-08-12 |
Not clear |
| Cornelia Kiewert, Alexander Mdzinarishvili, Joachim Hartmann, Ulrich Bickel, Jochen Klei. Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice. Brain research. vol 1312. 2010-03-25. PMID:19961839. |
in hippocampus, glycerol increased transiently while the increase of choline levels was moderate. |
2010-03-25 |
2023-08-12 |
mouse |
| Mihai G Mehedint, Mihai D Niculescu, Corneliu N Craciunescu, Steven H Zeise. Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 1. 2010-02-02. PMID:19752176. |
choline deprivation (cd) causes hypomethylation of specific cpg islands in genes controlling cell cycling in fetal hippocampus. |
2010-02-02 |
2023-08-12 |
mouse |
| Can-Jun Ruan, Jian-Yong Si, Li Zhang, Di-Hua Chen, Guan-Hua Du, Lan S. Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta(25-35)-induced cognitive deficits in mice. Neuroscience letters. vol 467. issue 2. 2010-02-01. PMID:19833171. |
furthermore, superoxide dismutase (sod), choline acetyl transferase (chat) and acetylcholine esterase (ache) activity in hippocampus and cortex were analyzed by spectrophotometric method. |
2010-02-01 |
2023-08-12 |
mouse |
| K J A Rodrigues, M B Santana, J L M Do Nascimento, D L W Picanço-Diniz, L A L Maués, S N Santos, V M M Ferreira, M Alfonso, R Durán, L R F Far. Behavioral and biochemical effects of neonicotinoid thiamethoxam on the cholinergic system in rats. Ecotoxicology and environmental safety. vol 73. issue 1. 2010-01-12. PMID:19481804. |
therefore, we aimed to determine the potential effects of thiamethoxam on mammalian brain, testing the performance in the open field and elevated plus-maze of rats exposed to this insecticide and, in order to establish the neurochemical endpoints, we measured the acetylcholinesterase activity in different brain regions (hippocampus, striatum and cortex) and the high-affinity choline uptake (hacu) in synaptosomes from rat hippocampus. |
2010-01-12 |
2023-08-12 |
rat |
| David J Mancuso, Paul Kotzbauer, David F Wozniak, Harold F Sims, Christopher M Jenkins, Shaoping Guan, Xianlin Han, Kui Yang, Gang Sun, Ibrahim Malik, Sara Conyers, Karen G Green, Robert E Schmidt, Richard W Gros. Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction. The Journal of biological chemistry. vol 284. issue 51. 2010-01-06. PMID:19840936. |
shotgun lipidomics demonstrated multiple alterations in hippocampal lipid metabolism in ipla(2)gamma(-/-) mice including: 1) a markedly elevated hippocampal cardiolipin content with an altered molecular species composition characterized by a shift to shorter chain length molecular species; 2) alterations in both choline and ethanolamine glycerophospholipids, including a decreased plasmenylethanolamine content; 3) increased oxidized phosphatidylethanolamine molecular species; and 4) an increased content of ceramides. |
2010-01-06 |
2023-08-12 |
mouse |
| Warren H Meck, Christina L Williams, Jennifer Marie Cermak, Jan Krzysztof Blusztaj. Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia. Frontiers in integrative neuroscience. vol 1. 2009-12-15. PMID:18958235. |
two sensitive periods were identified, ed 12-17 and pd 16-30, during which choline supplementation facilitated spatial memory and produced increases in dendritic spine density in ca1 and dentate gyrus (dg) regions of the hippocampus while also changing the dendritic fields of dg granule cells. |
2009-12-15 |
2023-08-12 |
rat |
| Mir Sajad, Jamil Zargan, Raman Chawla, Sadiq Umar, Mir Sadaqat, Haider A Kha. Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase. Molecular and cellular biochemistry. vol 328. issue 1-2. 2009-11-03. PMID:19301098. |
the assessment of the damage to the hippocampus was done 16 days post induction by the immunolocalization of chat (choline acetyl transferase). |
2009-11-03 |
2023-08-12 |
human |
| Gretchen Y López-Hernández, Jeffrey S Thinschmidt, Philippe Morain, Caryn Trocme-Thibierge, William R Kem, Ferenc Soti, Roger L Papk. Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795. Neuropharmacology. vol 56. issue 4. 2009-09-17. PMID:19705574. |
hippocampal interneurons were stimulated by ach, choline, s 24795, or 4oh-gts-21, before and after bath perfusion with the positive modulators. |
2009-09-17 |
2023-08-12 |
rat |
| Susan J Astley, Todd Richards, Elizabeth H Aylward, Heather Carmichael Olson, Kimberly Kerns, Allison Brooks, Truman E Coggins, Julian Davies, Susan Dorn, Beth Gendler, Tracy Jirikowic, Paul Kraegel, Kenneth Maravill. Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Magnetic resonance imaging. vol 27. issue 6. 2009-09-02. PMID:19342189. |
mrs was used to compare neurometabolite concentrations [choline (cho), n-acetyl-aspartate (naa) and creatine (cre)] in a white matter region and a hippocampal region between the four study groups. |
2009-09-02 |
2023-08-12 |
Not clear |
| S-T Hong, C-B Choi, C Park, H-Y Moon, K S Hong, C Cheong, J-H Chae, B-Y Cho. Specific hippocampal choline decrease in an animal model of depression. The British journal of radiology. vol 82. issue 979. 2009-08-28. PMID:19221187. |
specific hippocampal choline decrease in an animal model of depression. |
2009-08-28 |
2023-08-12 |
rat |
| S-T Hong, C-B Choi, C Park, H-Y Moon, K S Hong, C Cheong, J-H Chae, B-Y Cho. Specific hippocampal choline decrease in an animal model of depression. The British journal of radiology. vol 82. issue 979. 2009-08-28. PMID:19221187. |
a decreased level of the hippocampal choline signal was found in patients with depression in previous proton magnetic resonance spectroscopy ((1)h-mrs) studies. |
2009-08-28 |
2023-08-12 |
rat |
| Zhi-bin Liu, Wen-min Niu, Xiao-hang Yang, Xiao-mei Niu, Yuan Wan. [Effect of "Xiusanzhen" on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526808. |
to explore the effect of "xiusanzhen" [bilateral "yingxiang" (li 20) + "yintang" (ex-hn 3)] on learning-memory ability and choline acetyl transferase (chat) and acetyl cholinesterase (ache) activity of hippocampus tissue in alzheimer disease (ad) rats. |
2009-07-09 |
2023-08-12 |
rat |
| Karen E Stevens, Catherine E Adams, Tiffany J Mellott, Emily Robbins, Michael A Kisle. Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. Brain research. vol 1237. 2009-04-09. PMID:18778692. |
assessment of hippocampal alpha-bungarotoxin to visualize nicotinic alpha7 receptors revealed no difference between the gestational choline levels. |
2009-04-09 |
2023-08-12 |
human |
| Sarah J E Wong-Goodrich, Melissa J Glenn, Tiffany J Mellott, Jan K Blusztajn, Warren H Meck, Christina L William. Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. Brain research. vol 1237. 2009-04-09. PMID:18778697. |
spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. |
2009-04-09 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Melissa J Glenn, Tiffany J Mellott, Jan K Blusztajn, Warren H Meck, Christina L William. Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. Brain research. vol 1237. 2009-04-09. PMID:18778697. |
altered dietary choline availability early in life leads to persistent changes in spatial memory and hippocampal plasticity in adulthood. |
2009-04-09 |
2023-08-12 |
rat |
| Melissa J Glenn, Elizabeth D Kirby, Erin M Gibson, Sarah J Wong-Goodrich, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain research. vol 1237. 2009-04-09. PMID:18786518. |
age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. |
2009-04-09 |
2023-08-12 |
rat |
| Melissa J Glenn, Elizabeth D Kirby, Erin M Gibson, Sarah J Wong-Goodrich, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain research. vol 1237. 2009-04-09. PMID:18786518. |
supplemental choline in the maternal diet produces a lasting enhancement in memory in offspring that resists age-related decline and is accompanied by neuroanatomical, neurophysiological and neurochemical changes in the hippocampus. |
2009-04-09 |
2023-08-12 |
rat |
| Melissa J Glenn, Elizabeth D Kirby, Erin M Gibson, Sarah J Wong-Goodrich, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain research. vol 1237. 2009-04-09. PMID:18786518. |
the present study was designed to examine: 1) if prenatal choline supplementation alters behaviors that contribute to risk or resilience in cognitive aging, and 2) whether, at old age (25 months), prenatally choline-supplemented rats show evidence of preserved hippocampal plasticity. |
2009-04-09 |
2023-08-12 |
rat |