| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G L Wenk, K L Engisch, L D McCall, S J Mitchell, T G Aigner, R L Struble, D L Price, D S Olto. [(3)H]ketanserin binding increases in monkey cortex following basal forebrain lesions with ibotenic acid. Neurochemistry international. vol 9. issue 4. 2012-10-02. PMID:20493162. |
ten months later, [(3)h]ketanserin binding was increased in the neocortex, but not in the hippocampus, while levels of choline acetyltransferase (acetyl-coa: choline o-acetyltransferase, ec 2.3.1.6) activity decreased in the neocortex and hippocampus. |
2012-10-02 |
2023-08-12 |
monkey |
| S B Waller, E D Londo. Choline acetyltransferase activity and muscarinic binding in brain regions of aging fischer-344 rats. Neurochemistry international. vol 14. issue 4. 2012-10-02. PMID:20504454. |
although the k(m) of choline acetyltransferase for choline chloride did not change in any region tested, the k(m) for acetyl coenzyme a decreased in the hippocampus (24 vs 12 months), but increased (4 vs 12 months) and then decreased (12 vs 24 months) in the striatum. |
2012-10-02 |
2023-08-12 |
human |
| Murad Atmaca, Hanefi Yildirim, M Gurkan Gurok, Muammer Akyol, Filiz Koseogl. Hippocampal neurochemical pathology in patients with panic disorder. Psychiatry investigation. vol 9. issue 2. 2012-10-02. PMID:22707967. |
in the present study, we measured hippocampal n-acetyl-l-aspartate (naa), choline (cho) and creatine (cre) values in patients with panic disorder and healthy control subjects using in vivo(1)h mrs. |
2012-10-02 |
2023-08-12 |
human |
| Nafisa M Jadavji, Liyuan Deng, Daniel Leclerc, Olga Malysheva, Barry J Bedell, Marie A Caudill, Rima Roze. Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Molecular genetics and metabolism. vol 106. issue 2. 2012-09-18. PMID:22521626. |
volumes (whole brain and hippocampus) and morphology, global dna methylation, apoptosis, expression of choline acetyltransferase (chat) and glucocorticoid receptor (gr), and concentrations of choline metabolites were assessed in hippocampus. |
2012-09-18 |
2023-08-12 |
mouse |
| Nafisa M Jadavji, Liyuan Deng, Daniel Leclerc, Olga Malysheva, Barry J Bedell, Marie A Caudill, Rima Roze. Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Molecular genetics and metabolism. vol 106. issue 2. 2012-09-18. PMID:22521626. |
we identified structural changes, increased apoptosis, altered choline metabolism and gr dysregulation in hippocampus. |
2012-09-18 |
2023-08-12 |
mouse |
| Shuang-Qing Chen, Qing Cai, Yu-Ying Shen, Pei-Jun Wang, Gao-Jun Teng, Ming-Hua Li, Wei Zhang, Feng-Chao Zan. (1)H-MRS evaluation of therapeutic effect of neural stem cell transplantation on Alzheimer's disease in AβPP/PS1 double transgenic mice. Journal of Alzheimer's disease : JAD. vol 28. issue 1. 2012-09-12. PMID:21955813. |
(1)h-mrs was performed before transplantation and 6 weeks after transplantation to measure the change of n-acetylaspartate (naa), myo-inositol (mi), glutamate (glu), choline (cho), and creatine (cr) in the hippocampus. |
2012-09-12 |
2023-08-12 |
mouse |
| Melissa J Glenn, Raven S Adams, Lauren McClur. Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats. Brain research. vol 1443. 2012-09-04. PMID:22305146. |
we previously found that choline supplementation increased adult hippocampal neurogenesis, a function compromised by stress, lowered in depression, and boosted by antidepressants; and increased levels of growth factors linked to depression, like brain-derived neurotrophic factor. |
2012-09-04 |
2023-08-12 |
rat |
| Jennifer D Thomas, Tuan D Tra. Choline supplementation mitigates trace, but not delay, eyeblink conditioning deficits in rats exposed to alcohol during development. Hippocampus. vol 22. issue 3. 2012-07-23. PMID:21542051. |
we previously reported that choline supplementation can mitigate alcohol's effects on cognitive development, specifically on tasks which depend on the functional integrity of the hippocampus. |
2012-07-23 |
2023-08-12 |
human |
| Zdena Krištofiková, Zdeněk Kříž, Daniela Rípová, Jaroslav Koč. Interactions of amyloid β peptide 1-40 and cerebrosterol. Neurochemical research. vol 37. issue 3. 2012-06-29. PMID:22089933. |
in this study, stereospecificity in the interactions of natural 24(s)hydroxycholesterol (cerebrosterol) or synthetic 24(r)hydroxycholesterol with soluble fragment 1-40 was evaluated by means of an in vitro test based on increased vulnerability of the hemicholinium-3 sensitive high-affinity choline uptake system in rat hippocampal cholesterol-depleted synaptosomes to the actions of amyloid β; computational simulations were also performed. |
2012-06-29 |
2023-08-12 |
rat |
| Shao-Feng Li, Mei-Na Wu, Xiao-Hui Wang, Li Yuan, Dong Yang, Jin-Shun Q. Requirement of α7 nicotinic acetylcholine receptors for amyloid β protein-induced depression of hippocampal long-term potentiation in CA1 region of rats in vivo. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584864. |
the results show that: (1) intracerebroventicular injection of aβ25-35 or aβ31-35 significantly and similarly suppressed hippocampal ltp in ca1 region in rats; (2) choline, a selective α7 nachr agonist, did not affect the ltp induction but enhanced ltp suppression induced by aβ31-35; and (3) methyllycaconitine, a specific α7 nachr antagonist, slightly suppressed hippocamal ltp but effectively prevented against aβ31-35-induced ltp depression in the presence of aβ31-35. |
2012-06-18 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Christina M Tognoni, Tiffany J Mellott, Melissa J Glenn, Jan K Blusztajn, Christina L William. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain research. vol 1413. 2012-06-12. PMID:21840511. |
prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. |
2012-06-12 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Christina M Tognoni, Tiffany J Mellott, Melissa J Glenn, Jan K Blusztajn, Christina L William. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain research. vol 1413. 2012-06-12. PMID:21840511. |
severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. |
2012-06-12 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Christina M Tognoni, Tiffany J Mellott, Melissa J Glenn, Jan K Blusztajn, Christina L William. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain research. vol 1413. 2012-06-12. PMID:21840511. |
because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. |
2012-06-12 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Christina M Tognoni, Tiffany J Mellott, Melissa J Glenn, Jan K Blusztajn, Christina L William. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain research. vol 1413. 2012-06-12. PMID:21840511. |
although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury. |
2012-06-12 |
2023-08-12 |
rat |
| Yonglin Gao, Chunmei Li, Jungang Yin, Jingyu Shen, Hongtao Wang, Yuzhen Wu, Haizhu Ji. Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats. Environmental toxicology and pharmacology. vol 33. issue 2. 2012-06-12. PMID:22301160. |
furthermore, fucoidan reversed the decreased activity of choline acetyl transferase (chat), superoxide dismutase (sod), glutathione peroxidase (gsh-px) and content of acetylcholine (ach), as well as the increased activity of acetylcholine esterase (ache) and content of malondialdehyde (mda) in hippocampal tissue of aβ-injected rats. |
2012-06-12 |
2023-08-12 |
rat |
| Judith Espinosa-Raya, Teresa Neri-Gómez, Sandra Orozco-Suárez, María G Campos, Christian Guerra-Araiz. Chronic administration of tibolone modulates anxiety-like behavior and enhances cognitive performance in ovariectomized rats. Hormones and behavior. vol 61. issue 1. 2012-05-25. PMID:22067260. |
the concentrations of acetyl choline transferase (chat) and tryptophan hydroxylase (tph) in the hippocampus were directly measured by western blot. |
2012-05-25 |
2023-08-12 |
rat |
| Catherine M L Foy, Eileen M Daly, Amanda Glover, Ruth O'Gorman, Andrew Simmons, Declan G M Murphy, Simon Loveston. Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment. Brain topography. vol 24. issue 3-4. 2012-03-01. PMID:21298332. |
we measured the hippocampal concentration of naa, mi, choline (cho) and creatine + phosphocreatine (cr + pcr) in 39 patients with ad, 21 subjects with mci and 38 age matched healthy elderly controls. |
2012-03-01 |
2023-08-12 |
human |
| Peidang Liu, Ling Chen, Xiuying Bai, Andrew Karaplis, Dengshun Miao, Ning G. Impairment of spatial learning and memory in transgenic mice overexpressing human fibroblast growth factor-23. Brain research. vol 1412. 2012-02-21. PMID:21824606. |
furthermore, these mice exhibited the impairment of long-term potentiation in hippocampal ca1 region, and the reduction of hippocampal adenosine-triphosphate content and of choline acetyltransferase-positive neurons in basal forebrain, possibly as pathogenetic factors contributing to the cognitive deficit. |
2012-02-21 |
2023-08-12 |
mouse |
| Sarah J E Wong-Goodrich, Melissa J Glenn, Tiffany J Mellott, Yi B Liu, Jan K Blusztajn, Christina L William. Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. Hippocampus. vol 21. issue 6. 2012-02-10. PMID:20232399. |
water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. |
2012-02-10 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Melissa J Glenn, Tiffany J Mellott, Yi B Liu, Jan K Blusztajn, Christina L William. Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. Hippocampus. vol 21. issue 6. 2012-02-10. PMID:20232399. |
prenatal choline supplementation (sup) also protects against spatial memory deficits observed shortly after se in adulthood, and we have previously reported that sup attenuates the neuropathological response to se in the adult hippocampus just 16 days after se. |
2012-02-10 |
2023-08-12 |
rat |