| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangqin Fan, Fankun Zhou, Chang Feng, Fengyun Wu, Weiwei Ye, Chunhong Wang, Fen Lin, Ji Yan, Yanshu Li, Ying Chen, Yongyi B. Lead-induced ER calcium release and inhibitory effects of methionine choline in cultured rat hippocampal neurons. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 1. 2013-09-17. PMID:22921426. |
in this study, laser scanning confocal microscopy was used to examine the effects of pb(2+) on intracellular and endoplasmic reticulum free calcium concentration ([ca(2+)](i) and [ca(2+)](er)) in cultured neonatal rat hippocampal neurons and their possible antagonism by methionine choline; understanding these effects would help explain the lead-induced cognitive and learning dysfunction and explore efficient safety and relief strategies. |
2013-09-17 |
2023-08-12 |
rat |
| Chang Feng, Guang-qin Fan, Feng-yun Wu, Fen Lin, Yan-shu Li, Ying Che. [The effects of methionine and choline on the expression levels of CaMKII and CREB mRNA and proteins in rats exposed to lead]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 30. issue 7. 2013-09-16. PMID:22931811. |
to study the effects of methionine and choline on the expression levels of camkii and creb mrna and proteins in hippocampus of rats exposed to lead. |
2013-09-16 |
2023-08-12 |
rat |
| Pingfu Feng, Chunfa Huan. Phospholipase D-mTOR signaling is compromised in a rat model of depression. Journal of psychiatric research. vol 47. issue 5. 2013-09-10. PMID:23421961. |
using neonatal clomipramine (cl)-treated rats as a model to elucidate the association of phospholipase d (pld) and mammalian target of rapamycin (mtor) signaling with depressive pathology, we found that the hippocampus of cl-treated rats showed significantly down-regulation of pld1 expression and attenuation of pld activity which leads to the less formation of phosphatidic acid (pa), an activator of mtor, and free choline, a potential biomarker for depression. |
2013-09-10 |
2023-08-12 |
rat |
| Nicha K H Otero, Jennifer D Thomas, Christopher A Saski, Xiaoxia Xia, Sandra J Kell. Choline supplementation and DNA methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development. Alcoholism, clinical and experimental research. vol 36. issue 10. 2013-07-12. PMID:22509990. |
choline supplementation and dna methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development. |
2013-07-12 |
2023-08-12 |
rat |
| Mario Marchi, Stefania Zappettini, Guendalina Olivero, Anna Pittaluga, Massimo Grill. Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes. Neurochemistry international. vol 60. issue 6. 2013-07-11. PMID:22417725. |
hippocampal synaptosomes were stimulated with kcl, 4ap, nicotine or with choline (ch) and 5-iodo-a-85380 dihydrochloride (5ia85380). |
2013-07-11 |
2023-08-12 |
rat |
| Abdulla S Al Mansouri, Dietrich E Lorke, Syed M Nurulain, Abrar Ashoor, Susan Yang Keun-Hang, Georg Petroianu, Dmytro Isaev, Murat O. Methylene blue inhibits the function of α7-nicotinic acetylcholine receptors. CNS & neurological disorders drug targets. vol 11. issue 6. 2013-06-03. PMID:22483305. |
in hippocampal slices, whole-cell recordings from ca1 pyramidal neurons indicated that the increases in the frequency and amplitudes of the γ-aminobutyric acid-mediated spontaneous postsynaptic currents induced by bath application of 2 mm choline, a specific agonist for α7 nachrs, were abolished after 10 min application of 3 μm mb. |
2013-06-03 |
2023-08-12 |
human |
| Peter Dobelis, Kevin J Staley, Donald C Coope. Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PloS one. vol 7. issue 7. 2013-04-02. PMID:22848433. |
in this study, the α7*-selective agonist, choline, was pressure-applied to interneurons in hippocampal subregions, ca1 stratum radiatum and hilus of acute brain hippocampal slices from adolescent to adult mice and adolescent rats. |
2013-04-02 |
2023-08-12 |
mouse |
| Ying Wang, Yanbin Jia, Xinjian Chen, Xueying Ling, Sirun Liu, Guiyun Xu, Li Huan. Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment. Journal of psychopharmacology (Oxford, England). vol 26. issue 11. 2013-03-18. PMID:22706518. |
comparison of baseline values indicated that there were no significant differences in any of the metabolite ratios (n-acetyl aspartate/creatine (naa/cr) and choline (cho)/cr) in the bilateral hippocampus. |
2013-03-18 |
2023-08-12 |
human |
| Lei Zhang, Xuefeng Tan, Chuanming Dong, Linqing Zou, Heyan Zhao, Xinhua Zhang, Meiling Tian, Guohua Ji. In vitro differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs), derived from Wharton's jelly, into choline acetyltransferase (ChAT)-positive cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22683696. |
after treatment with nim, supplemented with hippocampal cholinergic neurostimulating peptide (hcnp) or rat denervated hippocampal extract [rdhe; derived from rat fimbria fornix (ff) transected hippocampus], hucmscs expressed choline acetytransferase (chat) and this action could be enhanced when cells were cultured with nim, supplemented with hcnp and rdhe in combination. |
2013-02-05 |
2023-08-12 |
human |
| Shuang-qing Chen, Qing Cai, Yu-ying Shen, Pei-jun Wang, Gao-jun Teng, Wei Zhang, Feng-chao Zan. Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behavioural brain research. vol 235. issue 1. 2013-01-23. PMID:22828014. |
the concentration of n-acetylaspartate (naa), glutamate (glu), myo-inositol (mi), choline (cho) and creatine (cr) in the hippocampus were measured, and the naa/cr, glu/cr, mi/cr and cho/cr ratios were quantified. |
2013-01-23 |
2023-08-12 |
mouse |
| M G Blake, M M Boccia, M C Krawczyk, A Delorenzi, C M Baratt. Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation. Neurobiology of learning and memory. vol 98. issue 2. 2013-01-09. PMID:22776591. |
the administration of the α(7)-nicotinic receptor agonist choline (ch) in the dorsal hippocampus (0.8μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. |
2013-01-09 |
2023-08-12 |
mouse |
| Linn H Nilsen, Torun M Melø, Oddbjørn Saether, Menno P Witter, Ursula Sonnewal. Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22943908. |
at age 9 months, lower levels of glutamate, gaba, n-acetylaspartate and total choline and elevated myo-inositol and taurine were found in dorsal hippocampus, whereas lower levels of glutamate, gaba, glutamine and n-acetylaspartate were found in frontal cortex. |
2012-12-21 |
2023-08-12 |
rat |
| V G Moti. Acetylcholine precursor choline evokes NMDA-dependent epileptoid activity in rat hippocampal CA1 area. Bulletin of experimental biology and medicine. vol 152. issue 1. 2012-11-19. PMID:22803032. |
application of choline (5 and 10 mm) to electrically stimulated (1 hz) rat hippocampal slices evoked epileptoid activity manifested by generation of extra population spikes. |
2012-11-19 |
2023-08-12 |
rat |
| Bradley R Monk, Frances M Leslie, Jennifer D Thoma. The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. Hippocampus. vol 22. issue 8. 2012-11-16. PMID:22431326. |
the effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. |
2012-11-16 |
2023-08-12 |
human |
| Bradley R Monk, Frances M Leslie, Jennifer D Thoma. The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. Hippocampus. vol 22. issue 8. 2012-11-16. PMID:22431326. |
choline may act by altering cholinergic signaling in the hippocampus. |
2012-11-16 |
2023-08-12 |
human |
| Bradley R Monk, Frances M Leslie, Jennifer D Thoma. The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. Hippocampus. vol 22. issue 8. 2012-11-16. PMID:22431326. |
this study examined the effects of developmental alcohol exposure and perinatal choline supplementation on hippocampal m(1) and m(2/4) muscarinic receptors. |
2012-11-16 |
2023-08-12 |
human |
| Bradley R Monk, Frances M Leslie, Jennifer D Thoma. The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. Hippocampus. vol 22. issue 8. 2012-11-16. PMID:22431326. |
developmental alcohol exposure significantly decreased the density of muscarinic m(1) receptors in the dorsal hippocampus, an effect that was not altered by choline supplementation. |
2012-11-16 |
2023-08-12 |
human |
| Bradley R Monk, Frances M Leslie, Jennifer D Thoma. The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. Hippocampus. vol 22. issue 8. 2012-11-16. PMID:22431326. |
these data suggest that developmental alcohol exposure can cause long-lasting changes in the hippocampal cholinergic system and that perinatal choline supplementation may attenuate alcohol-related behavioral changes by influencing cholinergic systems. |
2012-11-16 |
2023-08-12 |
human |
| Pravinkumar Bhutada, Yogita Mundhada, Vishwas Humane, Anand Rahigude, Prashant Deshmukh, Sandeep Latad, Kishor Jai. Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 37. issue 1. 2012-11-08. PMID:22300747. |
lipid peroxidation and glutathione levels as parameters of oxidative stress and choline esterase (che) activity as a marker of cholinergic function were assessed in the cerebral cortex and hippocampus. |
2012-11-08 |
2023-08-12 |
rat |
| Tasuku Katayama, Daisuke Mori, Hidekazu Miyake, Shuu Fujiwara, Yumie Ono, Toru Takahashi, Minoru Onozuka, Kin-Ya Kub. Effect of bite-raised condition on the hippocampal cholinergic system of aged SAMP8 mice. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22640898. |
aged bite-raised mice showed decreased acetylcholine release in the hippocampus and a reduced number of choline acetyltransferase-immunopositive neurons in the medial septal nucleus compared to age-matched control mice. |
2012-10-04 |
2023-08-12 |
mouse |