| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhou Lan, Lvyi Chen, Qiang Fu, Weiwei Ji, Shuyuan Wang, Zhaohui Liang, Rong Qu, Lingyi Kong, Shiping M. Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. Brain research. vol 1498. 2015-07-14. PMID:23295189. |
paeoniflorin also up-regulated the activity of choline acetyltrasferase and the expression of tyrosine kinase a receptor, and down-regulated the activity of acetylcholine esterase in the hippocampus of aβ(1-42)-treated rats. |
2015-07-14 |
2023-08-12 |
rat |
| Fanghao Hu, Lu Wei, Chaogu Zheng, Yihui Shen, Wei Mi. Live-cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling. The Analyst. vol 139. issue 10. 2015-07-02. PMID:24555181. |
by combining the emerging bond-selective stimulated raman scattering microscopy with metabolic incorporation of deuterated choline, herein we have achieved high resolution imaging of choline-containing metabolites in living mammalian cell lines, primary hippocampal neurons and the multicellular organism c. elegans. |
2015-07-02 |
2023-08-12 |
caenorhabditis_elegans |
| Murad Atmaca, Tevfik Karakoc, Osman Mermi, M Gurkan Gurok, Hanefi Yildiri. Neurochemical alterations associated with borderline personality disorder. International journal of psychiatry in medicine. vol 48. issue 4. 2015-05-29. PMID:25817526. |
n-acetylaspartate (naa), choline compounds (cho), and creatine (cre) values of hippocampal region were measured. |
2015-05-29 |
2023-08-13 |
human |
| Zhonghua Qi, Yinghui Xu, Zhanhua Liang, Sheng Li, Jie Wang, Yi Wei, Bin Don. Baicalein alters PI3K/Akt/GSK3β signaling pathway in rats with diabetes-associated cognitive deficits. International journal of clinical and experimental medicine. vol 8. issue 2. 2015-05-01. PMID:25932128. |
the activities of acetylcholinesterase (ache), choline acetylase (chat), caspase-9 and caspase-3 in stz-induced diabetic rats' hippocampus were detected via responsive commercial kits. |
2015-05-01 |
2023-08-13 |
rat |
| Shaoqiong Chen, Lisha Lai, Zhuang Kang, Xiao Luo, Jiansheng Zhang, Jianfang L. Imaging changes in neural circuits in patients with depression using (1)H-magnetic resonance spectroscopy and diffusion tensor imaging. Neural regeneration research. vol 7. issue 24. 2015-01-27. PMID:25624814. |
n-acetylaspartate, choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus, striatum, thalamus and prefrontal deep white matter. |
2015-01-27 |
2023-08-13 |
Not clear |
| Pui-Wai Chiu, Henry Ka-Fung Mak, Yung Chan, Tao Chan, King-Man H. Hippocampal MR spectroscopic abnormalities in a cohort of syphilitic patients with HIV and neurosyphilis infection. American journal of nuclear medicine and molecular imaging. vol 5. issue 1. 2015-01-27. PMID:25625030. |
however, metabolic changes were found in the left hippocampus of both the hiv-positive and ns subgroups, showing significantly higher choline (cho), creatine (cr) and myo-inositol (mi) compared to hc. |
2015-01-27 |
2023-08-13 |
human |
| Zhiyan Lu, Jinwei Wu, Guangyuan Cheng, Jianying Tian, Zeqing Lu, Yongyi B. Methylmercury chloride damage to the adult rat hippocampus cannot be detected by proton magnetic resonance spectroscopy. Neural regeneration research. vol 9. issue 17. 2014-11-04. PMID:25368649. |
the results of proton magnetic resonance spectroscopy revealed that the nitrogen-acetyl aspartate/creatine, choline complex/creatine and myoinositol/creatine ratio in rat hippocampal tissue were unchanged. |
2014-11-04 |
2023-08-13 |
rat |
| Alessia Salamone, Elisa Mura, Stefania Zappettini, Massimo Grilli, Guendalina Olivero, Stefania Preda, Stefano Govoni, Mario March. Inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution. European journal of pharmacology. vol 723. 2014-10-07. PMID:24275353. |
in hippocampal gliosomes nicotine elicited selectively glu overflow which was also evoked by 5ia85380 and by the α7 selective agonist choline. |
2014-10-07 |
2023-08-12 |
rat |
| Pui-Wai Chiu, Henry Ka-Fung Mak, Kelvin Kai-Wing Yau, Queenie Chan, Raymond Chuen-Chung Chang, Leung-Wing Ch. Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T. Age (Dordrecht, Netherlands). vol 36. issue 1. 2014-09-29. PMID:23709317. |
our results showed significant positive correlation of choline (r = 0.545, p = 0.002), creatine (r = 0.571, p = 0.001), and n-acetyl-aspartate (r = 0.674, p < 0.001) in the acc; choline (r = 0.614, p < 0.001), creatine (r = 0.670, p < 0.001), and n-acetyl-aspartate (r = 0.528, p = 0.003) in the pcc; and naa (r = 0.409, p = 0.025) in the left hippocampus, with age. |
2014-09-29 |
2023-08-12 |
human |
| Debin Huang, Zehua Hu, Zhaofen Y. Eleutheroside B or E enhances learning and memory in experimentally aged rats. Neural regeneration research. vol 8. issue 12. 2014-09-10. PMID:25206404. |
hippocampal homogenates showed enhanced cholinesterase activity, and dose-dependent increases in acetylcholine content and decreases in choline content following eleutheroside b or e treatment, similar to those seen in the huperzine a group. |
2014-09-10 |
2023-08-13 |
human |
| Debin Huang, Zehua Hu, Zhaofen Y. Eleutheroside B or E enhances learning and memory in experimentally aged rats. Neural regeneration research. vol 8. issue 12. 2014-09-10. PMID:25206404. |
these effects of eleutheroside b or e may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons. |
2014-09-10 |
2023-08-13 |
human |
| Guolin Ma, Tianbin Song, Min Chen, Yuan Fu, Yong Xu, Ensen Ma, Wu Wang, Jiang Du, Mingxiong Huan. Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia. Neural regeneration research. vol 8. issue 26. 2014-09-10. PMID:25206551. |
choline content was significantly greater in the hippocampus after transfection, while n-acetylaspartate and the ratio of n-acetylaspartate to creatine/phosphocreatine in the thalamus were lower than in controls. |
2014-09-10 |
2023-08-13 |
rat |
| Lei Zhang, Shuai Dong, Guixiang Zhao, Yu M. 7.0T nuclear magnetic resonance evaluation of the amyloid beta (1-40) animal model of Alzheimer's disease: comparison of cytology verification. Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206831. |
in this study, 7.0t magnetic resonance spectroscopy showed that in the hippocampus of alzheimer's disease rats, the n-acetylaspartate wave crest was reduced, and the creatine and choline wave crest was elevated. |
2014-09-10 |
2023-08-13 |
rat |
| Nafisa M Jadavji, Renata H Bahous, Liyuan Deng, Olga Malysheva, Marilyn Grand'maison, Barry J Bedell, Marie A Caudill, Rima Roze. Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism. The Biochemical journal. vol 461. issue 2. 2014-08-18. PMID:24800750. |
we also measured dna methylation, apoptosis, neurogenesis, choline metabolites and expression of chat (choline acetyltransferase) and ache (acetylcholinesterase) in the hippocampus. |
2014-08-18 |
2023-08-13 |
mouse |
| Nafisa M Jadavji, Renata H Bahous, Liyuan Deng, Olga Malysheva, Marilyn Grand'maison, Barry J Bedell, Marie A Caudill, Rima Roze. Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism. The Biochemical journal. vol 461. issue 2. 2014-08-18. PMID:24800750. |
we propose a mechanism whereby a deficiency in methionine synthesis leads to hypomethylation and compensatory disturbances in choline metabolism in the hippocampus. |
2014-08-18 |
2023-08-13 |
mouse |
| Mohamed Mahgoub, Susan Yang Keun-Hang, Vadym Sydorenko, Abrar Ashoor, Nadine Kabbani, Lina Al Kury, Bassem Sadek, Christopher F Howarth, Dmytro Isaev, Sehamuddin Galadari, Murat O. Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors. European journal of pharmacology. vol 720. issue 1-3. 2014-08-15. PMID:24140434. |
using whole cell patch clamp technique in ca1 stratum radiatum interneurons of rat hippocampal slices, currents induced by choline, a selective-agonist of α7-receptor induced currents were also recoded. |
2014-08-15 |
2023-08-12 |
rat |
| M G Blake, M M Boccia, M C Krawczyk, C M Baratt. Hippocampal α7-nicotinic cholinergic receptors modulate memory reconsolidation: a potential strategy for recovery from amnesia. Neurobiology of learning and memory. vol 106. 2014-08-11. PMID:24036397. |
the administration of the α7-nicotinic receptor agonist choline (ch) in the dorsal hippocampus (0.8 μg/hippocampus) immediately after the inhibitory avoidance memory reactivation, allowed memory recovery. |
2014-08-11 |
2023-08-12 |
mouse |
| Shankar Tumati, Sander Martens, André Alema. Magnetic resonance spectroscopy in mild cognitive impairment: systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 37. issue 10 Pt 2. 2014-08-06. PMID:23969177. |
choline (cho) concentration was reduced in the hippocampus while cho/cr ratio was raised in the pc. |
2014-08-06 |
2023-08-12 |
Not clear |
| Enea Traini, Vincenzo Bramanti, Francesco Ament. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent. Current Alzheimer research. vol 10. issue 10. 2014-08-05. PMID:24156263. |
choline alphoscerate increases the release of acetylcholine in rat hippocampus, facilitates learning and memory in experimental animals, improves brain transduction mechanisms and decreases age-dependent structural changes occurring in rat brain areas involved in learning and memory. |
2014-08-05 |
2023-08-12 |
rat |
| Viktoria Fischer, Martin Both, Andreas Draguhn, Alexei V Egoro. Choline-mediated modulation of hippocampal sharp wave-ripple complexes in vitro. Journal of neurochemistry. vol 129. issue 5. 2014-07-10. PMID:24673342. |
here, we asked whether the cellular actions of choline directly affect hippocampal network activity. |
2014-07-10 |
2023-08-12 |
mouse |