| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gayathri S Prabhu, Mohandas K G Rao, Kiranmai S Ra. Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats- exploring the comparable benefits of choline and DHA or environmental enrichment. The International journal of neuroscience. vol 131. issue 11. 2021-10-29. PMID:32498586. |
the objective of the study is to identify the effects of high fat diet-induced obesity in postnatal period on serum lipids, memory and neural cell survival in hippocampus and compare the role of choline and dha or environmental enrichment in attenuating the alterations. |
2021-10-29 |
2023-08-13 |
Not clear |
| Osman Mermi, Sema Baykara, Hanefi Yildirim, Murad Atmac. Noro psikiyatri arsivi. vol 58. issue 2. 2021-07-01. PMID:34188590. |
in this context, the present study was designed to determine the changes in hippocampal naa, cho (choline), and cre values in conversion disorder female patients, which has similar symptom basement and hypothesize that the patients with conversion disorder would have also changed neurochemicals in their hippocampal regions. |
2021-07-01 |
2023-08-13 |
Not clear |
| Calla M Goeke, Joel G Hashimoto, Marina Guizzetti, Annabella Vitalon. Effects of ethanol-and choline-treated astrocytes on hippocampal neuron neurite outgrowth in vitro. Science progress. vol 104. issue 2. 2021-05-25. PMID:34019432. |
culture media was then removed, replaced with fresh media containing no ethanol or choline treatments and primary rat hippocampal neurons were plated on top of the astrocyte monolayer and cultured for 16 h. |
2021-05-25 |
2023-08-13 |
human |
| Walaa A Keshk, Walaa S Elseady, Naglaa I Sarhan, Doaa H Zineldee. Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32172517. |
hippocampal glucose-regulated protein 78 (grp78), activating transcription factor 4 (atf-4), bcl2 and choline acetyl transferase (chat) genes expression were assessed. |
2021-05-11 |
2023-08-13 |
rat |
| Ruiting Chang, Zuojun Geng, Qingfeng Zhu, Zhenhu Song, Ya Wan. Proton magnetic resonance spectroscopy reveals significant decline in the contents of Archives of medical science : AMS. vol 13. issue 1. 2020-10-01. PMID:28144264. |
proton magnetic resonance spectroscopy reveals significant decline in the contents of to characterize the contents of choline (cho), creatine (cr) and n-acetylaspartylglutamate (naa) in the hippocampus of healthy volunteers, we investigated the contents and their correlationship with age, gender and laterality. |
2020-10-01 |
2023-08-13 |
human |
| Minjian Dong, Mengqian Ren, Chen Li, Xi Zhang, Changwei Yang, Liangcai Zhao, Hongchang Ga. Analysis of Metabolic Alterations Related to Pathogenic Process of Diabetic Encephalopathy Rats. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30692917. |
our findings indicated that the pathogenesis of de is associated with time-dependent alterations in metabolic features in hippocampal regions, such as glycolysis, osmoregulation, energy metabolism, choline metabolism, branched-chain amino acid metabolism, and the glutamate-glutamine cycle. |
2020-10-01 |
2023-08-13 |
rat |
| Huban Thomas Rajarethnem, Kumar Megur Ramakrishna Bhat, Malsawmzuali Jc, Siva Kumar Gopalkrishnan, Ramesh Babu Mugundhu Gopalram, Kiranmai Sesappa Ra. Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus. Neurology research international. vol 2017. 2020-09-30. PMID:28210506. |
combined supplementation of choline and docosahexaenoic acid during pregnancy enhances neurodevelopment of fetal hippocampus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Francesca Zoratto, Luisa Altabella, Naomi Tistarelli, Giovanni Laviola, Walter Adriani, Rossella Canes. Inside the Developing Brain to Understand Teen Behavior From Rat Models: Metabolic, Structural, and Functional-Connectivity Alterations Among Limbic Structures Across Three Pre-adolescent Stages. Frontiers in behavioral neuroscience. vol 12. 2020-09-30. PMID:30319367. |
finally, levels of metabolites were investigated by 1h-mrs in the anterior part of the hippocampus: we put into evidence an increase in myo-inositol during juvenile transition and a taurine reduction plus a total choline increase during adolescent transition. |
2020-09-30 |
2023-08-13 |
rat |
| Austin T Mudd, Caitlyn M Getty, Ryan N Dilge. Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs. Current developments in nutrition. vol 2. issue 6. 2020-09-29. PMID:29955727. |
research in animal models suggests that perinatal choline deficiency influences neuron development in the hippocampus and cortex, yet these observations require invasive techniques. |
2020-09-29 |
2023-08-13 |
Not clear |
| Anna L Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Palasz, Charles R Harrington, Franz Theuring, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954291. |
a significant lowering of choline acetyltransferase-positive neurons and p75-positive neurons in the basal forebrain of line 1 at 3, 6 and 9 months was observed in two independent studies, alongside a significant decrease in acetylcholinesterase staining in the cortex and hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Hongchang Gao, Qiaoying Jiang, Hui Ji, Jie Ning, Chen Li, Hong Zhen. Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 12. 2020-05-29. PMID:31472216. |
the results demonstrated that ast1d rats possessed peculiar metabolic phenotypes in serum and hippocampus relative to amc rats, as characterized by decreases in tricarboxylic acid (tca) cycle and amino acid and choline metabolism as well as disturbances in glutamate/gaba-glutamine cycle and astrocyte-neuron metabolism. |
2020-05-29 |
2023-08-13 |
rat |
| Jing Xu, Weihao Sun, Li Yan. Association between iron metabolism and cognitive impairment in older non-alcoholic fatty liver disease individuals: A cross-sectional study in patients from a Chinese center. Medicine. vol 98. issue 48. 2019-12-06. PMID:31770275. |
no statistically significant associations were observed between mci and age or blood glucose or choline (cho) /creatine (cr) of theright hippocampus head.increased age and low levels of stfr and hb were associated with mci in nafld individuals aged over 60 years. |
2019-12-06 |
2023-08-13 |
human |
| Stillman, Shukitt-Hale, Coffey, Levy, Lieberma. In Vivo Hippocampal Acetylcholine Release During Exposure to Acute Stress. Stress (Amsterdam, Netherlands). vol 1. issue 4. 2019-11-20. PMID:9787244. |
hippocampal extracellular acetylcholine (ach) and choline levels were evaluated using in vivo microdialysis in male fischer 344 rats before, during, and following an 80-min exposure to two different stress conditions. |
2019-11-20 |
2023-08-12 |
rat |
| Nora McCall, Darshini Mahadevia, Jennifer A Corriveau, Melissa J Glen. Adult emotionality and neural plasticity as a function of adolescent nutrient supplementation in male rats. Pharmacology, biochemistry, and behavior. vol 132. 2019-11-20. PMID:25782746. |
the present study explored the effects of supplementing male rats with either choline, omega-3 fatty acids, or phytoestrogens, from weaning into early adulthood, on emotionality and hippocampal plasticity. |
2019-11-20 |
2023-08-13 |
rat |
| Nora McCall, Darshini Mahadevia, Jennifer A Corriveau, Melissa J Glen. Adult emotionality and neural plasticity as a function of adolescent nutrient supplementation in male rats. Pharmacology, biochemistry, and behavior. vol 132. 2019-11-20. PMID:25782746. |
histological findings followed a pattern consistent with the behavioral findings: choline supplementation, followed by omega-3 fatty acid supplementation, but not phytoestrogen supplementation, significantly increased the numbers of new-born hippocampal neurons. |
2019-11-20 |
2023-08-13 |
rat |
| Tiffany J Mellott, Olivia M Huleatt, Bethany N Shade, Sarah M Pender, Yi B Liu, Barbara E Slack, Jan K Blusztaj. Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PloS one. vol 12. issue 3. 2019-11-20. PMID:28334015. |
correction: perinatal choline supplementation reduces amyloidosis and increases choline acetyltransferase expression in the hippocampus of the appsweps1de9 alzheimer's disease model mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Jiale Xu, Yingying Tang, C Cecilio Baro, Xiaoliu Zhang, Ziyu Meng, Yao L. Left fimbria atrophy is associated with hippocampal metabolism in female major depressive disorder patients. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2018. 2019-10-24. PMID:30440590. |
we found a significant decrease in left fimbria volume in mdd group, which was negatively correlated with left hippocampal choline level. |
2019-10-24 |
2023-08-13 |
Not clear |
| Bai Hui Chen, Joon Ha Park, Dae Won Kim, Jinseu Park, Soo Young Choi, In Hye Kim, Jeong Hwi Cho, Tae-Kyeong Lee, Jae Chul Lee, Choong-Hyun Lee, In Koo Hwang, Young-Myeong Kim, Bing Chun Yan, Il Jun Kang, Bich Na Shin, Yun Lyul Lee, Myoung Cheol Shin, Jun Hwi Cho, Young Joo Lee, Yong Hwan Jeon, Moo-Ho Won, Ji Hyeon Ah. Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia. ACS chemical neuroscience. vol 9. issue 8. 2019-10-03. PMID:28901737. |
in addition, scopolamine treatments significantly decreased protein levels and immunoreactivities of choline acetyltransferase (chat), high-affinity choline transporter (cht), vesicular acetylcholine transporter (vacht), and muscarinic acetylcholine receptor m1 (m1r) in the septum and hippocampus. |
2019-10-03 |
2023-08-13 |
mouse |
| Yingying Tang, Xiaoliu Zhang, Jianhua Sheng, Xuanhong Zhang, Jianye Zhang, Jiale Xu, Yajing Zhu, Junjie Wang, Tianhong Zhang, Shanbao Tong, Lipeng Ning, Manhua Liu, Yao Li, Jijun Wan. Elevated hippocampal choline level is associated with altered functional connectivity in females with major depressive disorder: A pilot study. Psychiatry research. Neuroimaging. vol 278. 2019-09-24. PMID:29880254. |
elevated hippocampal choline level is associated with altered functional connectivity in females with major depressive disorder: a pilot study. |
2019-09-24 |
2023-08-13 |
Not clear |
| Miri Gitik, Erica D Holliday, Ming Leung, Qiaoping Yuan, Sheree F Logue, Roope Tikkanen, David Goldman, Thomas J Goul. Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30099202. |
this study examined whether adolescent nicotine exposure alters adult hippocampus-dependent learning, involving persistent changes in hippocampal dna methylation and if choline, a dietary methyl donor, would reverse and mitigate these alterations. |
2019-09-23 |
2023-08-13 |
mouse |