| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anja Meissner, Alba M Garcia-Serrano, Lotte Vanherle, Zeinab Rafiee, Nicholas Don-Doncow, Cecilia Skoug, Sara Larsson, Michael Gottschalk, Martin Magnusson, João M N Duart. Alterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613742. |
compared to nd, hsd increased hippocampal glutamine and phosphocreatine levels and decreased creatine and choline levels. |
2023-01-08 |
2023-08-14 |
mouse |
| Siamak Sheikhi, Leila Derafshpour, Razieh Aghazadeh, Hojat Sayyadi, Ehsan Saboory, Morteza Bagher. Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats. Molecular biology reports. 2022-12-28. PMID:36577834. |
regarding the well-known effects of choline on brain-derived neurotrophic factor (bdnf), the study examined the effects of choline on hippocampal bdnf gene expression in maternal hypothyroidism rats. |
2022-12-28 |
2023-08-14 |
rat |
| Rishi Gupta, Mamta Sood, Uma Sharma, Rachna Bhargava, N R Jagannathan, R K Chadd. Neurochemical correlates of cognitive functions in euthymic patients with bipolar disorder: Asian journal of psychiatry. vol 78. 2022-10-21. PMID:36270047. |
neurochemical correlates of cognitive functions in euthymic patients with bipolar disorder: we assessed and correlated neurochemical levels and cognitive functions in left dorsolateral prefrontal cortex (dlpfc) and left hippocampus in euthymic patients with bipolar disorder and compared these with healthy controls methodology: twenty-five right-handed euthymic patients (ham-d score < 7, and ymrs score < 7) with bipolar disorder and 20 age and gender matched controls were compared for neurometabolites (n-acetylaspartate - tnaa, choline - cho, creatinine - cr, myoinositol - ins, and glutamine/glutamate - glu/gln) measured in left dlpfc and left hippocampus using single voxel magnetic resonance spectroscopy (mrs) and cognitive functions assessed using trail making test (tmt - a and b), wisconsin card sorting test (wcst), and wechsler memory scale (wms-iii indian adaptation). |
2022-10-21 |
2023-08-14 |
Not clear |
| Emma Muñoz-Moreno, Rui Vasco Simões, Raúl Tudela, Xavier López-Gil, Guadalupe Sori. Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-10-10. PMID:36216838. |
thus, in cortex, strong couplings of n-acetylaspartate and creatine with myo-inositol in wt, but with taurine in tgf344-ad rats were observed; whereas in the hippocampus, myo-inositol, taurine and choline compounds levels were highly correlated in wt but not in tgf344-ad animals. |
2022-10-10 |
2023-08-14 |
rat |
| Jessica A Baker, Kristen R Breit, Tamara S Bodnar, Joanne Weinberg, Jennifer D Thoma. Choline Supplementation Modifies the Effects of Developmental Alcohol Exposure on Immune Responses in Adult Rats. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889826. |
importantly, supplementation with the essential nutrient choline can improve performance in hippocampal-dependent behaviors; thus, the present study examined the effects of choline on plasma and hippocampal cytokines in adult rats exposed to ethanol in early development. |
2022-07-27 |
2023-08-14 |
human |
| Jessica A Baker, Kristen R Breit, Tamara S Bodnar, Joanne Weinberg, Jennifer D Thoma. Choline Supplementation Modifies the Effects of Developmental Alcohol Exposure on Immune Responses in Adult Rats. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889826. |
prior to the immune challenge, ethanol-exposed subjects showed an overall increase in hippocampal pro-inflammatory cytokines, an effect mitigated by choline supplementation. |
2022-07-27 |
2023-08-14 |
human |
| Jessica A Baker, Kristen R Breit, Tamara S Bodnar, Joanne Weinberg, Jennifer D Thoma. Choline Supplementation Modifies the Effects of Developmental Alcohol Exposure on Immune Responses in Adult Rats. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889826. |
these results suggest that early choline can mitigate some long-term effects of ethanol exposure on hippocampal inflammation, which may contribute to improved hippocampal function, and could also influence peripheral immune responses that may impact overall health. |
2022-07-27 |
2023-08-14 |
human |
| Illsung L Joo, Wilfred W Lam, Wendy Oakden, Mary E Hill, Margaret M Koletar, Christopher D Morrone, Greg J Stanisz, JoAnne McLaurin, Bojana Stefanovi. Early alterations in brain glucose metabolism and vascular function in a transgenic rat model of Alzheimer's disease. Progress in neurobiology. 2022-07-23. PMID:35870681. |
tgad rats also showed a 59±42% increase in total choline level in the hippocampus, suggesting increased membrane turnover. |
2022-07-23 |
2023-08-14 |
rat |
| Liu Xianchu, Peng Huan, Liu Kang, Deng Beiwang, Liu Min. Protective effect of rutin against diabetes-associated cognitive decline in rats. Pakistan journal of pharmaceutical sciences. vol 35. issue 3. 2022-07-06. PMID:35791475. |
in hippocampus tissue, spectrophotometer was performed to evaluate super oxide dismutase (sod), catalase (cat), reduced glutathione (gsh), malondialdehyde (mda), acetyl cholinesterase (ache) and choline acetyl transferase (chat) levels. |
2022-07-06 |
2023-08-14 |
rat |
| Ryusei Satoh, Kiyoharu Kawakami, Kazuhiko Nakadat. Effects of Smart Drugs on Cholinergic System and Non-Neuronal Acetylcholine in the Mouse Hippocampus: Histopathological Approach. Journal of clinical medicine. vol 11. issue 12. 2022-06-24. PMID:35743382. |
however, in he, we found perivascular edema, and choline acetyltransferase staining showed increased staining throughout the hippocampus and new signal induction in the perivascular area in the ca3, especially in the aniracetam and α-glyceryl phosphoryl choline group. |
2022-06-24 |
2023-08-14 |
mouse |
| Erin L Grafe, Mira M M Wade, Claire E Hodson, Jennifer D Thomas, Brian R Christi. Postnatal Choline Supplementation Rescues Deficits in Synaptic Plasticity Following Prenatal Ethanol Exposure. Nutrients. vol 14. issue 10. 2022-05-28. PMID:35631142. |
this study used an animal model to determine if choline supplementation could restore hippocampal synaptic plasticity that is normally impaired by prenatal alcohol. |
2022-05-28 |
2023-08-13 |
rat |
| Beatrix Krause-Sorio, Prabha Siddarth, Lisa Kilpatrick, Michaela M Milillo, Yesenia Aguilar-Faustino, Linda Ercoli, Katherine L Narr, Dharma S Khalsa, Helen Lavretsk. Yoga Prevents Gray Matter Atrophy in Women at Risk for Alzheimer's Disease: A Randomized Controlled Trial. Journal of Alzheimer's disease : JAD. 2022-03-11. PMID:35275541. |
we previously demonstrated that yoga improved depression, resilience, memory and executive functions, increased hippocampal choline concentrations, and modulated brain connectivity in older adults with mild cognitive impairment. |
2022-03-11 |
2023-08-13 |
Not clear |
| Mumin Alper Erdogan, Mehmet Kirazlar, Gurkan Yigitturk, Oytun Erba. Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia. Neurochemical research. 2022-01-22. PMID:35064518. |
the levels of tumor necrosis factor-alpha (tnf-α) and choline acetyl transferase (chat) were measured in the brain, and neurons were counted using cresyl violet staining in cornu ammonis-1 (ca1) and cornu ammonis-3 (ca3) cornu ammonis (ca3). |
2022-01-22 |
2023-08-13 |
human |
| Qiong Fang, Jing Liu, Lang Chen, Qiaobin Chen, Yan Wang, Zuanfang Li, Wei Fu, Ying Li. Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis. Metabolic brain disease. 2022-01-20. PMID:35048325. |
antenatal taurine supplementation increased the ratios of n-acetylaspartate (naa) /creatine (cr) and glutamate (glu) /cr of the hippocampus in the iugr immature rats, but reduced the ratios of choline (cho) /cr and myoinositol (mi) /cr. |
2022-01-20 |
2023-08-13 |
rat |
| Thomas W Bastian, William C von Hohenberg, Olivia R Kaus, Lorene M Lanier, Michael K Georgief. Choline Supplementation Partially Restores Dendrite Structural Complexity in Developing Iron-Deficient Mouse Hippocampal Neurons. The Journal of nutrition. 2021-12-27. PMID:34958369. |
choline supplementation partially restores dendrite structural complexity in developing iron-deficient mouse hippocampal neurons. |
2021-12-27 |
2023-08-13 |
mouse |
| Kartheek Gavini, Euitaek Yang, Kodeeswaran Parameshwara. Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain research bulletin. vol 176. 2021-12-10. PMID:34358612. |
analysis of transcripts for proteins that are known to regulate acetylcholine levels revealed a decline in mrna levels of high affinity choline transporters in the hippocampus of nicotine exposed mice but those of vesicular acetylcholine transporter, choline acetyltransferase, and α7-nicotinic acetylcholine receptors were not altered. |
2021-12-10 |
2023-08-13 |
mouse |
| Lu Wang, Min Zhang, Jing Wen, Yalan Xiang, Xiaoyu Duan, Changwei Yu, Miao Yan, Bikui Zhang, Pingfei Fan. Isoliquiritigenin Alleviates Semen Strychni-Induced Neurotoxicity by Restoring the Metabolic Pathway of Neurotransmitters in Rats. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867385. |
the concentration of monoamines, amino acids, and choline neurotransmitters, the dopamine (da) and 5-hydroxytryptamine (5-ht) metabolic pathway in the hippocampus, cerebellum, striatum, prefrontal cortex, hypothalamus, serum, and plasma were detected by lc-ms/ms. |
2021-12-07 |
2023-08-13 |
rat |
| Tri Yuliani, Sebastian Lobentanzer, Jochen Klei. Central cholinergic function and metabolic changes in streptozotocin-induced rat brain injury. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33448390. |
high-affinity choline uptake, choline acetyltransferase, and acetylcholine esterase (ache) activities in the hippocampus were reduced by 16%, 28%, and 30%, respectively. |
2021-11-17 |
2023-08-13 |
rat |
| Erin L Grafe, Christine J Fontaine, Jennifer D Thomas, Brian R Christi. Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. Journal of neurophysiology. vol 126. issue 5. 2021-11-17. PMID:34495785. |
in the current work, we study how the direct application of choline can affect synaptic transmission in the dentate gyrus (dg) of hippocampal slices obtained from adolescent ( |
2021-11-17 |
2023-08-13 |
Not clear |
| Gayathri S Prabhu, Mohandas K G Rao, Kiranmai S Ra. Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats- exploring the comparable benefits of choline and DHA or environmental enrichment. The International journal of neuroscience. vol 131. issue 11. 2021-10-29. PMID:32498586. |
hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats- exploring the comparable benefits of choline and dha or environmental enrichment. |
2021-10-29 |
2023-08-13 |
Not clear |