| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu Rui, Li Wenfang, Cheng Jing, Chen Meng, Ding Chengcheng, Xu Jiqu, Rong Shuan. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat. Food & function. vol 8. issue 3. 2017-07-07. PMID:28256666. |
furthermore, pse improved cholinergic activities by restoring the acetylcholine (ach) content and decreasing acetylcholinesterase (ache) activity in the cerebral cortex, as well as by elevating choline acetyl transferase (chat) activity in the hippocampus and the cerebral cortex. |
2017-07-07 |
2023-08-13 |
rat |
| Song Hee Lee, Bo Young Choi, Jin Hee Kim, A Ra Kho, Min Sohn, Hong Ki Song, Hui Chul Choi, Sang Won Su. Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain research. vol 1654. issue Pt A. 2017-05-24. PMID:27765578. |
late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-gpc) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. |
2017-05-24 |
2023-08-13 |
rat |
| Xianchu Liu, Yanzhi Mo, Jingbo Gong, Zhuang Li, Huan Peng, Jiaxue Chen, Qichao Wang, Zhaowen Ke, Jingtao Xi. Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Metabolic brain disease. vol 31. issue 2. 2017-01-10. PMID:26686502. |
the acetylcholinesterase (ache), choline acetylase (chat), oxidative indicators [malondialdehyde (mda) and superoxide dismutase (sod)] and inflammatory cytokine (tnf-a, il-1β and il-6) were measured in hippocampus by using corresponding commercial kits. |
2017-01-10 |
2023-08-13 |
rat |
| M Jozefovicova, V Herynek, F Jiru, M Dezortova, J Juhasova, S Juhas, J Motlik, M Haje. Minipig model of Huntington's disease: ¹H magnetic resonance spectroscopy of the brain. Physiological research. vol 65. issue 1. 2016-12-30. PMID:26596319. |
increase of the ratio choline compounds (tcho)/tcr was found in all examined areas: striatum (p=0.010), thalamus (p=0.011) as well as hippocampus (p=0.027). |
2016-12-30 |
2023-08-13 |
Not clear |
| Christy M Kelley, Jessica A Ash, Brian E Powers, Ramon Velazquez, Melissa J Alldred, Milos D Ikonomovic, Stephen D Ginsberg, Barbara J Strupp, Elliott J Mufso. Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. Current Alzheimer research. vol 13. issue 1. 2016-09-19. PMID:26391045. |
here we determined the effects of age and maternal choline supplementation (mcs) on hippocampal cholinergic deficits in ts65dn mice compared to 2n mice sacrificed at 6-8 and 14-18 months of age. |
2016-09-19 |
2023-08-13 |
mouse |
| Barbara J Strupp, Brian E Powers, Ramon Velazquez, Jessica A Ash, Christy M Kelley, Melissa J Alldred, Myla Strawderman, Marie A Caudill, Elliott J Mufson, Stephen D Ginsber. Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. Current Alzheimer research. vol 13. issue 1. 2016-09-19. PMID:26391046. |
studies demonstrate that maternal choline supplementation (mcs) markedly improves spatial cognition and attentional function, as well as normalizes adult hippocampal neurogenesis and offers protection to basal forebrain cholinergic neurons (bfcns) in the ts65dn mouse model of ds. |
2016-09-19 |
2023-08-13 |
mouse |
| Phu V Tran, Bruce C Kennedy, Marc T Pisansky, Kyoung-Jae Won, Jonathan C Gewirtz, Rebecca A Simmons, Michael K Georgief. Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus. The Journal of nutrition. vol 146. issue 3. 2016-07-11. PMID:26865644. |
prenatal choline supplementation diminishes early-life iron deficiency-induced reprogramming of molecular networks associated with behavioral abnormalities in the adult rat hippocampus. |
2016-07-11 |
2023-08-13 |
rat |
| Tian-Xia Yu, Peng Zhang, Yan Guan, Min Wang, Ming-Qing Zhe. Protective effects of luteolin against cognitive impairment induced by infusion of Aβ peptide in rats. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-06-10. PMID:26261557. |
in hippocampal tissue, the activity of choline acetyl transferase (chat), superoxide dismutase (sod) and glutathione peroxidase (gsh-px) increased after treated by luteolin. |
2016-06-10 |
2023-08-13 |
rat |
| Lejun Lin, Bofeng Cao, Zhiying Xu, Yanbin Sui, Jiao Chen, Qiang Luan, Ruifang Yang, Shanchun Li, Ke Feng L. In vivo HMRS and lipidomic profiling reveals comprehensive changes of hippocampal metabolism during aging in mice. Biochemical and biophysical research communications. vol 470. issue 1. 2016-06-07. PMID:26707637. |
we found n-acetylaspartic acid (naa), gama-aminobutyric acid (gaba), glutamate/glutamine, taurine, choline, sphingolipids (sms), phosphatidylethanolamines (pes), phosphatidylinositols (pis), phosphatidylglycerols (pgs) and phosphatidylserines (pss), all of them decreasing with the aging process in mice hippocampus. |
2016-06-07 |
2023-08-13 |
mouse |
| Imran Imran, Markus H Hillert, Jochen Klei. Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. Journal of neurochemistry. vol 135. issue 5. 2016-05-16. PMID:26365376. |
increases in lactate, glycerol and isoprostanes were abrogated, and increases in choline were completely prevented, when hippocampal probes were perfused with calcium-free solution. |
2016-05-16 |
2023-08-13 |
rat |
| Andrea Aurélio Borges, Philipe Nicolas El-Batah, Lilia Fumie Yamashita, Aline dos Santos Santana, Antonio Carlos Lopes, Edna Freymuller-Haapalainen, Cicero Galli Coimbra, Rita Sinigaglia-Coimbr. Neuroprotective effect of oral choline administration after global brain ischemia in rats. Nutritional neuroscience. vol 18. issue 6. 2016-04-28. PMID:24754536. |
this work aimed at verifying the effects of 7-day oral administration with different doses of choline on survival of ca1 hippocampal neurons following transient global forebrain ischemia in rats. |
2016-04-28 |
2023-08-13 |
rat |
| O U Scremin, M Roch, K M Norman, S Djazayeri, Y-Y Li. Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. Neuroscience. vol 301. 2016-04-18. PMID:26117713. |
brain endogenous ach (d0ach), free choline (d0ch), their deuterated variants d4ach and d4ch and mole ratios (achmr and chmr) were measured by gas chromatography-mass spectrometry in the cerebral hemisphere, cerebral cortex, hippocampus and cerebellum, following d4ch administration. |
2016-04-18 |
2023-08-13 |
mouse |
| N M Jadavji, L Deng, O Malysheva, M A Caudill, R Roze. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. vol 300. 2016-03-29. PMID:25956258. |
mthfr deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. |
2016-03-29 |
2023-08-13 |
mouse |
| N M Jadavji, L Deng, O Malysheva, M A Caudill, R Roze. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. vol 300. 2016-03-29. PMID:25956258. |
short-term memory was assessed in offspring, and hippocampal tissue was evaluated for morphological changes, apoptosis, proliferation and choline metabolism. |
2016-03-29 |
2023-08-13 |
mouse |
| N M Jadavji, L Deng, O Malysheva, M A Caudill, R Roze. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. vol 300. 2016-03-29. PMID:25956258. |
we suggest that deficiencies in maternal one-carbon metabolism during pregnancy can contribute to hippocampal dysfunction in offspring through apoptosis or altered choline metabolism. |
2016-03-29 |
2023-08-13 |
mouse |
| Wayne R Hawley, Christine F Witty, Jill M Daniel, Gary P Dohanic. Choline acetyltransferase in the hippocampus is associated with learning strategy preference in adult male rats. Behavioural brain research. vol 289. 2016-02-05. PMID:25930215. |
with this in mind, the primary aim of the current study was to determine if higher levels of chat and the high-affinity choline uptake transporter (cht) in the hippocampus were associated with a preference for a hippocampus-based place learning strategy on a task that also could be solved by relying on a striatum-based stimulus--response learning strategy. |
2016-02-05 |
2023-08-13 |
rat |
| Chun-Li Liu, Hong Chen, Yong Jiang, Peng-Fei Tu, Ming Zhong, Jing-Yi Ma, Hui Ding, Wan-Xin Zhang, Xiao-Min Ji. [Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 5. 2016-01-25. PMID:23888706. |
[effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats]. |
2016-01-25 |
2023-08-12 |
rat |
| Chun-Li Liu, Hong Chen, Yong Jiang, Peng-Fei Tu, Ming Zhong, Jing-Yi Ma, Hui Ding, Wan-Xin Zhang, Xiao-Min Ji. [Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 5. 2016-01-25. PMID:23888706. |
the content of acetylcholine (ach) and choline (ch) of microdialysate extracellular of hippocampus and striatum was determined by hplc-imer-ecd and the ache activity in the hippocampus was measured. |
2016-01-25 |
2023-08-12 |
rat |
| Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Maricela Franco-Lira, Hongtu Zhu, Zhaohua Lu, Edelmira Solorio, Ricardo Torres-Jardón, Amedeo D'Angiull. Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution. Journal of Alzheimer's disease : JAD. vol 45. issue 3. 2016-01-19. PMID:25633678. |
n-acetylaspartate (naa)/creatine (cr), choline (cho)/cr, myo-inositol (mi)/cr, and naa/mi were calculated using proton magnetic resonance spectroscopy in the white matter of the frontal and parietal lobes, hippocampus, and pons. |
2016-01-19 |
2023-08-13 |
Not clear |
| Fang Han, Bing Xiao, Lili Wen, Yuxiu Sh. Effects of fluoxetine on the amygdala and the hippocampus after administration of a single prolonged stress to male Wistar rates: In vivo proton magnetic resonance spectroscopy findings. Psychiatry research. vol 232. issue 2. 2015-10-16. PMID:25841890. |
sps increased the n-acetylaspartate (naa)/creatine (cr) and choline moieties (cho)/cr ratios in the bilateral amygdala on day 4, decreased the naa/cr ratio in the left hippocampus on day 1, and increased both ratios in the right hippocampus on day 14. |
2015-10-16 |
2023-08-13 |
rat |