| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melissa J Glenn, Elizabeth D Kirby, Erin M Gibson, Sarah J Wong-Goodrich, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain research. vol 1237. 2009-04-09. PMID:18786518. |
the present study was designed to examine: 1) if prenatal choline supplementation alters behaviors that contribute to risk or resilience in cognitive aging, and 2) whether, at old age (25 months), prenatally choline-supplemented rats show evidence of preserved hippocampal plasticity. |
2009-04-09 |
2023-08-12 |
rat |
| Melissa J Glenn, Elizabeth D Kirby, Erin M Gibson, Sarah J Wong-Goodrich, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain research. vol 1237. 2009-04-09. PMID:18786518. |
taken together, these findings provide the first evidence that prenatal choline supplementation causes changes in exploratory behaviors over the lifespan and preserves some features of hippocampal plasticity that can be seen even at 2 years of age. |
2009-04-09 |
2023-08-12 |
rat |
| Isabella Napoli, Jan Krzysztof Blusztajn, Tiffany J Mellot. Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. Brain research. vol 1237. 2009-04-09. PMID:18786520. |
prenatal choline supplementation in rats increases the expression of igf2 and its receptor igf2r and enhances igf2-induced acetylcholine release in hippocampus and frontal cortex. |
2009-04-09 |
2023-08-12 |
rat |
| Isabella Napoli, Jan Krzysztof Blusztajn, Tiffany J Mellot. Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. Brain research. vol 1237. 2009-04-09. PMID:18786520. |
rats that obtain supplemental choline during embryonic day (e) 11-17 have enhanced depolarization-evoked acetylcholine (ach) release from hippocampal slices, whereas choline deficiency during this time reduces this release. |
2009-04-09 |
2023-08-12 |
rat |
| Isabella Napoli, Jan Krzysztof Blusztajn, Tiffany J Mellot. Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. Brain research. vol 1237. 2009-04-09. PMID:18786520. |
on p18, igf2/depolarization-evoked ach release from hippocampal slices was enhanced by prenatal choline supplementation. |
2009-04-09 |
2023-08-12 |
rat |
| Ruey-Kuang Cheng, Christina L Williams, Warren H Mec. Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. Brain research. vol 1237. 2009-04-09. PMID:18793620. |
oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. |
2009-04-09 |
2023-08-12 |
rat |
| Ruey-Kuang Cheng, Christina L Williams, Warren H Mec. Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. Brain research. vol 1237. 2009-04-09. PMID:18793620. |
adult offspring of time-pregnant dams that were given a deficient level of choline (def=0.0 g/kg), sufficient choline (con=1.1 g/kg) or supplemental choline (sup=3.5 g/kg) in their chow during embryonic days (ed) 12-17 were implanted with an electroencephalograph (eeg) electrode in the hippocampal dentate gyrus in combination with an electromyograph (emg) electrode patch implanted in the nuchal muscle. |
2009-04-09 |
2023-08-12 |
rat |
| Jeffrey A Lamoureux, Warren H Meck, Christina L William. Prenatal choline availability alters the context sensitivity of Pavlovian conditioning in adult rats. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 12. 2009-04-08. PMID:19050158. |
these data support the view that configural associations that rely on hippocampal function are selectively sensitive to prenatal manipulations of dietary choline during prenatal development. |
2009-04-08 |
2023-08-12 |
rat |
| Xu Ling Li, De Sheng Wang, Bao Quan Zhao, Qian Li, Heng Yan Qu, Ting Zhang, Jian Ping Zhou, Man Ji Su. Effects of Chinese herbal medicine fuzhisan on aged rats. Experimental gerontology. vol 43. issue 9. 2009-04-02. PMID:18606218. |
the spectrophotometry and western blot showed that fzs obviously increased the activity and the production of choline o-acetyltransferase (chat, ec 2.3.1.6) and the acetylcholine (ach) contents in the hippocampus, thus regulated and ameliorated the impaired cholinergic functions of the aged rats. |
2009-04-02 |
2023-08-12 |
mouse |
| Bjørnar Hassel, Volker Solyga, Andreas Lossiu. High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study. Neurochemistry international. vol 53. issue 6-8. 2009-03-09. PMID:18674580. |
we compared white structures of pig brain (fimbria, corpus callosum, pyramidal tracts, and occipital white matter) to gray structures (temporal, parietal and cerebellar cortices, hippocampus, and caudate) and found that sodium-dependent, high-affinity choline uptake in white structures was 25-31% of that in hippocampus. |
2009-03-09 |
2023-08-12 |
Not clear |
| Steven H Zeise. Importance of methyl donors during reproduction. The American journal of clinical nutrition. vol 89. issue 2. 2009-02-11. PMID:19116320. |
similarly, maternal dietary choline is important for normal neural tube closure in the fetus and, later in gestation, for neurogenesis in the fetal hippocampus, with effects on memory that persist in adult offspring; higher choline intake is associated with enhanced memory performance. |
2009-02-11 |
2023-08-12 |
Not clear |
| Ken Takashina, Tomoko Bessho, Reiko Mori, Junichi Eguchi, Ken-Ichi Sait. MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 7. 2008-11-05. PMID:18446264. |
produced significant reduction of high-affinity choline uptake (hacu) and high k+-induced ach release in hippocampal synaptosomes. |
2008-11-05 |
2023-08-12 |
rat |
| Kui Wang, Chao Zheng, Chen Wu, Ming Gao, Qiang Liu, Kechun Yang, Kevin Ellsworth, Lin Xu, Jie W. alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices. Neuroscience letters. vol 441. issue 1. 2008-11-05. PMID:18597935. |
it is concluded that alpha-chloralose suppresses hippocampal gamma oscillations without significantly affecting basic synaptic transmission or ionotropic glutamate, choline and glycine receptor function. |
2008-11-05 |
2023-08-12 |
rat |
| Sarah J E Wong-Goodrich, Tiffany J Mellott, Melissa J Glenn, Jan K Blusztajn, Christina L William. Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. Neurobiology of disease. vol 30. issue 2. 2008-10-13. PMID:18353663. |
prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. |
2008-10-13 |
2023-08-12 |
rat |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18023504. |
choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice. |
2008-07-28 |
2023-08-12 |
mouse |
| Cornelia Kiewert, Vikas Kumar, Oksana Hildmann, Joachim Hartmann, Markus Hillert, Jochen Klei. Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide. Brain research. vol 1201. 2008-07-28. PMID:18325484. |
in rat hippocampal slices exposed to n-methyl-d-aspartate (nmda), release of choline indicates breakdown of membrane phospholipids. |
2008-07-28 |
2023-08-12 |
rat |
| J J Arnaiz-Cot, J C González, M Sobrado, P Baldelli, E Carbone, L Gandía, A G García, J M Hernández-Guij. Allosteric modulation of alpha 7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission. The European journal of neuroscience. vol 27. issue 5. 2008-06-03. PMID:18312591. |
here we have studied the modulation of synaptic transmission by an agonist (choline) and an allosteric modulator (5-oh-indole) of alpha7 nachrs in rat hippocampal neuronal cultures. |
2008-06-03 |
2023-08-12 |
rat |
| b' Zdena Kristofikov\\xc3\\xa1, Vladim\\xc3\\xadr Kopeck\\xc3\\xbd, Katerina Hofbauerov\\xc3\\xa1, Petra Hovorkov\\xc3\\xa1, Daniela R\\xc3\\xadpov\\xc3\\xa. Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. Neurochemical research. vol 33. issue 3. 2008-05-06. PMID:17717740.' |
in this study, effects of amyloid beta peptides and of racemic 24-hydroxycholesterol were evaluated in vitro on undepleted or cholesterol-depleted hippocampal synaptosomes of young and old rats via a high-affinity choline transport and membrane anisotropy measurements. |
2008-05-06 |
2023-08-12 |
rat |
| Michael C Craig, Eileen M Daly, Ruth O'Gorman, Janice Rymer, David Lythgoe, Ginny Ng, Andrew Simmons, Pauline M Maki, Declan G M Murph. Effects of acute ovarian hormone suppression on the human brain: an in vivo 1H MRS study. Psychoneuroendocrinology. vol 32. issue 8-10. 2008-03-11. PMID:17658694. |
a previous proton magnetic resonance spectroscopy ((1)h mrs) study carried out by our group indicated that post-menopausal women who started taking oestrogen therapy (et) at or around the menopause had a significantly lower choline (cho) concentration in the hippocampus and parietal lobe than those who were et naïve, suggesting that long-term et positively modulates neuronal/glial membrane turnover in older females. |
2008-03-11 |
2023-08-12 |
human |
| Manickavasagom Alkondon, Edna F R Pereira, Edson X Albuquerqu. Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17645875. |
as previously observed in the hippocampus of rat pups, ca1 sr interneurons in the hippocampus of adult rats responded to choline (10mm, 12s) with whole-cell currents that decayed to the baseline within the agonist pulse, were sensitive to inhibition by methyllycaconitine (10nm) or alpha-bungarotoxin (50 nm), and were, therefore, mediated by alpha7*(1)[1] nachrs. |
2007-11-06 |
2023-08-12 |
rat |