| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariano G Blake, Mariano M Boccia, Gabriela B Acosta, Christian Höcht, Carlos M Baratt. Opposite effects of a single versus repeated doses of gabapentin on retention performance of an inhibitory avoidance response in mice. Neurobiology of learning and memory. vol 87. issue 2. 2007-03-21. PMID:16987675. |
the impairment on retention performance was correlated with a significant decrease in the high affinity choline uptake in the hippocampus at the end of the retention test. |
2007-03-21 |
2023-08-12 |
mouse |
| Alexander Sartorius, Patrick Schloss, Barbara Vollmayr, Gabriele Ende, Claudia Neumann-Haefelin, Mathias Hoehn, Fritz A Hen. Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 4. 2007-02-23. PMID:17071545. |
correlation between mr-spectroscopic rat hippocampal choline levels and phospholipase a2. |
2007-02-23 |
2023-08-12 |
human |
| Daniele Tomassoni, Roberto Avola, Fiorenzo Mignini, Lucilla Parnetti, Francesco Ament. Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain research. vol 1120. issue 1. 2007-01-23. PMID:16989788. |
effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. |
2007-01-23 |
2023-08-12 |
rat |
| Daniele Tomassoni, Roberto Avola, Fiorenzo Mignini, Lucilla Parnetti, Francesco Ament. Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain research. vol 1120. issue 1. 2007-01-23. PMID:16989788. |
the influence of long term treatment with choline alphoscerate on microanatomy of hippocampus and glial reaction was assessed in spontaneously hypertensive rats (shr) used as an animal model of cerebrovascular disease. |
2007-01-23 |
2023-08-12 |
rat |
| Daniele Tomassoni, Roberto Avola, Fiorenzo Mignini, Lucilla Parnetti, Francesco Ament. Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain research. vol 1120. issue 1. 2007-01-23. PMID:16989788. |
treatment with choline alphoscerate countered nerve cell loss and glial reaction primarily in the ca1 subfields and in the dentate gyrus of the hippocampus of shr. |
2007-01-23 |
2023-08-12 |
rat |
| Daniele Tomassoni, Roberto Avola, Fiorenzo Mignini, Lucilla Parnetti, Francesco Ament. Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain research. vol 1120. issue 1. 2007-01-23. PMID:16989788. |
these data suggest that choline alphoscerate may play a role in the countering hippocampal changes induced by cerebrovascular involvement. |
2007-01-23 |
2023-08-12 |
rat |
| Daniele Tomassoni, Roberto Avola, Fiorenzo Mignini, Lucilla Parnetti, Francesco Ament. Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain research. vol 1120. issue 1. 2007-01-23. PMID:16989788. |
the observation that treatment with choline alphoscerate attenuates the extent of glial reaction in the hippocampus of shr suggests also that the compound may afford neuroprotection in this animal model of vascular brain damage. |
2007-01-23 |
2023-08-12 |
rat |
| Amanda M Ill, Todd R Mitchell, Elizabeth B Neely, James R Conno. Metabolic analysis of mouse brains that have compromised iron storage. Metabolic brain disease. vol 21. issue 2-3. 2007-01-10. PMID:16855871. |
in h-ferritin deficient mice, we found significant increases in striatal glutamate, hippocampal choline, and n-acetyl-aspartyl-glutamate in both the cortex and the hippocampus (t-test, p < 0.05). |
2007-01-10 |
2023-08-12 |
mouse |
| Vikas Kumar, Alexander Mdzinarishvili, Cornelia Kiewert, Thomas Abbruscato, Ulrich Bickel, Cornelis J van der Schyf, Jochen Klei. NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort. Journal of pharmacological sciences. vol 102. issue 1. 2006-11-14. PMID:16936454. |
in rat hippocampal slices, hyperforin inhibited the nmda-receptor-mediated release of choline from phospholipids. |
2006-11-14 |
2023-08-12 |
mouse |
| Elizabeth A Donarum, Dietrich A Stephan, Kay Larkin, Eric J Murphy, Maneesh Gupta, Henry Senephansiri, Robert C Switzer, Phillip L Pearl, O Carter Snead, C Jakobs, K Michael Gibso. Expression profiling reveals multiple myelin alterations in murine succinate semialdehyde dehydrogenase deficiency. Journal of inherited metabolic disease. vol 29. issue 1. 2006-10-16. PMID:16601881. |
these results were confirmed by: (1) myelin basic protein (mbp) immunohistochemistry; (2) western blotting of myelin-associated glycoprotein (mag) and mbp; (3) qrt-pcr analyses of myelin-associated oligodendrocytic basic protein (mobp), mag, mbp and proteolipid protein (plp) in hippocampus, cortex and spinal cord; (4) quantitation of ethanolamine and choline plasmalogens, all core myelin components; (5) evaluation of myelin content in brain sections employing toluidine blue staining; and (6) ultrastructural evaluation of myelin sheath thickness via electron microscopy. |
2006-10-16 |
2023-08-12 |
mouse |
| Corneliu N Craciunescu, Renan Wu, Steven H Zeise. Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 10. 2006-10-05. PMID:16873886. |
dermal administration of dea diminishes hepatic stores of the essential nutrient choline, and we previously reported that dietary choline deficiency during pregnancy reduces neurogenesis and increases apoptosis in the hippocampus of fetal rats and mice. |
2006-10-05 |
2023-08-12 |
mouse |
| Manickavasagom Alkondon, Edson X Albuquerqu. Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16565162. |
using whole-cell patch-clamp recordings from neurons of rat hippocampal and dorsal striatal slices, we demonstrate that choline inhibited type iii nachr-mediated glutamate excitatory postsynaptic currents (epscs). |
2006-08-14 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerqu. Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16565162. |
choline inhibited ach-induced n-methyl-d-aspartate (nmda) epscs in ca1 stratum radiatum (sr) interneurons of rat hippocampal slices with an ic50 of approximately 15 microm. |
2006-08-14 |
2023-08-12 |
rat |
| Z Kristofiková, J Rícný, I Kozmiková, D Rípová, P Zach, J Klaschk. Sex-dependent actions of amyloid beta peptides on hippocampal choline carriers of postnatal rats. Neurochemical research. vol 31. issue 3. 2006-07-20. PMID:16733811. |
sex-dependent actions of amyloid beta peptides on hippocampal choline carriers of postnatal rats. |
2006-07-20 |
2023-08-12 |
human |
| Francesco Amenta, Seyed Khosrow Tayebati, Daniela Vitali, Maria Antonietta Di Tulli. Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission. Mechanisms of ageing and development. vol 127. issue 2. 2006-04-21. PMID:16297435. |
the effects of association of cholinergic precursors choline or choline alphoscerate with the cholinesterase inhibitor rivastigmine on acetylcholine levels and [(3)h]hemicholinium-3 binding were assessed in rat frontal cortex, hippocampus and striatum. |
2006-04-21 |
2023-08-12 |
rat |
| Kelly R Bales, Eleni T Tzavara, Su Wu, Mark R Wade, Frank P Bymaster, Steven M Paul, George G Nomiko. Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody. The Journal of clinical investigation. vol 116. issue 3. 2006-04-06. PMID:16498501. |
treatment of pdapp mice with the anti-a beta antibody m266 rapidly and completely restored hippocampal ach release and high-affinity choline uptake while greatly reducing impaired habituation learning that is characteristic of these mice. |
2006-04-06 |
2023-08-12 |
mouse |
| Mihai D Niculescu, Corneliu N Craciunescu, Steven H Zeise. Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 1. 2006-03-23. PMID:16394266. |
dietary choline deficiency alters global and gene-specific dna methylation in the developing hippocampus of mouse fetal brains. |
2006-03-23 |
2023-08-12 |
mouse |
| Mihai D Niculescu, Corneliu N Craciunescu, Steven H Zeise. Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 1. 2006-03-23. PMID:16394266. |
the availability of choline during critical periods of fetal development alters hippocampal development and affects memory function throughout life. |
2006-03-23 |
2023-08-12 |
mouse |
| Mihai D Niculescu, Corneliu N Craciunescu, Steven H Zeise. Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 1. 2006-03-23. PMID:16394266. |
choline deficiency during fetal development reduces proliferation and migration of neuronal precursor cells in the mouse fetal hippocampus and these changes are associated with modifications in the protein levels of some cell cycle regulators and early differentiation markers. |
2006-03-23 |
2023-08-12 |
mouse |
| X-M Meng, D-M Zhu, D-Y Ruan, J-Q She, L Lu. Effects of chronic lead exposure on 1H MRS of hippocampus and frontal lobes in children. Neurology. vol 64. issue 9. 2006-01-06. PMID:15883337. |
levels of n-acetyl aspartate (neuronal density and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabolism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs controls. |
2006-01-06 |
2023-08-12 |
Not clear |