| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tsung-Ming Shih, Oscar U Scremin, Margareth Roch, Ly Huynh, Wei Sun, Donald J Jende. Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats. Archives of toxicology. vol 80. issue 11. 2007-08-30. PMID:16628397. |
tissue levels of endogenous acetylcholine (d0ach), endogenous choline (d0ch), d4ch, and ach synthesized from d4ch (d4ach) were measured by gas-chromatography mass-spectrometry in hippocampus, infundibulum, mesencephalon, neocortex, piriform cortex, and striatum. |
2007-08-30 |
2023-08-12 |
rat |
| Cristiane Lopes, Edna F R Pereira, Hui-Qiu Wu, Puranik Purushottamachar, Vincent Njar, Robert Schwarcz, Edson X Albuquerqu. Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17446300. |
in the presence of tetrodotoxin (ttx), approximately 85% of cultured hippocampal neurons responded to choline (0.3-30 mm) with alpha7* nachr-subserved whole-cell (type ia) currents. |
2007-08-30 |
2023-08-12 |
rat |
| Kerry A Broom, Daniel C Anthony, John P Lowe, Julian L Griffin, Helen Scott, Andrew M Blamire, Peter Styles, V Hugh Perry, Nicola R Sibso. MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. Neurobiology of disease. vol 26. issue 3. 2007-08-24. PMID:17490889. |
using in vivo mrs, we found early (12 weeks) decreases in the ratio of n-acetyl aspartate to both choline (naa/cho) and creatine (naa/cr) in the thalamus and hippocampus, which were associated with early behavioural deficits. |
2007-08-24 |
2023-08-12 |
Not clear |
| Kazuya Miyagawa, Minoru Narita, Michiko Narita, Hisahiko Akama, Tsutomu Suzuk. Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A. Neuroscience letters. vol 418. issue 3. 2007-08-03. PMID:17467901. |
immunohistochemical study showed the dramatic reduction in choline acetyltransferase-like immunoreactivity, which is a marker of acetylcholine (ach) production, in the hippocampus of mice prenatally and neonatally exposed to bisphenol-a. |
2007-08-03 |
2023-08-12 |
mouse |
| Tiffany J Mellott, Neil W Kowall, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain research. vol 1151. 2007-07-24. PMID:17399691. |
prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. |
2007-07-24 |
2023-08-12 |
rat |
| Tiffany J Mellott, Neil W Kowall, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain research. vol 1151. 2007-07-24. PMID:17399691. |
the mechanism by which choline influences learning and memory remains unclear; however, it may involve changes to the hippocampal cholinergic system. |
2007-07-24 |
2023-08-12 |
rat |
| Tiffany J Mellott, Neil W Kowall, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain research. vol 1151. 2007-07-24. PMID:17399691. |
in the current study, we found that, during postnatal period [postnatal days (p) 18-480], prenatal choline deficiency increased the expression of cht mrna in the septum and cht mrna and protein levels in the hippocampus and altered the pattern of cht immunoreactivity in the dentate gyrus. |
2007-07-24 |
2023-08-12 |
rat |
| Melissa J Glenn, Erin M Gibson, Elizabeth D Kirby, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. The European journal of neuroscience. vol 25. issue 8. 2007-07-12. PMID:17445242. |
prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. |
2007-07-12 |
2023-08-12 |
rat |
| Melissa J Glenn, Erin M Gibson, Elizabeth D Kirby, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. The European journal of neuroscience. vol 25. issue 8. 2007-07-12. PMID:17445242. |
because neurogenesis in the adult hippocampus also declines with age, we investigated whether prenatal choline availability affects hippocampal neurogenesis in adult sprague-dawley rats and modifies their neurogenic response to environmental stimulation. |
2007-07-12 |
2023-08-12 |
rat |
| Melissa J Glenn, Erin M Gibson, Elizabeth D Kirby, Tiffany J Mellott, Jan K Blusztajn, Christina L William. Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. The European journal of neuroscience. vol 25. issue 8. 2007-07-12. PMID:17445242. |
we conclude that prenatal choline intake has enduring effects on adult hippocampal neurogenesis, possibly via up-regulation of bdnf levels, and suggest that these alterations of neurogenesis may contribute to the mechanism of life-long changes in cognitive function governed by the availability of choline during gestation. |
2007-07-12 |
2023-08-12 |
rat |
| L Wecker, W D Dettbarn, D E Schmid. Choline administration: modification of the central actions of atropine. Science (New York, N.Y.). vol 199. issue 4324. 2007-07-12. PMID:17569493. |
the anticholinergic agent atropine decreases acetylcholine concentrations and increases high-affinity choline uptake in cortical and hippocampal regions of rat brain. |
2007-07-12 |
2023-08-12 |
rat |
| Tiffany J Mellott, Maximillian T Follettie, Veronica Diesl, Andrew A Hill, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17264169. |
prenatal choline availability modulates hippocampal and cerebral cortical gene expression. |
2007-05-30 |
2023-08-12 |
rat |
| Tiffany J Mellott, Maximillian T Follettie, Veronica Diesl, Andrew A Hill, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17264169. |
we analyzed mrna expression in brains of prenatally choline-deficient, choline-supplemented, or control rats of various ages [postnatal days (p) 1 to 34 for hippocampus and e16 to p34 for cortex] using oligonucleotide microarrays and found alterations in gene expression levels evoked by prenatal choline intake that were, in most cases, transient occurring during the p15-p34 period. |
2007-05-30 |
2023-08-12 |
rat |
| Tiffany J Mellott, Maximillian T Follettie, Veronica Diesl, Andrew A Hill, Ignacio Lopez-Coviella, Jan Krzysztof Blusztaj. Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 7. 2007-05-30. PMID:17264169. |
prenatally choline deficient rats had the highest expression of camkiibeta, protein kinase cbeta2, and gaba(b) receptor 1 isoforms c and d in the hippocampus. |
2007-05-30 |
2023-08-12 |
rat |
| Sachin K Singhal, Li Zhang, Marisela Morales, Murat O. Antipsychotic clozapine inhibits the function of alpha7-nicotinic acetylcholine receptors. Neuropharmacology. vol 52. issue 2. 2007-04-10. PMID:17161853. |
in hippocampal slices, the whole-cell recordings from ca1 pyramidal neurons indicated that the increases in the frequency and amplitudes of the gaba-mediated spontaneous inhibitory postsynaptic currents induced by bath application of 2 mm choline, a specific agonist for alpha(7)-nach receptors, were abolished after 10 min application of 5 microm clozapine. |
2007-04-10 |
2023-08-12 |
xenopus_laevis |
| Steven H Zeise. The fetal origins of memory: the role of dietary choline in optimal brain development. The Journal of pediatrics. vol 149. issue 5 Suppl. 2007-04-03. PMID:17212955. |
the currently available animal data on choline and hippocampal development are compelling, but studies are needed to determine whether the same is true in humans. |
2007-04-03 |
2023-08-12 |
Not clear |
| Manickavasagom Alkondon, Edna F R Pereira, Michelle C Potter, Frederick C Kauffman, Robert Schwarcz, Edson X Albuquerqu. Strain-specific nicotinic modulation of glutamatergic transmission in the CA1 field of the rat hippocampus: August Copenhagen Irish versus Sprague-Dawley. Journal of neurophysiology. vol 97. issue 2. 2007-04-02. PMID:17151218. |
in hippocampal slices from both rat strains, choline (10 mm) evoked alpha7* nachr-mediated type ia currents in ca1 stratum radiatum (sr) interneurons. |
2007-04-02 |
2023-08-12 |
rat |
| Cornelia Kiewert, Vikas Kumar, Oksana Hildmann, Misty Rueda, Joachim Hartmann, Runa S Naik, Jochen Klei. Role of GABAergic antagonism in the neuroprotective effects of bilobalide. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17134681. |
in rat hippocampal slices exposed to nmda, release of choline indicates breakdown of membrane phospholipids. |
2007-03-27 |
2023-08-12 |
rat |
| Paul R Lockman, Julie Gaasch, Ghia McAfee, Thomas J Abbruscato, Cornelis J Van der Schyf, David D Alle. Nicotine exposure does not alter plasma to brain choline transfer. Neurochemical research. vol 31. issue 4. 2007-03-22. PMID:16758358. |
of considerable interest was a significant decrease in regional brain choline uptake measured in the hippocampus after chronic nicotine exposure (28 d). |
2007-03-22 |
2023-08-12 |
rat |
| Mariano G Blake, Mariano M Boccia, Gabriela B Acosta, Christian Höcht, Carlos M Baratt. Opposite effects of a single versus repeated doses of gabapentin on retention performance of an inhibitory avoidance response in mice. Neurobiology of learning and memory. vol 87. issue 2. 2007-03-21. PMID:16987675. |
the impairment on retention performance was correlated with a significant decrease in the high affinity choline uptake in the hippocampus at the end of the retention test. |
2007-03-21 |
2023-08-12 |
mouse |