| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Keefe, C R Gerfe. D1 dopamine receptor-mediated induction of zif268 and c-fos in the dopamine-depleted striatum: differential regulation and independence from NMDA receptors. The Journal of comparative neurology. vol 367. issue 2. 1996-09-11. PMID:8708002. |
however, unlike competitive antagonists, local infusion of 1 mm mk-801 potentiated d1-mediated increases in c-fos and zif268 mrnas in lateral striatum. |
1996-09-11 |
2023-08-12 |
rat |
| S A Thornberg, S R Sakla. A review of NMDA receptors and the phencyclidine model of schizophrenia. Pharmacotherapy. vol 16. issue 1. 1996-09-04. PMID:8700797. |
by decreasing glutamatergic neurotransmission, phencyclidine decreases gamma-aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by mk-801); may inhibit tonic release of dopamine from the nucleus accumbens and striatum, resulting in increased dopamine phasic reactivity; and decreases long-term potentiation. |
1996-09-04 |
2023-08-12 |
Not clear |
| C J Schmidt, G M Fadaye. Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade. The Journal of pharmacology and experimental therapeutics. vol 277. issue 3. 1996-08-06. PMID:8667221. |
mk-801 stimulated dopamine release in both the medial prefrontal cortex and the nucleus accumbens but tended to decrease release in the striatum. |
1996-08-06 |
2023-08-12 |
rat |
| I Liste, G Rozas, M J Guerra, J L Labandeira-Garci. Cortical stimulation induces Fos expression in striatal neurons via NMDA glutamate and dopamine receptors. Brain research. vol 700. issue 1-2. 1996-06-24. PMID:8624698. |
pretreatment with the non-competitive n-methyl-d-aspartate (nmda) glutamate receptor antagonist mk-801 led to a marked reduction in the stimulation-induced density of fos-immunoreactive nuclei in both the medial (about 80% reduction) and lateral (about 50-60% reduction) striatum. |
1996-06-24 |
2023-08-12 |
Not clear |
| S Tomitaka, K Hashimoto, N Narita, Y Minabe, A Tamur. Amantadine induces c-fos in rat striatum: reversal with dopamine D1 and NMDA receptor antagonists. European journal of pharmacology. vol 285. issue 2. 1996-03-05. PMID:8566141. |
pretreatment with the dopamine d1 receptor antagonist, sch23390, and the nmda receptor antagonist, mk-801, blocked amantadine induction of fos in the striatum. |
1996-03-05 |
2023-08-12 |
rat |
| N Laprade, J J Soghomonia. MK-801 decreases striatal and cortical GAD65 mRNA levels. Neuroreport. vol 6. issue 14. 1996-02-22. PMID:8547590. |
levels of mrnas encoding for the two isoforms of glutamate decarboxylase, gad67 and gad65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive nmda receptor antagonist mk-801. |
1996-02-22 |
2023-08-12 |
rat |
| W D Dietrich, B Lin, M Y Globus, E J Green, M D Ginsberg, R Bust. Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 15. issue 6. 1995-12-13. PMID:7593357. |
within the dorsolateral striatum, significant protection was documented with either postischemic hypothermia alone or delayed mk-801 treatment alone. |
1995-12-13 |
2023-08-12 |
rat |
| R N Aue. Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia. Neurological research. vol 17. issue 2. 1995-08-11. PMID:7609850. |
the neocortex showed a trend toward a progressively increasing benefit with the addition of u74006f, mk-801, insulin and diazepam, but no clear trends were apparent in hippocampus, striatum, or other brain regions. |
1995-08-11 |
2023-08-12 |
rat |
| H N Bhargava, P L Reddy, K P Gudehithl. Down-regulation of N-methyl-D-aspartate (NMDA) receptors of brain regions and spinal cord of rats treated chronically with morphine. General pharmacology. vol 26. issue 1. 1995-05-18. PMID:7713352. |
the binding of [3h]mk-801, an nmda receptor antagonist, to membranes prepared from spinal cord and brain regions (cortex, striatum, amygdala, hippocampus, hypothalamus, midbrain and pons-medulla) was determined using 5 nm concentration of the ligand in the presence of 30 microm glycine and 50 microm of glutamate. |
1995-05-18 |
2023-08-12 |
rat |
| E Aliaga, G Bustos, K Gyslin. Release of endogenous catecholamines from the striatum and bed nucleus of stria terminalis evoked by potassium and N-methyl-D-aspartate: in vitro microdialysis studies. Journal of neuroscience research. vol 40. issue 1. 1995-05-17. PMID:7714929. |
we confirmed that n-methyl-d-aspartate (2.5 and 5.0 mm in the dialysis perfusion solution) induces the release of dopamine from the striatum, and this effect was blocked by prior dialysis perfusion with 500 microm mk-801, a noncompetitive n-methyl-d-aspartate receptor antagonist. |
1995-05-17 |
2023-08-12 |
Not clear |
| H Dai, K Gebhardt, R J Care. Time course effects of MK-801: the relationship between brain neurochemistry and behavior. Brain research bulletin. vol 36. issue 2. 1995-04-24. PMID:7534612. |
serotonin metabolism was unaffected in striatum or medial prefrontal cortex across all injection intervals, and there was no effect of mk-801 on plasma corticosterone levels. |
1995-04-24 |
2023-08-12 |
rat |
| J Q Wang, J B Daunais, J F McGint. NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. Synapse (New York, N.Y.). vol 18. issue 4. 1995-04-10. PMID:7886627. |
mk-801 and cpp (at higher dose) alone suppressed basal (constitutive) zif/268 mrna levels in both striatum and cortex regions. |
1995-04-10 |
2023-08-12 |
rat |
| J A St-Pierre, P J Bédar. Intranigral but not intrastriatal microinjection of the NMDA antagonist MK-801 induces contralateral circling in the 6-OHDA rat model. Brain research. vol 660. issue 2. 1995-02-16. PMID:7820694. |
a similar injection of mk-801 (5 micrograms/1.0 microliter) in the striatum causes no rotation response. |
1995-02-16 |
2023-08-12 |
rat |
| Y Kanai, T Araki, H Kato, K Kogur. Effect of pentobarbital on postischemic MK-801, muscimol, and naloxone bindings in the gerbil brain. Brain research. vol 657. issue 1-2. 1995-02-14. PMID:7820643. |
five hours after ischemia, no conspicuous alteration in [3h]mk-801, [3h]muscimol, and [3h]naloxone binding was found in the striatum and hippocampus. |
1995-02-14 |
2023-08-12 |
Not clear |
| Y Kanai, T Araki, H Kato, K Kogur. Effect of pentobarbital on postischemic MK-801, muscimol, and naloxone bindings in the gerbil brain. Brain research. vol 657. issue 1-2. 1995-02-14. PMID:7820643. |
seven days after ischemia, [3h]mk-801 and [3h]naloxone binding was significantly decreased in the striatum and hippocampal area where histological neuronal damage was noted. |
1995-02-14 |
2023-08-12 |
Not clear |
| Y Kanai, T Araki, H Kato, K Kogur. Effect of pentobarbital on postischemic MK-801, muscimol, and naloxone bindings in the gerbil brain. Brain research. vol 657. issue 1-2. 1995-02-14. PMID:7820643. |
seven days after ischemia, pentobarbital partly ameliorated a significant reduction in [3h]mk-801 and [3h]naloxone binding in the striatum and hippocampus. |
1995-02-14 |
2023-08-12 |
Not clear |
| H Dai, R J Care. The NMDA antagonist MK-801 can impair attention to exteroceptive stimuli. Behavioural brain research. vol 62. issue 2. 1994-12-07. PMID:7945965. |
these findings are consistent with the hypothesis that blockade of glutamate neurotransmission by mk-801 impairs the flow of information from the external world to response mechanisms in the striatum. |
1994-12-07 |
2023-08-12 |
rat |
| C K Meshul, R K Stallbaumer, B Taylor, A Janowsk. Haloperidol-induced morphological changes in striatum are associated with glutamate synapses. Brain research. vol 648. issue 2. 1994-11-21. PMID:7922533. |
injection of mk-801 into the striatum also attenuated the haloperidol-induced increase in perforated synapses. |
1994-11-21 |
2023-08-12 |
Not clear |
| U Wüllner, A B Young, J B Penney, M F Bea. 3-Nitropropionic acid toxicity in the striatum. Journal of neurochemistry. vol 63. issue 5. 1994-11-16. PMID:7523600. |
three hours after a single injection of 3-np at a dose of 30 mg/kg there was a three- to fivefold increase in [3h]mk-801 binding in cortex and striatum as compared with saline-treated animals, consistent with an activation of nmda receptors. |
1994-11-16 |
2023-08-12 |
rat |
| T Shirotani, K Shima, M Iwata, H Kita, H Chigasak. Calcium accumulation following middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 14. issue 5. 1994-09-20. PMID:8063878. |
mk-801 significantly reduced 45ca uptake in the cortex, striatum, and thalamus. |
1994-09-20 |
2023-08-12 |
rat |