| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Kobayashi, O Inou. An increase in the in vivo binding of [3H]SCH 23390 induced by MK-801 in the mouse striatum. Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8497337. |
it was found that mk-801 increased the [3h]sch 23390 binding in the striatum in a dose-dependent manner, but did not influence the binding in the cerebral cortex. |
1993-06-21 |
2023-08-12 |
mouse |
| K Kobayashi, O Inou. An increase in the in vivo binding of [3H]SCH 23390 induced by MK-801 in the mouse striatum. Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8497337. |
an in vivo saturation study using varying doses of [3h]sch 23390 indicated that the maximum binding sites available (bmax) in the striatum was not altered by mk-801. |
1993-06-21 |
2023-08-12 |
mouse |
| S Subramaniam, P McGonigl. Regional heterogeneity of polyamine effects on the N-methyl-D-aspartate receptor in rat brain. Journal of neurochemistry. vol 60. issue 6. 1993-06-15. PMID:8492131. |
for example, spermidine enhances the binding of [3h]mk-801 to a much greater extent in the striatum than in the cortex. |
1993-06-15 |
2023-08-12 |
rat |
| S Subramaniam, P McGonigl. Regional heterogeneity of polyamine effects on the N-methyl-D-aspartate receptor in rat brain. Journal of neurochemistry. vol 60. issue 6. 1993-06-15. PMID:8492131. |
to further explore the basis for this regional heterogeneity, the effects of polyamines on [3h]mk-801 binding were measured in well-washed membranes prepared from frontal cortex and striatum. |
1993-06-15 |
2023-08-12 |
rat |
| L J Bristow, P H Hutson, L Thorn, M D Trickleban. The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents. British journal of pharmacology. vol 108. issue 4. 1993-06-04. PMID:8485625. |
in rats, pretreatment with pcp (5 and 10 mg kg-1) or mk-801 (0.25 and 0.5 mg kg-1) dose-dependently stimulated dopamine turnover in nucleus accumbens, amygdala and medial prefrontal cortex, but had no effect in striatum. |
1993-06-04 |
2023-08-12 |
mouse |
| D K Von Lubitz, R J McKenzie, R C Lin, T M Devlin, P Skolnic. MK-801 is neuroprotective but does not improve survival in severe forebrain ischemia. European journal of pharmacology. vol 233. issue 1. 1993-05-19. PMID:8472751. |
the effects of mk-801 on postischemic recovery, survival and neuronal preservation in the cortex, hippocampus and striatum were studied in mongolian gerbils. |
1993-05-19 |
2023-08-12 |
Not clear |
| M Morari, W T O'Connor, U Ungerstedt, K Fux. N-methyl-D-aspartic acid differentially regulates extracellular dopamine, GABA, and glutamate levels in the dorsolateral neostriatum of the halothane-anesthetized rat: an in vivo microdialysis study. Journal of neurochemistry. vol 60. issue 5. 1993-05-18. PMID:8097237. |
the effects of local perfusion with the glutamate receptor agonist nmda and the noncompetitive nmda receptor antagonist dizolcipine (mk-801) on extracellular dopamine (da), gaba, and glutamate (glu) levels in the dorsolateral striatum were monitored using in vivo microdialysis in the halothane-anesthetized rat. |
1993-05-18 |
2023-08-12 |
rat |
| S Y Sakurai, J B Penney, A B Youn. Regionally distinct N-methyl-D-aspartate receptors distinguished by quantitative autoradiography of [3H]MK-801 binding in rat brain. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8095974. |
cpp inhibited [3h]mk-801 binding in outer cortex (oc) and medial cortex (mc) with apparent ki values of 0.32-0.48 microm, whereas in the medial striatum (ms), lateral striatum (ls), ca1, and dentate gyrus (dg) of hippocampus, apparent ki values were 1.1-1.6 microm. |
1993-04-19 |
2023-08-12 |
rat |
| L K Fellows, M G Boutelle, M Fillen. Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8455025. |
local application of the noncompetitive n-methyl-d-aspartate receptor antagonist mk-801 had no effect on the tail pinch-stimulated increase in lactate in the striatum. |
1993-04-19 |
2023-08-12 |
rat |
| O Gandolfi, R Dall'Oli. Chronic treatment with MK-801 decreases D2 dopamine receptor function in rat striatum. Pharmacology, biochemistry, and behavior. vol 44. issue 3. 1993-04-12. PMID:8095727. |
chronic treatment with mk-801 decreases d2 dopamine receptor function in rat striatum. |
1993-04-12 |
2023-08-12 |
rat |
| O Gandolfi, R Rimondini, R Dall'Oli. The modulation of dopaminergic transmission in the striatum by MK-801 is independent of presynaptic mechanisms. Neuropharmacology. vol 31. issue 11. 1993-02-02. PMID:1335556. |
the modulation of dopaminergic transmission in the striatum by mk-801 is independent of presynaptic mechanisms. |
1993-02-02 |
2023-08-11 |
rat |
| O Gandolfi, R Rimondini, R Dall'Oli. The modulation of dopaminergic transmission in the striatum by MK-801 is independent of presynaptic mechanisms. Neuropharmacology. vol 31. issue 11. 1993-02-02. PMID:1335556. |
single or repeated administrations of mk-801 (0.25 mg/kg, i.p., daily for 21 consecutive days) failed to change levels of either dopamine (da) and dihydroxyphenylacetic acid (dopac) in the striatum of the rat or the haloperidol-induced (0.125 mg/kg, i.p.) |
1993-02-02 |
2023-08-11 |
rat |
| R W Fuller, S K Hemrick-Luecke, P L Ornstei. Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1436384. |
this prolonged depletion of dopamine in the striatum was antagonized by dizocilpine (mk-801, a non-competitive antagonist of nmda receptors) or by ly274614 (a competitive antagonist of nmda receptors). |
1992-12-17 |
2023-08-11 |
mouse |
| S P Sivam, T Cherma. Neonatal administration of L-cysteine does not produce long-term effects on neurotransmitter or neuropeptide systems in the rat striatum. Research communications in chemical pathology and pharmacology. vol 77. issue 2. 1992-11-27. PMID:1359616. |
previous studies by other investigators have shown that neonatal administration of high doses of l-cysteine produces within 6 hrs morphological damage to neurons in many areas of the brain including the striatum; the damage could be blocked by nmda antagonist mk-801. |
1992-11-27 |
2023-08-11 |
rat |
| P S Whitton, C S Biggs, B R Pearce, L J Fowle. Regional effects of MK-801 on dopamine and its metabolites studied by in vivo microdialysis. Neuroscience letters. vol 142. issue 1. 1992-11-04. PMID:1407718. |
in rat anterior striatum, mk-801 transiently decreased extracellular dopamine, in spite of inducing intense circling behaviour which is generally associated with an increase in this neurotransmitter. |
1992-11-04 |
2023-08-11 |
rat |
| T Ohmori, F Nakamura, T Koyama, I Yamashit. Amygdala kindling does not alter the N-methyl-D-aspartate receptor-channel complex which modulates dopamine release in the rat striatum and amygdala. Brain research. vol 587. issue 2. 1992-10-22. PMID:1388086. |
when assayed 5-7 days after the last evoked seizure, no difference was observed between kindled and non-kindled striatum in the ability of nmda to induce da release, or in the effect of mk-801 or 7-chlorokynurenic acid to inhibit the amino acid-induced transmitter release. |
1992-10-22 |
2023-08-11 |
rat |
| G Micheletti, B Lannes, C Haby, E Borrelli, E Kempf, J M Warter, J Zwille. Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat striatum. Brain research. Molecular brain research. vol 14. issue 4. 1992-10-19. PMID:1382178. |
dopamine d2 receptor gene expression was examined in rat striatum after chronic treatment with n-methyl-d-aspartate (nmda) receptor antagonists (ketamine at 15 mg/kg/day or mk-801 at 0.1, 0.2 and 0.4 mg/kg/day per os, for 50 days). |
1992-10-19 |
2023-08-11 |
rat |
| M Tamaru, Y Yoneda, K Ogita, J Shimizu, T Matsutani, Y Nagat. Excitatory amino acid receptors in brains of rats with methylazoxymethanol-induced microencephaly. Neuroscience research. vol 14. issue 1. 1992-09-21. PMID:1324453. |
however, specific bindings of radioligands in the striatum of mam rats were elevated by more than 60% of those in controls, and scatchard analysis revealed that elevations of [3h]glu, [3h]gly and [3h]mk-801 bindings were due to a significant increase in the densities of binding sites, with their affinities remaining unaltered. |
1992-09-21 |
2023-08-11 |
rat |
| K E Sabol, J B Richards, L S Seide. The NMDA receptor antagonist MK-801 does not protect against serotonin depletions caused by high doses of DL-fenfluramine. Brain research. vol 582. issue 1. 1992-09-14. PMID:1386771. |
two weeks post-treatment, mk-801 alone caused a small but significant decrease in 5ht tissue concentrations in striatum and amygdala. |
1992-09-14 |
2023-08-11 |
rat |
| K E Sabol, J B Richards, L S Seide. The NMDA receptor antagonist MK-801 does not protect against serotonin depletions caused by high doses of DL-fenfluramine. Brain research. vol 582. issue 1. 1992-09-14. PMID:1386771. |
mk-801 + fen enhanced 5ht depletions in striatum, hypothalamus and amygdala. |
1992-09-14 |
2023-08-11 |
rat |