| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Carboni, F Melis, L Pani, M Hadjiconstantinou, Z L Rossett. The non-competitive NMDA-receptor antagonist MK-801 prevents the massive release of glutamate and aspartate from rat striatum induced by 1-methyl-4-phenylpyridinium (MPP+). Neuroscience letters. vol 117. issue 1-2. 1991-04-01. PMID:1981252. |
the non-competitive nmda-receptor antagonist mk-801 prevents the massive release of glutamate and aspartate from rat striatum induced by 1-methyl-4-phenylpyridinium (mpp+). |
1991-04-01 |
2023-08-11 |
rat |
| S Subramaniam, P McGonigl. Quantitative autoradiographic characterization of the binding of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine ([3H]MK-801) in rat brain: regional effects of polyamines. The Journal of pharmacology and experimental therapeutics. vol 256. issue 2. 1991-03-21. PMID:1671602. |
the polyamine agonists spermine and spermidine enhanced [3h]mk-801 binding in all regions studied, with increases ranging from 18% in the thalamus to 106% in the ventromedial striatum. |
1991-03-21 |
2023-08-11 |
rat |
| S Subramaniam, P McGonigl. Quantitative autoradiographic characterization of the binding of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine ([3H]MK-801) in rat brain: regional effects of polyamines. The Journal of pharmacology and experimental therapeutics. vol 256. issue 2. 1991-03-21. PMID:1671602. |
diethylenetriamine, which blocks the effects of spermidine, by itself produced decreases in the binding of [3h]mk-801 in most regions ranging from 5 to 21% but increased binding in parts of the striatum by 3 to 22%. |
1991-03-21 |
2023-08-11 |
rat |
| J W McDonald, F S Silverstein, M V Johnsto. MK-801 pretreatment enhances N-methyl-D-aspartate-mediated brain injury and increases brain N-methyl-D-aspartate recognition site binding in rats. Neuroscience. vol 38. issue 1. 1991-01-24. PMID:2255390. |
a 2 h mk-801 pretreatment produced a 30-50% increase in [3h]glutamate binding at n-methyl-d-aspartate preferring recognition sites in all four brain regions examined (areas ca1 and ca3 of the hippocampus, corpus striatum, cingulate cortex) in comparison with saline-treated controls (p less than 0.05, anova). |
1991-01-24 |
2023-08-11 |
rat |
| M R Rod, I Q Whishaw, R N Aue. The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801. Canadian journal of psychology. vol 44. issue 2. 1990-09-20. PMID:2200595. |
mk-801 totally prevented neuronal necrosis in both the cerebral cortex and striatum and also prevented infarction in the neocortex and thalamus. |
1990-09-20 |
2023-08-11 |
rat |
| W Dimpfel, M Spüle. Dizocilpine (MK-801), ketamine and phencyclidine: low doses affect brain field potentials in the freely moving rat in the same way as activation of dopaminergic transmission. Psychopharmacology. vol 101. issue 3. 1990-08-08. PMID:2163537. |
mk-801 produced strongly dose-dependent effects which could be followed quantitatively over a time of 4 h. during this time spectral analysis of the field potentials continuously recorded from frontal cortex, hippocampus, striatum, and reticular formation revealed a particular pattern of changes which was very stable over time, and after low doses of 0.05 and 0.1 mg/kg, matched that produced by phencyclidine (2 and 4 mg/kg) or ketamine chloride (10 and 20 mg/kg). |
1990-08-08 |
2023-08-11 |
rat |
| A B Norman, L M Ford, M Kolmonpunporn, P R Sanber. Chronic treatment with MK-801 increases the quinolinic acid-induced loss of D-1 dopamine receptors in rat striatum. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:2139415. |
chronic treatment with mk-801 increases the quinolinic acid-induced loss of d-1 dopamine receptors in rat striatum. |
1990-05-31 |
2023-08-11 |
rat |
| A B Norman, L M Ford, M Kolmonpunporn, P R Sanber. Chronic treatment with MK-801 increases the quinolinic acid-induced loss of D-1 dopamine receptors in rat striatum. European journal of pharmacology. vol 176. issue 3. 1990-05-31. PMID:2139415. |
following withdrawal from short-term treatment with the non-competitive n-methyl-d-aspartate receptor antagonist mk-801 (1 mg/kg per day) there was no significant change in the bmax or kd of [3h]sch23390 binding to dopamine d-1 receptors in rat striatum. |
1990-05-31 |
2023-08-11 |
rat |
| T S Rao, H S Kim, J Lehmann, L L Martin, P L Woo. Interactions of phencyclidine receptor agonist MK-801 with dopaminergic system: regional studies in the rat. Journal of neurochemistry. vol 54. issue 4. 1990-04-20. PMID:2156013. |
mk-801 increased dopamine (da) metabolism in the pyriform cortex, entorhinal cortex, prefrontal cortex, striatum, olfactory tubercle, amygdala, and septum without affecting da metabolism in the cingulate cortex and nucleus accumbens. |
1990-04-20 |
2023-08-11 |
rat |
| A C Foster, R Gill, G N Woodruf. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 12. 1989-01-26. PMID:2904493. |
the ability of the noncompetitive n-methyl-d-aspartate (nmda) receptor antagonist mk-801 to prevent neuronal degeneration in the rat striatum and hippocampus caused by intracerebral injection of excitotoxins has been examined. |
1989-01-26 |
2023-08-11 |
rat |
| A C Foster, R Gill, G N Woodruf. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 12. 1989-01-26. PMID:2904493. |
in the striatum, significant protection of cholinergic neurons (assessed by chat measurements) was observed when mk-801 was given up to 5 hr after injection of nmda or quinolinate, whereas protection of gabaergic neurons (assessed by gad measurements) was obtained up to 2 hr. |
1989-01-26 |
2023-08-11 |
rat |
| G E Marti. Catecholamine release within the striatum of the freely moving rat. Annals of the New York Academy of Sciences. vol 473. 1987-02-19. PMID:3541735. |
in the second experiment, mk-801, a novel experimental compound, was found to be dissimilar from amphetamine insofar as it does not produce the release of [3h]dopamine from the striatum during its local application. |
1987-02-19 |
2023-08-11 |
rat |