| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D M Bronstein, H Ye, K R Pennypacker, P M Hudson, J S Hon. Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat. Brain research. Molecular brain research. vol 23. issue 3. 1994-09-12. PMID:7914658. |
while co-administration of the nmda receptor antagonist, mk-801, inhibited apo-induced increases in dyn and fos/fra expression in the intact striatum, its only effect in the da-denervated striatum was a partial (35%) inhibition of the apo-induced increase in dyn-ir concentrations. |
1994-09-12 |
2023-08-12 |
rat |
| K P Gudehithlu, P L Reddy, H N Bhargav. Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat. Brain research. vol 639. issue 2. 1994-07-13. PMID:7911390. |
the binding constants, bmax and kd values of [3h]mk-801 were determined in cortex, hippocampus, hypothalamus, corpus striatum, midbrain and spinal cord. |
1994-07-13 |
2023-08-12 |
rat |
| Z H Qin, S P Zhang, B Weis. Dopaminergic and glutamatergic blocking drugs differentially regulate glutamic acid decarboxylase mRNA in mouse brain. Brain research. Molecular brain research. vol 21. issue 3-4. 1994-06-01. PMID:8170353. |
infusion of mk-801 produced a rapid and marked decrease in the levels of gad mrna in corpus striatum, nucleus accumbens, olfactory tubercle, septum and frontal and parietal cortex; significant changes were seen as early as 2 days of treatment. |
1994-06-01 |
2023-08-12 |
mouse |
| Z H Qin, S P Zhang, B Weis. Dopaminergic and glutamatergic blocking drugs differentially regulate glutamic acid decarboxylase mRNA in mouse brain. Brain research. Molecular brain research. vol 21. issue 3-4. 1994-06-01. PMID:8170353. |
cellular analysis of emulsion autoradiograms from corpus striatum revealed that mk-801 reduced the amount of gad mrna in individual cells as well as the proportion of cells expressing high levels of gad mrna. |
1994-06-01 |
2023-08-12 |
mouse |
| S Goto, K Korematsu, N Inoue, K Yamada, T Oyama, S Nagahiro, Y Ushi. N-methyl-D-aspartate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions or nigral 6-hydroxydopamine lesions. Acta neuropathologica. vol 86. issue 5. 1994-03-14. PMID:8310798. |
in relation to a functional model of the basal ganglia-thalamocortical 'motor' circuit, the present data suggest that the striatum may be one of the most important sites where mk-801 acts in the basal ganglia, with its being responsible for the circling behavior of the animal models. |
1994-03-14 |
2023-08-12 |
rat |
| P Gass, T Herdegen, R Bravo, M Kiesslin. Spatiotemporal induction of immediate early genes in the rat brain after limbic seizures: effects of NMDA receptor antagonist MK-801. The European journal of neuroscience. vol 5. issue 7. 1994-02-15. PMID:8281303. |
in contrast, mk-801 abolished ieg induction in the somatosensory cortex and striatum, suggesting that ieg expression in non-limbic neurons occurs transsynaptically and is mediated by nmda receptors. |
1994-02-15 |
2023-08-12 |
rat |
| P Chan, J W Langston, D A Di Mont. MK-801 temporarily prevents MPTP-induced acute dopamine depletion and MPP+ elimination in the mouse striatum. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263813. |
mk-801 temporarily prevents mptp-induced acute dopamine depletion and mpp+ elimination in the mouse striatum. |
1994-01-27 |
2023-08-12 |
mouse |
| A Santamaría, C Río. MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neuroscience letters. vol 159. issue 1-2. 1994-01-25. PMID:8264978. |
mk-801, an n-methyl-d-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. |
1994-01-25 |
2023-08-12 |
rat |
| K Wedzony, V Klimek, K Gołembiowsk. MK-801 elevates the extracellular concentration of dopamine in the rat prefrontal cortex and increases the density of striatal dopamine D1 receptors. Brain research. vol 622. issue 1-2. 1994-01-06. PMID:8242376. |
mk-801 used in similar range of doses (0.2, 0.4 mg/kg) failed to alter the da content in superfusates of the rat striatum (str). |
1994-01-06 |
2023-08-12 |
rat |
| L Massieu, K H Thedinga, M McVey, G E Fag. A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy. Neuroscience. vol 55. issue 4. 1993-12-02. PMID:7694181. |
competition studies indicated that, when coinjected with 100-400 nmol quinolinic acid into the striatum, cgp 37849 exhibited kinetics predicted of a competitive n-methyl-d-aspartate receptor antagonist (declining neuroprotective potency with increasing doses of agonist), whereas mk-801 displayed a complex picture, with weak protective activity at low doses of quinolinic acid. |
1993-12-02 |
2023-08-12 |
rat |
| B Ziólkowska, V Höll. The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum. Neuroscience letters. vol 156. issue 1-2. 1993-11-16. PMID:8414186. |
the nmda receptor antagonist mk-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum. |
1993-11-16 |
2023-08-12 |
mouse |
| B Lin, W D Dietrich, M D Ginsberg, M Y Globus, R Bust. MK-801 (dizocilpine) protects the brain from repeated normothermic global ischemic insults in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 13. issue 6. 1993-11-12. PMID:8408318. |
the degree of mk-801 protection of striatal neurons was less complete than that seen in other vulnerable structures, amounting to 63% for central striatum (p = 0.02, mann-whitney u test) and 48% in the dorsolateral striatum (ns). |
1993-11-12 |
2023-08-12 |
rat |
| T Araki, Y Kanai, F Murakami, H Kato, K Kogur. Postischemic changes in the binding of excitatory and inhibitory neurotransmitters in the gerbil brain. Pharmacology, biochemistry, and behavior. vol 45. issue 4. 1993-10-26. PMID:8105492. |
[3h]mk-801 binding showed no significant changes in the striatum and hippocampus at an early stage (1-24 h) after ischemia. |
1993-10-26 |
2023-08-12 |
Not clear |
| T Araki, Y Kanai, F Murakami, H Kato, K Kogur. Postischemic changes in the binding of excitatory and inhibitory neurotransmitters in the gerbil brain. Pharmacology, biochemistry, and behavior. vol 45. issue 4. 1993-10-26. PMID:8105492. |
thereafter, [3h]mk-801 binding exhibited a significant reduction in the dorsolateral striatum, most of hippocampal ca1 sector and dentate gyrus 48 h or 7 days of recirculation. |
1993-10-26 |
2023-08-12 |
Not clear |
| J G Greene, R H Porter, R V Eller, J T Greenamyr. Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8360680. |
we now report that reversible inhibition of succinate dehydrogenase (sdh), an enzyme central to both the tricarboxylic acid cycle and the electron transport chain, produces an "excitotoxic" lesion in rat striatum that can be blocked by the nmda antagonist mk-801. |
1993-09-27 |
2023-08-12 |
rat |
| D Burtrum, F S Silverstei. Excitotoxic injury stimulates glial fibrillary acidic protein mRNA expression in perinatal rat brain. Experimental neurology. vol 121. issue 1. 1993-06-24. PMID:8495707. |
injection of nmda into the posterior striatum elicits dose-dependent ipsilateral injury to striatum, hippocampus, and overlying cortex; treatment with the non-competitive nmda antagonist mk-801 is neuroprotective. |
1993-06-24 |
2023-08-12 |
rat |
| D Burtrum, F S Silverstei. Excitotoxic injury stimulates glial fibrillary acidic protein mRNA expression in perinatal rat brain. Experimental neurology. vol 121. issue 1. 1993-06-24. PMID:8495707. |
to examine regionally specific changes in gfap mrna expression after lesioning, gfap mrna content was assayed, by northern analysis, in pooled tissue samples of striatum, hippocampus, and cortex, derived from the injected and contralateral hemispheres of animals killed 1-16 days after lesioning with nmda (12.5 nmol), and in samples derived from lesioned animals and littermates treated with mk-801. |
1993-06-24 |
2023-08-12 |
rat |
| H E Criswell, K B Johnson, R A Mueller, G R Brees. Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8098756. |
in support of a regional action of mk-801, mk-801 induced c-fos-like immunoreactivity in the cerebral cortex, but not in the nucleus accumbens or striatum. |
1993-06-22 |
2023-08-12 |
rat |
| H E Criswell, K B Johnson, R A Mueller, G R Brees. Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8098756. |
additionally, mk-801 reduced, but did not eliminate, d1-dopamine agonist induced c-fos-like immunoreactivity in striatum. |
1993-06-22 |
2023-08-12 |
rat |
| K Kobayashi, O Inou. An increase in the in vivo binding of [3H]SCH 23390 induced by MK-801 in the mouse striatum. Neuropharmacology. vol 32. issue 4. 1993-06-21. PMID:8497337. |
an increase in the in vivo binding of [3h]sch 23390 induced by mk-801 in the mouse striatum. |
1993-06-21 |
2023-08-12 |
mouse |