| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Nakano, K Takatoku, Y Matoba, B Iwamoto, M Nishiura, O Inoue, T Nishimur. Enhancement of in vivo binding of [123I]beta-CIT by MK-801 in rat brain. Synapse (New York, N.Y.). vol 30. issue 4. 1999-01-22. PMID:9826232. |
the in vivo [123i]beta-cit binding in the striatum, frontal cortex, occipital cortex, hypothalamus, and thalamus was significantly increased by pretreatment with 1 mg/kg of mk-801. |
1999-01-22 |
2023-08-12 |
rat |
| Y Ikarashi, A Takahashi, H Ishimaru, T Shiobara, Y Maruyam. The role of nitric oxide in striatal acetylcholine release induced by N-methyl-D-aspartate. Neurochemistry international. vol 33. issue 3. 1998-12-11. PMID:9759921. |
nmda caused a significant increase in ach release in the striatum, which was blocked by the specific nmda receptor antagonists, (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (cpp) and (+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (mk-801), indicating that agonist-evoked increase in ach release in the striatum was through an nmda receptor-mediated mechanism. |
1998-12-11 |
2023-08-12 |
rat |
| J J Mitchell, K J Anderso. Age-related changes in [3H]MK-801 binding in the Fischer 344 rat brain. Neurobiology of aging. vol 19. issue 3. 1998-09-16. PMID:9662001. |
the number of nmda receptors, as determined by [3h]mk-801 binding in the presence of a saturating concentration of l-glutamate, was reduced in the inner frontal cortex, entorhinal cortex and the lateral striatum in aged rats when compared with young adults. |
1998-09-16 |
2023-08-12 |
rat |
| A K Butler, K Uryu, M F Chessele. A role for N-methyl-D-aspartate receptors in the regulation of synaptogenesis and expression of the polysialylated form of the neural cell adhesion molecule in the developing striatum. Developmental neuroscience. vol 20. issue 2-3. 1998-09-11. PMID:9691199. |
administration of mk-801, an antagonist of n-methyl-d-aspartate receptors, on day 20, either peripherally or locally into the striatum, decreases asymmetric synapse number by 30% and totally abolishes immunolabelling for psa-ncam in the dorsolateral striatum. |
1998-09-11 |
2023-08-12 |
rat |
| A Snyder-Keller, R W Kelle. Stimulant-mediated c-fos induction in striatum as a function of age, sex, and prenatal cocaine exposure. Brain research. vol 794. issue 1. 1998-09-02. PMID:9630536. |
in females only, mk-801 pretreatment resulted in a dramatic increase in the number of fos-immunoreactive cells in lateral striatum. |
1998-09-02 |
2023-08-12 |
rat |
| E Lopez-Martin, G Rozas, J Rodriguez, M J Guerra, J L Labandeira-Garci. The corticostriatal system mediates the "paradoxical" contraversive rotation but not the striatal hyperexpression of Fos induced by amphetamine early after 6-hydroxydopamine lesion of the nigrostriatal pathway. Experimental brain research. vol 120. issue 2. 1998-08-27. PMID:9629957. |
pretreatment with the n-methyl-d-aspartate (nmda) glutamate receptor antagonist mk-801 (either 0.5 mg/kg or 5 mg/kg) did not significantly affect the hyperexpression of fos in the lesioned striatum, but suppressed the contraversive rotation. |
1998-08-27 |
2023-08-12 |
rat |
| M F Kuo, D Song, S Murphy, M D Papadopoulos, D F Wilson, A Pastuszk. Excitatory amino acid receptor antagonists decrease hypoxia induced increase in extracellular dopamine in striatum of newborn piglets. Neurochemistry international. vol 32. issue 3. 1998-07-14. PMID:9587922. |
the nmda receptor antagonist, mk-801, may exert part of its reported neuroprotective effect to hypoxic stress in striatum by decreasing the levels of extracellular dopamine. |
1998-07-14 |
2023-08-12 |
Not clear |
| E Nakazato, M Ohno, S Watanab. MK-801 reverses Fos expression induced by the full dopamine D1 receptor agonist SKF-82958 in the rat striatum. European journal of pharmacology. vol 342. issue 2-3. 1998-06-08. PMID:9548387. |
mk-801 reverses fos expression induced by the full dopamine d1 receptor agonist skf-82958 in the rat striatum. |
1998-06-08 |
2023-08-12 |
rat |
| H Ozer, A C Ekinci, M S Star. Dopamine D1- and D2-dependent catalepsy in the rat requires functional NMDA receptors in the corpus striatum, nucleus accumbens and substantia nigra pars reticulata. Brain research. vol 777. issue 1-2. 1998-02-24. PMID:9449412. |
mk-801, 0.2 mg/kg i.p., strongly opposed the cataleptogenic actions of sch 23390 and raclopride administered systemically (1 and 3 mg/kg i.p., respectively), or directly into the corpus striatum (cs) or nucleus accumbens (nac; 1 and 10 microg, respectively). |
1998-02-24 |
2023-08-12 |
rat |
| H N Bhargava, S Kumar, J T Bia. Up-regulation of brain N-methyl-D-aspartate receptors following multiple intracerebroventricular injections of [D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin II in mice. Peptides. vol 18. issue 10. 1998-02-18. PMID:9437723. |
the binding of [3h]mk-801 was determined in brain regions (cortex, midbrain, pons and medulla, hippocampus, striatum, hypothalamus and amygdala). |
1998-02-18 |
2023-08-12 |
mouse |
| P Hartvig, J Valtysson, G Antoni, G Westerberg, B Långström, E Ratti Moberg, I Oy. Brain kinetics of (R)- and (S)-[N-methyl-11C]ketamine in the rhesus monkey studied by positron emission tomography (PET). Nuclear medicine and biology. vol 21. issue 7. 1997-09-22. PMID:9234346. |
the binding in the striatum and cortical areas of (s)-[n-methyl-11c]ketamine was selective and displaceable by the (r)-enantiomer and by mk-801. |
1997-09-22 |
2023-08-12 |
monkey |
| B Lannes, G Michelett. Sensitization of the striatal dopaminergic system induced by chronic administration of a glutamate antagonist in the rat. Neuroscience and biobehavioral reviews. vol 21. issue 4. 1997-08-05. PMID:9195599. |
the aim of the present study was to assess in the rat the pharmacological, biochemical and molecular (including in situ hybridization) consequences in the striatum of a prolonged (50 days) treatment with dizocilpine maleate (mk-801), an n-methyl-d-aspartate (nmda) antagonist. |
1997-08-05 |
2023-08-12 |
rat |
| B Lannes, G Michelett. Sensitization of the striatal dopaminergic system induced by chronic administration of a glutamate antagonist in the rat. Neuroscience and biobehavioral reviews. vol 21. issue 4. 1997-08-05. PMID:9195599. |
in rats chronically treated with mk-801, this hyperresponsiveness was associated with an increased d2 receptor (d2r) density in the striatum. |
1997-08-05 |
2023-08-12 |
rat |
| A Mele, D Fontana, A Per. Alterations in striatal dopamine overflow during rotational behavior induced by amphetamine, phencyclidine, and MK-801. Synapse (New York, N.Y.). vol 26. issue 3. 1997-08-01. PMID:9183811. |
mk-801 also had a comparable behavioral effect but failed to alter da overflow in the intact striatum. |
1997-08-01 |
2023-08-12 |
rat |
| A Mele, D Fontana, A Per. Alterations in striatal dopamine overflow during rotational behavior induced by amphetamine, phencyclidine, and MK-801. Synapse (New York, N.Y.). vol 26. issue 3. 1997-08-01. PMID:9183811. |
since mk-801, a noncompetitive nmda antagonist which does not enhance extracellular dopamine in the striatum, is able to produce ipsilateral rotational behavior in rats with unilateral nigrostriatal lesions, it is likely that the effects of pcp may also be determined predominantly through nmda blockade in this model. |
1997-08-01 |
2023-08-12 |
rat |
| C Malcon, M Achaval, F Komlos, W Partata, M Sauressig, G Ramírez, D O Souz. GMP protects against quinolinic acid-induced loss of NADPH-diaphorase-positive cells in the rat striatum. Neuroscience letters. vol 225. issue 3. 1997-07-18. PMID:9147391. |
the latter cells are destroyed by quinolinic acid injections of 180 nmol per striatum, this effect being blocked by the concomitant administration of 5 mg/kg of the non-competitive n-methyl-d-aspartate antagonist mk-801. |
1997-07-18 |
2023-08-12 |
rat |
| D A Cory-Slechta, M Garcia-Osuna, J T Greenamyr. Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration. Behavioural brain research. vol 85. issue 2. 1997-07-15. PMID:9105573. |
it examined correlations between pb-induced changes in [3h]mk-801 and [3h]cgp-39653 binding sites in 4 different brain regions (frontal cortex, dentate gyrus, ca1 and striatum) and (1) changes in learning accuracy on a multiple repeated acquisition and performance schedule, and (2) sensitivity to the accuracy-impairing effects of mk-801 and nmda on this learning baseline. |
1997-07-15 |
2023-08-12 |
rat |
| A A Mathé, S Gruber, P A Jiménez, E Theodorsson, C Stenfor. Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain. Neurochemical research. vol 22. issue 5. 1997-06-20. PMID:9131643. |
although the higher mk-801 dose reduced seizure duration by 50%, the ecs induced npy-li increase in striatum, occipital cortex and hippocampus, and nka-li in occipital cortex was not diminished. |
1997-06-20 |
2023-08-12 |
rat |
| S Consolo, G Baldi, S Giorgi, L Nannin. The cerebral cortex and parafascicular thalamic nucleus facilitate in vivo acetylcholine release in the rat striatum through distinct glutamate receptor subtypes. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996820. |
or 12.8 microm infused into the striatum), but not the nmda-type receptor antagonist mk-801 (0.2 mg/kg, i.p. |
1997-05-29 |
2023-08-12 |
rat |
| M D Hajji, P Salin, L Kerkerian-Le Gof. Repeated injections of dizocilpine maleate (MK-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (GAD67) mRNA expression in the adult rat striatum. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037536. |
repeated injections of dizocilpine maleate (mk-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (gad67) mrna expression in the adult rat striatum. |
1997-05-29 |
2023-08-12 |
rat |