| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ganguly, K A Keef. Effects of MK-801 on D1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum. Brain research. vol 871. issue 1. 2000-09-29. PMID:10882795. |
effects of mk-801 on d1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum. |
2000-09-29 |
2023-08-12 |
rat |
| J Storgaard, B T Kornblit, J Zimmer, J B Gramsberge. 3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877933. |
furthermore, striatum from corticostriatal cocultures was more sensitive to 3-npa than striatum without cortex and tetrodotoxin, mk-801, and d-2-amino-5-phosphonopentanoic acid prevented or attenuated 3-npa neurotoxicity, suggesting that membrane depolarization and/or neuronal activity of the glutamatergic corticostriatal pathway contributes to striatal pathology. |
2000-08-16 |
2023-08-12 |
Not clear |
| M Sitges, V Nekrassov, A Guarnero. Simultaneous action of MK-801 (dizclopine) on dopamine, glutamate, aspartate and GABA release from striatum isolated nerve endings. Brain research. vol 854. issue 1-2. 2000-07-27. PMID:10784106. |
simultaneous action of mk-801 (dizclopine) on dopamine, glutamate, aspartate and gaba release from striatum isolated nerve endings. |
2000-07-27 |
2023-08-12 |
rat |
| M Sitges, V Nekrassov, A Guarnero. Simultaneous action of MK-801 (dizclopine) on dopamine, glutamate, aspartate and GABA release from striatum isolated nerve endings. Brain research. vol 854. issue 1-2. 2000-07-27. PMID:10784106. |
the simultaneous effect of mk-801 on the baseline- and depolarization (20 microm veratridine or 30 mm high k+)-evoked release of endogenous dopamine, glutamate (glu), aspartate (asp), and gaba is investigated in the same preparation of rat striatum isolated nerve endings. |
2000-07-27 |
2023-08-12 |
rat |
| M Sitges, V Nekrassov, A Guarnero. Simultaneous action of MK-801 (dizclopine) on dopamine, glutamate, aspartate and GABA release from striatum isolated nerve endings. Brain research. vol 854. issue 1-2. 2000-07-27. PMID:10784106. |
(2) the voltage-dependent action, which inhibits all the veratridine-evoked responses including the evoked release of the excitatory amino acids (which are particularly concentrated in striatum nerve endings), and might contribute to the anticonvulsant and neuroprotective effects of mk-801. |
2000-07-27 |
2023-08-12 |
rat |
| F J Wan, H C Lin, Y S Lin, C J Tsen. Intra-striatal infusion of D-amphetamine induces hydroxyl radical formation: inhibition by MK-801 pretreatment. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698008. |
additionally, infusion of amph in the striatum increased extracellular dopamine concentration and this effect was potentiated by mk-801 pretreatment. |
2000-05-16 |
2023-08-12 |
rat |
| P Teismann, B Ferge. Comparison of the novel drug Ensaculin with MK-801 on the reduction of hydroxyl radical production in rat striatum after local application of glutamate. Brain research. vol 857. issue 1-2. 2000-05-04. PMID:10700564. |
comparison of the novel drug ensaculin with mk-801 on the reduction of hydroxyl radical production in rat striatum after local application of glutamate. |
2000-05-04 |
2023-08-12 |
rat |
| G D Zeevalk, L Manzino, P K Sonsall. NMDA receptors modulate dopamine loss due to energy impairment in the substantia nigra but not striatum. Experimental neurology. vol 161. issue 2. 2000-03-29. PMID:10686083. |
mk-801 (0.1 micromol) provided significant protection against both nigral dopamine and gaba loss and against anterograde damage to dopamine terminals in the striatum. |
2000-03-29 |
2023-08-12 |
rat |
| M R Griffiths, A J Cooper, D J Barber, I J Mitchel. Pharmacological mechanisms mediating phencyclidine-induced apoptosis of striatopallidal neurons: the roles of glutamate, dopamine, acetylcholine and corticosteroids. Brain research. vol 855. issue 1. 2000-03-17. PMID:10650124. |
injection of neither mk-801 nor amphetamine induced elevations of apoptotic-like cells in the striatum nor did co-administration of sch23390 or scopolamine affect the levels of pcp-induced striatal cell death. |
2000-03-17 |
2023-08-12 |
rat |
| W T Lee, Y Z Shen, C Chan. Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy. Neuroscience. vol 95. issue 1. 2000-01-31. PMID:10619465. |
there were no significant differences in t2 values of the striatum and hippocampus among rats pretreated with mk-801, lamotrigine (20 mg/kg) and sham controls. |
2000-01-31 |
2023-08-12 |
rat |
| G W Kim, J C Copin, M Kawase, S F Chen, S Sato, G T Gobbel, P H Cha. Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616800. |
also, the n-methyl-d-aspartate (nmda) receptor antagonist, mk-801, prevented apoptosis in the striatum after 3-np treatment for 5 days, whereas the non-nmda receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline, was ineffective. |
2000-01-13 |
2023-08-12 |
mouse |
| E Acquas, S Fenu, P Loddo, G Di Chiar. A within-subjects microdialysis/behavioural study of the role of striatal acetylcholine in D1-dependent turning. Behavioural brain research. vol 103. issue 2. 1999-11-22. PMID:10513590. |
in rats lesioned with 6-hydroxydopamine (6-ohda) the effect of the noncompetitive n-methyl d-aspartate (nmda) receptor antagonist, mk-801, the dopamine (da) d2 receptor agonist quinpirole and the a2a adenosine antagonist sch 58261 was studied on acetylcholine (ach) release in the lesioned striatum and contralateral turning behaviour stimulated by the administration of the da d1 receptor agonist cy 208-243. |
1999-11-22 |
2023-08-12 |
rat |
| E Acquas, S Fenu, P Loddo, G Di Chiar. A within-subjects microdialysis/behavioural study of the role of striatal acetylcholine in D1-dependent turning. Behavioural brain research. vol 103. issue 2. 1999-11-22. PMID:10513590. |
these observations do not support the hypothesis that the potentiation of d1-dependent contralateral turning by mk-801, quinpirole or sch 58261 is mediated by changes in d1-stimulated release of ach in the striatum. |
1999-11-22 |
2023-08-12 |
rat |
| D A Cory-Slechta, D J O'Mara, B J Brocke. Learning versus performance impairments following regional administration of MK-801 into nucleus accumbens and dorsomedial striatum. Behavioural brain research. vol 102. issue 1-2. 1999-09-10. PMID:10403026. |
learning versus performance impairments following regional administration of mk-801 into nucleus accumbens and dorsomedial striatum. |
1999-09-10 |
2023-08-12 |
rat |
| D A Cory-Slechta, D J O'Mara, B J Brocke. Learning versus performance impairments following regional administration of MK-801 into nucleus accumbens and dorsomedial striatum. Behavioural brain research. vol 102. issue 1-2. 1999-09-10. PMID:10403026. |
to further ascertain the relative contributions of nucleus accumbens (nac) and dorsomedial striatum (ds) to cognitive behaviors, the comparative effects in rats of mk-801 microinjections into these regions on a multiple schedule of repeated learning (rl) and performance (p) were examined. |
1999-09-10 |
2023-08-12 |
rat |
| K Ossowska, M Pietraszek, J Wardas, G Nowak, S Wolfart. Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 4. 1999-07-23. PMID:10344526. |
the binding of [3h]mk-801 ([3h](5r, 10s)-(+)-5-methyl-10,1 11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine) and [3h]cgp 39653([3h]d,l-(e)-2-amino-4-propyl-5-phosphono-3-pentenoic acid) to nmda receptors in different cortical areas, as well as the binding of [3h]spiperone to dopamine d2 receptors in the striatum, were analysed by quantitative autoradiography. |
1999-07-23 |
2023-08-12 |
rat |
| O Inoue, S Wakahara, K Kobayashi, A Ge. Enhancement of 3H-N-methylspiperone binding but not 3H-raclopride binding in mouse striatum by MK-801: evidence that factors other than competition by endogenous dopamine are responsible for changes in D2 receptor binding in vivo. Short communication. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 2. 1999-06-21. PMID:10226933. |
enhancement of 3h-n-methylspiperone binding but not 3h-raclopride binding in mouse striatum by mk-801: evidence that factors other than competition by endogenous dopamine are responsible for changes in d2 receptor binding in vivo. |
1999-06-21 |
2023-08-12 |
mouse |
| O Inoue, S Wakahara, K Kobayashi, A Ge. Enhancement of 3H-N-methylspiperone binding but not 3H-raclopride binding in mouse striatum by MK-801: evidence that factors other than competition by endogenous dopamine are responsible for changes in D2 receptor binding in vivo. Short communication. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 2. 1999-06-21. PMID:10226933. |
in the striatum, mk-801 significantly increase 3h-nmsp binding, whereas no significant alterations in 3h-rac binding were seen. |
1999-06-21 |
2023-08-12 |
mouse |
| K Ogita, M Shuto, N Kuramoto, T Manabe, E Hinoi, T Kitayama, K Sakata, Y Yoned. Differential inhibition by ferrous ions of [3H]MK-801 binding to native N-methyl-D-aspartate channel in neonatal and adult rat brains. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082845. |
in the absence of spermidine, ferrous chloride was more potent in inhibiting binding in the cerebral cortex and hippocampus in adult rats than in those in rats at 3 days after birth, while in the striatum [3h]mk-801 binding was 10 times more sensitive to inhibition by added ferrous chloride in neonatal rats than in adult rats. |
1999-05-06 |
2023-08-12 |
rat |
| S Oh, C G Jang, I K H. Activation of protein kinase C by phorbol dibutyrate potentiates [3H]MK-801 binding in rat brain slices. Brain research. vol 793. issue 1-2. 1999-03-29. PMID:9630713. |
the density of [3h]mk-801 binding was highest in hippocampus and high levels were found in cortex, striatum and thalamus. |
1999-03-29 |
2023-08-12 |
rat |