| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julie Lemay-Clermont, Christine Robitaille, Yves P Auberson, Geneviève Bureau, Michel Cy. Blockade of NMDA receptors 2A subunit in the dorsal striatum impairs the learning of a complex motor skill. Behavioral neuroscience. vol 125. issue 5. 2012-06-28. PMID:21859173. |
to this end, we injected directly into the dorsal striatum of mice, via chronically implanted cannula, the nmdar channel blocker mk-801 as well as the nr2a and nr2b subunit-selective antagonists nvp-aam077 and ro 25-6981, respectively, before rotarod training. |
2012-06-28 |
2023-08-12 |
mouse |
| Philipp Singer, Detlev Boison, Hanns Möhler, Joram Feldon, Benjamin K Ye. Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 5. 2011-08-04. PMID:20647165. |
in contrast, restricting glyt1 deletion to neurons in forebrain including the striatum significantly attenuated ppi, and the animals remained sensitive to the ppi-disruptive effect of mk-801 at the same dose. |
2011-08-04 |
2023-08-12 |
mouse |
| Nada M-B Ben Abdallah, Johannes Fuss, Massimo Trusel, Michael J Galsworthy, Kristin Bobsin, Giovanni Colacicco, Robert M J Deacon, Marco A Riva, Christoph Kellendonk, Rolf Sprengel, Hans-Peter Lipp, Peter Gas. The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20851119. |
we evaluated the use of the puzzle box to explore executive functioning in five different mouse models of schizophrenia: mice with prefrontal cortex and hippocampus lesions, mice treated sub-chronically with the nmda-receptor antagonist mk-801, mice constitutively lacking the glua1 subunit of ampa-receptors, and mice over-expressing dopamine d2 receptors in the striatum. |
2011-02-04 |
2023-08-12 |
mouse |
| Bin Xu, Zhao-Fa Xu, Yu Den. Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 4. 2010-12-10. PMID:19540097. |
protective effects of mk-801 on manganese-induced glutamate metabolism disorder in rat striatum. |
2010-12-10 |
2023-08-12 |
rat |
| Bin Xu, Zhao-Fa Xu, Yu Den. Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 4. 2010-12-10. PMID:19540097. |
the present study has been carried out to investigate the mechanisms of glu metabolism disorder and the neuroprotective role of mk-801, a non-competitive n-methyl-d-aspartate receptor antagonist, against mn-induced excitotoxicity in rat striatum. |
2010-12-10 |
2023-08-12 |
rat |
| Bin Xu, Zhao-Fa Xu, Yu Den. Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 4. 2010-12-10. PMID:19540097. |
in addition, pre-treatment with mk-801 significantly reduced the striatum cell apoptosis rate. |
2010-12-10 |
2023-08-12 |
rat |
| Bin Xu, Zhao-Fa Xu, Yu Den. Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 4. 2010-12-10. PMID:19540097. |
in conclusion, the results suggest that mk-801 possesses the ability to attenuate mn-induced glu metabolism disorder in the striatum through mechanisms involving disruption enzyme activities of gs and pag. |
2010-12-10 |
2023-08-12 |
rat |
| Ke Jia, Zhaofa Xu, Bin X. [Effect of dizocilpine maleate and taurine on the circuitry of glutamate and glutamine in rat striatum exposed by manganese]. Wei sheng yan jiu = Journal of hygiene research. vol 37. issue 1. 2010-08-31. PMID:18421852. |
to observe the effect of mk-801 and taurine on the activities of gs and pag and the glutamatic neuron content in the rat striatum exposed by manganese. |
2010-08-31 |
2023-08-12 |
rat |
| b' Vesna Pesi\\xc4\\x87, Jelena Popi\\xc4\\x87, Desanka Milanovi\\xc4\\x87, Natasa Loncarevi\\xc4\\x87-Vasiljkovi\\xc4\\x87, Ljubisa Raki\\xc4\\x87, Selma Kanazir, Sabera Ruzdiji\\xc4\\x8. The effect of MK-801 on motor activity and c-Fos protein expression in the brain of adolescent Wistar rats. Brain research. vol 1321. 2010-06-09. PMID:20114033.' |
we also report a surprising finding that systemic application of mk-801 induced a similar age-related profile of changes in motor activity and c-fos protein expression in the motor cortex but no c-fos induction in the striatum. |
2010-06-09 |
2023-08-12 |
rat |
| Harald D Müller, Christian Berger, Stefan Schwab, Clemens Somme. Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition. Brain research. vol 1316. 2010-05-06. PMID:20026313. |
using quantitative receptor autoradiography, ligand binding densities of [(3)h]mk-801, [(3)h]ampa, and [(3)h]muscimol for labeling of nmda, ampa, and gaba(a) receptors were analyzed in sensorimotor cortices par1 and par2, the striatum, and the hippocampus. |
2010-05-06 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Krystyna Gołembiowska, Małgorzata Pietraszek, Jadwiga Warda. Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain. Pharmacological reports : PR. vol 61. issue 5. 2010-02-26. PMID:19904002. |
treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3h]mk-801 to nmda receptors in the dopaminergic structures of the rat brain. |
2010-02-26 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Krystyna Gołembiowska, Małgorzata Pietraszek, Jadwiga Warda. Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain. Pharmacological reports : PR. vol 61. issue 5. 2010-02-26. PMID:19904002. |
this study aimed to examine the effect of acute administration of 1,2,3,4-tetrahydroisoquinoline (tiq), an endo- and exogenous amine suspected of inducing parkinsonism in humans on the release of glutamate in the striatum as well as to assess the impact of its chronic treatment on the binding of [(3)h]mk-801 to nmda receptors in the dopaminergic structures of the rat brain. |
2010-02-26 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Krystyna Gołembiowska, Małgorzata Pietraszek, Jadwiga Warda. Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain. Pharmacological reports : PR. vol 61. issue 5. 2010-02-26. PMID:19904002. |
[(3)h]mk-801 binding to nmda receptors was examined in the striatum, nucleus accumbens and prefrontal cortex by autoradiographic method. |
2010-02-26 |
2023-08-12 |
rat |
| Harikesh Kalonia, Puneet Kumar, Bimla Nehru, Anil Kuma. Neuroprotective effect of MK-801 against intra-striatal quinolinic acid induced behavioral, oxidative stress and cellular alterations in rats. Indian journal of experimental biology. vol 47. issue 11. 2010-02-18. PMID:20099461. |
besides, mk-801 treatment significantly reversed histopathological alterations in striatum. |
2010-02-18 |
2023-08-12 |
rat |
| Vasily Vorobyov, Frank Sengpie. Apomorphine-induced differences in cortical and striatal EEG and their glutamatergic mediation in 6-hydroxydopamine-treated rats. Experimental brain research. vol 191. issue 3. 2008-12-16. PMID:18682921. |
in the 6-hydroxydopamine (6-ohda) rat model of parkinson's disease (pd), the frequency spectra of eeg in the cortex and the striatum were studied following injection of the dopamine agonist, apomorphine (apo) alone or in combination with the nmda antagonist, mk-801. |
2008-12-16 |
2023-08-12 |
rat |
| Vasily Vorobyov, Frank Sengpie. Apomorphine-induced differences in cortical and striatal EEG and their glutamatergic mediation in 6-hydroxydopamine-treated rats. Experimental brain research. vol 191. issue 3. 2008-12-16. PMID:18682921. |
pretreatment with mk-801 in 6-ohda rats eliminated the apo-induced difference between cortex and striatum in the beta range, inversed the effect in the alpha range, and intensified delta activity stronger in the striatum than in the cortex. |
2008-12-16 |
2023-08-12 |
rat |
| Mónica Padilla-de la Torre, Javier Franco-Pérez, Abel Santamaría, Sonia Galvan, Edith González, Carlos Pa. Effect of acetaldehyde on behavioral and neurochemical changes induced by MK-801 in rats. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991871. |
neurochemical analysis showed an increase in dopamine content in the striatum and frontal cortex after mk-801 administration, however; the increase was reversed by giving 200 mg/kg of ach. |
2008-12-09 |
2023-08-12 |
rat |
| Diego Centonze, Silvia Rossi, Paola De Bartolo, Valentina De Chiara, Francesca Foti, Alessandra Musella, Giorgia Mataluni, Stefano Rossi, Giorgio Bernardi, Giacomo Koch, Laura Petrosin. Adaptations of glutamatergic synapses in the striatum contribute to recovery from cerebellar damage. The European journal of neuroscience. vol 27. issue 8. 2008-07-01. PMID:18412636. |
accordingly, pharmacological blockade of glutamate n-methyl-d-aspartate (nmda) receptors with mk-801 prevented the rearrangement of excitatory synapses in the striatum and interfered with the recovery from motor disturbances in rats with cerebellar lesions. |
2008-07-01 |
2023-08-12 |
rat |
| Lucía Vidal, Rafael Durán, Lilian F Faro, Francisco Campos, Rosa C Cervantes, Miguel Alfons. Protection from inorganic mercury effects on the in vivo dopamine release by ionotropic glutamate receptor antagonists and nitric oxide synthase inhibitors. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17624650. |
the possible role of ionotropics glutamate receptors on the hgcl(2)-induced dopamine (da) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective nmda and ampa/kainate receptors antagonists dizocilpine (mk-801), d (-)-2-amino-5-phoshonopentanoic acid (ap5), and 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx). |
2007-10-31 |
2023-08-12 |
rat |
| Shinichiro Hirose, Yukiko Umetani, Misato Amitani, Rie Hosoi, Sotaro Momosaki, Jun Hatazawa, Antony Gee, Osamu Inou. Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate. Neuroscience letters. vol 415. issue 3. 2007-06-01. PMID:17280781. |
in addition, the enhancement of glucose metabolism in the striatum induced by fc was almost completely abolished by pretreatment with mk-801. |
2007-06-01 |
2023-08-12 |
rat |