| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deborah N D'Souza, Richard E Harlan, Meredith M Garci. Modulation of glutamate receptor expression by gonadal steroid hormones in the rat striatum. Brain research bulletin. vol 59. issue 4. 2003-02-27. PMID:12464400. |
the non-competitive n-methyl-d-aspartate (nmda) receptor antagonist dizocilpine (mk-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids. |
2003-02-27 |
2023-08-12 |
rat |
| Miriam Kolko, Elena B de Turco, Nils Henrik Diemer, Nicolas G Baza. Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors. Neuroreport. vol 13. issue 15. 2003-02-07. PMID:12395100. |
systemic administration of mk-801 to rats that had spla injected into the right striatum significantly decreased neuronal cell death. |
2003-02-07 |
2023-08-12 |
rat |
| Jean-Jacques Bacci, Pascal Salin, Lydia Kerkerian-Le Gof. Systemic administration of dizocilpine maleate (MK-801) or L-dopa reverses the increases in GAD65 and GAD67 mRNA expression in the globus pallidus in a rat hemiparkinsonian model. Synapse (New York, N.Y.). vol 46. issue 4. 2002-12-31. PMID:12373737. |
this study examined the consequences of systemic treatment with either l-dopa or mk-801 on the levels of mrnas encoding the 65 and 67 kda isoforms of glutamate decarboxylase (gad65 and gad67) in the striatum and globus pallidus (gp) of rats rendered hemiparkinsonian by intranigral 6-hydroxydopamine injection. |
2002-12-31 |
2023-08-12 |
rat |
| Shinya Kagawa, Takayuki Nakano, Osamu Inoue, Tsunehiko Nishimur. Effect of glutamatergic systems on in vivo binding of [(125)I]beta-CIT in the brain of a rat model of Parkinson's disease. Synapse (New York, N.Y.). vol 46. issue 1. 2002-10-16. PMID:12211097. |
however, in vivo [(125)i]beta-cit binding to the dopamine transporter in both nonlesioned and 6-ohda-lesioned striatum was significantly increased by pretreatment with mk-801. |
2002-10-16 |
2023-08-12 |
rat |
| Michaela M Kraus, Valentina Bashkatova, Anatoly Vanin, Athineos Philippu, Helmut Pras. Dizocilpine inhibits amphetamine-induced formation of nitric oxide and amphetamine-induced release of amino acids and acetylcholine in the rat brain. Neurochemical research. vol 27. issue 3. 2002-10-04. PMID:11958521. |
the effects of the non-competitive nmda receptor antagonist dizocilpine (mk-801) on amphetamine-induced toxicity and formation of nitric oxide (no) in both striatum and cortex and on induced transmitter release in the nucleus accumbens were investigated. |
2002-10-04 |
2023-08-12 |
rat |
| Joanne E Nash, Jonathan M Brotchi. Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 3. 2002-09-16. PMID:12112191. |
ifenprodil (100 nmol) and 7-chlorokynurenate (37 nmol), but not mk-801 (15 nmol) or d-apv (25 nmol) elicited a dramatic rotational response when injected into the dopamine-depleted striatum. |
2002-09-16 |
2023-08-12 |
rat |
| L R F Faro, J L M do Nascimento, M Alfonso, R Durá. Protection of methylmercury effects on the in vivo dopamine release by NMDA receptor antagonists and nitric oxide synthase inhibitors. Neuropharmacology. vol 42. issue 5. 2002-09-10. PMID:11985818. |
the possible protective effects of nmda receptor antagonists dizocilpine (mk-801) and d(-)-2-amino-5-phosphonopentanoic acid (ap5), and nitric oxide synthase (nos) inhibitors l-nitro-arginine methyl ester (l-name) and 7-nitro-indazol (7-ni) on the methylmercury (mehg)-induced dopamine (da) release from rat striatum were investigated using in vivo microdialysis. |
2002-09-10 |
2023-08-12 |
rat |
| A M Pacchioni, G Gioino, A Assis, L M Cancel. A single exposure to restraint stress induces behavioral and neurochemical sensitization to stimulating effects of amphetamine: involvement of NMDA receptors. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105099. |
we studied the following issues: (a) influence of a single restraint exposure on the stimulating effects of amphetamine on dopamine release by microdialysis from striatum and (b) involvement of glutamatergic pathways, specifically those innervating striatum, on stress-induced sensitization to amphetamine, by administering mk-801 ip (0.1 mg/kg) or intrastriatally (1 microg/0.5 microl) previous to an acute restraint stress. |
2002-08-02 |
2023-08-12 |
rat |
| A M Pacchioni, G Gioino, A Assis, L M Cancel. A single exposure to restraint stress induces behavioral and neurochemical sensitization to stimulating effects of amphetamine: involvement of NMDA receptors. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105099. |
for microdialysis studies (a) or intrastriatal administration of mk-801 (b), wistar rats (250-330 g) were implanted stereotactically under anesthesia with a guide cannula in the striatum. |
2002-08-02 |
2023-08-12 |
rat |
| T Araki, T Kumagai, K Tanaka, M Matsubara, H Kato, Y Itoyama, Y Ima. Neuroprotective effect of riluzole in MPTP-treated mice. Brain research. vol 918. issue 1-2. 2002-01-04. PMID:11684056. |
on the other hand, mk-801 prevented the mptp-induced decrease in dopac levels, but not in dopamine levels in the striatum. |
2002-01-04 |
2023-08-12 |
mouse |
| S Fenu, E Acquas, G Di Chiar. Role of striatal acetylcholine on dopamine D1 receptor agonist-induced turning behavior in 6-hydroxydopamine lesioned rats: a microdialysis-behavioral study. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 22. issue 1. 2001-12-13. PMID:11487203. |
the effects of mk-801, a non-competitive n-methyl d-aspartate (nmda) receptor antagonist, of quinpirole, a dopamine (da) d2 receptor agonist, and of sch 58261, an a2a adenosine antagonist, were studied on acetylcholine (ach) release in the striatum of 6-hydroxydopamine (60hda) lesioned rats and on turning behavior induced by the administration of the da d1 agonist cy 208-243. |
2001-12-13 |
2023-08-12 |
rat |
| S Fenu, E Acquas, G Di Chiar. Role of striatal acetylcholine on dopamine D1 receptor agonist-induced turning behavior in 6-hydroxydopamine lesioned rats: a microdialysis-behavioral study. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 22. issue 1. 2001-12-13. PMID:11487203. |
these results indicate that potentiation of d1-dependent turning behavior by mk-801, quinpirole and sch 58261 is not mediated by a reduced ability of d1-agonists to stimulate ach release from the denervated striatum. |
2001-12-13 |
2023-08-12 |
rat |
| B M Campbell, P D Walke. NMDA receptor antagonism modifies the synergistic regulation of striatal tachykinin gene expression induced by dopamine D(1) and serotonin(2) receptor stimulation following neonatal dopamine depletion. Brain research. Molecular brain research. vol 93. issue 1. 2001-12-07. PMID:11532342. |
injection of mk-801 (nmda antagonist; 0.1 mg/kg) administered prior to dopamine d(1) (d(1)) and serotonin(2) (5-ht(2)) receptor co-stimulation suppressed the synergistic regulation of ppt mrna expression in the dm striatum, but also produced a large increase in ppt message levels within the dl striatum (321+/-17% of lesion). |
2001-12-07 |
2023-08-12 |
rat |
| S Robinson, L Krentz, C Moore, C K Meshu. Blockade of NMDA receptors by MK-801 reverses the changes in striatal glutamate immunolabeling in 6-OHDA-lesioned rats. Synapse (New York, N.Y.). vol 42. issue 1. 2001-12-04. PMID:11668591. |
whether the effect of mk-801 is directly on the striatum or acts through other excitatory pathways of the basal ganglia remains unclear. |
2001-12-04 |
2023-08-12 |
rat |
| G Escames, M Macías, J León, J García, H Khaldy, M Martín, F Vives, D Acuña-Castroviej. Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum. Journal of neuroendocrinology. vol 13. issue 5. 2001-06-28. PMID:11328457. |
binding experiments with [3h]mk-801 in membrane preparations from rat striatum showed that melatonin did not compete with the mk-801 binding sites themselves although, in the presence of mg2+, melatonin increased the affinity of mk-801. |
2001-06-28 |
2023-08-12 |
rat |
| N Hussain, B A Flumerfelt, N Rajakuma. Glutamatergic regulation of haloperidol-induced c-fos expression in the rat striatum and nucleus accumbens. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166125. |
pretreatment with mk-801, a non-competitive antagonist of nmda receptors, significantly reduced the number of neurons showing c-fos immunoreactivity in the rostral aspect of the dorsolateral striatum and the entire rostrocaudal extent of the ventrolateral striatum following an acute injection of haloperidol. |
2001-05-03 |
2023-08-12 |
rat |
| T Araki, T Kumagai, M Matsubara, T Ido, Y Imai, Y Itoyam. Protective effect of riluzole on MPTP-induced depletion of dopamine and its metabolite content in mice. Metabolic brain disease. vol 15. issue 3. 2001-04-05. PMID:11206588. |
on the other hand, mk-801 failed to protect against mptp-induced decrease in dopamine levels in the striatum. |
2001-04-05 |
2023-08-12 |
mouse |
| M Roceri, R Molteni, F Fumagalli, G Racagni, M Gennarelli, G Corsini, R Maggio, M Riv. Stimulatory role of dopamine on fibroblast growth factor-2 expression in rat striatum. Journal of neurochemistry. vol 76. issue 4. 2001-03-22. PMID:11181818. |
however, injection of the nmda receptor antagonist mk-801 produced a significant increment of fgf-2 mrna and protein levels in rat striatum similar to the effect produced by (-)nicotine alone. |
2001-03-22 |
2023-08-12 |
rat |
| S Pogun, S Demirgoren, D Taskiran, L Kanit, O Yilmaz, E O Koylu, B Balkan, E D Londo. Nicotine modulates nitric oxide in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 6. 2001-02-08. PMID:11115736. |
while nicotine appeared to increase no indirectly via glutamate receptors in the cortex and hippocampus, this was not true of the corpus striatum, where blocking nmda-type glutamate receptors with mk-801 had no effect. |
2001-02-08 |
2023-08-12 |
rat |
| M R Hoane, S Barbay, T M Bart. Large cortical lesions produce enduring forelimb placing deficits in un-treated rats and treatment with NMDA antagonists or anti-oxidant drugs induces behavioral recovery. Brain research bulletin. vol 53. issue 2. 2000-12-07. PMID:11044594. |
anatomical analysis of the striatum showed that mk-801 and mgcl(2) but not pbn reduced the extent of lesion-induced striatal atrophy. |
2000-12-07 |
2023-08-12 |
rat |