| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Wei, G Fiskum, R E Rosenthal, D C Perr. Global cerebral ischemia and reperfusion alters NMDA receptor binding in canine brain. Molecular and chemical neuropathology. vol 30. issue 1-2. 1997-05-06. PMID:9138427. |
modest decreases in [3h]glutamate and [3h]mk-801 binding were seen in several regions of hippocampus, and parietal and temporal cortex at early times after reperfusion, with values returning toward control by 24 h. in the striatum, a different pattern was seen: [3h]glutamate and [3h]mk-801 binding increased 50-200% at 0.5-4 h after the start of reperfusion, returning toward control levels by 24 h. these increases correlate with findings of increased sensitivity to nmda-stimulated release of dopamine from striatal tissue in the same model (werling et al., 1993), and suggest that changes in tissue receptors may contribute to the selective vulnerability to ischemic damage during the first hours following reperfusion. |
1997-05-06 |
2023-08-12 |
Not clear |
| H N Bhargava, S Kuma. Modification of the binding of [3H]MK-801 to brain regions and spinal cord of rats treated chronically with U-50,488H, a kappa-opioid receptor agonist. Brain research. vol 749. issue 2. 1997-05-06. PMID:9138737. |
in tolerant rats, the binding of [3h]mk-801 was increased in pons and medulla and corpus striatum but decreased in midbrain and hippocampus and was due to changes in bmax values. |
1997-05-06 |
2023-08-12 |
rat |
| R N Auer, S G Coupland, G W Jason, D P Archer, J Payne, A J Belzberg, M Ohtaki, B I Tranme. Postischemic therapy with MK-801 (dizocilpine) in a primate model of transient focal brain ischemia. Molecular and chemical neuropathology. vol 29. issue 2-3. 1997-04-02. PMID:8971696. |
mk-801 did not reduce infarction in either neocortex (p > 0.05) or striatum (p > 0.05). |
1997-04-02 |
2023-08-12 |
monkey |
| T Takahashi, H Yamashita, Y X Zhang, S Nakamur. Inhibitory effect of MK-801 on amantadine-induced dopamine release in the rat striatum. Brain research bulletin. vol 41. issue 6. 1997-03-28. PMID:8973841. |
inhibitory effect of mk-801 on amantadine-induced dopamine release in the rat striatum. |
1997-03-28 |
2023-08-12 |
rat |
| P Pichiule, J C Chávez, J Boero, A Arregu. Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain. Neuroscience letters. vol 218. issue 2. 1997-03-14. PMID:8945733. |
this study examined [3h]mk-801 binding to the n-methyl-d-aspartate (nmda) receptor in membranes prepared from cerebral cortex, hippocampus and corpus striatum of 3 week old rats exposed to 10 weeks of intermittent hypobaric hypoxia (4300 m; 450 torr) and compared results with those of normoxic controls. |
1997-03-14 |
2023-08-12 |
rat |
| M E Gnegy, G H Hewlett, G Pimputka. Haloperidol and MK-801 block increases in striatal calmodulin resulting from repeated amphetamine treatment. Brain research. vol 734. issue 1-2. 1997-02-18. PMID:8896805. |
twice weekly amphetamine treatment increased calmodulin in the cytosol fraction of striatum and limbic forebrain and the increase was blocked by pretreatment with either haloperidol or mk-801. |
1997-02-18 |
2023-08-12 |
rat |
| J Maj, Z Rogóz, G Skuza, K Wedzon. The synergistic effect of fluoxetine on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 1-2. 1997-02-18. PMID:9026367. |
fluoxetine increased the release of dopamine (measured by a microdialysis method) in the striatum, induced by mk-801. |
1997-02-18 |
2023-08-12 |
rat |
| P Pérez, A Flores, A Santamaría, C Ríos, S Galván-Arzat. Changes in transition metal contents in rat brain regions after in vivo quinolinate intrastriatal administration. Archives of medical research. vol 27. issue 4. 1997-01-30. PMID:8987176. |
quin-induced increases in regional copper content were partially prevented in hippocampus, midbrain and striatum (17, 57, and 23% vs. control, respectively) by pretreatment of rats with an nmda receptor antagonist, dizocilpine (mk-801, 10 mg/kg, i.p. |
1997-01-30 |
2023-08-12 |
rat |
| M Klarica, D Fage, C Carte. Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord. European journal of pharmacology. vol 308. issue 2. 1997-01-15. PMID:8840124. |
in comparison with previously characterised nmda responses in the striatum, (release of dopamine, gaba, acetylcholine or spermidine) the spinal response was particularly sensitive to mk-801 and magnesium and to l-689,560 but not to other glycine receptor antagonists (7-chlorokynurenate, cnqx (6-cyano-7-nitroquinoxaline-2,3-dione), dnqx (6,7-dichloroquinoxaline-2,3-dione), (+)-ha966). |
1997-01-15 |
2023-08-12 |
rat |
| Y Ishida, I Kuwahara, K Todaka, H Hashiguchi, T Nishimori, Y Mitsuyam. Dopaminergic transplants suppress L-DOPA-induced Fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease. Brain research. vol 727. issue 1-2. 1996-12-23. PMID:8842399. |
we examined the effects of mk-801, a non-competitive antagonist of the n-methyl-d-aspartate (nmda) receptor, and fetal ventral mesencephalic (vm) transplants on l-3,4-dihydroxyphenylalanine (l-dopa)-induced fos protein expression in the dopamine (da)-depleted striatum. |
1996-12-23 |
2023-08-12 |
rat |
| D J Healy, J H Meador-Woodruf. Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801. European journal of pharmacology. vol 306. issue 1-3. 1996-12-18. PMID:8813639. |
glutamate agonists have been shown to stimulate the release of dopamine in the striatum, while the nmda receptor antagonist mk-801 has been shown to cause an increase in extracellular dopamine in the hippocampus. |
1996-12-18 |
2023-08-12 |
rat |
| H W Clement, C Grote, L Svensson, J Engel, P Zöfel, W Weseman. In vivo studies on the effects of memantine on dopamine metabolism in the striatum and n. accumbens of the rat. Journal of neural transmission. Supplementum. vol 46. 1996-12-10. PMID:8821046. |
under chloral hydrate anaesthesia the effect of memantine on extracellular dopac levels in the striatum and the n. accumbens was compared with mk-801, a well-known non-competitive nmda-antagonist. |
1996-12-10 |
2023-08-12 |
rat |
| D W Miller, E D Abercrombi. Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain research bulletin. vol 40. issue 1. 1996-11-18. PMID:8722754. |
effects of mk-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. |
1996-11-18 |
2023-08-12 |
rat |
| D W Miller, E D Abercrombi. Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain research bulletin. vol 40. issue 1. 1996-11-18. PMID:8722754. |
in vivo microdialysis was used to examine the effects of the noncompetitive nmda receptor antagonist dizocilpine maleate (mk-801) on basal and d-amphetamine (amph)-induced release of dopamine (da) in the striatum of freely moving rats. |
1996-11-18 |
2023-08-12 |
rat |
| D W Miller, E D Abercrombi. Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain research bulletin. vol 40. issue 1. 1996-11-18. PMID:8722754. |
mk-801 [0.2 or 0.5 mg/kg, intraperitoneally (ip)] significantly increased spontaneous da release in the striatum, whereas treatment with vehicle elicited no change in this variable. |
1996-11-18 |
2023-08-12 |
rat |
| D W Miller, E D Abercrombi. Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain research bulletin. vol 40. issue 1. 1996-11-18. PMID:8722754. |
pretreatment with 0.2 mg/kg mk-801 did not alter amph-induced da release in striatum. |
1996-11-18 |
2023-08-12 |
rat |
| M D Hajji, P Salin, L Kerkerian-Le Gof. Chronic dizocilpine maleate (MK-801) treatment suppresses the effects of nigrostriatal dopamine deafferentation on enkephalin but not on substance P expression in the rat striatum. The European journal of neuroscience. vol 8. issue 5. 1996-11-06. PMID:8743739. |
chronic dizocilpine maleate (mk-801) treatment suppresses the effects of nigrostriatal dopamine deafferentation on enkephalin but not on substance p expression in the rat striatum. |
1996-11-06 |
2023-08-12 |
rat |
| P H Hutson, J E Hog. Effects of and interactions between antagonists for different sites on the NMDA receptor complex on hippocampal and striatal acetylcholine efflux in vivo. European journal of pharmacology. vol 295. issue 1. 1996-10-29. PMID:8925873. |
intraperitoneal administration of the non-competitive nmda receptor antagonists (5r,10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d] cyclohepten-5,10-imine (mk-801, 0.25 and 0.5 mg/kg) and 1-(1-phenylcyclohexyl)piperidine (pcp, 5 and 10 mg/kg) increased the extracellular concentration of acetylcholine in rat hippocampus but not striatum. |
1996-10-29 |
2023-08-12 |
rat |
| P A Noailles, M Villegas, M Ledoux, L R Lucas, B S McEwen, J A Angul. Acute treatment with the N-methyl-D-aspartate receptor antagonist MK-801: effect of concurrent administration of haloperidol or scopolamine on preproenkephalin mRNA levels of the striatum and nucleus accumbens of the rat brain. Neuroscience letters. vol 202. issue 3. 1996-10-24. PMID:8848257. |
acute treatment with the n-methyl-d-aspartate receptor antagonist mk-801: effect of concurrent administration of haloperidol or scopolamine on preproenkephalin mrna levels of the striatum and nucleus accumbens of the rat brain. |
1996-10-24 |
2023-08-12 |
rat |
| K P Gudehithlu, H N Bhargav. Differential binding of [3H]MK-801 to brain regions and spinal cord of mice treated chronically with morphine. General pharmacology. vol 27. issue 1. 1996-10-10. PMID:8742501. |
the binding of [3h]mk-801 to membranes prepared from spinal cord and brain regions (cortex, pons-medulla, hypothalamus, hippocampus, amygdala, striatum, and midbrain) was determined by using a 5 nm concentration of the ligand in the presence of 30 microm glycine and 50 microm of glutamate. |
1996-10-10 |
2023-08-12 |
mouse |