| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen M Chao, Mary Ann Richardso. Aromatic amino acid hydroxylase genes and schizophrenia. American journal of medical genetics. vol 114. issue 6. 2003-02-03. PMID:12210276. |
phenylalanine hydroxylase (pah), which catalyzes the conversion of phenylalanine to tyrosine, shares physical, structural and catalytic properties with tyrosine hydroxylase (th) and tryptophan hydroxylase (tph) that catalyze the rate-limiting steps in the biosynthesis of the neurotransmitters dopamine, noradrenaline, and serotonin. |
2003-02-03 |
2023-08-12 |
human |
| Masami Nakai, Atsushi Mori, Akihito Watanabe, Yasuhide Mitsumot. 1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Experimental neurology. vol 179. issue 1. 2003-01-30. PMID:12504872. |
at this time point, tyrosine hydroxylase (th) and dopamine transporter (dat) protein levels were not altered, but both decreased at 7 days after mpp+ (40 nmol) infusion. |
2003-01-30 |
2023-08-12 |
rat |
| Chad R Borges, Timothy Geddes, J Throck Watson, Donald M Kuh. Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress. The Journal of biological chemistry. vol 277. issue 50. 2003-01-28. PMID:12376535. |
tyrosine hydroxylase (th), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter dopamine, is inhibited by the sulfhydryl oxidant diamide in a concentration-dependent manner. |
2003-01-28 |
2023-08-12 |
Not clear |
| T Antonelli, M C Tomasini, S Finetti, L Giardino, L Calzà, K Fuxe, P Soubriè, S Tanganelli, L Ferrar. Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444598. |
the role of neurotensin in modulating glutamate excitotoxicity and the possible neuroprotective action of the neurotensin receptor antagonist sr48692 were investigated in primary cultures of mesencephalic neurons by measuring [(3)h]dopamine uptake and tyrosine hydroxylase immunocytochemistry 24 hr after glutamate treatment. |
2003-01-24 |
2023-08-12 |
rat |
| Todd Freeman Roberts, William Sterling Hall, Steven Earle Braut. Organization of the avian basal forebrain: chemical anatomy in the parrot (Melopsittacus undulatus). The Journal of comparative neurology. vol 454. issue 4. 2003-01-22. PMID:12455005. |
immunological and histological stains, including choline acetyltransferase, acetylcholinesterase, tyrosine hydroxylase, dopamine and camp-regulated phosphoprotein (darpp)-32, the calcium binding proteins calbindin d-28k and parvalbumin, calcitonin gene-related peptide, iron, substance p, methionine enkephalin, nicotinamide adenine dinucleotide phosphotase diaphorase, and arginine vasotocin were used in the present study. |
2003-01-22 |
2023-08-12 |
pigeon |
| Qing-Ping Ma, Catherine Bleasdal. Modulation of brain stem monoamines and gamma-aminobutyric acid by NK1 receptors in rats. Neuroreport. vol 13. issue 14. 2003-01-15. PMID:12395129. |
in the periaqueductal gray and dorsal raphe nucleus, there was no colocalization between nk1 and 5-ht or between nk1 and tyrosine hydroxylase (a marker for adrenaline and dopamine neurons). |
2003-01-15 |
2023-08-12 |
rat |
| Waldemar Sienkiewic. Ontogeny of the expression of some catecholamine synthesising enzymes in the female porcine preoptic area. Folia histochemica et cytobiologica. vol 40. issue 2. 2003-01-09. PMID:12056663. |
nerve structures immunoreactive for the studied substances: tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah) and phenylethanoloamine-n-metylthransferase (pnmt) were observed in different periods. |
2003-01-09 |
2023-08-12 |
mouse |
| Jennifer L Tillerson, W Michael Caudle, Maria E Reverón, Gary W Mille. Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Experimental neurology. vol 178. issue 1. 2003-01-08. PMID:12460610. |
in addition, these behavioral measures are correlated to dopamine transporter, vesicular monoamine transporter, and tyrosine hydroxylase expression and are improved following l-dopa administration. |
2003-01-08 |
2023-08-12 |
mouse |
| Lidia Serova, Esther L Sabba. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438507. |
nicotine elicited a dose-dependent elevation of mrna for tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis in vta and sn. |
2002-12-24 |
2023-08-12 |
rat |
| J W Grimm, Y Shaham, B T Hop. Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats. Behavioural pharmacology. vol 13. issue 5-6. 2002-12-23. PMID:12394414. |
effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats. |
2002-12-23 |
2023-08-12 |
rat |
| J W Grimm, Y Shaham, B T Hop. Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats. Behavioural pharmacology. vol 13. issue 5-6. 2002-12-23. PMID:12394414. |
we also examined whether the time-dependent changes in cocaine seeking correlate with the levels of the dopamine transporter (dat) and tyrosine hydroxylase (th) proteins in the amygdala, nucleus accumbens, prefrontal cortex and orbitofrontal cortex. |
2002-12-23 |
2023-08-12 |
rat |
| Mimoun Azzouz, Enca Martin-Rendon, Robert D Barber, Kyriacos A Mitrophanous, Emma E Carter, Jonathan B Rohll, Susan M Kingsman, Alan J Kingsman, Nicholas D Mazaraki. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451130. |
multicistronic lentiviral vector-mediated striatal gene transfer of aromatic l-amino acid decarboxylase, tyrosine hydroxylase, and gtp cyclohydrolase i induces sustained transgene expression, dopamine production, and functional improvement in a rat model of parkinson's disease. |
2002-12-23 |
2023-08-12 |
rat |
| Jane A Foster, Patricia L Christopherson, Robert A Levin. GTP cyclohydrolase I induction in striatal astrocytes following intrastriatal kainic acid lesion. Journal of chemical neuroanatomy. vol 24. issue 3. 2002-12-20. PMID:12297263. |
gtp cyclohydrolase i (gch1) is the first and rate-limiting enzyme in the synthesis of bh(4), an essential cofactor for tyrosine hydroxylase and nitric oxide synthase in dopamine and nitric oxide production, respectively. |
2002-12-20 |
2023-08-12 |
Not clear |
| Masayuki Hasegawa, Toshinobu Sasaki, Koichi Sadakane, Masahiro Tabuchi, Yasunori Takeda, Masayuki Kimura, Yuichi Fuji. Studies for the emetic mechanisms of ipecac syrup (TJN-119) and its active components in ferrets: involvement of 5-hydroxytryptamine receptors. Japanese journal of pharmacology. vol 89. issue 2. 2002-12-19. PMID:12120752. |
3) cephaeline and emetine did not affect activities of metabolic enzymes of 5-ht and dopamine (mao-a, mao-b, tryptophan 5-hydroxylase and tyrosine hydroxylase) in vitro. |
2002-12-19 |
2023-08-12 |
Not clear |
| C A Nurse, I M Fearo. Carotid body chemoreceptors in dissociated cell culture. Microscopy research and technique. vol 59. issue 3. 2002-12-10. PMID:12384969. |
in the rat, type 1 cells are immunopositive for several monoaminergic markers, including tyrosine hydroxylase (th), dopamine transporter (dat), and 5-ht. |
2002-12-10 |
2023-08-12 |
rat |
| Pier Andrea Serra, Luigi Sciola, Maria Rosaria Delogu, Alessandra Spano, Gianni Monaco, Egidio Miele, Gaia Rocchitta, Maddalena Miele, Rossana Migheli, Maria Speranza Desol. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes. The Journal of biological chemistry. vol 277. issue 37. 2002-12-03. PMID:12084711. |
decreases in striatal tyrosine hydroxylase activity and levels of dopamine and its metabolites were observed 1 day after mptp discontinuance. |
2002-12-03 |
2023-08-12 |
mouse |
| Yu Mi Kim, Jae Joon Lee, Shou Yu Yin, Youngsoo Kim, Jong Kil Lee, Yeo Pyo Yoon, Min Hee Kang, Myung Koo Le. Inhibitory effects of tributyltin on dopamine biosynthesis in rat PC12 cells. Neuroscience letters. vol 332. issue 1. 2002-11-27. PMID:12377373. |
the decreased dopamine level was maintained for up to 48 h. under these conditions, tyrosine hydroxylase (th) activity was inhibited at 6 h following the treatment with tbtc and the activity was maintained at a reduced level for up to 48 h (20-35% inhibition at 0.5 microm of tbtc). |
2002-11-27 |
2023-08-12 |
rat |
| Jing Yu, Jean Lud Cadet, Jesus A Angul. Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. Journal of neurochemistry. vol 83. issue 3. 2002-11-26. PMID:12390523. |
administration of nk-1 receptor antagonist prevented the loss of dopamine transporters assessed by autoradiography and western blotting, the loss of tissue dopamine assessed by high-pressure liquid chromatography, and the loss of tyrosine hydroxylase, as well as the induction of glial fibrillary acidic protein determined by western blotting. |
2002-11-26 |
2023-08-12 |
mouse |
| Biljana Georgievska, Deniz Kirik, Anders Björklun. Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. Experimental neurology. vol 177. issue 2. 2002-11-26. PMID:12429192. |
aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. |
2002-11-26 |
2023-08-12 |
rat |
| Zhizhong Dong, Boris Ferger, Joram Feldon, Hansruedi Büele. Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP. Journal of neurobiology. vol 53. issue 1. 2002-11-19. PMID:12360578. |
determination of dopaminergic neuron survival, striatal tyrosine hydroxylase fiber density, and striatal content of dopamine and its metabolites in raav-injected and uninjected hemispheres demonstrated that alpha-synuclein(a53t) does not increase the susceptibility of dopaminergic neurons to mptp. |
2002-11-19 |
2023-08-12 |
mouse |