| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle Yuri Arita, Giovana Seno Di Marco, Nestor Schor, Dulce Elena Casarin. Purification and characterization of the active form of tyrosine hydroxylase from mesangial cells in culture. Journal of cellular biochemistry. vol 87. issue 1. 2003-04-15. PMID:12210722. |
tyrosine hydroxylase (th) catalyzes the rate-limiting step in the biosynthesis of these biogenic amines (dopamine (da), norepinephrine (ne), and epinephrine (epi)). |
2003-04-15 |
2023-08-12 |
mouse |
| Anne Nosjean, Michel Hamon, Michèle Darmo. 5-HT2A receptors are expressed by catecholaminergic neurons in the rat nucleus tractus solitarii. Neuroreport. vol 13. issue 17. 2003-04-15. PMID:12488828. |
tyrosine hydroxylase, dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyltransferase, we investigated whether 5-ht effects could be mediated by 5-ht2a receptors located on ca perikarya and/or processes within the nts. |
2003-04-15 |
2023-08-12 |
rat |
| M J Acerbo, B Hellmann, O Güntürkü. Catecholaminergic and dopamine-containing neurons in the spinal cord of pigeons: an immunohistochemical study. Journal of chemical neuroanatomy. vol 25. issue 1. 2003-04-10. PMID:12573456. |
therefore, we examined the distribution of dopamine (da)- and tyrosine hydroxylase (th)-positive cells and fibers in the spinal cord of the adult pigeon by immunohistochemistry. |
2003-04-10 |
2023-08-12 |
pigeon |
| S Remzi Erdem, Christopher S Broxson, Aysen Erdem, David S Spar, Raquel T Williams, Nihal Tüme. The age-related discrepancy in the effect of neuropeptide Y on select catecholamine biosynthetic enzymes in the adrenal medulla and hypothalamus in rats. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527477. |
the elevated levels of circulating catecholamines (cas) with age may be related to the increased expression of ca biosynthetic enzymes, tyrosine hydroxylase (th) and dopamine beta hydroxylase (dbetah) in the adrenal medulla of senescent compared with younger animals. |
2003-03-28 |
2023-08-12 |
rat |
| Carl Rosenblad, Biljana Georgievska, Deniz Kiri. Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system. The European journal of neuroscience. vol 17. issue 2. 2003-03-28. PMID:12542662. |
taken together our findings indicate that sustained gdnf administration to intact nigrostriatal dopamine neurons selectively reduces tyrosine hydroxylase expression, without altering striatal dopamine transmission to the extent that compensatory changes in several other components related to dopamine storage and signalling occur. |
2003-03-28 |
2023-08-12 |
rat |
| Teresa Gomez-Isla, Michael C Irizarry, Ami Mariash, Bonnie Cheung, Oscar Soto, Stefanie Schrump, Jesse Sondel, Linda Kotilinek, John Day, Michael A Schwarzschild, Jang-Ho J Cha, Kathy Newell, David W Miller, Kenji Uéda, Anne B Young, Bradley T Hyman, Karen H Ash. Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice. Neurobiology of aging. vol 24. issue 2. 2003-03-26. PMID:12498958. |
despite strong expression of the transgene in the nigra, there was no specific deterioration of the nigrostriatal dopaminergic system as assessed by quantitation of nigral tyrosine hydroxylase (th) containing neurons, striatal th immunoreactivity, dopamine levels, or dopamine receptor number and function. |
2003-03-26 |
2023-08-12 |
mouse |
| Scott W Brown, Randall T Meyers, Karen M Brennan, Julie M Rumble, Nedathur Narasimhachari, Edmund F Perozzi, John J Ryan, Jennifer K Stewart, Krista Fischer-Stenge. Catecholamines in a macrophage cell line. Journal of neuroimmunology. vol 135. issue 1-2. 2003-03-20. PMID:12576223. |
although catecholamines were low in unstimulated cells, activation with lipopolysaccharide (lps) induced tyrosine hydroxylase (th) mrna and increased extracellular norepinephrine and intracellular dopamine within 48 h. the catecholamine synthesis inhibitor alpha-methyl-para-tyrosine (alpha-mpt) decreased extracellular norepinephrine levels, suggesting release and rapid turnover of newly synthesized norepinephrine. |
2003-03-20 |
2023-08-12 |
Not clear |
| Ann Jane Tierney, Taylor Kim, Reilly Abram. Dopamine in crayfish and other crustaceans: distribution in the central nervous system and physiological functions. Microscopy research and technique. vol 60. issue 3. 2003-03-19. PMID:12539162. |
the distribution of tyrosine hydroxylase (an enzyme in the synthetic pathway between tyrosine and dopamine) in o. rusticus is similar to that reported for marine species. |
2003-03-19 |
2023-08-12 |
Not clear |
| R J Grant, P B S Clark. Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453497. |
in addition, autoradiographic labeling of tyrosine hydroxylase protein and dopamine transporter was quantified in dopamine terminal fields and cell body areas. |
2003-03-12 |
2023-08-12 |
rat |
| K Sriram, S A Benkovic, D B Miller, J P O'Callagha. Obesity exacerbates chemically induced neurodegeneration. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453501. |
while meth caused dopaminergic nerve terminal degeneration as indicated by decreased striatal dopamine (49%) and tyrosine hydroxylase protein (68%), as well as an increase in glial fibrillary acidic protein by 313% in the lean mice, these effects were exacerbated under the obese condition (96%, 86% and 602%, respectively). |
2003-03-12 |
2023-08-12 |
mouse |
| Myreille D'Astous, Marc Morissette, Bastien Tanguay, Sophie Callier, Thérèse Di Paol. Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422368. |
furthermore, in the substantia nigra dhea and 17beta-estradiol prevented the mptp-induced dopamine transporter and tyrosine hydroxylase mrna decreases measured by in situ hybridization. |
2003-03-07 |
2023-08-12 |
mouse |
| Cristina Sánchez-Camacho, Juan J Peña, Agustín Gonzále. Catecholaminergic innervation of the septum in the frog: a combined immunohistochemical and tract-tracing study. The Journal of comparative neurology. vol 455. issue 3. 2003-03-06. PMID:12483684. |
immunohistochemistry for dopamine and two enzymes required for the synthesis of catecholamines, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) revealed a complex pattern of catecholaminergic (ca) innervation in the anuran septum. |
2003-03-06 |
2023-08-12 |
Not clear |
| Michael J Zigmond, Teresa G Hastings, Ruth G Pere. Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity? Parkinsonism & related disorders. vol 8. issue 6. 2003-03-05. PMID:12217625. |
first, we discuss our use of 6-ohda to produce an animal model of pd; second, we comment on our studies on dopamine's neurotoxic effects; and finally, we discuss our finding that tyrosine hydroxylase is regulated in part by an interaction with alpha-synuclein. |
2003-03-05 |
2023-08-12 |
Not clear |
| Sangmi Chung, Kai-C Sonntag, Therese Andersson, Lars M Bjorklund, Jae-Joon Park, Dong-Wook Kim, Un Jung Kang, Ole Isacson, Kwang-Soo Ki. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. The European journal of neuroscience. vol 16. issue 10. 2003-03-05. PMID:12453046. |
several lines of evidence suggest that these neurons may represent midbrain da neuronal phenotypes; firstly, they coexpress midbrain da markers such as aromatic l-amino acid decarboxylase, calretinin, and dopamine transporter, in addition to tyrosine hydroxylase and secondly, they do not coexpress other neurotransmitters such as gaba or serotonin. |
2003-03-05 |
2023-08-12 |
mouse |
| P Muglia, A Petronis, E Mundo, S Lander, T Cate, J L Kenned. Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4. Molecular psychiatry. vol 7. issue 8. 2003-02-25. PMID:12232779. |
dopamine d4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of drd4. |
2003-02-25 |
2023-08-12 |
Not clear |
| P Muglia, A Petronis, E Mundo, S Lander, T Cate, J L Kenned. Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4. Molecular psychiatry. vol 7. issue 8. 2003-02-25. PMID:12232779. |
in particular, the functional vntrs in the exon iii of the dopamine d4 (drd4) and in intron i of the tyrosine hydroxylase (th) genes have been investigated in numerous association studies that have produced contrasting results. |
2003-02-25 |
2023-08-12 |
Not clear |
| Maria J Martí, Josep Saura, Robert E Burke, Vernice Jackson-Lewis, Anna Jiménez, Mercé Bonastre, Eduard Tolos. Striatal 6-hydroxydopamine induces apoptosis of nigral neurons in the adult rat. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468044. |
6-hydroxydopamine infused in the striatum of adult rats induced progressive loss of dopamine neurons, identified as tyrosine hydroxylase immunoreactive profiles, in the ipsilateral substantia nigra starting at day 5 post-lesion (32%). |
2003-02-25 |
2023-08-12 |
rat |
| Masayuki Hanaoka, Yunden Droma, Junichi Hotta, Yukinori Matsuzawa, Toshio Kobayashi, Keishi Kubo, Masao Ot. Polymorphisms of the tyrosine hydroxylase gene in subjects susceptible to high-altitude pulmonary edema. Chest. vol 123. issue 1. 2003-02-25. PMID:12527603. |
tyrosine hydroxylase (th) is a rate-limiting enzyme in the carotid body responding to hypoxia to synthesize dopamine neurotransmitter to heighten ventilation. |
2003-02-25 |
2023-08-12 |
human |
| Masashi Ikeda, Tsuyoshi Kitajima, Nakao Iwata, Norio Ozak. [Molecular genetics of mood disorders]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 22. issue 5. 2003-02-20. PMID:12451683. |
most association studies have until now focused on the neurotransmitter system as a candidate molecule including serotonin transporter, serotonin receptors, dopamine receptors, tyrosine hydroxylase, mao-a, comt, and tryptophan hydroxylase. |
2003-02-20 |
2023-08-12 |
human |
| Cristina Sánchez-Camacho, Oscar Marín, Agustín Gonzále. Distribution and origin of the catecholaminergic innervation in the amphibian mesencephalic tectum. Visual neuroscience. vol 19. issue 3. 2003-02-04. PMID:12392181. |
immunohistochemistry for dopamine and two enzymes required for the synthesis of catecholamines, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh), revealed a complex pattern of catecholaminergic (ca) innervation in the anuran and urodele mesencephalic tectum. |
2003-02-04 |
2023-08-12 |
Not clear |