| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Metzger, S Jiang, K Brau. A quantitative immuno-electron microscopic study of dopamine terminals in forebrain regions of the domestic chick involved in filial imprinting. Neuroscience. vol 111. issue 3. 2002-08-22. PMID:12031348. |
to better understand the functional role of dopamine in these forebrain regions, the ultrastructure of dopamine terminals was studied by serial section electron microscopy using immunohistochemical labeling with antibodies to tyrosine hydroxylase and dopamine. |
2002-08-22 |
2023-08-12 |
chicken |
| Fátima Adrio, Ramón Anadón, Isabel Rodríguez-Molde. Distribution of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) immunoreactivity in the central nervous system of two chondrostean fishes (Acipenser baeri and Huso huso). The Journal of comparative neurology. vol 448. issue 3. 2002-08-21. PMID:12115709. |
distribution of tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) immunoreactivity in the central nervous system of two chondrostean fishes (acipenser baeri and huso huso). |
2002-08-21 |
2023-08-12 |
Not clear |
| M V Ugryumov, V I Mel'nikova, P V Ershov, I S Balan, A Kala. Non-dopaminergic neurons expressing dopamine synthesis enzymes: differentiation and functional significance. Neuroscience and behavioral physiology. vol 32. issue 3. 2002-08-19. PMID:12135344. |
thus, dopamine is probably synthesized in the arcuate nucleus not only by dopaminergic neurons, but also by neurons expressing only tyrosine hydroxylase or aromatic l-amino acid decarboxylase. |
2002-08-19 |
2023-08-12 |
rat |
| L Nagy, L Hirip. Role of tyrosine, DOPA and decarboxylase enzymes in the synthesis of monoamines in the brain of the locust. Neurochemistry international. vol 41. issue 1. 2002-08-13. PMID:11918967. |
our results suggest that no tyrosine hydroxylase is present in the locust cns and the dopa uptake into the ganglia by a high affinity uptake process as well as the dopa decarboxylase enzyme may be responsible for the regulation of the ganglionic dopamine (da) level. |
2002-08-13 |
2023-08-12 |
Not clear |
| Yossef Itzhak, Syed F Al. Behavioral consequences of methamphetamine-induced neurotoxicity in mice: relevance to the psychopathology of methamphetamine addiction. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105090. |
a high dose of meth given to mice and rats causes long-lasting depletion of tyrosine hydroxylase activity, dopamine (da), and da-transporter (dat) binding sites in the striatum. |
2002-08-02 |
2023-08-12 |
mouse |
| Yoshiaki Furukawa, Gregory Kapatos, John W Haycock, Julian Worsley, Henry Wong, Stephen J Kish, Torbjoern G Nygaar. Brain biopterin and tyrosine hydroxylase in asymptomatic dopa-responsive dystonia. Annals of neurology. vol 51. issue 5. 2002-07-31. PMID:12112113. |
however, tyrosine hydroxylase protein and dopamine levels (-52 and -44%, respectively) were not as severely affected as in symptomatic patients (exceeding -97 and -88%, respectively). |
2002-07-31 |
2023-08-12 |
Not clear |
| Anne Philippe, Michel Guilloud-Bataille, Maria Martinez, Christopher Gillberg, Maria Råstam, Eili Sponheim, Mary Coleman, Michele Zappella, Harald Aschauer, Christiane Penet, Josué Feingold, Alexis Brice, Marion Leboye. Analysis of ten candidate genes in autism by association and linkage. American journal of medical genetics. vol 114. issue 2. 2002-07-19. PMID:11857571. |
we studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors d2 and d5, monoamine oxidases a and b (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). |
2002-07-19 |
2023-08-12 |
Not clear |
| C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
we discovered that 5-ht(2a) receptor-like immunoreactivity colocalized with tyrosine hydroxylase, a marker for dopamine neurons, throughout the a10 dopamine cell population. |
2002-07-18 |
2023-08-12 |
rat |
| C Nocjar, B L Roth, E A Pehe. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience. vol 111. issue 1. 2002-07-18. PMID:11955720. |
the linear raphe a10 dopamine subdivisions also displayed a low degree of 5-ht(2a) receptor and tyrosine hydroxylase colocalization. |
2002-07-18 |
2023-08-12 |
rat |
| Den'etsu Sutoo, Kayo Akiyama, Kazunori Yab. Comparison analysis of distributions of tyrosine hydroxylase, calmodulin and calcium/calmodulin-dependent protein kinase II in a triple stained slice of rat brain. Brain research. vol 933. issue 1. 2002-07-16. PMID:11929630. |
the immunohistochemical distributions of tyrosine hydroxylase (th), calmodulin (cam) and calcium/cam-dependent protein kinase ii (camkii) in the rat forebrain were compared quantitatively to confirm our previous finding that th activity and dopamine synthesis in the brain are regulated by a calcium/cam-dependent system. |
2002-07-16 |
2023-08-12 |
rat |
| Donald M Kuhn, Timothy J Gedde. Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxynitrite. Brain research. vol 933. issue 1. 2002-07-16. PMID:11929639. |
tyrosine hydroxylase (th) is the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter dopamine (da). |
2002-07-16 |
2023-08-12 |
Not clear |
| Stephane Palfi, Liza Leventhal, Yaping Chu, Shuang Y Ma, Marina Emborg, Roy Bakay, Nicole Déglon, Philippe Hantraye, Patrick Aebischer, Jeffrey H Kordowe. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 12. 2002-07-15. PMID:12077191. |
the primate striatum contains tyrosine hydroxylase (th)-immunoreactive (ir) neurons, the numbers of which are augmented after dopamine depletion. |
2002-07-15 |
2023-08-12 |
monkey |
| Masashi Kitazawa, Jarrad R Wagner, Michael L Kirby, Vellareddy Anantharam, Anumantha G Kanthasam. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. The Journal of pharmacology and experimental therapeutics. vol 302. issue 1. 2002-07-12. PMID:12065696. |
predepletion of dopamine by using alpha-methyl-p-tyrosine (tyrosine hydroxylase inhibitor) treatment partially prevented caspase-3 activation, denoting a significant dopamine and/or dopamine by-product contribution to initiation of apoptosis. |
2002-07-12 |
2023-08-12 |
Not clear |
| G Battaglia, C L Busceti, L Cuomo, F S Giorgi, F Orzi, A De Blasi, F Nicoletti, S Ruggieri, F Forna. Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice. Neuropharmacology. vol 42. issue 3. 2002-06-27. PMID:11897115. |
similarly, striatal immunoreactivity for tyrosine hydroxylase and dopamine transporter was markedly reduced at this time interval. |
2002-06-27 |
2023-08-12 |
mouse |
| Takahiro Suzuki, Hidehito Inagaki, Tohru Yamakuni, Toshiharu Nagatsu, Hiroshi Ichinos. Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. Biochemical and biophysical research communications. vol 293. issue 3. 2002-06-27. PMID:12051753. |
three of the catecholamine-synthesizing enzymes, i.e., tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase, and dopamine beta-hydroxylase, were earlier shown to be up-regulated in cloned pc12d cells overexpressing v-1, a cdc10/swi6 motif-containing protein. |
2002-06-27 |
2023-08-12 |
human |
| Martina Ballmaier, Michele Zoli, Giuseppina Leo, Luigi Francesco Agnati, PierFranco Span. Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia. The European journal of neuroscience. vol 15. issue 7. 2002-06-21. PMID:11982630. |
we report that heterozygous reeler mice exhibit a reduction in the number of tyrosine hydroxylase-immunoreactive cell bodies and tyrosine hydroxylase mrna levels in the ventral tegmental area, as well as a reduction of tyrosine hydroxylase and dopamine transporter immunoreactivity in the dopamine terminal fields of the limbic striatum. |
2002-06-21 |
2023-08-12 |
mouse |
| Christelle Gouhier, Sylvie Chalon, Anne Aubert-Pouessel, Marie-Claire Venier-Julienne, Christophe Jollivet, Jean-Pierre Benoit, Denis Guillotea. Protection of dopaminergic nigrostriatal afferents by GDNF delivered by microspheres in a rodent model of Parkinson's disease. Synapse (New York, N.Y.). vol 44. issue 3. 2002-06-20. PMID:11954043. |
the effects of gdnf released from microspheres were assessed by classical methods such as amphetamine-induced rotating behavior and tyrosine hydroxylase (th) immunoreactivity, as well as by quantitative autoradiography using pe2i, a dopamine transporter (dat) radiotracer, which is also suitable for spet imaging in humans. |
2002-06-20 |
2023-08-12 |
rat |
| O Bandmann, N W Woo. Dopa-responsive dystonia -- the story so far. Neuropediatrics. vol 33. issue 1. 2002-06-12. PMID:11930268. |
bh4 is an essential co-factor for tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of dopamine. |
2002-06-12 |
2023-08-12 |
Not clear |
| Donald M Kuhn, Mahdieh Sadidi, Xiuli Liu, Christian Kreipke, Timothy Geddes, Chad Borges, J Throck Watso. Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11834745. |
tyrosine hydroxylase (th), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter dopamine, is inactivated by peroxynitrite. |
2002-06-07 |
2023-08-12 |
Not clear |
| Mary J Eaton, Jean-Paul Herman, Nicolas Jullien, Tomas L Lopez, Miguel Martinez, Jian Huan. Immortalized chromaffin cells disimmortalized with Cre/lox site-directed recombination for use in cell therapy for pain after partial nerve injury. Experimental neurology. vol 175. issue 1. 2002-05-23. PMID:12009759. |
these immortalized loxtstag/crepr1/rad cells expressed immunoreactivities (ir) for all the catecholamine enzymes: tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah), and phenylethanolamine-n-methyltransferase (pnmt). |
2002-05-23 |
2023-08-12 |
rat |